NAD

"NAD" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH). (Dorland, 27th ed)

Descriptor ID	D009243
MeSH Number(s)	D03.633.100.759.646.138.694 D08.211.589 D13.695.667.138.694 D13.695.827.068.694
Concept/Terms	NAD NAD Dihydronicotinamide Adenine Dinucleotide Adenine Dinucleotide, Dihydronicotinamide Dinucleotide, Dihydronicotinamide Adenine Diphosphopyridine Nucleotide Nucleotide, Diphosphopyridine Nadide Nicotinamide-Adenine Dinucleotide Dinucleotide, Nicotinamide-Adenine Nicotinamide Adenine Dinucleotide Coenzyme I DPN NADH NADH

Below are MeSH descriptors whose meaning is more general than "NAD".

Chemicals and Drugs [D]
Heterocyclic Compounds [D03]
Heterocyclic Compounds, Fused-Ring [D03.633]
Heterocyclic Compounds, 2-Ring [D03.633.100]
Purines [D03.633.100.759]
Purine Nucleotides [D03.633.100.759.646]
Adenine Nucleotides [D03.633.100.759.646.138]
NAD [D03.633.100.759.646.138.694]
Enzymes and Coenzymes [D08]
Coenzymes [D08.211]
NAD [D08.211.589]
Nucleic Acids, Nucleotides, and Nucleosides [D13]
Nucleotides [D13.695]
Purine Nucleotides [D13.695.667]
Adenine Nucleotides [D13.695.667.138]
NAD [D13.695.667.138.694]
Ribonucleotides [D13.695.827]
Adenine Nucleotides [D13.695.827.068]
NAD [D13.695.827.068.694]

Below are MeSH descriptors whose meaning is more specific than "NAD".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "NAD" by people in this website by year, and whether "NAD" was a major or minor topic of these publications.

Bar chart showing 28 publications over 14 distinct years, with a maximum of 5 publications in 2018

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1996	0	1	1
1997	2	0	2
1999	0	1	1
2000	0	1	1
2006	0	1	1
2007	1	2	3
2013	0	1	1
2015	0	2	2
2018	3	2	5
2019	2	1	3
2020	1	1	2
2021	0	1	1
2022	1	3	4
2023	1	0	1

Below are the most recent publications written about "NAD" by people in Profiles.

Basse AL, Nielsen KN, Karavaeva I, Ingerslev LR, Ma T, Havelund JF, Nielsen TS, Frost M, Peics J, Dalbram E, Dall M, Zierath JR, Barr?s R, F?rgeman NJ, Treebak JT, Gerhart-Hines Z. NAMPT-dependent NAD+ biosynthesis controls circadian metabolism in a tissue-specific manner. Proc Natl Acad Sci U S A. 2023 04 04; 120(14):e2220102120.

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Icso JD, Thompson PR. The chemical biology of NAD+ regulation in axon degeneration. Curr Opin Chem Biol. 2022 08; 69:102176.

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Peterson ND, Icso JD, Salisbury JE, Rodr?guez T, Thompson PR, Pukkila-Worley R. Pathogen infection and cholesterol deficiency activate the C. elegans p38 immune pathway through a TIR-1/SARM1 phase transition. Elife. 2022 01 31; 11.

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Becker-Krail DD, Parekh PK, Ketchesin KD, Yamaguchi S, Yoshino J, Hildebrand MA, Dunham B, Ganapathiraju MK, Logan RW, McClung CA. Circadian transcription factor NPAS2 and the NAD+ -dependent deacetylase SIRT1 interact in the mouse nucleus accumbens and regulate reward. Eur J Neurosci. 2022 02; 55(3):675-693.

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Erlandsen H, Jecrois AM, Nichols JC, Cole JL, Royer WE. NADH/NAD+ binding and linked tetrameric assembly of the oncogenic transcription factors CtBP1 and CtBP2. FEBS Lett. 2022 02; 596(4):479-490.

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Nichols JC, Schiffer CA, Royer WE. NAD(H) phosphates mediate tetramer assembly of human C-terminal binding protein (CtBP). J Biol Chem. 2021 Jan-Jun; 296:100351.

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Loring HS, Parelkar SS, Mondal S, Thompson PR. Identification of the first noncompetitive SARM1 inhibitors. Bioorg Med Chem. 2020 09 15; 28(18):115644.

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Goodman RP, Markhard AL, Shah H, Sharma R, Skinner OS, Clish CB, Deik A, Patgiri A, Hsu YH, Masia R, Noh HL, Suk S, Goldberger O, Hirschhorn JN, Yellen G, Kim JK, Mootha VK. Hepatic NADH reductive stress underlies common variation in metabolic traits. Nature. 2020 07; 583(7814):122-126.

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Ralto KM, Rhee EP, Parikh SM. NAD+ homeostasis in renal health and disease. Nat Rev Nephrol. 2020 02; 16(2):99-111.

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Lynch MR, Tran MT, Ralto KM, Zsengeller ZK, Raman V, Bhasin SS, Sun N, Chen X, Brown D, Rovira II, Taguchi K, Brooks CR, Stillman IE, Bhasin MK, Finkel T, Parikh SM. TFEB-driven lysosomal biogenesis is pivotal for PGC1a-dependent renal stress resistance. JCI Insight. 2019 03 14; 5.

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