Tetanus Toxin

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"Tetanus Toxin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Protein synthesized by CLOSTRIDIUM TETANI as a single chain of ~150 kDa with 35% sequence identity to BOTULINUM TOXIN that is cleaved to a light and a heavy chain that are linked by a single disulfide bond. Tetanolysin is the hemolytic and tetanospasmin is the neurotoxic principle. The toxin causes disruption of the inhibitory mechanisms of the CNS, thus permitting uncontrolled nervous activity, leading to fatal CONVULSIONS.

Descriptor ID	D013744
MeSH Number(s)	D12.776.097.872 D23.946.123.893
Concept/Terms	Tetanus Toxin Tetanus Toxin Toxin, Tetanus Clostridium tetani Toxin Toxin, Clostridium tetani Tetanus Toxins Toxins, Tetanus Clostridial Neurotoxin Clostridial Neurotoxin Neurotoxin, Clostridial

Below are MeSH descriptors whose meaning is more general than "Tetanus Toxin".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Bacterial Proteins [D12.776.097]
Tetanus Toxin [D12.776.097.872]
Biological Factors [D23]
Toxins, Biological [D23.946]
Bacterial Toxins [D23.946.123]
Tetanus Toxin [D23.946.123.893]

Below are MeSH descriptors whose meaning is related to "Tetanus Toxin".

Below are MeSH descriptors whose meaning is more specific than "Tetanus Toxin".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Tetanus Toxin" by people in this website by year, and whether "Tetanus Toxin" was a major or minor topic of these publications.

Bar chart showing 5 publications over 4 distinct years, with a maximum of 2 publications in 2009

To see the data from this visualization as text, click here.

Year	Major Topic	Total
2005	1	1
2006	1	1
2009	2	2
2022	1	1

Below are the most recent publications written about "Tetanus Toxin" by people in Profiles.

Chang MJ, Ollivault-Shiflett M, Schuman R, Ngoc Nguyen S, Kaltashov IA, Bobst C, Rajagopal SP, Przedpelski A, Barbieri JT, Lees A. Genetically detoxified tetanus toxin as a vaccine and conjugate carrier protein. Vaccine. 2022 08 19; 40(35):5103-5113.

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Morishima C, Di Bisceglie AM, Rothman AL, Bonkovsky HL, Lindsay KL, Lee WM, Koziel MJ, Fontana RJ, Kim HY, Wright EC. Antigen-specific T lymphocyte proliferation decreases over time in advanced chronic hepatitis C. J Viral Hepat. 2012 Jun; 19(6):404-13.

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Li J, Chian RJ, Ay I, Kashi BB, Celia SA, Tamrazian E, Pepinsky RB, Fishman PS, Brown RH, Francis JW. Insect GDNF:TTC fusion protein improves delivery of GDNF to mouse CNS. Biochem Biophys Res Commun. 2009 Dec 18; 390(3):947-51.

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Li J, Chian RJ, Ay I, Celia SA, Kashi BB, Tamrazian E, Matthews JC, Remington MP, Pepinsky RB, Fishman PS, Brown RH, Francis JW. Recombinant GDNF: tetanus toxin fragment C fusion protein produced from insect cells. Biochem Biophys Res Commun. 2009 Jul 31; 385(3):380-4.

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Larsen KE, Benn SC, Ay I, Chian RJ, Celia SA, Remington MP, Bejarano M, Liu M, Ross J, Carmillo P, Sah D, Phillips KA, Sulzer D, Pepinsky RB, Fishman PS, Brown RH, Francis JW. A glial cell line-derived neurotrophic factor (GDNF):tetanus toxin fragment C protein conjugate improves delivery of GDNF to spinal cord motor neurons in mice. Brain Res. 2006 Nov 20; 1120(1):1-12.

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Benn SC, Ay I, Bastia E, Chian RJ, Celia SA, Pepinsky RB, Fishman PS, Brown RH, Francis JW. Tetanus toxin fragment C fusion facilitates protein delivery to CNS neurons from cerebrospinal fluid in mice. J Neurochem. 2005 Nov; 95(4):1118-31.

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Ho JL, Klempner MS. Diminished activity of protein kinase C in tetanus toxin-treated macrophages and in the spinal cord of mice manifesting generalized tetanus intoxication. J Infect Dis. 1988 May; 157(5):925-33.

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Ho JL, Klempner MS. Inhibition of macrophage secretion by tetanus toxin is not directly linked to cytosolic calcium homeostasis. Biochem Biophys Res Commun. 1986 Feb 26; 135(1):16-24.

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Ho JL, Klempner MS. Tetanus toxin inhibits secretion of lysosomal contents from human macrophages. J Infect Dis. 1985 Nov; 152(5):922-9.

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Marcus DM, Schwarting GA. Immunochemical properties of glycolipids and phospholipids. Adv Immunol. 1976; 23:203-40.

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