"SRS-A" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A group of LEUKOTRIENES; (LTC4; LTD4; and LTE4) that is the major mediator of BRONCHOCONSTRICTION; HYPERSENSITIVITY; and other allergic reactions. Earlier studies described a "slow-reacting substance of ANAPHYLAXIS" released from lung by cobra venom or after anaphylactic shock. The relationship between SRS-A leukotrienes was established by UV which showed the presence of the conjugated triene. (From Merck Index, 11th ed)
| Descriptor ID |
D013189
|
| MeSH Number(s) |
D10.251.355.255.100.450.855 D10.251.355.310.166.887.855 D23.469.050.175.450.725
|
| Concept/Terms |
SRS-A- SRS-A
- Slow Reacting Substance of Anaphylaxis
|
Below are MeSH descriptors whose meaning is more general than "SRS-A".
Below are MeSH descriptors whose meaning is more specific than "SRS-A".
This graph shows the total number of publications written about "SRS-A" by people in this website by year, and whether "SRS-A" was a major or minor topic of these publications.
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Below are the most recent publications written about "SRS-A" by people in Profiles.
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Carraway RE, Cochrane DE, Salmonsen R. Increased plasma levels of leukotrienes in response to neurotensin. Ann N Y Acad Sci. 1992; 668:317-9.
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Weber C, Aepfelbacher M, Lux I, Zimmer B, Weber PC. Docosahexaenoic acid inhibits PAF and LTD4 stimulated [Ca2+]i-increase in differentiated monocytic U937 cells. Biochim Biophys Acta. 1991 Dec 03; 1133(1):38-45.
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Carraway RE, Cochrane DE, Salmonsen R, Muraki K, Boucher W. Neurotensin elevates hematocrit and plasma levels of the leukotrienes, LTB4, LTC4, LTD4 and LTE4, in anesthetized rats. Peptides. 1991 Sep-Oct; 12(5):1105-11.
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Morel DR, Skoskiewicz M, Robinson DR, Bloch KJ, Hoaglin DC, Zapol WM. Leukotrienes, thromboxane A2, and prostaglandins during systemic anaphylaxis in sheep. Am J Physiol. 1991 Sep; 261(3 Pt 2):H782-92.
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Aepfelbacher M, Hrboticky N, Lux I, Weber PC. Cholesterol modulates PAF-stimulated Ca2(+)-mobilization in monocytic U937 cells. Biochim Biophys Acta. 1991 May 24; 1074(1):125-9.
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Pullman-Mooar S, Laposata M, Lem D, Holman RT, Leventhal LJ, DeMarco D, Zurier RB. Alteration of the cellular fatty acid profile and the production of eicosanoids in human monocytes by gamma-linolenic acid. Arthritis Rheum. 1990 Oct; 33(10):1526-33.
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Aepfelbacher M, Korth R, Weber PC. 1,25-(OH)2 vitamin D-3 enhances Paf-stimulated calcium mobilization in U937 cells by expression of specific Paf binding sites. Biochim Biophys Acta. 1990 Feb 19; 1051(2):179-84.
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O'Sullivan BP, Mong S. Binding of radiolabeled high affinity antagonist to leukotriene D4 receptor in guinea pig lung membranes: interconversion of agonist-receptor binding affinity states. Mol Pharmacol. 1989 Jun; 35(6):795-802.