Granulocyte-Macrophage Colony-Stimulating Factor

"Granulocyte-Macrophage Colony-Stimulating Factor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

An acidic glycoprotein of MW 23 kDa with internal disulfide bonds. The protein is produced in response to a number of inflammatory mediators by mesenchymal cells present in the hemopoietic environment and at peripheral sites of inflammation. GM-CSF is able to stimulate the production of neutrophilic granulocytes, macrophages, and mixed granulocyte-macrophage colonies from bone marrow cells and can stimulate the formation of eosinophil colonies from fetal liver progenitor cells. GM-CSF can also stimulate some functional activities in mature granulocytes and macrophages.

Descriptor ID	D016178
MeSH Number(s)	D12.644.276.374.410.240.375 D12.776.395.240.300 D12.776.467.374.410.240.375 D23.529.374.410.240.375
Concept/Terms	Granulocyte-Macrophage Colony-Stimulating Factor Granulocyte-Macrophage Colony-Stimulating Factor Granulocyte Macrophage Colony Stimulating Factor CSF-2 Tumor-Cell Human GM Colony-Stimulating Factor Tumor Cell Human GM Colony Stimulating Factor GM-CSF Histamine-Producing Cell-Stimulating Factor Cell-Stimulating Factor, Histamine-Producing Histamine Producing Cell Stimulating Factor TC-GM-CSF Colony-Stimulating Factor, Granulocyte-Macrophage Colony Stimulating Factor, Granulocyte Macrophage CSF-GM

Below are MeSH descriptors whose meaning is more general than "Granulocyte-Macrophage Colony-Stimulating Factor".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intercellular Signaling Peptides and Proteins [D12.644.276]
Cytokines [D12.644.276.374]
Hematopoietic Cell Growth Factors [D12.644.276.374.410]
Colony-Stimulating Factors [D12.644.276.374.410.240]
Granulocyte-Macrophage Colony-Stimulating Factor [D12.644.276.374.410.240.375]
Proteins [D12.776]
Glycoproteins [D12.776.395]
Colony-Stimulating Factors [D12.776.395.240]
Granulocyte-Macrophage Colony-Stimulating Factor [D12.776.395.240.300]
Intercellular Signaling Peptides and Proteins [D12.776.467]
Cytokines [D12.776.467.374]
Hematopoietic Cell Growth Factors [D12.776.467.374.410]
Colony-Stimulating Factors [D12.776.467.374.410.240]
Granulocyte-Macrophage Colony-Stimulating Factor [D12.776.467.374.410.240.375]
Biological Factors [D23]
Intercellular Signaling Peptides and Proteins [D23.529]
Cytokines [D23.529.374]
Hematopoietic Cell Growth Factors [D23.529.374.410]
Colony-Stimulating Factors [D23.529.374.410.240]
Granulocyte-Macrophage Colony-Stimulating Factor [D23.529.374.410.240.375]

Below are MeSH descriptors whose meaning is related to "Granulocyte-Macrophage Colony-Stimulating Factor".

Below are MeSH descriptors whose meaning is more specific than "Granulocyte-Macrophage Colony-Stimulating Factor".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Granulocyte-Macrophage Colony-Stimulating Factor" by people in this website by year, and whether "Granulocyte-Macrophage Colony-Stimulating Factor" was a major or minor topic of these publications.

Bar chart showing 50 publications over 27 distinct years, with a maximum of 4 publications in 2014

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1992	1	0	1
1993	0	2	2
1994	1	0	1
1995	2	0	2
1996	1	2	3
1997	1	1	2
1998	3	0	3
1999	3	0	3
2000	0	2	2
2001	0	2	2
2002	2	1	3
2003	1	1	2
2005	0	2	2
2006	0	1	1
2007	1	0	1
2008	0	1	1
2009	0	1	1
2010	0	1	1
2012	2	0	2
2013	1	0	1
2014	1	3	4
2015	0	2	2
2016	2	1	3
2017	1	1	2
2020	1	0	1
2021	1	0	1
2022	0	1	1

Below are the most recent publications written about "Granulocyte-Macrophage Colony-Stimulating Factor" by people in Profiles.

Li Y, Qi X, Zhao D, Urban JF, Huang H. IL-3 Expands Pre-Basophil and Mast Cell Progenitors by Upregulating the IL-3 Receptor Expression. Cell Immunol. 2022 Apr; 374:104498.

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Zhao Y, Kilian C, Turner JE, Bosurgi L, Roedl K, Bartsch P, Gnirck AC, Cortesi F, Schultheiß C, Hellmig M, Enk LUB, Hausmann F, Borchers A, Wong MN, Paust HJ, Siracusa F, Scheibel N, Herrmann M, Rosati E, Bacher P, Kylies D, Jarczak D, Lütgehetmann M, Pfefferle S, Steurer S, Zur-Wiesch JS, Puelles VG, Sperhake JP, Addo MM, Lohse AW, Binder M, Huber S, Huber TB, Kluge S, Bonn S, Panzer U, Gagliani N, Krebs CF. Clonal expansion and activation of tissue-resident memory-like Th17 cells expressing GM-CSF in the lungs of severe COVID-19 patients. Sci Immunol. 2021 02 23; 6(56).

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Jarjour NN, Bradstreet TR, Schwarzkopf EA, Cook ME, Lai CW, Huang SC, Taneja R, Stappenbeck TS, Van Dyken SJ, Urban JF, Edelson BT. BHLHE40 Promotes TH2 Cell-Mediated Antihelminth Immunity and Reveals Cooperative CSF2RB Family Cytokines. J Immunol. 2020 02 15; 204(4):923-932.

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Sander J, Schmidt SV, Cirovic B, McGovern N, Papantonopoulou O, Hardt AL, Aschenbrenner AC, Kreer C, Quast T, Xu AM, Schmidleithner LM, Theis H, Thi Huong LD, Sumatoh HRB, Lauterbach MAR, Schulte-Schrepping J, Günther P, Xue J, Baßler K, Ulas T, Klee K, Katzmarski N, Herresthal S, Krebs W, Martin B, Latz E, Händler K, Kraut M, Kolanus W, Beyer M, Falk CS, Wiegmann B, Burgdorf S, Melosh NA, Newell EW, Ginhoux F, Schlitzer A, Schultze JL. Cellular Differentiation of Human Monocytes Is Regulated by Time-Dependent Interleukin-4 Signaling and the Transcriptional Regulator NCOR2. Immunity. 2017 12 19; 47(6):1051-1066.e12.

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Rothchild AC, Stowell B, Goyal G, Nunes-Alves C, Yang Q, Papavinasasundaram K, Sassetti CM, Dranoff G, Chen X, Lee J, Behar SM. Role of Granulocyte-Macrophage Colony-Stimulating Factor Production by T Cells during Mycobacterium tuberculosis Infection. mBio. 2017 10 24; 8(5).

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Tavakoli S, Short JD, Downs K, Nguyen HN, Lai Y, Zhang W, Jerabek P, Goins B, Sadeghi MM, Asmis R. Differential Regulation of Macrophage Glucose Metabolism by Macrophage Colony-stimulating Factor and Granulocyte-Macrophage Colony-stimulating Factor: Implications for 18F FDG PET Imaging of Vessel Wall Inflammation. Radiology. 2017 04; 283(1):87-97.

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Jangalwe S, Shultz LD, Mathew A, Brehm MA. Improved B cell development in humanized NOD-scid IL2R?null mice transgenically expressing human stem cell factor, granulocyte-macrophage colony-stimulating factor and interleukin-3. Immun Inflamm Dis. 2016 12; 4(4):427-440.

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Ronchi F, Basso C, Preite S, Reboldi A, Baumjohann D, Perlini L, Lanzavecchia A, Sallusto F. Experimental priming of encephalitogenic Th1/Th17 cells requires pertussis toxin-driven IL-1? production by myeloid cells. Nat Commun. 2016 05 18; 7:11541.

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Zhang L, Agarwal S, Shohet JM, Zage PE. CD114 Expression Mediates Melanoma Tumor Cell Growth and Treatment Resistance. Anticancer Res. 2015 Jul; 35(7):3787-92.

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Nobles C, Bertone-Johnson ER, Ronnenberg AG, Faraj JM, Zagarins S, Takashima-Uebelhoer BB, Whitcomb BW. Correlation of urine and plasma cytokine levels among reproductive-aged women. Eur J Clin Invest. 2015 May; 45(5):460-5.

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