 Integrins
"Integrins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of transmembrane glycoproteins (MEMBRANE GLYCOPROTEINS) consisting of noncovalent heterodimers. They interact with a wide variety of ligands including EXTRACELLULAR MATRIX PROTEINS; COMPLEMENT, and other cells, while their intracellular domains interact with the CYTOSKELETON. The integrins consist of at least three identified families: the cytoadhesin receptors(RECEPTORS, CYTOADHESIN), the leukocyte adhesion receptors (RECEPTORS, LEUKOCYTE ADHESION), and the VERY LATE ANTIGEN RECEPTORS. Each family contains a common beta-subunit (INTEGRIN BETA CHAINS) combined with one or more distinct alpha-subunits (INTEGRIN ALPHA CHAINS). These receptors participate in cell-matrix and cell-cell adhesion in many physiologically important processes, including embryological development; HEMOSTASIS; THROMBOSIS; WOUND HEALING; immune and nonimmune defense mechanisms; and oncogenic transformation.
| Descriptor ID |
D016023
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| MeSH Number(s) |
D12.776.543.750.705.408
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Integrins".
Below are MeSH descriptors whose meaning is more specific than "Integrins".
This graph shows the total number of publications written about "Integrins" by people in this website by year, and whether "Integrins" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
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| 1990 | 3 | 1 | 4 | | 1991 | 1 | 0 | 1 | | 1992 | 1 | 1 | 2 | | 1993 | 4 | 0 | 4 | | 1994 | 5 | 0 | 5 | | 1995 | 4 | 2 | 6 | | 1996 | 3 | 0 | 3 | | 1997 | 5 | 0 | 5 | | 1998 | 3 | 3 | 6 | | 1999 | 5 | 3 | 8 | | 2000 | 3 | 0 | 3 | | 2001 | 6 | 0 | 6 | | 2002 | 2 | 4 | 6 | | 2003 | 1 | 0 | 1 | | 2004 | 1 | 0 | 1 | | 2005 | 0 | 4 | 4 | | 2006 | 0 | 1 | 1 | | 2007 | 2 | 3 | 5 | | 2008 | 1 | 1 | 2 | | 2009 | 1 | 0 | 1 | | 2010 | 1 | 0 | 1 | | 2012 | 0 | 1 | 1 | | 2014 | 2 | 2 | 4 | | 2015 | 0 | 1 | 1 | | 2016 | 0 | 1 | 1 |
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Below are the most recent publications written about "Integrins" by people in Profiles.
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Reboldi A, Arnon TI, Rodda LB, Atakilit A, Sheppard D, Cyster JG. IgA production requires B cell interaction with subepithelial dendritic cells in Peyer's patches. Science. 2016 May 13; 352(6287):aaf4822.
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Barney LE, Dandley EC, Jansen LE, Reich NG, Mercurio AM, Peyton SR. A cell-ECM screening method to predict breast cancer metastasis. Integr Biol (Camb). 2015 Feb; 7(2):198-212.
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Byrareddy SN, Kallam B, Arthos J, Cicala C, Nawaz F, Hiatt J, Kersh EN, McNicholl JM, Hanson D, Reimann KA, Brameier M, Walter L, Rogers K, Mayne AE, Dunbar P, Villinger T, Little D, Parslow TG, Santangelo PJ, Villinger F, Fauci AS, Ansari AA. Targeting a4ß7 integrin reduces mucosal transmission of simian immunodeficiency virus and protects gut-associated lymphoid tissue from infection. Nat Med. 2014 Dec; 20(12):1397-400.
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Kourouklis AP, Lerum RV, Bermudez H. Cell adhesion mechanisms on laterally mobile polymer films. Biomaterials. 2014 Jun; 35(17):4827-34.
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Taylor A, Tang W, Bruscia EM, Zhang PX, Lin A, Gaines P, Wu D, Halene S. SRF is required for neutrophil migration in response to inflammation. Blood. 2014 May 8; 123(19):3027-36.
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Parra M, Herrera D, Calvo-Calle JM, Stern LJ, Parra-López CA, Butcher E, Franco M, Angel J. Circulating human rotavirus specific CD4 T cells identified with a class II tetramer express the intestinal homing receptors a4ß7 and CCR9. Virology. 2014 Mar; 452-453:191-201.
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Dutta A, Li J, Lu H, Akech J, Pratap J, Wang T, Zerlanko BJ, FitzGerald TJ, Jiang Z, Birbe R, Wixted J, Violette SM, Stein JL, Stein GS, Lian JB, Languino LR. Integrin avß6 promotes an osteolytic program in cancer cells by upregulating MMP2. Cancer Res. 2014 Mar 1; 74(5):1598-608.
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Hensley HH, Roder NA, O'Brien SW, Bickel LE, Xiao F, Litwin S, Connolly DC. Combined in vivo molecular and anatomic imaging for detection of ovarian carcinoma-associated protease activity and integrin expression in mice. Neoplasia. 2012 Jun; 14(6):451-62.
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Cao L, Zeller MK, Fiore VF, Strane P, Bermudez H, Barker TH. Phage-based molecular probes that discriminate force-induced structural states of fibronectin in vivo. Proc Natl Acad Sci U S A. 2012 May 8; 109(19):7251-6.
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Ansari AA, Reimann KA, Mayne AE, Takahashi Y, Stephenson ST, Wang R, Wang X, Li J, Price AA, Little DM, Zaidi M, Lyles R, Villinger F. Blocking of a4ß7 gut-homing integrin during acute infection leads to decreased plasma and gastrointestinal tissue viral loads in simian immunodeficiency virus-infected rhesus macaques. J Immunol. 2011 Jan 15; 186(2):1044-59.
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