NAD

"NAD" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH). (Dorland, 27th ed)

Descriptor ID	D009243
MeSH Number(s)	D03.633.100.759.646.138.694 D08.211.589 D13.695.667.138.694 D13.695.827.068.694
Concept/Terms	NAD NAD Dihydronicotinamide Adenine Dinucleotide Adenine Dinucleotide, Dihydronicotinamide Dinucleotide, Dihydronicotinamide Adenine Diphosphopyridine Nucleotide Nucleotide, Diphosphopyridine Nadide Nicotinamide-Adenine Dinucleotide Dinucleotide, Nicotinamide-Adenine Nicotinamide Adenine Dinucleotide Coenzyme I DPN NADH NADH

Below are MeSH descriptors whose meaning is more general than "NAD".

Chemicals and Drugs [D]
Heterocyclic Compounds [D03]
Heterocyclic Compounds, Fused-Ring [D03.633]
Heterocyclic Compounds, 2-Ring [D03.633.100]
Purines [D03.633.100.759]
Purine Nucleotides [D03.633.100.759.646]
Adenine Nucleotides [D03.633.100.759.646.138]
NAD [D03.633.100.759.646.138.694]
Enzymes and Coenzymes [D08]
Coenzymes [D08.211]
NAD [D08.211.589]
Nucleic Acids, Nucleotides, and Nucleosides [D13]
Nucleotides [D13.695]
Purine Nucleotides [D13.695.667]
Adenine Nucleotides [D13.695.667.138]
NAD [D13.695.667.138.694]
Ribonucleotides [D13.695.827]
Adenine Nucleotides [D13.695.827.068]
NAD [D13.695.827.068.694]

Below are MeSH descriptors whose meaning is more specific than "NAD".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "NAD" by people in this website by year, and whether "NAD" was a major or minor topic of these publications.

Bar chart showing 42 publications over 17 distinct years, with a maximum of 7 publications in 2023

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1996	0	2	2
1997	2	0	2
1999	0	1	1
2000	0	1	1
2001	1	0	1
2006	0	1	1
2007	1	3	4
2008	0	1	1
2013	0	1	1
2015	1	2	3
2018	3	1	4
2019	2	1	3
2020	2	2	4
2021	0	1	1
2022	1	4	5
2023	4	3	7
2025	1	0	1

Below are the most recent publications written about "NAD" by people in Profiles.

Chubanava S, Karavaeva I, Ehrlich AM, Justicia RM, Basse AL, Kulik I, Dalbram E, Ahwazi D, Heaselgrave SR, Tro?t K, Stocks B, Hodek O, Rodrigues RN, Havelund JF, Schlabs FL, Larsen S, Yonamine CY, Henriquez-Olgu?n C, Giustarini D, Rossi R, Gerhart-Hines Z, Moritz T, Zierath JR, Sakamoto K, Jensen TE, F?rgeman NJ, Lavery GG, Deshmukh AS, Treebak JT. NAD depletion in skeletal muscle does not compromise muscle function or accelerate aging. Cell Metab. 2025 Jul 01; 37(7):1460-1481.e17.

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Shen Z, Lin Q, Yang XY, Fosuah E, Fu TM. Assembly-mediated activation of the SIR2-HerA supramolecular complex for anti-phage defense. Mol Cell. 2023 Dec 21; 83(24):4586-4599.e5.

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Icso JD, Thompson PR. A phase transition reduces the threshold for nicotinamide mononucleotide-based activation of SARM1, an NAD(P) hydrolase, to physiologically relevant levels. J Biol Chem. 2023 11; 299(11):105284.

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Shen Z, Yang XY, Xia S, Huang W, Taylor DJ, Nakanishi K, Fu TM. Oligomerization-mediated activation of a short prokaryotic Argonaute. Nature. 2023 09; 621(7977):154-161.

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Icso JD, Barasa L, Thompson PR. SARM1, an Enzyme Involved in Axon Degeneration, Catalyzes Multiple Activities through a Ternary Complex Mechanism. Biochemistry. 2023 07 04; 62(13):2065-2078.

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Zhou W, Simic P, Zhou IY, Caravan P, Vela Parada X, Wen D, Washington OL, Shvedova M, Pierce KA, Clish CB, Mannstadt M, Kobayashi T, Wein MN, J?ppner H, Rhee EP. Kidney glycolysis serves as a mammalian phosphate sensor that maintains phosphate homeostasis. J Clin Invest. 2023 04 17; 133(8).

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Basse AL, Nielsen KN, Karavaeva I, Ingerslev LR, Ma T, Havelund JF, Nielsen TS, Frost M, Peics J, Dalbram E, Dall M, Zierath JR, Barr?s R, F?rgeman NJ, Treebak JT, Gerhart-Hines Z. NAMPT-dependent NAD+ biosynthesis controls circadian metabolism in a tissue-specific manner. Proc Natl Acad Sci U S A. 2023 04 04; 120(14):e2220102120.

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Qu W, Ralto KM, Qin T, Cheng Y, Zong W, Luo X, Perez-Pinzon M, Parikh SM, Ayata C. NAD+ precursor nutritional supplements sensitize the brain to future ischemic events. J Cereb Blood Flow Metab. 2023 11; 43(2_suppl):37-48.

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Icso JD, Thompson PR. The chemical biology of NAD+ regulation in axon degeneration. Curr Opin Chem Biol. 2022 08; 69:102176.

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McCann KJ, Christensen SM, Colby DH, McGuire PJ, Myles IA, Zerbe CS, Dalgard CL, Sukumar G, Leonard WJ, McCormick BA, Holland SM. IFN? regulates NAD+ metabolism to promote the respiratory burst in human monocytes. Blood Adv. 2022 06 28; 6(12):3821-3834.

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