Extracellular Signal-Regulated MAP Kinases

"Extracellular Signal-Regulated MAP Kinases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A mitogen-activated protein kinase subfamily that is widely expressed and plays a role in regulation of MEIOSIS; MITOSIS; and post mitotic functions in differentiated cells. The extracellular signal regulated MAP kinases are regulated by a broad variety of CELL SURFACE RECEPTORS and can be activated by certain CARCINOGENS.

Descriptor ID	D048049
MeSH Number(s)	D08.811.913.696.620.682.700.567.249 D12.644.360.450.169 D12.776.476.450.169
Concept/Terms	Extracellular Signal-Regulated MAP Kinases Extracellular Signal-Regulated MAP Kinases Extracellular Signal Regulated MAP Kinases MAP Kinases, Extracellular Signal-Regulated MAP Kinases, Extracellular Signal Regulated ERK MAP Kinases Extracellular Signal-Regulated Kinases Extracellular Signal Regulated Kinases Kinases, Extracellular Signal-Regulated

Below are MeSH descriptors whose meaning is more general than "Extracellular Signal-Regulated MAP Kinases".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Transferases [D08.811.913]
Phosphotransferases [D08.811.913.696]
Phosphotransferases (Alcohol Group Acceptor) [D08.811.913.696.620]
Protein Kinases [D08.811.913.696.620.682]
Protein-Serine-Threonine Kinases [D08.811.913.696.620.682.700]
Mitogen-Activated Protein Kinases [D08.811.913.696.620.682.700.567]
Extracellular Signal-Regulated MAP Kinases [D08.811.913.696.620.682.700.567.249]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intracellular Signaling Peptides and Proteins [D12.644.360]
Mitogen-Activated Protein Kinases [D12.644.360.450]
Extracellular Signal-Regulated MAP Kinases [D12.644.360.450.169]
Proteins [D12.776]
Intracellular Signaling Peptides and Proteins [D12.776.476]
Mitogen-Activated Protein Kinases [D12.776.476.450]
Extracellular Signal-Regulated MAP Kinases [D12.776.476.450.169]

Below are MeSH descriptors whose meaning is related to "Extracellular Signal-Regulated MAP Kinases".

Below are MeSH descriptors whose meaning is more specific than "Extracellular Signal-Regulated MAP Kinases".

Extracellular Signal-Regulated MAP Kinases
Mitogen-Activated Protein Kinase 1
Mitogen-Activated Protein Kinase 3
Mitogen-Activated Protein Kinase 6
Mitogen-Activated Protein Kinase 7

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Extracellular Signal-Regulated MAP Kinases" by people in this website by year, and whether "Extracellular Signal-Regulated MAP Kinases" was a major or minor topic of these publications.

Bar chart showing 47 publications over 16 distinct years, with a maximum of 7 publications in 2010

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2004	0	1	1
2006	0	1	1
2007	1	4	5
2008	1	1	2
2009	2	3	5
2010	1	6	7
2011	1	2	3
2012	1	2	3
2013	1	4	5
2014	0	2	2
2015	0	3	3
2016	2	2	4
2018	1	0	1
2019	2	1	3
2020	1	0	1
2022	1	0	1

Below are the most recent publications written about "Extracellular Signal-Regulated MAP Kinases" by people in Profiles.

Kim JM, Yang YS, Hong J, Chaugule S, Chun H, van der Meulen MCH, Xu R, Greenblatt MB, Shim JH. Biphasic regulation of osteoblast development via the ERK MAPK-mTOR pathway. Elife. 2022 08 17; 11.

View in: PubMed
Bok S, Shin DY, Yallowitz AR, Eiseman M, Cung M, Xu R, Li N, Sun J, Williams AL, Scott JE, Su B, Shim JH, Greenblatt MB. MEKK2 mediates aberrant ERK activation in neurofibromatosis type I. Nat Commun. 2020 11 11; 11(1):5704.

View in: PubMed
Lee MH, Gallo PM, Hooper KM, Corradetti C, Ganea D, Caricchio R, Gallucci S. The cytokine network type I IFN-IL-27-IL-10 is augmented in murine and human lupus. J Leukoc Biol. 2019 10; 106(4):967-975.

View in: PubMed
Olea-Flores M, Zu?iga-Eulogio MD, Mendoza-Catal?n MA, Rodr?guez-Ruiz HA, Casta?eda-Saucedo E, Ortu?o-Pineda C, Padilla-Benavides T, Navarro-Tito N. Extracellular-Signal Regulated Kinase: A Central Molecule Driving Epithelial-Mesenchymal Transition in Cancer. Int J Mol Sci. 2019 Jun 13; 20(12).

View in: PubMed
Kim JM, Yang YS, Park KH, Oh H, Greenblatt MB, Shim JH. The ERK MAPK Pathway Is Essential for Skeletal Development and Homeostasis. Int J Mol Sci. 2019 Apr 12; 20(8).

View in: PubMed
Bugaj LJ, Sabnis AJ, Mitchell A, Garbarino JE, Toettcher JE, Bivona TG, Lim WA. Cancer mutations and targeted drugs can disrupt dynamic signal encoding by the Ras-Erk pathway. Science. 2018 08 31; 361(6405).

View in: PubMed
Shin M, Male I, Beane TJ, Villefranc JA, Kok FO, Zhu LJ, Lawson ND. Vegfc acts through ERK to induce sprouting and differentiation of trunk lymphatic progenitors. Development. 2016 10 15; 143(20):3785-3795.

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Biswas MHU, Almeida S, Lopez-Gonzalez R, Mao W, Zhang Z, Karydas A, Geschwind MD, Biernat J, Mandelkow EM, Futai K, Miller BL, Gao FB. MMP-9 and MMP-2 Contribute to Neuronal Cell Death in iPSC Models of Frontotemporal Dementia with MAPT Mutations. Stem Cell Reports. 2016 09 13; 7(3):316-324.

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Shin M, Beane TJ, Quillien A, Male I, Zhu LJ, Lawson ND. Vegfa signals through ERK to promote angiogenesis, but not artery differentiation. Development. 2016 10 15; 143(20):3796-3805.

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Bukong TN, Iracheta-Vellve A, Gyongyosi B, Ambade A, Catalano D, Kodys K, Szabo G. Therapeutic Benefits of Spleen Tyrosine Kinase Inhibitor Administration on Binge Drinking-Induced Alcoholic Liver Injury, Steatosis, and Inflammation in Mice. Alcohol Clin Exp Res. 2016 07; 40(7):1524-30.

View in: PubMed

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