Protein Interaction Domains and Motifs

"Protein Interaction Domains and Motifs" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Protein modules with conserved ligand-binding surfaces which mediate specific interaction functions in SIGNAL TRANSDUCTION PATHWAYS and the specific BINDING SITES of their cognate protein LIGANDS.

Descriptor ID	D054730
MeSH Number(s)	G02.111.570.820.709.275.750.500
Concept/Terms	Protein Interaction Domains and Motifs Protein Interaction Domains and Motifs Protein Interaction Motifs Protein Interaction Motifs Motif, Protein Interaction Motifs, Protein Interaction Protein Interaction Motif Binding Motifs, Protein Interaction Protein Interaction Binding Motifs Protein Interaction Domains Protein Interaction Domains Domain, Protein Interaction Domains, Protein Interaction Protein Interaction Domain Protein-Protein Interaction Domains Domain, Protein-Protein Interaction Domains, Protein-Protein Interaction Protein Protein Interaction Domains Protein-Protein Interaction Domain

Below are MeSH descriptors whose meaning is more general than "Protein Interaction Domains and Motifs".

Biological Sciences [G]
Chemical Phenomena [G02]
Biochemical Phenomena [G02.111]
Molecular Structure [G02.111.570]
Molecular Conformation [G02.111.570.820]
Protein Conformation [G02.111.570.820.709]
Protein Structural Elements [G02.111.570.820.709.275]
Protein Domains [G02.111.570.820.709.275.750]
Protein Interaction Domains and Motifs [G02.111.570.820.709.275.750.500]

Below are MeSH descriptors whose meaning is related to "Protein Interaction Domains and Motifs".

Below are MeSH descriptors whose meaning is more specific than "Protein Interaction Domains and Motifs".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Protein Interaction Domains and Motifs" by people in this website by year, and whether "Protein Interaction Domains and Motifs" was a major or minor topic of these publications.

Bar chart showing 72 publications over 16 distinct years, with a maximum of 10 publications in 2010

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2008	1	3	4
2009	0	4	4
2010	6	4	10
2011	1	2	3
2012	3	2	5
2013	2	4	6
2014	0	5	5
2015	0	5	5
2016	0	5	5
2017	0	7	7
2018	0	3	3
2019	1	5	6
2020	0	2	2
2021	1	3	4
2022	0	2	2
2023	1	0	1

Below are the most recent publications written about "Protein Interaction Domains and Motifs" by people in Profiles.

Kumar MS, Stallworth KM, Murthy AC, Lim SM, Li N, Jain A, Munro JB, Fawzi NL, Lagier-Tourenne C, Bosco DA. Interactions between FUS and the C-terminal Domain of Nup62 are Sufficient for their Co-phase Separation into Amorphous Assemblies. J Mol Biol. 2023 03 15; 435(6):167972.

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Karlsson E, Sorgenfrei FA, Andersson E, Dogan J, Jemth P, Chi CN. The dynamic properties of a nuclear coactivator binding domain are evolutionarily conserved. Commun Biol. 2022 03 30; 5(1):286.

View in: PubMed
Zhang J, Walker ME, Sanidad KZ, Zhang H, Liang Y, Zhao E, Chacon-Vargas K, Yeliseyev V, Parsonnet J, Haggerty TD, Wang G, Simpson JB, Jariwala PB, Beaty VV, Yang J, Yang H, Panigrahy A, Minter LM, Kim D, Gibbons JG, Liu L, Li Z, Xiao H, Borlandelli V, Overkleeft HS, Cloer EW, Major MB, Goldfarb D, Cai Z, Redinbo MR, Zhang G. Microbial enzymes induce colitis by reactivating triclosan in the mouse gastrointestinal tract. Nat Commun. 2022 01 10; 13(1):136.

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Maben Z, Arya R, Georgiadis D, Stratikos E, Stern LJ. Conformational dynamics linked to domain closure and substrate binding explain the ERAP1 allosteric regulation mechanism. Nat Commun. 2021 09 06; 12(1):5302.

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Arveseth CD, Happ JT, Hedeen DS, Zhu JF, Capener JL, Klatt Shaw D, Deshpande I, Liang J, Xu J, Stubben SL, Nelson IB, Walker MF, Kawakami K, Inoue A, Krogan NJ, Grunwald DJ, H?ttenhain R, Manglik A, Myers BR. Smoothened transduces Hedgehog signals via activity-dependent sequestration of PKA catalytic subunits. PLoS Biol. 2021 04; 19(4):e3001191.

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Lynch TL, Kumar M, McNamara JW, Kuster DWD, Sivaguru M, Singh RR, Previs MJ, Lee KH, Kuffel G, Zilliox MJ, Lin BL, Ma W, Gibson AM, Blaxall BC, Nieman ML, Lorenz JN, Leichter DM, Leary OP, Janssen PML, de Tombe PP, Gilbert RJ, Craig R, Irving T, Warshaw DM, Sadayappan S. Amino terminus of cardiac myosin binding protein-C regulates cardiac contractility. J Mol Cell Cardiol. 2021 07; 156:33-44.

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Robert Hollingsworth L, David L, Li Y, Griswold AR, Ruan J, Sharif H, Fontana P, Orth-He EL, Fu TM, Bachovchin DA, Wu H. Mechanism of filament formation in UPA-promoted CARD8 and NLRP1 inflammasomes. Nat Commun. 2021 01 08; 12(1):189.

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Ejemel M, Li Q, Hou S, Schiller ZA, Tree JA, Wallace A, Amcheslavsky A, Kurt Yilmaz N, Buttigieg KR, Elmore MJ, Godwin K, Coombes N, Toomey JR, Schneider R, Ramchetty AS, Close BJ, Chen DY, Conway HL, Saeed M, Ganesa C, Carroll MW, Cavacini LA, Klempner MS, Schiffer CA, Wang Y. A cross-reactive human IgA monoclonal antibody blocks SARS-CoV-2 spike-ACE2 interaction. Nat Commun. 2020 08 21; 11(1):4198.

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Vreven T, Vangaveti S, Borrman TM, Gaines JC, Weng Z. Performance of ZDOCK and IRAD in CAPRI rounds 39-45. Proteins. 2020 08; 88(8):1050-1054.

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Woodhead JL, Craig R. The mesa trail and the interacting heads motif of myosin II. Arch Biochem Biophys. 2020 02 15; 680:108228.

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