Catalytic Domain

"Catalytic Domain" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

The region of an enzyme that interacts with its substrate to cause the enzymatic reaction.

Descriptor ID	D020134
MeSH Number(s)	G02.111.570.120.704 G02.111.570.820.709.275.750.188
Concept/Terms	Catalytic Domain Catalytic Domain Catalytic Domains Domain, Catalytic Domains, Catalytic Catalytic Subunit Catalytic Subunits Subunit, Catalytic Subunits, Catalytic Catalytic Region Catalytic Regions Region, Catalytic Regions, Catalytic Catalytic Core Catalytic Cores Core, Catalytic Cores, Catalytic Active Site Active Site Active Sites Site, Active Sites, Active Catalytic Site Catalytic Sites Site, Catalytic Sites, Catalytic Reactive Site Reactive Sites Site, Reactive Sites, Reactive

Below are MeSH descriptors whose meaning is more general than "Catalytic Domain".

Biological Sciences [G]
Chemical Phenomena [G02]
Biochemical Phenomena [G02.111]
Molecular Structure [G02.111.570]
Binding Sites [G02.111.570.120]
Catalytic Domain [G02.111.570.120.704]
Molecular Conformation [G02.111.570.820]
Protein Conformation [G02.111.570.820.709]
Protein Structural Elements [G02.111.570.820.709.275]
Protein Domains [G02.111.570.820.709.275.750]
Catalytic Domain [G02.111.570.820.709.275.750.188]

Below are MeSH descriptors whose meaning is related to "Catalytic Domain".

Below are MeSH descriptors whose meaning is more specific than "Catalytic Domain".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Catalytic Domain" by people in this website by year, and whether "Catalytic Domain" was a major or minor topic of these publications.

Bar chart showing 142 publications over 27 distinct years, with a maximum of 12 publications in 2010 and 2012 and 2018 and 2021

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1998	1	0	1
1999	0	2	2
2000	0	2	2
2001	0	4	4
2002	0	4	4
2004	0	4	4
2005	0	2	2
2006	0	3	3
2007	2	1	3
2008	0	3	3
2009	0	2	2
2010	1	11	12
2011	0	6	6
2012	0	12	12
2013	0	6	6
2014	0	6	6
2015	1	4	5
2016	0	3	3
2017	1	9	10
2018	1	11	12
2019	1	8	9
2020	0	7	7
2021	0	12	12
2022	0	2	2
2023	0	1	1
2024	2	3	5
2025	0	4	4

Below are the most recent publications written about "Catalytic Domain" by people in Profiles.

Hong L, Ye T, Wang TZ, Srijay D, Liu H, Zhao L, Watson R, Vincoff S, Chen T, Kholina K, Goel S, DeLisa MP, Chatterjee P. Programmable protein stabilization with language model-derived peptide guides. Nat Commun. 2025 Apr 15; 16(1):3555.

View in: PubMed
Zvornicanin SN, Shaqra AM, Flynn J, Carias Martinez H, Jia W, Moquin S, Dovala D, Bolon DN, Kurt Yilmaz N, Schiffer CA. Molecular mechanisms of drug resistance and compensation in SARS-CoV-2 main protease: the interplay between E166 and L50. mBio. 2025 May 14; 16(5):e0406824.

View in: PubMed
Hedger AK, Myint W, Lee JM, Suchenski Loustaunau D, Balachandran V, Shaqra AM, Kurt Yilmaz N, Watts JK, Matsuo H, Schiffer CA. Next generation?APOBEC3 inhibitors: optimally designed for potency and nuclease stability. Nucleic Acids Res. 2025 Mar 20; 53(6).

View in: PubMed
Pardhe BD, Park H, Paudel P, Jeong J, Oh TJ, Choi KY, Ahn J. In-vitro optimization and active-site mutagenesis of CYP105D18 peroxygenase enhance the production of indigo. Enzyme Microb Technol. 2025 Jun; 187:110634.

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Azzolino VN, Shaqra AM, Ali A, Kurt Yilmaz N, Schiffer CA. Elucidating the Substrate Envelope of Enterovirus 68-3C Protease: Structural Basis of Specificity and Potential Resistance. Viruses. 2024 09 05; 16(9).

View in: PubMed
Loveland AB, Koh CS, Ganesan R, Jacobson A, Korostelev AA. Structural mechanism of angiogenin activation by the ribosome. Nature. 2024 Jun; 630(8017):769-776.

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Leo G, Leone P, Ataie Kachoie E, Tolomeo M, Galluccio M, Indiveri C, Barile M, Capaldi S. Structural insights into the bifunctional enzyme human FAD synthase. Structure. 2024 07 11; 32(7):953-965.e5.

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Cruz KG, Hill Eron M, Makhaik S, Savinov S, Hardy JA. A Non-Active-Site Inhibitor with Selectivity for Zika Virus NS2B-NS3 Protease. ACS Infect Dis. 2024 02 09; 10(2):412-425.

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Mpakali A, Barla I, Lu L, Ramesh KM, Thomaidis N, Stern LJ, Giastas P, Stratikos E. Mechanisms of Allosteric Inhibition of Insulin-Regulated Aminopeptidase. J Mol Biol. 2024 03 15; 436(6):168449.

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Icso JD, Barasa L, Thompson PR. SARM1, an Enzyme Involved in Axon Degeneration, Catalyzes Multiple Activities through a Ternary Complex Mechanism. Biochemistry. 2023 07 04; 62(13):2065-2078.

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