Complement Activation

"Complement Activation" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

The sequential activation of serum COMPLEMENT PROTEINS to create the COMPLEMENT MEMBRANE ATTACK COMPLEX. Factors initiating complement activation include ANTIGEN-ANTIBODY COMPLEXES, microbial ANTIGENS, or cell surface POLYSACCHARIDES.

Descriptor ID	D003167
MeSH Number(s)	G12.274
Concept/Terms	Complement Activation Complement Activation Activation, Complement Activations, Complement Complement Activations

Below are MeSH descriptors whose meaning is more general than "Complement Activation".

Biological Sciences [G]
Immune System Phenomena [G12]
Complement Activation [G12.274]

Below are MeSH descriptors whose meaning is more specific than "Complement Activation".

Complement Activation
Complement Pathway, Alternative
Complement Pathway, Classical
Complement Pathway, Mannose-Binding Lectin

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Complement Activation" by people in this website by year, and whether "Complement Activation" was a major or minor topic of these publications.

Bar chart showing 27 publications over 17 distinct years, with a maximum of 3 publications in 2006 and 2013 and 2019

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2002	0	1	1
2006	0	3	3
2007	1	0	1
2008	1	0	1
2009	1	1	2
2010	1	0	1
2011	1	1	2
2013	1	2	3
2014	0	1	1
2015	1	1	2
2016	1	0	1
2017	0	1	1
2018	0	1	1
2019	1	2	3
2020	1	0	1
2021	1	1	2
2022	1	0	1

Below are the most recent publications written about "Complement Activation" by people in Profiles.

Shaughnessy J, Chabeda A, Lewis LA, Ram S. Alternative pathway amplification and infections. Immunol Rev. 2023 01; 313(1):162-180.

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Bettoni S, Maziarz K, Stone MRL, Blaskovich MAT, Potempa J, Bazzo ML, Unemo M, Ram S, Blom AM. Serum Complement Activation by C4BP-IgM Fusion Protein Can Restore Susceptibility to Antibiotics in Neisseria gonorrhoeae. Front Immunol. 2021; 12:726801.

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Parzych EM, Gulati S, Zheng B, Bah MA, Elliott STC, Chu JD, Nowak N, Reed GW, Beurskens FJ, Schuurman J, Rice PA, Weiner DB, Ram S. Synthetic DNA Delivery of an Optimized and Engineered Monoclonal Antibody Provides Rapid and Prolonged Protection against Experimental Gonococcal Infection. mBio. 2021 03 16; 12(2).

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Wang X, Sahu KK, Cerny J. Coagulopathy, endothelial dysfunction, thrombotic microangiopathy and complement activation: potential role of complement system inhibition in COVID-19. J Thromb Thrombolysis. 2021 Apr; 51(3):657-662.

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Frye AM, Hart TM, Tufts DM, Ram S, Diuk-Wasser MA, Kraiczy P, Blom AM, Lin YP. A soft tick Ornithodoros moubata salivary protein OmCI is a potent inhibitor to prevent avian complement activation. Ticks Tick Borne Dis. 2020 03; 11(2):101354.

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Ermert D, Ram S, Laabei M. The hijackers guide to escaping complement: Lessons learned from pathogens. Mol Immunol. 2019 10; 114:49-61.

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Gulati S, Beurskens FJ, de Kreuk BJ, Roza M, Zheng B, DeOliveira RB, Shaughnessy J, Nowak NA, Taylor RP, Botto M, He X, Ingalls RR, Woodruff TM, Song WC, Schuurman J, Rice PA, Ram S. Complement alone drives efficacy of a chimeric antigonococcal monoclonal antibody. PLoS Biol. 2019 06; 17(6):e3000323.

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Ray TD, Mekasha S, Liang Y, Lu B, Ram S, Ingalls RR. Species-specific differences in regulation of macrophage inflammation by the C3a-C3a receptor axis. Innate Immun. 2018 01; 24(1):66-78.

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Bakke SS, Aune MH, Niyonzima N, Pilely K, Ryan L, Skjelland M, Garred P, Aukrust P, Halvorsen B, Latz E, Dam?s JK, Mollnes TE, Espevik T. Cyclodextrin Reduces Cholesterol Crystal-Induced Inflammation by Modulating Complement Activation. J Immunol. 2017 10 15; 199(8):2910-2920.

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Ram S, Shaughnessy J, DeOliveira RB, Lewis LA, Gulati S, Rice PA. Utilizing complement evasion strategies to design complement-based antibacterial immunotherapeutics: Lessons from the pathogenic Neisseriae. Immunobiology. 2016 10; 221(10):1110-23.

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