Peptide Nucleic Acids

"Peptide Nucleic Acids" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

DNA analogs containing neutral amide backbone linkages composed of aminoethyl glycine units instead of the usual phosphodiester linkage of deoxyribose groups. Peptide nucleic acids have high biological stability and higher affinity for complementary DNA or RNA sequences than analogous DNA oligomers.

Descriptor ID	D020135
MeSH Number(s)	D13.695.578.424.550
Concept/Terms	Peptide Nucleic Acids Peptide Nucleic Acids Acids, Peptide Nucleic Nucleic Acids, Peptide

Below are MeSH descriptors whose meaning is more general than "Peptide Nucleic Acids".

Chemicals and Drugs [D]
Nucleic Acids, Nucleotides, and Nucleosides [D13]
Nucleotides [D13.695]
Polynucleotides [D13.695.578]
Oligonucleotides [D13.695.578.424]
Peptide Nucleic Acids [D13.695.578.424.550]

Below are MeSH descriptors whose meaning is related to "Peptide Nucleic Acids".

Below are MeSH descriptors whose meaning is more specific than "Peptide Nucleic Acids".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Peptide Nucleic Acids" by people in this website by year, and whether "Peptide Nucleic Acids" was a major or minor topic of these publications.

Bar chart showing 12 publications over 10 distinct years, with a maximum of 2 publications in 2011 and 2018

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1999	0	1	1
2001	1	0	1
2004	1	0	1
2005	1	0	1
2009	0	1	1
2011	1	1	2
2012	1	0	1
2016	1	0	1
2017	0	1	1
2018	2	0	2

Below are the most recent publications written about "Peptide Nucleic Acids" by people in Profiles.

Debacker AJ, Sharma VK, Meda Krishnamurthy P, O'Reilly D, Greenhill R, Watts JK. Next-Generation Peptide Nucleic Acid Chimeras Exhibit High Affinity and Potent Gene Silencing. Biochemistry. 2019 02 12; 58(6):582-589.

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Sousa JM, Rocha R, Cerqueira L, Almeida C, Azevedo NF, Bastin B, Bird P, Benzinger MJ, Agin J, Goins D, Chen Y, Brodsky M, Odumoru J. Validation of Biomode S.A. Probe4CronobacterTM for the Identification of Cronobacter spp. J AOAC Int. 2019 May 01; 102(3):855-864.

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Godinho BMDC, Gilbert JW, Haraszti RA, Coles AH, Biscans A, Roux L, Nikan M, Echeverria D, Hassler M, Khvorova A. Pharmacokinetic Profiling of Conjugated Therapeutic Oligonucleotides: A High-Throughput Method Based Upon Serial Blood Microsampling Coupled to Peptide Nucleic Acid Hybridization Assay. Nucleic Acid Ther. 2017 Dec; 27(6):323-334.

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Bahal R, Ali McNeer N, Quijano E, Liu Y, Sulkowski P, Turchick A, Lu YC, Bhunia DC, Manna A, Greiner DL, Brehm MA, Cheng CJ, L?pez-Gir?ldez F, Ricciardi A, Beloor J, Krause DS, Kumar P, Gallagher PG, Braddock DT, Mark Saltzman W, Ly DH, Glazer PM. In vivo correction of anaemia in ?-thalassemic mice by ?PNA-mediated gene editing with nanoparticle delivery. Nat Commun. 2016 10 26; 7:13304.

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McNeer NA, Schleifman EB, Cuthbert A, Brehm M, Jackson A, Cheng C, Anandalingam K, Kumar P, Shultz LD, Greiner DL, Mark Saltzman W, Glazer PM. Systemic delivery of triplex-forming PNA and donor DNA by nanoparticles mediates site-specific genome editing of human hematopoietic cells in vivo. Gene Ther. 2013 Jun; 20(6):658-69.

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Schleifman EB, Bindra R, Leif J, del Campo J, Rogers FA, Uchil P, Kutsch O, Shultz LD, Kumar P, Greiner DL, Glazer PM. Targeted disruption of the CCR5 gene in human hematopoietic stem cells stimulated by peptide nucleic acids. Chem Biol. 2011 Sep 23; 18(9):1189-98.

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Hu J, Gagnon KT, Liu J, Watts JK, Syeda-Nawaz J, Bennett CF, Swayze EE, Randolph J, Chattopadhyaya J, Corey DR. Allele-selective inhibition of ataxin-3 (ATX3) expression by antisense oligomers and duplex RNAs. Biol Chem. 2011 Apr; 392(4):315-25.

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Aronin N. Expanded CAG repeats in the crosshairs. Nat Biotechnol. 2009 May; 27(5):451-2.

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Tonelli R, Purgato S, Camerin C, Fronza R, Bologna F, Alboresi S, Franzoni M, Corradini R, Sforza S, Faccini A, Shohet JM, Marchelli R, Pession A. Anti-gene peptide nucleic acid specifically inhibits MYCN expression in human neuroblastoma cells leading to cell growth inhibition and apoptosis. Mol Cancer Ther. 2005 May; 4(5):779-86.

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Vernille JP, Kovell LC, Schneider JW. Peptide nucleic acid (PNA) amphiphiles: synthesis, self-assembly, and duplex stability. Bioconjug Chem. 2004 Nov-Dec; 15(6):1314-21.

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