Protein Domains

"Protein Domains" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Discrete protein structural units that may fold independently of the rest of the protein and have their own functions.

Descriptor ID	D000072417
MeSH Number(s)	G02.111.570.820.709.275.750 G02.111.570.820.709.610.500
Concept/Terms	Protein Domains Protein Domains Peptide Domain Domain, Peptide Domains, Peptide Peptide Domains Protein Domain Domain, Protein Domains, Protein

Below are MeSH descriptors whose meaning is more general than "Protein Domains".

Biological Sciences [G]
Chemical Phenomena [G02]
Biochemical Phenomena [G02.111]
Molecular Structure [G02.111.570]
Molecular Conformation [G02.111.570.820]
Protein Conformation [G02.111.570.820.709]
Protein Structural Elements [G02.111.570.820.709.275]
Protein Domains [G02.111.570.820.709.275.750]
Protein Structure, Tertiary [G02.111.570.820.709.610]
Protein Domains [G02.111.570.820.709.610.500]

Below are MeSH descriptors whose meaning is related to "Protein Domains".

Below are MeSH descriptors whose meaning is more specific than "Protein Domains".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Protein Domains" by people in this website by year, and whether "Protein Domains" was a major or minor topic of these publications.

Bar chart showing 119 publications over 11 distinct years, with a maximum of 22 publications in 2018

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2016	0	13	13
2017	1	17	18
2018	2	20	22
2019	1	11	12
2020	1	18	19
2021	2	11	13
2022	0	4	4
2023	0	3	3
2024	0	7	7
2025	0	4	4
2026	0	4	4

Below are the most recent publications written about "Protein Domains" by people in Profiles.

Deorio HR, Duckworth AT, Forsythe GR, Sung AY, Sandler SJ, Grant T, Keck JL. Domain dynamics within the PriA DNA helicase regulate DNA replication restart. Nucleic Acids Res. 2026 Sep 22; 54(18).

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Sandmann M, Tajdar S, Sander S, Ruiz Carrillo D, Ganter B, Fischer C, Ocenas M, Etzold S, Pekarek N, Berger J, Meister TL, Selisko B, Canard B, Watt JM, Baszczy?ski O, Potter BV, Garcia Alai M, Tidow H, Pfefferle S, Meier C, Fliegert R. Design, structure-based optimization and antiviral evaluation of potent inhibitors for the macrodomain Mac1 of SARS-CoV-2. Nat Commun. 2026 07 27; 17(1).

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De Silva C, Kelch BA, McCollum D. Regulation of tension-dependent localization of LATS1 and LATS2 to adherens junctions. PLoS One. 2026; 21(2):e0342107.

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Maqtedar A, Rossi MA, Clerico EM, Williams RV, Gierasch LM. The nucleotide exchange factor, GrpE, modulates substrate affinity by interaction of its N-terminal tails with the DnaK substrate-binding domain. J Biol Chem. 2026 Mar; 302(3):111176.

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Nguyen BV, Özden C, Dong K, Koc OC, Torres-Ocampo AP, Dziedzic N, Flaherty D, Huang J, Sankara S, Abromson NL, Tomchick DR, Fissore RA, Chen J, Garman SC, Stratton MM. A domain-swapped CaMKII conformation facilitates linker-mediated allosteric regulation. Nat Commun. 2025 Sep 26; 16(1):8461.

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Webb J, Liew JJM, Gnann AD, Ilkhani K, Patterson M, Paul S, Forés M, Jiménez G, Veraksa A, Dowling DP. Molecular basis of DNA recognition by the HMG-box-C1 module of capicua. Structure. 2025 Dec 04; 33(12):2109-2121.e5.

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Figueroa-Meléndez A, Cante-Paz ME, Delgado-Álvarez DL, Hernández AC, Martínez-Andrade JM, Martínez-Núñez L, Oliva B, Rico-Ramírez AM, Salgado-Bautista D, Gallego O, Munson M, Riquelme M. The C-terminal domain of SEC-10 is fundamental for exocyst function, apical organization, and cell morphogenesis in Neurospora crassa. Mol Biol Cell. 2025 Aug 01; 36(8):ar102.

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Zheng C, Zhang G, Dean LJ, Sontheimer EJ, Xue W. The reverse transcriptase domain of prime editors contributes to DNA repair in mammalian cells. Nat Biotechnol. 2026 Jan; 44(1):146-153.

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Dey S, Pahari P, Mukherjee S, Munro JB, Das DK. Conformational dynamics of SARS-CoV-2 Omicron spike trimers during fusion activation at single molecule resolution. Structure. 2024 11 07; 32(11):1910-1925.e6.

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Ertekin A, Morgan BR, Ryder SP, Massi F. Structure and Dynamics of the CCCH-Type Tandem Zinc Finger Domain of POS-1 and Implications for RNA Binding Specificity. Biochemistry. 2024 10 15; 63(20):2632-2647.

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