Th1 Cells

"Th1 Cells" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A subset of helper-inducer T-lymphocytes which synthesize and secrete INTERLEUKIN-2; INTERFERON-GAMMA; and INTERLEUKIN-12. Due to their ability to kill antigen-presenting cells and their lymphokine-mediated effector activity, Th1 cells are associated with vigorous delayed-type hypersensitivity reactions.

Descriptor ID	D018417
MeSH Number(s)	A11.118.637.555.567.550.500.400.900 A11.118.637.555.567.569.200.400.900 A11.118.637.555.567.569.500.400.900 A15.145.229.637.555.567.550.500.400.500 A15.145.229.637.555.567.569.200.400.500 A15.145.229.637.555.567.569.500.400.500 A15.382.490.555.567.550.500.400.900 A15.382.490.555.567.569.200.400.900 A15.382.490.555.567.569.500.400.900
Concept/Terms	Th1 Cells Th1 Cells Cell, Th1 Cells, Th1 Th1 Cell TH-1 Cells Cell, TH-1 Cells, TH-1 TH 1 Cells TH-1 Cell T Helper 1 Cells Type 1 Helper T Cells

Below are MeSH descriptors whose meaning is more general than "Th1 Cells".

Anatomy [A]
Cells [A11]
Blood Cells [A11.118]
Leukocytes [A11.118.637]
Leukocytes, Mononuclear [A11.118.637.555]
Lymphocytes [A11.118.637.555.567]
Lymphocyte Subsets [A11.118.637.555.567.550]
T-Lymphocyte Subsets [A11.118.637.555.567.550.500]
T-Lymphocytes, Helper-Inducer [A11.118.637.555.567.550.500.400]
Th1 Cells [A11.118.637.555.567.550.500.400.900]
T-Lymphocytes [A11.118.637.555.567.569]
CD4-Positive T-Lymphocytes [A11.118.637.555.567.569.200]
T-Lymphocytes, Helper-Inducer [A11.118.637.555.567.569.200.400]
Th1 Cells [A11.118.637.555.567.569.200.400.900]
T-Lymphocyte Subsets [A11.118.637.555.567.569.500]
T-Lymphocytes, Helper-Inducer [A11.118.637.555.567.569.500.400]
Th1 Cells [A11.118.637.555.567.569.500.400.900]
Hemic and Immune Systems [A15]
Blood [A15.145]
Blood Cells [A15.145.229]
Leukocytes [A15.145.229.637]
Leukocytes, Mononuclear [A15.145.229.637.555]
Lymphocytes [A15.145.229.637.555.567]
Lymphocyte Subsets [A15.145.229.637.555.567.550]
T-Lymphocyte Subsets [A15.145.229.637.555.567.550.500]
T-Lymphocytes, Helper-Inducer [A15.145.229.637.555.567.550.500.400]
Th1 Cells [A15.145.229.637.555.567.550.500.400.500]
T-Lymphocytes [A15.145.229.637.555.567.569]
CD4-Positive T-Lymphocytes [A15.145.229.637.555.567.569.200]
T-Lymphocytes, Helper-Inducer [A15.145.229.637.555.567.569.200.400]
Th1 Cells [A15.145.229.637.555.567.569.200.400.500]
T-Lymphocyte Subsets [A15.145.229.637.555.567.569.500]
T-Lymphocytes, Helper-Inducer [A15.145.229.637.555.567.569.500.400]
Th1 Cells [A15.145.229.637.555.567.569.500.400.500]
Immune System [A15.382]
Leukocytes [A15.382.490]
Leukocytes, Mononuclear [A15.382.490.555]
Lymphocytes [A15.382.490.555.567]
Lymphocyte Subsets [A15.382.490.555.567.550]
T-Lymphocyte Subsets [A15.382.490.555.567.550.500]
T-Lymphocytes, Helper-Inducer [A15.382.490.555.567.550.500.400]
Th1 Cells [A15.382.490.555.567.550.500.400.900]
T-Lymphocytes [A15.382.490.555.567.569]
CD4-Positive T-Lymphocytes [A15.382.490.555.567.569.200]
T-Lymphocytes, Helper-Inducer [A15.382.490.555.567.569.200.400]
Th1 Cells [A15.382.490.555.567.569.200.400.900]
T-Lymphocyte Subsets [A15.382.490.555.567.569.500]
T-Lymphocytes, Helper-Inducer [A15.382.490.555.567.569.500.400]
Th1 Cells [A15.382.490.555.567.569.500.400.900]

Below are MeSH descriptors whose meaning is related to "Th1 Cells".

Below are MeSH descriptors whose meaning is more specific than "Th1 Cells".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Th1 Cells" by people in this website by year, and whether "Th1 Cells" was a major or minor topic of these publications.

Bar chart showing 139 publications over 27 distinct years, with a maximum of 13 publications in 1998

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1995	1	0	1
1996	1	1	2
1997	2	2	4
1998	8	5	13
1999	4	4	8
2000	1	2	3
2001	3	4	7
2002	3	2	5
2003	2	3	5
2004	3	3	6
2005	3	5	8
2006	2	3	5
2007	0	3	3
2008	2	3	5
2009	3	3	6
2010	1	1	2
2011	3	1	4
2012	3	5	8
2013	1	2	3
2014	1	1	2
2015	3	5	8
2016	6	5	11
2017	1	3	4
2018	4	6	10
2019	1	2	3
2022	0	2	2
2023	0	1	1

Below are the most recent publications written about "Th1 Cells" by people in Profiles.

Chen D, Varanasi SK, Hara T, Traina K, Sun M, McDonald B, Farsakoglu Y, Clanton J, Xu S, Garcia-Rivera L, Mann TH, Du V, Chung HK, Xu Z, Tripple V, Casillas E, Ma S, O'Connor C, Yang Q, Zheng Y, Hunter T, Lemke G, Kaech SM. CTLA-4 blockade induces a microglia-Th1 cell partnership that stimulates microglia phagocytosis and anti-tumor function in glioblastoma. Immunity. 2023 09 12; 56(9):2086-2104.e8.

View in: PubMed
Haddadi NS, Mande P, Brodeur TY, Hao K, Ryan GE, Moses S, Subramanian S, Picari X, Afshari K, Marshak-Rothstein A, Richmond JM. Th2 to Th1 Transition Is Required for Induction of Skin Lesions in an Inducible and Recurrent Murine Model of Cutaneous Lupus-Like Inflammation. Front Immunol. 2022; 13:883375.

View in: PubMed
Dhume K, Finn CM, Devarajan P, Singh A, Tejero JD, Prokop E, Strutt TM, Sell S, Swain SL, McKinstry KK. Bona Fide Th17 Cells without Th1 Functional Plasticity Protect against Influenza. J Immunol. 2022 04 15; 208(8):1998-2007.

View in: PubMed
Metwali A, Winckler S, Urban JF, Kaplan MH, Ince MN, Elliott DE. Helminth-induced regulation of T-cell transfer colitis requires intact and regulated T cell Stat6 signaling in mice. Eur J Immunol. 2021 02; 51(2):433-444.

View in: PubMed
Pawaria S, N?ndel K, Gao KM, Moses S, Busto P, Holt K, Sharma RB, Brehm MA, Gravallese EM, Socolovsky M, Christ A, Marshak-Rothstein A. Role of Interferon-?-Producing Th1 Cells in a Murine Model of Type I Interferon-Independent Autoinflammation Resulting From DNase II Deficiency. Arthritis Rheumatol. 2020 02; 72(2):359-370.

View in: PubMed
Ciecko AE, Foda B, Barr JY, Ramanathan S, Atkinson MA, Serreze DV, Geurts AM, Lieberman SM, Chen YG. Interleukin-27 Is Essential for Type 1 Diabetes Development and Sj?gren Syndrome-like Inflammation. Cell Rep. 2019 12 03; 29(10):3073-3086.e5.

View in: PubMed
Muhammad FY, Peters K, Wang D, Lee DJ. Exacerbation of autoimmune uveitis by obesity occurs through the melanocortin 5 receptor. J Leukoc Biol. 2019 10; 106(4):879-887.

View in: PubMed
Liu Y, Lightfoot YL, Seto N, Carmona-Rivera C, Moore E, Goel R, O'Neil L, Mistry P, Hoffmann V, Mondal S, Premnath PN, Gribbons K, Dell'Orso S, Jiang K, Thompson PR, Sun HW, Coonrod SA, Kaplan MJ. Peptidylarginine deiminases 2 and 4 modulate innate and adaptive immune responses in TLR-7-dependent lupus. JCI Insight. 2018 12 06; 3(23).

View in: PubMed
Chen Y, Sharma S, Assis PA, Jiang Z, Elling R, Olive AJ, Hang S, Bernier J, Huh JR, Sassetti CM, Knipe DM, Gazzinelli RT, Fitzgerald KA. CNBP controls IL-12 gene transcription and Th1 immunity. J Exp Med. 2018 12 03; 215(12):3136-3150.

View in: PubMed
Hung CY, Zhang H, Castro-Lopez N, Ostroff GR, Khoshlenar P, Abraham A, Cole GT, Negron A, Forsthuber T, Peng T, Galgiani JN, Ampel NM, Yu JJ. Glucan-Chitin Particles Enhance Th17 Response and Improve Protective Efficacy of a Multivalent Antigen (rCpa1) against Pulmonary Coccidioides posadasii Infection. Infect Immun. 2018 11; 86(11).

View in: PubMed

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