MicroRNAs

"MicroRNAs" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Small double-stranded, non-protein coding RNAs, 21-25 nucleotides in length generated from single-stranded microRNA gene transcripts by the same RIBONUCLEASE III, Dicer, that produces small interfering RNAs (RNA, SMALL INTERFERING). They become part of the RNA-INDUCED SILENCING COMPLEX and repress the translation (TRANSLATION, GENETIC) of target RNA by binding to homologous 3'UTR region as an imperfect match. The small temporal RNAs (stRNAs), let-7 and lin-4, from C. elegans, are the first 2 miRNAs discovered, and are from a class of miRNAs involved in developmental timing.

Descriptor ID	D035683
MeSH Number(s)	D13.150.650.319 D13.444.735.150.319 D13.444.735.790.552.500
Concept/Terms	MicroRNAs MicroRNAs MicroRNA miRNAs Micro RNA RNA, Micro miRNA Primary MicroRNA Primary MicroRNA MicroRNA, Primary Primary miRNA miRNA, Primary pri-miRNA pri miRNA RNA, Small Temporal RNA, Small Temporal Temporal RNA, Small stRNA Small Temporal RNA pre-miRNA pre-miRNA pre miRNA

Below are MeSH descriptors whose meaning is more general than "MicroRNAs".

Chemicals and Drugs [D]
Nucleic Acids, Nucleotides, and Nucleosides [D13]
Antisense Elements (Genetics) [D13.150]
RNA, Antisense [D13.150.650]
MicroRNAs [D13.150.650.319]
Nucleic Acids [D13.444]
RNA [D13.444.735]
RNA, Antisense [D13.444.735.150]
MicroRNAs [D13.444.735.150.319]
RNA, Untranslated [D13.444.735.790]
RNA, Small Untranslated [D13.444.735.790.552]
MicroRNAs [D13.444.735.790.552.500]

Below are MeSH descriptors whose meaning is related to "MicroRNAs".

Below are MeSH descriptors whose meaning is more specific than "MicroRNAs".

MicroRNAs
Circulating MicroRNA

publications

Timeline | Most Recent

This graph shows the total number of publications written about "MicroRNAs" by people in this website by year, and whether "MicroRNAs" was a major or minor topic of these publications.

Bar chart showing 430 publications over 22 distinct years, with a maximum of 39 publications in 2014

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2001	0	1	1
2002	0	1	1
2003	9	1	10
2004	10	2	12
2005	9	4	13
2006	6	0	6
2007	13	2	15
2008	18	2	20
2009	22	5	27
2010	23	4	27
2011	18	8	26
2012	22	7	29
2013	19	11	30
2014	30	9	39
2015	28	9	37
2016	25	5	30
2017	25	5	30
2018	19	4	23
2019	21	0	21
2020	12	8	20
2021	10	1	11
2022	2	0	2

Below are the most recent publications written about "MicroRNAs" by people in Profiles.

Duan Y, Veksler-Lublinsky I, Ambros V. Critical contribution of 3' non-seed base pairing to the in vivo function of the evolutionarily conserved let-7a microRNA. Cell Rep. 2022 04 26; 39(4):110745.

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Elghoroury EA, Abdelghaffar EE, Awadallah E, Kamel SA, Kandil D, Hassan EM, Hassan M, Kamel MM, Gomaa MM, Fathalla LA. Detection of exosomal miR-18a and miR-222 levels in Egyptian patients with hepatic cirrhosis and hepatocellular carcinoma. Int J Immunopathol Pharmacol. 2022 Jan-Dec; 36:3946320221097832.

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Babuta M, Szabo G. Extracellular vesicles in inflammation: Focus on the microRNA cargo of EVs in modulation of liver diseases. J Leukoc Biol. 2022 01; 111(1):75-92.

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Massart J, Sjögren RJO, Egan B, Garde C, Lindgren M, Gu W, Ferreira DMS, Katayama M, Ruas JL, Barrès R, O'Gorman DJ, Zierath JR, Krook A. Endurance exercise training-responsive miR-19b-3p improves skeletal muscle glucose metabolism. Nat Commun. 2021 10 12; 12(1):5948.

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Islam MR, Kaurani L, Berulava T, Heilbronner U, Budde M, Centeno TP, Elerdashvili V, Zafieriou MP, Benito E, Sertel SM, Goldberg M, Senner F, Kalman JL, Burkhardt S, Oepen AS, Sakib MS, Kerimoglu C, Wirths O, Bickeböller H, Bartels C, Brosseron F, Buerger K, Cosma NC, Fliessbach K, Heneka MT, Janowitz D, Kilimann I, Kleinedam L, Laske C, Metzger CD, Munk MH, Perneczky R, Peters O, Priller J, Rauchmann BS, Roy N, Schneider A, Spottke A, Spruth EJ, Teipel S, Tscheuschler M, Wagner M, Wiltfang J, Düzel E, Jessen F, Rizzoli SO, Zimmermann WH, Schulze TG, Falkai P, Sananbenesi F, Fischer A. A microRNA signature that correlates with cognition and is a target against cognitive decline. EMBO Mol Med. 2021 11 08; 13(11):e13659.

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Ilbay O, Nelson C, Ambros V. C. elegans LIN-28 controls temporal cell fate progression by regulating LIN-46 expression via the 5' UTR of lin-46 mRNA. Cell Rep. 2021 09 07; 36(10):109670.

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Bala S, Ganz M, Babuta M, Zhuang Y, Csak T, Calenda CD, Szabo G. Steatosis, inflammasome upregulation, and fibrosis are attenuated in miR-155 deficient mice in a high fat-cholesterol-sugar diet-induced model of NASH. Lab Invest. 2021 12; 101(12):1540-1549.

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Amin ND, Senturk G, Costaguta G, Driscoll S, O'Leary B, Bonanomi D, Pfaff SL. A hidden threshold in motor neuron gene networks revealed by modulation of miR-218 dose. Neuron. 2021 10 20; 109(20):3252-3267.e6.

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Suri K, Bubier JA, Wiles MV, Shultz LD, Amiji MM, Hosur V. Role of MicroRNA in Inflammatory Bowel Disease: Clinical Evidence and the Development of Preclinical Animal Models. Cells. 2021 08 26; 10(9).

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Szabo G. Exosomes and MicroRNA-223 at the Intersection of Inflammation and Fibrosis in NAFLD. Hepatology. 2021 07; 74(1):5-8.

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