NAD

"NAD" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH). (Dorland, 27th ed)

Descriptor ID	D009243
MeSH Number(s)	D03.633.100.759.646.138.694 D08.211.589 D13.695.667.138.694 D13.695.827.068.694
Concept/Terms	NAD NAD Dihydronicotinamide Adenine Dinucleotide Adenine Dinucleotide, Dihydronicotinamide Dinucleotide, Dihydronicotinamide Adenine Diphosphopyridine Nucleotide Nucleotide, Diphosphopyridine Nadide Nicotinamide-Adenine Dinucleotide Dinucleotide, Nicotinamide-Adenine Nicotinamide Adenine Dinucleotide Coenzyme I DPN NADH NADH

Below are MeSH descriptors whose meaning is more general than "NAD".

Chemicals and Drugs [D]
Heterocyclic Compounds [D03]
Heterocyclic Compounds, Fused-Ring [D03.633]
Heterocyclic Compounds, 2-Ring [D03.633.100]
Purines [D03.633.100.759]
Purine Nucleotides [D03.633.100.759.646]
Adenine Nucleotides [D03.633.100.759.646.138]
NAD [D03.633.100.759.646.138.694]
Enzymes and Coenzymes [D08]
Coenzymes [D08.211]
NAD [D08.211.589]
Nucleic Acids, Nucleotides, and Nucleosides [D13]
Nucleotides [D13.695]
Purine Nucleotides [D13.695.667]
Adenine Nucleotides [D13.695.667.138]
NAD [D13.695.667.138.694]
Ribonucleotides [D13.695.827]
Adenine Nucleotides [D13.695.827.068]
NAD [D13.695.827.068.694]

Below are MeSH descriptors whose meaning is more specific than "NAD".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "NAD" by people in this website by year, and whether "NAD" was a major or minor topic of these publications.

Bar chart showing 33 publications over 15 distinct years, with a maximum of 5 publications in 2023

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1996	0	1	1
1997	2	0	2
1999	0	1	1
2000	0	1	1
2001	1	0	1
2006	0	1	1
2007	1	2	3
2013	0	1	1
2015	0	2	2
2018	3	1	4
2019	2	1	3
2020	2	1	3
2021	0	1	1
2022	1	3	4
2023	4	1	5

Below are the most recent publications written about "NAD" by people in Profiles.

Icso JD, Thompson PR. A phase transition reduces the threshold for nicotinamide mononucleotide-based activation of SARM1, an NAD(P) hydrolase, to physiologically relevant levels. J Biol Chem. 2023 11; 299(11):105284.

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Icso JD, Barasa L, Thompson PR. SARM1, an Enzyme Involved in Axon Degeneration, Catalyzes Multiple Activities through a Ternary Complex Mechanism. Biochemistry. 2023 07 04; 62(13):2065-2078.

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Zhou W, Simic P, Zhou IY, Caravan P, Vela Parada X, Wen D, Washington OL, Shvedova M, Pierce KA, Clish CB, Mannstadt M, Kobayashi T, Wein MN, J?ppner H, Rhee EP. Kidney glycolysis serves as a mammalian phosphate sensor that maintains phosphate homeostasis. J Clin Invest. 2023 04 17; 133(8).

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Basse AL, Nielsen KN, Karavaeva I, Ingerslev LR, Ma T, Havelund JF, Nielsen TS, Frost M, Peics J, Dalbram E, Dall M, Zierath JR, Barr?s R, F?rgeman NJ, Treebak JT, Gerhart-Hines Z. NAMPT-dependent NAD+ biosynthesis controls circadian metabolism in a tissue-specific manner. Proc Natl Acad Sci U S A. 2023 04 04; 120(14):e2220102120.

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Qu W, Ralto KM, Qin T, Cheng Y, Zong W, Luo X, Perez-Pinzon M, Parikh SM, Ayata C. NAD+ precursor nutritional supplements sensitize the brain to future ischemic events. J Cereb Blood Flow Metab. 2023 11; 43(2_suppl):37-48.

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Icso JD, Thompson PR. The chemical biology of NAD+ regulation in axon degeneration. Curr Opin Chem Biol. 2022 08; 69:102176.

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Peterson ND, Icso JD, Salisbury JE, Rodr?guez T, Thompson PR, Pukkila-Worley R. Pathogen infection and cholesterol deficiency activate the C. elegans p38 immune pathway through a TIR-1/SARM1 phase transition. Elife. 2022 01 31; 11.

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Becker-Krail DD, Parekh PK, Ketchesin KD, Yamaguchi S, Yoshino J, Hildebrand MA, Dunham B, Ganapathiraju MK, Logan RW, McClung CA. Circadian transcription factor NPAS2 and the NAD+ -dependent deacetylase SIRT1 interact in the mouse nucleus accumbens and regulate reward. Eur J Neurosci. 2022 02; 55(3):675-693.

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Erlandsen H, Jecrois AM, Nichols JC, Cole JL, Royer WE. NADH/NAD+ binding and linked tetrameric assembly of the oncogenic transcription factors CtBP1 and CtBP2. FEBS Lett. 2022 02; 596(4):479-490.

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Nichols JC, Schiffer CA, Royer WE. NAD(H) phosphates mediate tetramer assembly of human C-terminal binding protein (CtBP). J Biol Chem. 2021 Jan-Jun; 296:100351.

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