Interleukin-12

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"Interleukin-12" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A heterodimeric cytokine that plays a role in innate and adaptive immune responses. Interleukin-12 is a 70 kDa protein that is composed of covalently linked 40 kDa and 35 kDa subunits. It is produced by DENDRITIC CELLS; MACROPHAGES and a variety of other immune cells and plays a role in the stimulation of INTERFERON-GAMMA production by T-LYMPHOCYTES and NATURAL KILLER CELLS.

Descriptor ID	D018664
MeSH Number(s)	D12.644.276.374.465.512 D12.776.467.374.465.512 D23.529.374.465.512
Concept/Terms	Interleukin-12 Interleukin-12 Natural Killer Cell Stimulatory Factor IL-12 Cytotoxic Lymphocyte Maturation Factor IL 12 Edodekin Alfa IL-12 p70 Interleukin-12 p70 Interleukin 12 p70 p70, Interleukin-12 Interleukin 12 IL12

Below are MeSH descriptors whose meaning is more general than "Interleukin-12".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intercellular Signaling Peptides and Proteins [D12.644.276]
Cytokines [D12.644.276.374]
Interleukins [D12.644.276.374.465]
Interleukin-12 [D12.644.276.374.465.512]
Proteins [D12.776]
Intercellular Signaling Peptides and Proteins [D12.776.467]
Cytokines [D12.776.467.374]
Interleukins [D12.776.467.374.465]
Interleukin-12 [D12.776.467.374.465.512]
Biological Factors [D23]
Intercellular Signaling Peptides and Proteins [D23.529]
Cytokines [D23.529.374]
Interleukins [D23.529.374.465]
Interleukin-12 [D23.529.374.465.512]

Below are MeSH descriptors whose meaning is related to "Interleukin-12".

Below are MeSH descriptors whose meaning is more specific than "Interleukin-12".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Interleukin-12" by people in this website by year, and whether "Interleukin-12" was a major or minor topic of these publications.

Bar chart showing 92 publications over 23 distinct years, with a maximum of 10 publications in 1999

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1994	1	1	2
1995	1	0	1
1996	6	2	8
1997	4	0	4
1998	5	2	7
1999	4	6	10
2000	1	2	3
2001	3	6	9
2002	3	2	5
2003	1	2	3
2004	1	6	7
2005	2	0	2
2006	1	2	3
2007	0	2	2
2008	1	5	6
2009	1	1	2
2010	0	3	3
2011	1	3	4
2012	0	3	3
2014	0	2	2
2015	1	2	3
2018	0	2	2
2022	0	1	1

Below are the most recent publications written about "Interleukin-12" by people in Profiles.

Shah JA, Warr AJ, Graustein AD, Saha A, Dunstan SJ, Thuong NTT, Thwaites GE, Caws M, Thai PVK, Bang ND, Chau TTH, Khor CC, Li Z, Hibberd M, Chang X, Nguyen FK, Hernandez CA, Jones MA, Sassetti CM, Fitzgerald KA, Musvosvi M, Gela A, Hanekom WA, Hatherill M, Scriba TJ, Hawn TR. REL and BHLHE40 Variants Are Associated with IL-12 and IL-10 Responses and Tuberculosis Risk. J Immunol. 2022 03 15; 208(6):1352-1361.

View in: PubMed
Kogan S, Ospina LH, Kimhy D. Inflammation in individuals with schizophrenia - Implications for neurocognition and daily function. Brain Behav Immun. 2018 11; 74:296-299.

View in: PubMed
Wongchana W, Kongkavitoon P, Tangtanatakul P, Sittplangkoon C, Butta P, Chawalitpong S, Pattarakankul T, Osborne BA, Palaga T. Notch signaling regulates the responses of lipopolysaccharide-stimulated macrophages in the presence of immune complexes. PLoS One. 2018; 13(6):e0198609.

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Kativhu CL, Libraty DH. A Model to Explain How the Bacille Calmette Guérin (BCG) Vaccine Drives Interleukin-12 Production in Neonates. PLoS One. 2016; 11(8):e0162148.

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Everts B, Tussiwand R, Dreesen L, Fairfax KC, Huang SC, Smith AM, O'Neill CM, Lam WY, Edelson BT, Urban JF, Murphy KM, Pearce EJ. Migratory CD103+ dendritic cells suppress helminth-driven type 2 immunity through constitutive expression of IL-12. J Exp Med. 2016 Jan 11; 213(1):35-51.

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Sun J, Qiao Y, Qi C, Jiang W, Xiao H, Shi Y, Le GW. High-fat-diet-induced obesity is associated with decreased antiinflammatory Lactobacillus reuteri sensitive to oxidative stress in mouse Peyer's patches. Nutrition. 2016 Feb; 32(2):265-72.

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Nobles C, Bertone-Johnson ER, Ronnenberg AG, Faraj JM, Zagarins S, Takashima-Uebelhoer BB, Whitcomb BW. Correlation of urine and plasma cytokine levels among reproductive-aged women. Eur J Clin Invest. 2015 May; 45(5):460-5.

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Bertone-Johnson ER, Ronnenberg AG, Houghton SC, Nobles C, Zagarins SE, Takashima-Uebelhoer BB, Faraj JL, Whitcomb BW. Association of inflammation markers with menstrual symptom severity and premenstrual syndrome in young women. Hum Reprod. 2014 Sep; 29(9):1987-94.

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Rothchild AC, Jayaraman P, Nunes-Alves C, Behar SM. iNKT cell production of GM-CSF controls Mycobacterium tuberculosis. PLoS Pathog. 2014 Jan; 10(1):e1003805.

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Childs TS, Webley WC. In vitro assessment of halobacterial gas vesicles as a Chlamydia vaccine display and delivery system. Vaccine. 2012 Sep 07; 30(41):5942-8.

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