Cross-Linking Reagents

"Cross-Linking Reagents" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Reagents with two reactive groups, usually at opposite ends of the molecule, that are capable of reacting with and thereby forming bridges between side chains of amino acids in proteins; the locations of naturally reactive areas within proteins can thereby be identified; may also be used for other macromolecules, like glycoproteins, nucleic acids, or other.

Descriptor ID	D003432
MeSH Number(s)	D27.720.470.410.210
Concept/Terms	Cross-Linking Reagents Cross-Linking Reagents Reagents, Cross-Linking Crosslinking Reagents Reagents, Crosslinking Bifunctional Reagents Reagents, Bifunctional Cross Linking Reagents Linking Reagents, Cross Reagents, Cross Linking

Below are MeSH descriptors whose meaning is more general than "Cross-Linking Reagents".

Chemicals and Drugs [D]
Chemical Actions and Uses [D27]
Specialty Uses of Chemicals [D27.720]
Laboratory Chemicals [D27.720.470]
Indicators and Reagents [D27.720.470.410]
Cross-Linking Reagents [D27.720.470.410.210]

Below are MeSH descriptors whose meaning is related to "Cross-Linking Reagents".

Below are MeSH descriptors whose meaning is more specific than "Cross-Linking Reagents".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Cross-Linking Reagents" by people in this website by year, and whether "Cross-Linking Reagents" was a major or minor topic of these publications.

Bar chart showing 96 publications over 27 distinct years, with a maximum of 11 publications in 2012

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1996	0	2	2
1997	0	1	1
1999	0	2	2
2000	0	1	1
2001	0	1	1
2002	0	6	6
2004	1	4	5
2005	1	3	4
2006	2	2	4
2007	0	3	3
2008	2	6	8
2009	2	4	6
2010	2	2	4
2011	0	2	2
2012	1	10	11
2013	0	1	1
2014	3	1	4
2015	0	2	2
2016	1	0	1
2017	1	4	5
2018	2	5	7
2019	0	1	1
2020	0	1	1
2021	1	3	4
2024	3	2	5
2025	1	2	3
2026	1	1	2

Below are the most recent publications written about "Cross-Linking Reagents" by people in Profiles.

Zhang X, Ma X, Xiao T, Cui S, Hu H, McClements DJ, Wang Q, Shi A. Comparison of plant and microbial protein particles fabricated by heat-induced aggregation or enzymatic cross-linking: structure, physicochemical properties, and stability. Food Chem. 2026 Oct 01; 525(Pt 4):150480.

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Zhang X, Ma X, Wu C, Zheng Y, Hu H, McClements DJ, Wang Q, Shi A. Effect of heat or enzymatic cross-linking treatments on the interfacial and foaming properties of soy, mung bean, and yeast proteins. Int J Biol Macromol. 2026 Apr; 354:151311.

View in: PubMed
Cheng H, McClements DJ, Xu H, Zhang Z, Zhang R, Jin Z, Chen L. Effect of various natural cross-linking agents on the properties of corn starch/soy protein isolate composite films. Carbohydr Polym. 2025 10 15; 366:123850.

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Chang SY, McAnena AP, Kim J, Song J. Tuning Hyaluronic Acid Microstructures by Engineered Amphiphilicity: From Dynamically Cross-Linked Gels to Multilayered Nanoparticles. ACS Appl Mater Interfaces. 2025 Jun 04; 17(22):31909-31922.

View in: PubMed
Yan X, Yan S, Cao Y, Fu Y, Chen J, Dai T, McClements DJ, Li Q. Effect of cation type on the formation, structure and functional properties of enzyme-crosslinked pea protein gels and emulsion gels. Food Chem. 2025 Sep 15; 486:144642.

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Rodríguez-López R, Webb JN, Erdi M, Kofinas P, Franco W, Zhang H, Randleman JB, Scarcelli G. Determining the Relationship Between Corneal Stiffening and Tissue Dehydration After Corneal Cross-Linking. Invest Ophthalmol Vis Sci. 2024 11 04; 65(13):14.

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Liu W, Liu K, Hu H, McClements DJ, Zhang Z, Zhang R, Qiu C, Long J, Chen G, Zou Y, Jin Z, Chen L. Modification of pea starch using ternary mixtures of natural crosslinking agents: Vanillin-chitosan-betaine and vanillin-gelatin-betaine. Int J Biol Macromol. 2024 Sep; 276(Pt 2):133949.

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Mohammadi MA, Alizadeh AM, Mousavi M, Hashempour-Baltork F, Kooki S, Shadan MR, Hosseini SM, McClements DJ. Advances and applications of crosslinked electrospun biomacromolecular nanofibers. Int J Biol Macromol. 2024 Jun; 271(Pt 2):132743.

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Xu W, He K, Lin Z, McClements DJ, Jin Z, Chen L. Progress in using cross-linking technologies to increase the thermal stability of colloidal delivery systems. Crit Rev Food Sci Nutr. 2025; 65(14):2654-2668.

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Li S, Yan J, Yang J, Chen G, McClements DJ, Ma C, Liu X, Liu F. Modulating peppermint oil flavor release properties of emulsion-filled protein gels: Impact of cross-linking method and matrix composition. Food Res Int. 2024 06; 185:114277.

View in: PubMed

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