Sirtuin 1

"Sirtuin 1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A sirtuin family member found primarily in the CELL NUCLEUS. It is an NAD-dependent deacetylase with specificity towards HISTONES and a variety of proteins involved in gene regulation.

Descriptor ID	D056564
MeSH Number(s)	D08.811.277.087.520.200.650.100 D12.776.476.900.100
Concept/Terms	Sirtuin 1 Sirtuin 1 Silent Mating Type Information Regulation 2 Homolog 1

Below are MeSH descriptors whose meaning is more general than "Sirtuin 1".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Hydrolases [D08.811.277]
Amidohydrolases [D08.811.277.087]
Histone Deacetylases [D08.811.277.087.520]
Group III Histone Deacetylases [D08.811.277.087.520.200]
Sirtuins [D08.811.277.087.520.200.650]
Sirtuin 1 [D08.811.277.087.520.200.650.100]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Intracellular Signaling Peptides and Proteins [D12.776.476]
Sirtuins [D12.776.476.900]
Sirtuin 1 [D12.776.476.900.100]

Below are MeSH descriptors whose meaning is related to "Sirtuin 1".

Below are MeSH descriptors whose meaning is more specific than "Sirtuin 1".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Sirtuin 1" by people in this website by year, and whether "Sirtuin 1" was a major or minor topic of these publications.

Bar chart showing 22 publications over 13 distinct years, with a maximum of 4 publications in 2010

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2004	0	1	1
2007	0	1	1
2009	0	1	1
2010	3	1	4
2011	1	0	1
2012	0	1	1
2013	1	2	3
2016	1	1	2
2017	1	0	1
2018	2	0	2
2019	1	0	1
2022	2	1	3
2024	0	1	1

Below are the most recent publications written about "Sirtuin 1" by people in Profiles.

Jadon N, Shanthalingam S, Tew GN, Minter LM. PRMT5 regulates epigenetic changes in suppressive Th1-like iTregs in response to IL-12 treatment. Front Immunol. 2023; 14:1292049.

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Rodriguez-Mu?oz D, S?nchez ?, P?rez-Benavente S, Contreras-Jurado C, Montero-Pedrazuela A, Toledo-Castillo M, Guti?rrez-Hern?ndez M, Rodrigues-D?ez R, Folgueira C, Briones AM, Sabio G, Monedero-Cobeta I, Chaves-Coira I, Castej?n D, Fern?ndez-Valle E, Regadera J, Bautista JM, Aranda A, Alemany S. Hypothyroidism confers tolerance to cerebral malaria. Sci Adv. 2022 04 08; 8(14):eabj7110.

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Kim JM, Yang YS, Xie J, Lee O, Kim J, Hong J, Boldyreff B, Filhol O, Chun H, Greenblatt MB, Gao G, Shim JH. Regulation of sclerostin by the SIRT1 stabilization pathway in osteocytes. Cell Death Differ. 2022 08; 29(8):1625-1638.

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Becker-Krail DD, Parekh PK, Ketchesin KD, Yamaguchi S, Yoshino J, Hildebrand MA, Dunham B, Ganapathiraju MK, Logan RW, McClung CA. Circadian transcription factor NPAS2 and the NAD+ -dependent deacetylase SIRT1 interact in the mouse nucleus accumbens and regulate reward. Eur J Neurosci. 2022 02; 55(3):675-693.

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Al-Massadi O, Qui?ones M, Clasadonte J, Hernandez-Bautista R, Romero-Pic? A, Folgueira C, Morgan DA, Kall? I, Heras V, Senra A, Funderburk SC, Krashes MJ, Souto Y, Fidalgo M, Luquet S, Chee MJ, Imbernon M, Beiroa D, Garc?a-Caballero L, Gallego R, Lam BYH, Yeo G, Lopez M, Liposits Z, Rahmouni K, Prevot V, Dieguez C, Nogueiras R. MCH Regulates SIRT1/FoxO1 and Reduces POMC Neuronal Activity to Induce Hyperphagia, Adiposity, and Glucose Intolerance. Diabetes. 2019 12; 68(12):2210-2222.

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Jung SM, Guertin DA. Insulin PACS a Punch in SIRT1 Activity. Mol Cell. 2018 12 20; 72(6):917-919.

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Logan RW, Parekh PK, Kaplan GN, Becker-Krail DD, Williams WP, Yamaguchi S, Yoshino J, Shelton MA, Zhu X, Zhang H, Waplinger S, Fitzgerald E, Oliver-Smith J, Sundarvelu P, Enwright JF, Huang YH, McClung CA. NAD+ cellular redox and SIRT1 regulate the diurnal rhythms of tyrosine hydroxylase and conditioned cocaine reward. Mol Psychiatry. 2019 11; 24(11):1668-1684.

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Cheng CY, B?hme J, Singhal A. Metabolic energy sensors as targets for designing host-directed therapies for tuberculosis. J Leukoc Biol. 2018 02; 103(2):215-223.

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Cui X, Chen Q, Dong Z, Xu L, Lu T, Li D, Zhang J, Zhang M, Xia Q. Inactivation of Sirt1 in mouse livers protects against endotoxemic liver injury by acetylating and activating NF-?B. Cell Death Dis. 2016 10 06; 7(10):e2403.

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Park EJ, Sang-Ngern M, Chang LC, Pezzuto JM. Induction of cell cycle arrest and apoptosis with downregulation of Hsp90 client proteins and histone modification by 4?-hydroxywithanolide E isolated from Physalis peruviana. Mol Nutr Food Res. 2016 06; 60(6):1482-500.

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