E2F1 Transcription Factor

"E2F1 Transcription Factor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

An E2F transcription factor that interacts directly with RETINOBLASTOMA PROTEIN and CYCLIN A and activates GENETIC TRANSCRIPTION required for CELL CYCLE entry and DNA synthesis. E2F1 is involved in DNA REPAIR and APOPTOSIS.

Descriptor ID	D050687
MeSH Number(s)	D12.644.360.024.328.049 D12.776.157.057.158.049 D12.776.476.024.420.049 D12.776.660.769.049 D12.776.930.211.500
Concept/Terms	E2F1 Transcription Factor E2F1 Transcription Factor Transcription Factor, E2F1 Transcription Factor E2F-1 Transcription Factor E2F 1 E2F Transcription Factor 1 Protein Retinoblastoma-Associated Protein 1 Retinoblastoma Associated Protein 1 Retinoblastoma Binding Protein 3 E2F-1 Transcription Factor Transcription Factor, E2F-1 Transcription Factor E2F1

Below are MeSH descriptors whose meaning is more general than "E2F1 Transcription Factor".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intracellular Signaling Peptides and Proteins [D12.644.360]
Adaptor Proteins, Signal Transducing [D12.644.360.024]
Retinoblastoma Binding Proteins [D12.644.360.024.328]
E2F1 Transcription Factor [D12.644.360.024.328.049]
Proteins [D12.776]
Carrier Proteins [D12.776.157]
Adaptor Proteins, Signal Transducing [D12.776.157.057]
Retinoblastoma Binding Proteins [D12.776.157.057.158]
E2F1 Transcription Factor [D12.776.157.057.158.049]
Intracellular Signaling Peptides and Proteins [D12.776.476]
Adaptor Proteins, Signal Transducing [D12.776.476.024]
Retinoblastoma Binding Proteins [D12.776.476.024.420]
E2F1 Transcription Factor [D12.776.476.024.420.049]
Nuclear Proteins [D12.776.660]
Retinoblastoma Binding Proteins [D12.776.660.769]
E2F1 Transcription Factor [D12.776.660.769.049]
Transcription Factors [D12.776.930]
E2F Transcription Factors [D12.776.930.211]
E2F1 Transcription Factor [D12.776.930.211.500]

Below are MeSH descriptors whose meaning is related to "E2F1 Transcription Factor".

Below are MeSH descriptors whose meaning is more specific than "E2F1 Transcription Factor".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "E2F1 Transcription Factor" by people in this website by year, and whether "E2F1 Transcription Factor" was a major or minor topic of these publications.

Bar chart showing 14 publications over 12 distinct years, with a maximum of 2 publications in 2004 and 2006

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1998	0	1	1
2002	0	1	1
2003	0	1	1
2004	1	1	2
2006	2	0	2
2008	1	0	1
2011	1	0	1
2015	1	0	1
2016	1	0	1
2017	1	0	1
2019	0	1	1
2022	1	0	1

Below are the most recent publications written about "E2F1 Transcription Factor" by people in Profiles.

Han W, Liu M, Han D, Li M, Toure AA, Wang Z, Besschetnova A, Patalano S, Macoska JA, Gao S, He HH, Cai C. RB1 loss in castration-resistant prostate cancer confers vulnerability to LSD1 inhibition. Oncogene. 2022 Feb; 41(6):852-864.

View in: PubMed
Han D, Chen S, Han W, Gao S, Owiredu JN, Li M, Balk SP, He HH, Cai C. ZBTB7A Mediates the Transcriptional Repression Activity of the Androgen Receptor in Prostate Cancer. Cancer Res. 2019 10 15; 79(20):5260-5271.

View in: PubMed
Shats I, Deng M, Davidovich A, Zhang C, Kwon JS, Manandhar D, Gord?n R, Yao G, You L. Expression level is a key determinant of E2F1-mediated cell fate. Cell Death Differ. 2017 04; 24(4):626-637.

View in: PubMed
Ghari F, Quirke AM, Munro S, Kawalkowska J, Picaud S, McGouran J, Subramanian V, Muth A, Williams R, Kessler B, Thompson PR, Fillipakopoulos P, Knapp S, Venables PJ, La Thangue NB. Citrullination-acetylation interplay guides E2F-1 activity during the inflammatory response. Sci Adv. 2016 Feb; 2(2):e1501257.

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Wang B, Ma A, Zhang L, Jin WL, Qian Y, Xu G, Qiu B, Yang Z, Liu Y, Xia Q, Liu Y. POH1 deubiquitylates and stabilizes E2F1 to promote tumour formation. Nat Commun. 2015 Oct 29; 6:8704.

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Zhang W, Chen H, Chen Y, Liu J, Wang X, Yu X, Chen JJ, Zhao W. Cancerous inhibitor of protein phosphatase 2A contributes to human papillomavirus oncoprotein E7-induced cell proliferation via E2F1. Oncotarget. 2015 Mar 10; 6(7):5253-62.

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E X, Pickering MT, Debatis M, Castillo J, Lagadinos A, Wang S, Lu S, Kowalik TF. An E2F1-mediated DNA damage response contributes to the replication of human cytomegalovirus. PLoS Pathog. 2011 May; 7(5):e1001342.

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Pickering MT, Stadler BM, Kowalik TF. miR-17 and miR-20a temper an E2F1-induced G1 checkpoint to regulate cell cycle progression. Oncogene. 2009 Jan 08; 28(1):140-5.

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Choi JK, Murillo G, Su BN, Pezzuto JM, Kinghorn AD, Mehta RG. Ixocarpalactone A isolated from the Mexican tomatillo shows potent antiproliferative and apoptotic activity in colon cancer cells. FEBS J. 2006 Dec; 273(24):5714-23.

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Pickering MT, Kowalik TF. Rb inactivation leads to E2F1-mediated DNA double-strand break accumulation. Oncogene. 2006 Feb 02; 25(5):746-55.

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