Type C Phospholipases

"Type C Phospholipases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A subclass of phospholipases that hydrolyze the phosphoester bond found in the third position of GLYCEROPHOSPHOLIPIDS. Although the singular term phospholipase C specifically refers to an enzyme that catalyzes the hydrolysis of PHOSPHATIDYLCHOLINE (EC 3.1.4.3), it is commonly used in the literature to refer to broad variety of enzymes that specifically catalyze the hydrolysis of PHOSPHATIDYLINOSITOLS.

Descriptor ID	D010738
MeSH Number(s)	D08.811.277.352.640.700.700
Concept/Terms	Type C Phospholipases Type C Phospholipases Phospholipases, Type C Phospholipases C Phospholipase C Phospholipase C Lecithinase C

Below are MeSH descriptors whose meaning is more general than "Type C Phospholipases".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Hydrolases [D08.811.277]
Esterases [D08.811.277.352]
Phosphoric Diester Hydrolases [D08.811.277.352.640]
Phospholipases [D08.811.277.352.640.700]
Type C Phospholipases [D08.811.277.352.640.700.700]

Below are MeSH descriptors whose meaning is related to "Type C Phospholipases".

Below are MeSH descriptors whose meaning is more specific than "Type C Phospholipases".

Type C Phospholipases
Glycosylphosphatidylinositol Diacylglycerol-Lyase
Phosphatidylinositol Diacylglycerol-Lyase
Phosphoinositide Phospholipase C

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Type C Phospholipases" by people in this website by year, and whether "Type C Phospholipases" was a major or minor topic of these publications.

Bar chart showing 23 publications over 15 distinct years, with a maximum of 4 publications in 2003

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1997	0	1	1
2000	1	0	1
2001	1	2	3
2003	4	0	4
2004	2	1	3
2005	1	0	1
2006	1	0	1
2008	1	0	1
2009	0	1	1
2010	1	0	1
2013	2	0	2
2014	1	0	1
2015	0	1	1
2016	1	0	1
2025	1	0	1

Below are the most recent publications written about "Type C Phospholipases" by people in Profiles.

Mishra N, Mohs M, Wittmann N, Gross S, Thompson PR, Bossaller L. PLC and PAD2 Regulate Extracellular Calcium-Triggered Release of Macrophage Extracellular DNA Traps. Eur J Immunol. 2025 Apr; 55(4):e202350942.

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Thai T, Zhong F, Dang L, Chan E, Ku J, Malle E, Geczy CL, Keaney JF, Thomas SR. Endothelial-transcytosed myeloperoxidase activates endothelial nitric oxide synthase via a phospholipase C-dependent calcium signaling pathway. Free Radic Biol Med. 2021 04; 166:255-264.

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Najibi M, Labed SA, Visvikis O, Irazoqui JE. An Evolutionarily Conserved PLC-PKD-TFEB Pathway for Host Defense. Cell Rep. 2016 05 24; 15(8):1728-42.

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Strachan-Whaley MR, Reilly K, Dobson J, Kalisch BE. Map kinase and PKC signaling pathways modulate NGF-mediated apoE transcription. Neurosci Lett. 2015 May 19; 595:54-9.

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Escoffier J, Yassine S, Lee HC, Martinez G, Delaroche J, Coutton C, Karaouz?ne T, Zouari R, Metzler-Guillemain C, Pernet-Gallay K, Hennebicq S, Ray PF, Fissore R, Arnoult C. Subcellular localization of phospholipase C? in human sperm and its absence in DPY19L2-deficient sperm are consistent with its role in oocyte activation. Mol Hum Reprod. 2015 Feb; 21(2):157-68.

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Villaverde AI, Fioratti EG, Fissore RA, He C, Lee HC, Souza FF, Landim-Alvarenga FC, Lopes MD. Identification of phospholipase C zeta in normospermic and teratospermic domestic cat sperm. Theriogenology. 2013 Oct 15; 80(7):722-9.

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Sato K, Wakai T, Seita Y, Takizawa A, Fissore RA, Ito J, Kashiwazaki N. Molecular characteristics of horse phospholipase C zeta (PLC?). Anim Sci J. 2013 Apr; 84(4):359-68.

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Fenton RA, Shea LG, Doddi C, Dobson JG. Myocardial adenosine A(1)-receptor-mediated adenoprotection involves phospholipase C, PKC-epsilon, and p38 MAPK, but not HSP27. Am J Physiol Heart Circ Physiol. 2010 Jun; 298(6):H1671-8.

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Dasgupta U, Bamba T, Chiantia S, Karim P, Tayoun AN, Yonamine I, Rawat SS, Rao RP, Nagashima K, Fukusaki E, Puri V, Dolph PJ, Schwille P, Acharya JK, Acharya U. Ceramide kinase regulates phospholipase C and phosphatidylinositol 4, 5, bisphosphate in phototransduction. Proc Natl Acad Sci U S A. 2009 Nov 24; 106(47):20063-8.

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Fenton RA, Komatsu S, Ikebe M, Shea LG, Dobson JG. Adenoprotection of the heart involves phospholipase C-induced activation and translocation of PKC-epsilon to RACK2 in adult rat and mouse. Am J Physiol Heart Circ Physiol. 2009 Aug; 297(2):H718-25.

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