Immunoglobulin Constant Regions
"Immunoglobulin Constant Regions" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The domains of the immunoglobulin molecules that are invariable in their amino acid sequence within any class or subclass of immunoglobulin. They confer biological as well as structural functions to immunoglobulins. One each on both the light chains and the heavy chains comprises the C-terminus half of the IMMUNOGLOBULIN FAB FRAGMENT and two or three of them make up the rest of the heavy chains (all of the IMMUNOGLOBULIN FC FRAGMENT)
| Descriptor ID |
D007127
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| MeSH Number(s) |
D12.776.124.486.485.538 D12.776.124.790.651.538 D12.776.377.715.548.538
|
| Concept/Terms |
Immunoglobulin Constant Regions- Immunoglobulin Constant Regions
- Constant Regions, Immunoglobulin
- Constant Region, Ig
- Immunoglobulin Constant Region
- Constant Region, Immunoglobulin
|
Below are MeSH descriptors whose meaning is more general than "Immunoglobulin Constant Regions".
Below are MeSH descriptors whose meaning is more specific than "Immunoglobulin Constant Regions".
This graph shows the total number of publications written about "Immunoglobulin Constant Regions" by people in this website by year, and whether "Immunoglobulin Constant Regions" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 0 | 1 | 1 |
| 1996 | 1 | 0 | 1 |
| 2004 | 0 | 1 | 1 |
| 2005 | 0 | 1 | 1 |
| 2012 | 1 | 0 | 1 |
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Below are the most recent publications written about "Immunoglobulin Constant Regions" by people in Profiles.
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Yu X, Duval M, Lewis C, Gawron MA, Wang R, Posner MR, Cavacini LA. Impact of IgA constant domain on HIV-1 neutralizing function of monoclonal antibody F425A1g8. J Immunol. 2013 Jan 01; 190(1):205-10.
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Giuntini S, Reason DC, Granoff DM. Complement-mediated bactericidal activity of anti-factor H binding protein monoclonal antibodies against the meningococcus relies upon blocking factor H binding. Infect Immun. 2011 Sep; 79(9):3751-9.
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Schrader CE, Linehan EK, Mochegova SN, Woodland RT, Stavnezer J. Inducible DNA breaks in Ig S regions are dependent on AID and UNG. J Exp Med. 2005 Aug 15; 202(4):561-8.
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Shen L, Sigal LJ, Boes M, Rock KL. Important role of cathepsin S in generating peptides for TAP-independent MHC class I crosspresentation in vivo. Immunity. 2004 Aug; 21(2):155-65.
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Lin SC, Stavnezer J. Activation of NF-kappaB/Rel by CD40 engagement induces the mouse germ line immunoglobulin Cgamma1 promoter. Mol Cell Biol. 1996 Sep; 16(9):4591-603.
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Socolovsky M, Hockaday AR, Allen JM. Human high-affinity Fc IgG receptor (Fc gamma RI)-mediated phagocytosis and pinocytosis in COS cells. Eur J Cell Biol. 1994 Jun; 64(1):29-44.
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Stavnezer J, Radcliffe G, Lin YC, Nietupski J, Berggren L, Sitia R, Severinson E. Immunoglobulin heavy-chain switching may be directed by prior induction of transcripts from constant-region genes. Proc Natl Acad Sci U S A. 1988 Oct; 85(20):7704-8.