"Sirtuin 3" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A sirtuin family member found primarily in MITOCHONDRIA. It is a multifunctional enzyme that contains a NAD-dependent deacetylase activity that is specific for HISTONES and a mono-ADP-ribosyltransferase activity.
| Descriptor ID |
D056566
|
| MeSH Number(s) |
D08.811.277.087.520.200.650.600 D08.811.913.400.725.115.961.600 D12.776.476.900.600 D12.776.575.875
|
| Concept/Terms |
Sirtuin 3- Sirtuin 3
- Silent Mating Type Information Regulation 2 Homolog 3
|
Below are MeSH descriptors whose meaning is more general than "Sirtuin 3".
Below are MeSH descriptors whose meaning is more specific than "Sirtuin 3".
This graph shows the total number of publications written about "Sirtuin 3" by people in this website by year, and whether "Sirtuin 3" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2014 | 1 | 1 | 2 |
| 2015 | 0 | 1 | 1 |
| 2018 | 1 | 0 | 1 |
| 2021 | 1 | 0 | 1 |
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Below are the most recent publications written about "Sirtuin 3" by people in Profiles.
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Smulan LJ, Martinez N, Kiritsy MC, Kativhu C, Cavallo K, Sassetti CM, Singhal A, Remold HG, Kornfeld H. Sirtuin 3 Downregulation in Mycobacterium tuberculosis-Infected Macrophages Reprograms Mitochondrial Metabolism and Promotes Cell Death. mBio. 2021 02 02; 12(1).
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Gonzalez Herrera KN, Zaganjor E, Ishikawa Y, Spinelli JB, Yoon H, Lin JR, Satterstrom FK, Ringel A, Mulei S, Souza A, Gorham JM, Benson CC, Seidman JG, Sorger PK, Clish CB, Haigis MC. Small-Molecule Screen Identifies De Novo Nucleotide Synthesis as a Vulnerability of Cells Lacking SIRT3. Cell Rep. 2018 02 20; 22(8):1945-1955.
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Akie TE, Liu L, Nam M, Lei S, Cooper MP. OXPHOS-Mediated Induction of NAD+ Promotes Complete Oxidation of Fatty Acids and Interdicts Non-Alcoholic Fatty Liver Disease. PLoS One. 2015; 10(5):e0125617.
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Rahman M, Nirala NK, Singh A, Zhu LJ, Taguchi K, Bamba T, Fukusaki E, Shaw LM, Lambright DG, Acharya JK, Acharya UR. Drosophila Sirt2/mammalian SIRT3 deacetylates ATP synthase ? and regulates complex V activity. J Cell Biol. 2014 Jul 21; 206(2):289-305.
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Liu L, Nam M, Fan W, Akie TE, Hoaglin DC, Gao G, Keaney JF, Cooper MP. Nutrient sensing by the mitochondrial transcription machinery dictates oxidative phosphorylation. J Clin Invest. 2014 Feb; 124(2):768-84.