Polymerase Chain Reaction
"Polymerase Chain Reaction" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.
Descriptor ID |
D016133
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MeSH Number(s) |
E05.393.620.500
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Concept/Terms |
Polymerase Chain Reaction- Polymerase Chain Reaction
- Polymerase Chain Reactions
- Reaction, Polymerase Chain
- Reactions, Polymerase Chain
- PCR
Inverse PCR- Inverse PCR
- PCR, Inverse
- Inverse Polymerase Chain Reaction
Anchored PCR- Anchored PCR
- PCR, Anchored
- Anchored Polymerase Chain Reaction
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Below are MeSH descriptors whose meaning is more general than "Polymerase Chain Reaction".
Below are MeSH descriptors whose meaning is more specific than "Polymerase Chain Reaction".
This graph shows the total number of publications written about "Polymerase Chain Reaction" by people in this website by year, and whether "Polymerase Chain Reaction" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
Year | Major Topic | Minor Topic | Total |
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1990 | 1 | 6 | 7 | 1991 | 0 | 4 | 4 | 1992 | 2 | 11 | 13 | 1993 | 1 | 11 | 12 | 1994 | 1 | 16 | 17 | 1995 | 0 | 20 | 20 | 1996 | 3 | 16 | 19 | 1997 | 1 | 19 | 20 | 1998 | 0 | 13 | 13 | 1999 | 0 | 11 | 11 | 2000 | 1 | 13 | 14 | 2001 | 0 | 12 | 12 | 2002 | 1 | 18 | 19 | 2003 | 4 | 19 | 23 | 2004 | 3 | 16 | 19 | 2005 | 3 | 25 | 28 | 2006 | 1 | 13 | 14 | 2007 | 3 | 12 | 15 | 2008 | 4 | 13 | 17 | 2009 | 3 | 16 | 19 | 2010 | 0 | 13 | 13 | 2011 | 2 | 9 | 11 | 2012 | 2 | 15 | 17 | 2013 | 1 | 9 | 10 | 2014 | 0 | 11 | 11 | 2015 | 0 | 10 | 10 | 2016 | 1 | 6 | 7 | 2017 | 0 | 4 | 4 |
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Below are the most recent publications written about "Polymerase Chain Reaction" by people in Profiles.
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Lv J, Jiao W, Guo H, Liu P, Wang R, Zhang L, Zeng Q, Hu X, Bao Z, Wang S. HD-Marker: a highly multiplexed and flexible approach for targeted genotyping of more than 10,000 genes in a single-tube assay. Genome Res. 2018 12; 28(12):1919-1930.
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Termini JM, Magnani DM, Maxwell HS, Lauer W, Castro I, Pecotte J, Barber GN, Watkins DI, Desrosiers RC. Simian T Lymphotropic Virus 1 Infection of Papio anubis: tax Sequence Heterogeneity and T Cell Recognition. J Virol. 2017 10 15; 91(20).
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Shin HM, Kapoor VN, Kim G, Li P, Kim HR, Suresh M, Kaech SM, Wherry EJ, Selin LK, Leonard WJ, Welsh RM, Berg LJ. Transient expression of ZBTB32 in anti-viral CD8+ T cells limits the magnitude of the effector response and the generation of memory. PLoS Pathog. 2017 Aug; 13(8):e1006544.
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Lockhart CM, Smith TB, Yang P, Naidu M, Rettie AE, Nath A, Weleber R, Kelly EJ. Longitudinal characterisation of function and structure of Bietti crystalline dystrophy: report on a novel homozygous mutation in CYP4V2. Br J Ophthalmol. 2018 02; 102(2):187-194.
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Ai J, Ibraheim R, Tai PWL, Gao G. A Scalable and Accurate Method for Quantifying Vector Genomes of Recombinant Adeno-Associated Viruses in Crude Lysate. Hum Gene Ther Methods. 2017 06; 28(3):139-147.
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Ahmadi Moghaddam P, Cornejo KM, Hutchinson L, Tomaszewicz K, Dresser K, Deng A, O'Donnell P. Complete Spontaneous Regression of Merkel Cell Carcinoma After Biopsy: A Case Report and Review of the Literature. Am J Dermatopathol. 2016 Nov; 38(11):e154-e158.
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Bradbury AM, Peterson TA, Gross AL, Wells SZ, McCurdy VJ, Wolfe KG, Dennis JC, Brunson BL, Gray-Edwards H, Randle AN, Johnson AK, Morrison EE, Cox NR, Baker HJ, Sena-Esteves M, Martin DR. AAV-mediated gene delivery attenuates neuroinflammation in feline Sandhoff disease. Neuroscience. 2017 Jan 06; 340:117-125.
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Bolduc P, Roder N, Colgate E, Cheeseman SH. Care of Patients With HIV Infection: Diagnosis and Monitoring. FP Essent. 2016 Apr; 443:11-5.
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Selove W, Rao LV. Performance of rapid SOFIA Influenza A+B test compared to Luminex x-TAG respiratory viral panel assay in the diagnosis of influenza A, B, and subtype H3. J Investig Med. 2016 Apr; 64(4):905-7.
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Li RW, Li W, Sun J, Yu P, Baldwin RL, Urban JF. The effect of helminth infection on the microbial composition and structure of the caprine abomasal microbiome. Sci Rep. 2016 Feb 08; 6:20606.
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