Nuclear Receptor Subfamily 4, Group A, Member 1
"Nuclear Receptor Subfamily 4, Group A, Member 1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An orphan nuclear receptor that is closely related to members of the thyroid-steroid receptor gene family. It was originally identified in NERVE CELLS and may play a role in mediation of NERVE GROWTH FACTOR-induced CELL DIFFERENTIATION. However, several other functions have been attributed to this protein including the positive and negative regulation of APOPTOSIS.
| Descriptor ID |
D057105
|
| MeSH Number(s) |
D12.776.260.643.400 D12.776.826.209.400
|
| Concept/Terms |
Nuclear Receptor Subfamily 4, Group A, Member 1- Nuclear Receptor Subfamily 4, Group A, Member 1
- Nerve Growth Factor-inducible B Protein
- Nerve Growth Factor inducible B Protein
- Orphan Nuclear Receptor HMR
- Orphan Nuclear Receptor NGFI-B
- Orphan Nuclear Receptor NGFI B
- Orphan Nuclear Receptor NR4A1
- Nuclear Receptor NR4A1
- TR3 Orphan Nuclear Receptor
- Nur77 Orphan Nuclear Receptor
- NGFI-B Orphan Nuclear Receptor
- NGFI B Orphan Nuclear Receptor
- Early Response Protein NAK1
- Orphan Nuclear Receptor TR3
|
Below are MeSH descriptors whose meaning is more general than "Nuclear Receptor Subfamily 4, Group A, Member 1".
Below are MeSH descriptors whose meaning is more specific than "Nuclear Receptor Subfamily 4, Group A, Member 1".
This graph shows the total number of publications written about "Nuclear Receptor Subfamily 4, Group A, Member 1" by people in this website by year, and whether "Nuclear Receptor Subfamily 4, Group A, Member 1" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 0 | 1 | 1 |
| 1996 | 0 | 1 | 1 |
| 1997 | 0 | 1 | 1 |
| 1999 | 0 | 3 | 3 |
| 2002 | 0 | 1 | 1 |
| 2009 | 0 | 1 | 1 |
| 2014 | 1 | 0 | 1 |
| 2015 | 1 | 0 | 1 |
| 2019 | 0 | 1 | 1 |
To return to the timeline,
click here.
Below are the most recent publications written about "Nuclear Receptor Subfamily 4, Group A, Member 1" by people in Profiles.
-
Intlekofer KA, Clements K, Woods H, Adams H, Suvorov A, Petersen SL. Progesterone receptor membrane component 1 inhibits tumor necrosis factor alpha induction of gene expression in neural cells. PLoS One. 2019; 14(4):e0215389.
-
Xie L, Yang R, Liu S, Lyle S, Cotsarelis G, Xiang L, Zhang L, Li B, Wan M, Xu X. TR3 is preferentially expressed by bulge epithelial stem cells in human hair follicles. Lab Invest. 2016 Jan; 96(1):81-8.
-
Niu G, Ye T, Qin L, Bourbon PM, Chang C, Zhao S, Li Y, Zhou L, Cui P, Rabinovitz I, Mercurio AM, Zhao D, Zeng H. Orphan nuclear receptor TR3/Nur77 improves wound healing by upregulating the expression of integrin ?4. FASEB J. 2015 Jan; 29(1):131-40.
-
Wang A, Rud J, Olson CM, Anguita J, Osborne BA. Phosphorylation of Nur77 by the MEK-ERK-RSK cascade induces mitochondrial translocation and apoptosis in T cells. J Immunol. 2009 Sep 01; 183(5):3268-77.
-
Lee JM, Lee KH, Weidner M, Osborne BA, Hayward SD. Epstein-Barr virus EBNA2 blocks Nur77- mediated apoptosis. Proc Natl Acad Sci U S A. 2002 Sep 03; 99(18):11878-83.
-
Amsen D, Revilla Calvo C, Osborne BA, Kruisbeek AM. Costimulatory signals are required for induction of transcription factor Nur77 during negative selection of CD4(+)CD8(+) thymocytes. Proc Natl Acad Sci U S A. 1999 Jan 19; 96(2):622-7.
-
Jehn BM, Bielke W, Pear WS, Osborne BA. Cutting edge: protective effects of notch-1 on TCR-induced apoptosis. J Immunol. 1999 Jan 15; 162(2):635-8.
-
Morgan G, Smith S, Pak J, Marshak-Rothstein A, Fissore R, Osborne B. Characterization of a mutant T-cell hybridoma line with defects in the TCR-mediated apoptotic pathway. Cell Death Differ. 1999 Jan; 6(1):36-47.
-
Chan FK, Chen A, Winoto A. Thymic expression of the transcription factor Nur77 rescues the T cell but not the B cell abnormality of gld/gld mice. J Immunol. 1998 Oct 15; 161(8):4252-6.
-
Cheng LE, Chan FK, Cado D, Winoto A. Functional redundancy of the Nur77 and Nor-1 orphan steroid receptors in T-cell apoptosis. EMBO J. 1997 Apr 15; 16(8):1865-75.