Thrombopoietin

"Thrombopoietin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A humoral factor that stimulates the production of thrombocytes (BLOOD PLATELETS). Thrombopoietin stimulates the proliferation of bone marrow MEGAKARYOCYTES and their release of blood platelets. The process is called THROMBOPOIESIS.

Descriptor ID	D013926
MeSH Number(s)	D12.644.276.374.410.240.750 D12.776.395.240.750 D12.776.467.374.410.240.750 D23.529.374.410.240.750
Concept/Terms	Thrombopoietin Thrombopoietin Megakaryocyte Colony Stimulating Factor Megakaryocyte Growth and Development Factor Thrombocytopoietin mpl Ligand Ligand, mpl Myeloproliferative Leukemia Virus Oncogene Ligand Thrombocytopoiesis-Stimulating Factor Thrombocytopoiesis Stimulating Factor c-mpl Ligand Ligand, c-mpl MGDF Factor

Below are MeSH descriptors whose meaning is more general than "Thrombopoietin".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intercellular Signaling Peptides and Proteins [D12.644.276]
Cytokines [D12.644.276.374]
Hematopoietic Cell Growth Factors [D12.644.276.374.410]
Colony-Stimulating Factors [D12.644.276.374.410.240]
Thrombopoietin [D12.644.276.374.410.240.750]
Proteins [D12.776]
Glycoproteins [D12.776.395]
Colony-Stimulating Factors [D12.776.395.240]
Thrombopoietin [D12.776.395.240.750]
Intercellular Signaling Peptides and Proteins [D12.776.467]
Cytokines [D12.776.467.374]
Hematopoietic Cell Growth Factors [D12.776.467.374.410]
Colony-Stimulating Factors [D12.776.467.374.410.240]
Thrombopoietin [D12.776.467.374.410.240.750]
Biological Factors [D23]
Intercellular Signaling Peptides and Proteins [D23.529]
Cytokines [D23.529.374]
Hematopoietic Cell Growth Factors [D23.529.374.410]
Colony-Stimulating Factors [D23.529.374.410.240]
Thrombopoietin [D23.529.374.410.240.750]

Below are MeSH descriptors whose meaning is related to "Thrombopoietin".

Below are MeSH descriptors whose meaning is more specific than "Thrombopoietin".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Thrombopoietin" by people in this website by year, and whether "Thrombopoietin" was a major or minor topic of these publications.

Bar chart showing 8 publications over 7 distinct years, with a maximum of 2 publications in 1998

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1998	1	1	2
2000	0	1	1
2004	0	1	1
2007	1	0	1
2012	1	0	1
2019	1	0	1
2025	1	0	1

Below are the most recent publications written about "Thrombopoietin" by people in Profiles.

Araki D, Hong SG, Linde N, Fisk B, Redekar N, Salisbury-Ruf C, Krouse A, Engels T, Golomb J, Dagur P, Panicker SR, Kanthi Y, Magnani DM, Wang Z, Larochelle A. cMPL-based purification and depletion of human hematopoietic stem cells: implications for pretransplant conditioning. Blood. 2025 Jun 19; 145(25):2978-2991.

View in: PubMed
Zhao JC, Arnall JR, Martin AL, Atrash S, Bhutani M, Voorhees P, Avalos B, Copelan E, Ghosh N, Hamadani M, Usmani S, Ford P. A Review of Growth Factor Support in Bloodless Autologous Hematopoietic Stem Cell Transplant. Biol Blood Marrow Transplant. 2019 10; 25(10):e305-e309.

View in: PubMed
Xiao N, Laha S, Das SP, Morlock K, Jesneck JL, Raffel GD. Ott1 (Rbm15) regulates thrombopoietin response in hematopoietic stem cells through alternative splicing of c-Mpl. Blood. 2015 Feb 05; 125(6):941-8.

View in: PubMed
Pulikkan JA, Madera D, Xue L, Bradley P, Landrette SF, Kuo YH, Abbas S, Zhu LJ, Valk P, Castilla LH. Thrombopoietin/MPL participates in initiating and maintaining RUNX1-ETO acute myeloid leukemia via PI3K/AKT signaling. Blood. 2012 Jul 26; 120(4):868-79.

View in: PubMed
Whitcomb BW, Schisterman EF, Klebanoff MA, Baumgarten M, Luo X, Chegini N. Circulating levels of cytokines during pregnancy: thrombopoietin is elevated in miscarriage. Fertil Steril. 2008 Jun; 89(6):1795-802.

View in: PubMed
Colvin GA, Lambert JF, Moore BE, Carlson JE, Dooner MS, Abedi M, Cerny J, Quesenberry PJ. Intrinsic hematopoietic stem cell/progenitor plasticity: Inversions. J Cell Physiol. 2004 Apr; 199(1):20-31.

View in: PubMed
Ballen K, Becker PS, Greiner D, Valinski H, Shearin D, Berrios V, Dooner G, Hsieh CC, Wuu J, Shultz L, Cerny J, Leif J, Stewart FM, Quesenberry P. Effect of ex vivo cytokine treatment on human cord blood engraftment in NOD-scid mice. Br J Haematol. 2000 Mar; 108(3):629-40.

View in: PubMed
Deng B, Banu N, Malloy B, Hass P, Wang JF, Cavacini L, Eaton D, Avraham H. An agonist murine monoclonal antibody to the human c-Mpl receptor stimulates megakaryocytopoiesis. Blood. 1998 Sep 15; 92(6):1981-8.

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Coleman D, Fairchild D, Schindler-Horvat J, Munyakazi L, Neumann TA. Systemic effects of pegylated recombinant human megakaryocyte growth and development factor in combination with recombinant murine granulocyte colony-stimulating factor in a murine model of myelosuppression. Toxicol Sci. 1998 Sep; 45(1):77-87.

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Newburger PE. Hematology and oncology. Curr Opin Pediatr. 1998 Feb; 10(1):47-8.

View in: PubMed

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