"Immunoglobulin mu-Chains" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The class of heavy chains found in IMMUNOGLOBULIN M. They have a molecular weight of approximately 72 kDa and they contain about 57 amino acid residues arranged in five domains and have more oligosaccharide branches and a higher carbohydrate content than the heavy chains of IMMUNOGLOBULIN G.
Descriptor ID |
D007148
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MeSH Number(s) |
D12.776.124.486.485.114.619.574.500 D12.776.124.486.485.705.500.500 D12.776.124.790.651.114.619.574.500 D12.776.124.790.651.705.500.500 D12.776.377.715.548.114.619.574.500 D12.776.377.715.548.705.500.500
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Concept/Terms |
Immunoglobulin mu-Chains- Immunoglobulin mu-Chains
- Immunoglobulin mu Chains
- mu-Chains, Immunoglobulin
- mu-Chain Immunoglobulins
- mu Chain Immunoglobulins
- mu Immunoglobulin Heavy Chain
- mu Immunoglobulin Heavy Chains
- Immunoglobulin mu-Chain
- Immunoglobulin mu Chain
- mu-Chain, Immunoglobulin
- Immunoglobulins, mu-Chain
- Immunoglobulins, mu Chain
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Below are MeSH descriptors whose meaning is more general than "Immunoglobulin mu-Chains".
Below are MeSH descriptors whose meaning is more specific than "Immunoglobulin mu-Chains".
This graph shows the total number of publications written about "Immunoglobulin mu-Chains" by people in this website by year, and whether "Immunoglobulin mu-Chains" was a major or minor topic of these publications.
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Year | Major Topic | Minor Topic | Total |
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1994 | 0 | 1 | 1 |
1996 | 1 | 1 | 2 |
2002 | 0 | 1 | 1 |
2003 | 0 | 1 | 1 |
2005 | 1 | 0 | 1 |
2007 | 1 | 0 | 1 |
2009 | 0 | 1 | 1 |
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Below are the most recent publications written about "Immunoglobulin mu-Chains" by people in Profiles.
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Nakajima PB, Kiefer K, Price A, Bosma GC, Bosma MJ. Two distinct populations of H chain-edited B cells show differential surrogate L chain dependence. J Immunol. 2009 Mar 15; 182(6):3583-96.
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Kumazaki K, Tirosh B, Maehr R, Boes M, Honjo T, Ploegh HL. AID-/-mus-/- mice are agammaglobulinemic and fail to maintain B220-CD138+ plasma cells. J Immunol. 2007 Feb 15; 178(4):2192-203.
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Schrader CE, Linehan EK, Mochegova SN, Woodland RT, Stavnezer J. Inducible DNA breaks in Ig S regions are dependent on AID and UNG. J Exp Med. 2005 Aug 15; 202(4):561-8.
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Serreze DV, Silveira PA. The role of B lymphocytes as key antigen-presenting cells in the development of T cell-mediated autoimmune type 1 diabetes. Curr Dir Autoimmun. 2003; 6:212-27.
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Drouin EE, Schrader CE, Stavnezer J, Hansen U. The ubiquitously expressed DNA-binding protein late SV40 factor binds Ig switch regions and represses class switching to IgA. J Immunol. 2002 Mar 15; 168(6):2847-56.
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Serreze DV, Chapman HD, Varnum DS, Hanson MS, Reifsnyder PC, Richard SD, Fleming SA, Leiter EH, Shultz LD. B lymphocytes are essential for the initiation of T cell-mediated autoimmune diabetes: analysis of a new "speed congenic" stock of NOD.Ig mu null mice. J Exp Med. 1996 Nov 01; 184(5):2049-53.
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Phillips JA, Romball CG, Hobbs MV, Ernst DN, Shultz L, Weigle WO. CD4+ T cell activation and tolerance induction in B cell knockout mice. J Exp Med. 1996 Apr 01; 183(4):1339-44.
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Fischer G, Kent SC, Joseph L, Green DR, Scott DW. Lymphoma models for B cell activation and tolerance. X. Anti-mu-mediated growth arrest and apoptosis of murine B cell lymphomas is prevented by the stabilization of myc. J Exp Med. 1994 Jan 01; 179(1):221-8.
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Schweitzer PA, Taylor SE, Shultz LD. Synthesis of abnormal immunoglobulins by hybridomas from autoimmune "viable motheaten" mutant mice. J Cell Biol. 1991 Jul; 114(1):35-43.
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Stavnezer J, Sirlin S, Abbott J. Induction of immunoglobulin isotype switching in cultured I.29 B lymphoma cells. Characterization of the accompanying rearrangements of heavy chain genes. J Exp Med. 1985 Mar 01; 161(3):577-601.