"Receptor, Muscarinic M1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A specific subtype of muscarinic receptor that has a high affinity for the drug PIRENZEPINE. It is found in the peripheral GANGLIA where it signals a variety of physiological functions such as GASTRIC ACID secretion and BRONCHOCONSTRICTION. This subtype of muscarinic receptor is also found in neuronal tissues including the CEREBRAL CORTEX and HIPPOCAMPUS where it mediates the process of MEMORY and LEARNING.
| Descriptor ID |
D043643
|
| MeSH Number(s) |
D12.776.543.750.695.475.100 D12.776.543.750.720.360.500.099
|
| Concept/Terms |
Receptor, Muscarinic M1- Receptor, Muscarinic M1
- M1 Receptor, Muscarinic
- Muscarinic M1 Receptor
- Receptors, Muscarinic M1
- M1 Receptors, Muscarinic
- Muscarinic M1 Receptors
- Muscarinic Receptor M1
- M1, Muscarinic Receptor
- Receptor M1, Muscarinic
- Muscarinic Receptors M1
- M1, Muscarinic Receptors
- Receptors M1, Muscarinic
|
Below are MeSH descriptors whose meaning is more general than "Receptor, Muscarinic M1".
- Chemicals and Drugs [D]
- Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
- Membrane Proteins [D12.776.543]
- Receptors, Cell Surface [D12.776.543.750]
- Receptors, G-Protein-Coupled [D12.776.543.750.695]
- Receptors, Muscarinic [D12.776.543.750.695.475]
- Receptor, Muscarinic M1 [D12.776.543.750.695.475.100]
- Receptors, Neurotransmitter [D12.776.543.750.720]
- Receptors, Cholinergic [D12.776.543.750.720.360]
- Receptors, Muscarinic [D12.776.543.750.720.360.500]
- Receptor, Muscarinic M1 [D12.776.543.750.720.360.500.099]
Below are MeSH descriptors whose meaning is more specific than "Receptor, Muscarinic M1".
This graph shows the total number of publications written about "Receptor, Muscarinic M1" by people in this website by year, and whether "Receptor, Muscarinic M1" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 0 | 1 | 1 |
| 2004 | 1 | 0 | 1 |
| 2006 | 1 | 0 | 1 |
| 2008 | 1 | 0 | 1 |
| 2009 | 1 | 0 | 1 |
| 2018 | 1 | 1 | 2 |
To return to the timeline,
click here.
Below are the most recent publications written about "Receptor, Muscarinic M1" by people in Profiles.
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Galvin VC, Yang ST, Paspalas CD, Yang Y, Jin LE, Datta D, Morozov YM, Lightbourne TC, Lowet AS, Rakic P, Arnsten AFT, Wang M. Muscarinic M1 Receptors Modulate Working Memory Performance and Activity via KCNQ Potassium Channels in the Primate Prefrontal Cortex. Neuron. 2020 05 20; 106(4):649-661.e4.
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Liu L, Bonventre JV, Rittenhouse AR. cPLA2a-/- sympathetic neurons exhibit increased membrane excitability and loss of N-Type Ca2+ current inhibition by M1 muscarinic receptor signaling. PLoS One. 2018; 13(12):e0201322.
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Roberts-Crowley ML, Rittenhouse AR. Modulation of CaV1.3b L-type calcium channels by M1 muscarinic receptors varies with CaV? subunit expression. BMC Res Notes. 2018 Sep 27; 11(1):681.
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Heneghan JF, Mitra-Ganguli T, Stanish LF, Liu L, Zhao R, Rittenhouse AR. The Ca2+ channel beta subunit determines whether stimulation of Gq-coupled receptors enhances or inhibits N current. J Gen Physiol. 2009 Nov; 134(5):369-84.
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Cabadak H, Cuadra AE, El-Fakahany EE, Kan B. M2, M3, and M4 muscarinic receptors are expressed in the guinea pig gallbladder. J Recept Signal Transduct Res. 2009; 29(1):63-6.
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Liu L, Heneghan JF, Michael GJ, Stanish LF, Egertov? M, Rittenhouse AR. L- and N-current but not M-current inhibition by M1 muscarinic receptors requires DAG lipase activity. J Cell Physiol. 2008 Jul; 216(1):91-100.
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Liu L, Zhao R, Bai Y, Stanish LF, Evans JE, Sanderson MJ, Bonventre JV, Rittenhouse AR. M1 muscarinic receptors inhibit L-type Ca2+ current and M-current by divergent signal transduction cascades. J Neurosci. 2006 Nov 08; 26(45):11588-98.
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Cuadra AE, El-Fakahany EE. Mechanisms of M(1) muscarinic receptor-mediated up-regulation of neuronal nitric oxide synthase in N1E-115 neuroblastoma cells. Brain Res Mol Brain Res. 2005 Apr 04; 134(2):198-204.
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Liu L, Roberts ML, Rittenhouse AR. Phospholipid metabolism is required for M1 muscarinic inhibition of N-type calcium current in sympathetic neurons. Eur Biophys J. 2004 May; 33(3):255-64.
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Liu L, Rittenhouse AR. Arachidonic acid mediates muscarinic inhibition and enhancement of N-type Ca2+ current in sympathetic neurons. Proc Natl Acad Sci U S A. 2003 Jan 07; 100(1):295-300.