Header Logo

David M Harlan MD

Endowed TitleWilliam and Doris Krupp Professor in Medicine
InstitutionUMass Chan Medical School
AddressUMass Chan Medical School
55 Lake Avenue North
Worcester MA 01655
vCardDownload vCard
    Other Positions
    InstitutionT.H. Chan School of Medicine

    InstitutionT.H. Chan School of Medicine

    InstitutionT.H. Chan School of Medicine
    DepartmentRNA Therapeutics Institute

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentMasters in Clinical Investigation

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentMD/PhD Program

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentMillennium MD/PhD Program

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentPopulation Health Sciences

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentTranslational Science

    Collapse Biography 
    Collapse education and training
    University of Michigan, Ann Arbor, Ann Arbor, MI, United StatesBSPhysiology
    Duke University, Durham, NC, United StatesMDMedicine

    Collapse Overview 
    Collapse overview


    • Medical School, Duke University School of Medicine, Durham, North Carolina

    • Residency in Medicine, Duke University Medical Center, Durham, North Carolina

    • Fellowship in Endocrinology, Duke University Medical Center, Durham, NC


    • Chief, Diabetes, UMass Memorial Medical Center

    • Co-Director, Diabetes Center of Excellence, UMass Memorial Medical Center

    • Professor of Medicine, University of Massachusetts Medical School


    • Tolerance mechanisms and organ/tissue transplantation

    • Autoimmune illnesses, especially insulin dependent diabetes mellitus

    • Human beta cell biology

    • Improving diabetes care delivery systems


    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Derr AG, Arowosegbe A, Satish B, Redick SD, Qaisar N, Guo Z, Vanderleeden E, Trombly MI, Baer CE, Harlan DM, Greiner DL, Garber M, Wang JP. An Early Islet Transcriptional Signature Is Associated With Local Inflammation in Autoimmune Diabetes. Diabetes. 2023 Feb 01; 72(2):261-274. PMID: 36346618.
      Citations: 1     Fields:    Translation:HumansAnimals
    2. Harrison VS, Khan MH, Chamberlain CE, Harlan DM. The Noble and Often Nobel Role Played by Insulin-Focused Research in Modern Medicine. Diabetes Care. 2022 01 01; 45(1):23-27. PMID: 34986255.
      Citations: 1     Fields:    Translation:Humans
    3. Haliyur R, Walker JT, Sanyoura M, Reihsmann CV, Shrestha S, Aramandla R, Poffenberger G, Ramirez AH, Redick SD, Babon JAB, Prasad N, Hegele RA, Kent SC, Harlan DM, Bottino R, Philipson LH, Brissova M, Powers AC. Integrated Analysis of the Pancreas and Islets Reveals Unexpected Findings in Human Male With Type 1 Diabetes. J Endocr Soc. 2021 Dec 01; 5(12):bvab162. PMID: 34870058.
    4. Amante DJ, Harlan DM, Lemon SC, McManus DD, Olaitan OO, Pagoto SL, Gerber BS, Thompson MJ. Evaluation of a Diabetes Remote Monitoring Program Facilitated by Connected Glucose Meters for Patients With Poorly Controlled Type 2 Diabetes: Randomized Crossover Trial. JMIR Diabetes. 2021 Mar 11; 6(1):e25574. PMID: 33704077.
    5. Leite NC, Sintov E, Meissner TB, Brehm MA, Greiner DL, Harlan DM, Melton DA. Modeling Type 1 Diabetes In?Vitro Using Human Pluripotent Stem Cells. Cell Rep. 2020 07 14; 32(2):107894. PMID: 32668238.
      Citations: 36     Fields:    Translation:HumansAnimalsCells
    6. Wright JJ, Saunders DC, Dai C, Poffenberger G, Cairns B, Serreze DV, Harlan DM, Bottino R, Brissova M, Powers AC. Decreased pancreatic acinar cell number in type 1 diabetes. Diabetologia. 2020 07; 63(7):1418-1423. PMID: 32388592.
      Citations: 28     Fields:    Translation:AnimalsCells
    7. Nyalwidhe JO, Jurczyk A, Satish B, Redick S, Qaisar N, Trombly MI, Vangala P, Racicot R, Bortell R, Harlan DM, Greiner DL, Brehm MA, Nadler JL, Wang JP. Proteomic and Transcriptional Profiles of Human Stem Cell-Derived ? Cells Following Enteroviral Challenge. Microorganisms. 2020 Feb 20; 8(2). PMID: 32093375.
    8. Redick SD, Leehy L, Rittenhouse AR, Blodgett DM, Derr AG, Kucukural A, Garber MG, Shultz LD, Greiner DL, Wang JP, Harlan DM, Bortell R, Jurczyk A. Recovery of viable endocrine-specific cells and transcriptomes from human pancreatic islet-engrafted mice. FASEB J. 2020 01; 34(1):1901-1911. PMID: 31914605.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    9. Russell MA, Redick SD, Blodgett DM, Richardson SJ, Leete P, Krogvold L, Dahl-J?rgensen K, Bottino R, Brissova M, Spaeth JM, Babon JAB, Haliyur R, Powers AC, Yang C, Kent SC, Derr AG, Kucukural A, Garber MG, Morgan NG, Harlan DM. HLA Class II Antigen Processing and Presentation Pathway Components Demonstrated by Transcriptome and Protein Analyses of Islet ?-Cells From Donors With Type 1 Diabetes. Diabetes. 2019 05; 68(5):988-1001. PMID: 30833470.
      Citations: 52     Fields:    Translation:HumansCells
    10. Haliyur R, Tong X, Sanyoura M, Shrestha S, Lindner J, Saunders DC, Aramandla R, Poffenberger G, Redick SD, Bottino R, Prasad N, Levy SE, Blind RD, Harlan DM, Philipson LH, Stein RW, Brissova M, Powers AC. Human islets expressing HNF1A variant have defective ? cell transcriptional regulatory networks. J Clin Invest. 2019 01 02; 129(1):246-251. PMID: 30507613.
      Citations: 46     Fields:    Translation:HumansCells
    11. Siddiqui UM, Ayyoub S, Raja S, Yeasmin S, Harlan DM, Aronin N, Torres MS. IMPROVING AFTER-HOURS CALLS TO ENDOCRINOLOGY FELLOWS. Endocr Pract. 2019 Jan; 25(1):51-54. PMID: 30383491.
      Citations:    Fields:    Translation:Humans
    12. Barry SA, Harlan DM, Johnson NL, MacGregor KL. State of Behavioral Health Integration in U.S. Diabetes Care: How Close Are We to ADA Recommendations? Diabetes Care. 2018 07; 41(7):e115-e116. PMID: 29712714.
      Citations: 4     Fields:    
    13. Marre ML, McGinty JW, Chow IT, DeNicola ME, Beck NW, Kent SC, Powers AC, Bottino R, Harlan DM, Greenbaum CJ, Kwok WW, Piganelli JD, James EA. Modifying Enzymes Are Elicited by ER Stress, Generating Epitopes That Are Selectively Recognized by CD4+ T Cells in Patients With Type 1 Diabetes. Diabetes. 2018 07; 67(7):1356-1368. PMID: 29654212.
      Citations: 42     Fields:    Translation:HumansAnimalsCells
    14. Brissova M, Haliyur R, Saunders D, Shrestha S, Dai C, Blodgett DM, Bottino R, Campbell-Thompson M, Aramandla R, Poffenberger G, Lindner J, Pan FC, von Herrath MG, Greiner DL, Shultz LD, Sanyoura M, Philipson LH, Atkinson M, Harlan DM, Levy SE, Prasad N, Stein R, Powers AC. a Cell Function and Gene Expression Are Compromised in Type 1 Diabetes. Cell Rep. 2018 03 06; 22(10):2667-2676. PMID: 29514095.
      Citations: 96     Fields:    Translation:HumansAnimalsCells
    15. Draznin B, Kahn PA, Wagner N, Hirsch IB, Korytkowski M, Harlan DM, McDonnell ME, Gabbay RA. Clinical Diabetes Centers of Excellence: A Model for Future Adult Diabetes Care. J Clin Endocrinol Metab. 2018 03 01; 103(3):809-812. PMID: 29309595.
      Citations: 3     Fields:    Translation:Humans
    16. Nyalwidhe JO, Gallagher GR, Glenn LM, Morris MA, Vangala P, Jurczyk A, Bortell R, Harlan DM, Wang JP, Nadler JL. Coxsackievirus-Induced Proteomic Alterations in Primary Human Islets Provide Insights for the Etiology of Diabetes. J Endocr Soc. 2017 Oct 01; 1(10):1272-1286. PMID: 29264452.
    17. Babon JAB, DeNicola ME, Blodgett DM, Cr?vecoeur I, Buttrick TS, Maehr R, Bottino R, Naji A, Kaddis J, Elyaman W, James EA, Haliyur R, Brissova M, Overbergh L, Mathieu C, Delong T, Haskins K, Pugliese A, Campbell-Thompson M, Mathews C, Atkinson MA, Powers AC, Harlan DM, Kent SC. Corrigendum: Analysis of self-antigen specificity of islet-infiltrating T cells from human donors with type 1 diabetes. Nat Med. 2017 08 04; 23(8):1004. PMID: 28777787.
      Citations: 1     Fields:    
    18. Harlan DM. Response to Comment on Harlan. Islet Transplantation for Hypoglycemia Unawareness/Severe Hypoglycemia: Caveat Emptor. Diabetes Care 2016;39:1072-1074. Diabetes Care. 2017 08; 40(8):e113-e114. PMID: 28733383.
      Citations: 1     Fields:    Translation:Humans
    19. Roberts FR, Hupple C, Norowski E, Walsh NC, Przewozniak N, Aryee KE, Van Dessel FM, Jurczyk A, Harlan DM, Greiner DL, Bortell R, Yang C. Possible type 1 diabetes risk prediction: Using ultrasound imaging to assess pancreas inflammation in the inducible autoimmune diabetes BBDR model. PLoS One. 2017; 12(6):e0178641. PMID: 28605395.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    20. Gourgari EA, Mete M, Sampson ML, Harlan DM, Remaley AT, Rother KI. Exenatide Improves HDL Particle Counts and Size Distribution in Patients With Long-standing Type 1 Diabetes. Diabetes Care. 2017 07; 40(7):e88-e89. PMID: 28515131.
      Citations:    Fields:    
    21. Harlan DM. Editorial. Curr Opin Endocrinol Diabetes Obes. 2017 04; 24(2):81-82. PMID: 28098595.
      Citations:    Fields:    
    22. Harlan DM, Hirsch IB. The upside down world of diabetes care medical economics and what we might do to improve it. Curr Opin Endocrinol Diabetes Obes. 2017 Apr; 24(2):112-118. PMID: 28099208.
      Citations:    Fields:    Translation:Humans
    23. Babon JA, DeNicola ME, Blodgett DM, Cr?vecoeur I, Buttrick TS, Maehr R, Bottino R, Naji A, Kaddis J, Elyaman W, James EA, Haliyur R, Brissova M, Overbergh L, Mathieu C, Delong T, Haskins K, Pugliese A, Campbell-Thompson M, Mathews C, Atkinson MA, Powers AC, Harlan DM, Kent SC. Corrigendum: Analysis of self-antigen specificity of islet-infiltrating T cells from human donors with type 1 diabetes. Nat Med. 2017 Feb 07; 23(2):264. PMID: 28170374.
      Citations: 4     Fields:    
    24. El-Khatib FH, Balliro C, Hillard MA, Magyar KL, Ekhlaspour L, Sinha M, Mondesir D, Esmaeili A, Hartigan C, Thompson MJ, Malkani S, Lock JP, Harlan DM, Clinton P, Frank E, Wilson DM, DeSalvo D, Norlander L, Ly T, Buckingham BA, Diner J, Dezube M, Young LA, Goley A, Kirkman MS, Buse JB, Zheng H, Selagamsetty RR, Damiano ER, Russell SJ. Home use of a bihormonal bionic pancreas versus insulin pump therapy in adults with type 1 diabetes: a multicentre randomised crossover trial. Lancet. 2017 01 28; 389(10067):369-380. PMID: 28007348.
      Citations: 91     Fields:    Translation:Humans
    25. Malkani S, Keitz SA, Harlan DM. Redesigning Diabetes Care: Defining the Role of Endocrinologists Among Alternative Providers. Curr Diab Rep. 2016 12; 16(12):121. PMID: 27766581.
      Citations: 3     Fields:    Translation:Humans
    26. Babon JA, DeNicola ME, Blodgett DM, Cr?vecoeur I, Buttrick TS, Maehr R, Bottino R, Naji A, Kaddis J, Elyaman W, James EA, Haliyur R, Brissova M, Overbergh L, Mathieu C, Delong T, Haskins K, Pugliese A, Campbell-Thompson M, Mathews C, Atkinson MA, Powers AC, Harlan DM, Kent SC. Analysis of self-antigen specificity of islet-infiltrating T cells from human donors with type 1 diabetes. Nat Med. 2016 12; 22(12):1482-1487. PMID: 27798614.
      Citations: 170     Fields:    Translation:HumansCells
    27. Blodgett DM, Redick SD, Harlan DM. Surprising Heterogeneity of Pancreatic Islet Cell Subsets. Cell Syst. 2016 10 26; 3(4):330-332. PMID: 27788358.
      Citations: 3     Fields:    Translation:Cells
    28. Derr A, Yang C, Zilionis R, Sergushichev A, Blodgett DM, Redick S, Bortell R, Luban J, Harlan DM, Kadener S, Greiner DL, Klein A, Artyomov MN, Garber M. End Sequence Analysis Toolkit (ESAT) expands the extractable information from single-cell RNA-seq data. Genome Res. 2016 10; 26(10):1397-1410. PMID: 27470110.
      Citations: 36     Fields:    Translation:AnimalsCells
    29. Harlan DM. Islet Transplantation for Hypoglycemia Unawareness/Severe Hypoglycemia: Caveat Emptor. Diabetes Care. 2016 07; 39(7):1072-4. PMID: 27330121.
      Citations: 10     Fields:    Translation:Humans
    30. Vegas AJ, Veiseh O, Doloff JC, Ma M, Tam HH, Bratlie K, Li J, Bader AR, Langan E, Olejnik K, Fenton P, Kang JW, Hollister-Locke J, Bochenek MA, Chiu A, Siebert S, Tang K, Jhunjhunwala S, Aresta-Dasilva S, Dholakia N, Thakrar R, Vietti T, Chen M, Cohen J, Siniakowicz K, Qi M, McGarrigle J, Lyle S, Harlan DM, Greiner DL, Oberholzer J, Weir GC, Langer R, Anderson DG. Corrigendum: Combinatorial hydrogel library enables identification of materials that mitigate the foreign body response in primates. Nat Biotechnol. 2016 06 09; 34(6):666. PMID: 27281428.
      Citations: 6     Fields:    
    31. Delong T, Wiles TA, Baker RL, Bradley B, Barbour G, Reisdorph R, Armstrong M, Powell RL, Reisdorph N, Kumar N, Elso CM, DeNicola M, Bottino R, Powers AC, Harlan DM, Kent SC, Mannering SI, Haskins K. Pathogenic CD4 T cells in type 1 diabetes recognize epitopes formed by peptide fusion. Science. 2016 Feb 12; 351(6274):711-4. PMID: 26912858.
      Citations: 259     Fields:    Translation:AnimalsCells
    32. Vegas AJ, Veiseh O, Doloff JC, Ma M, Tam HH, Bratlie K, Li J, Bader AR, Langan E, Olejnik K, Fenton P, Kang JW, Hollister-Locke J, Bochenek MA, Chiu A, Siebert S, Tang K, Jhunjhunwala S, Aresta-Dasilva S, Dholakia N, Thakrar R, Vietti T, Chen M, Cohen J, Siniakowicz K, Qi M, McGarrigle J, Graham AC, Lyle S, Harlan DM, Greiner DL, Oberholzer J, Weir GC, Langer R, Anderson DG. Combinatorial hydrogel library enables identification of materials that mitigate the foreign body response in primates. Nat Biotechnol. 2016 03; 34(3):345-52. PMID: 26807527.
      Citations: 161     Fields:    Translation:HumansAnimalsCells
    33. Conrad E, Dai C, Spaeth J, Guo M, Cyphert HA, Scoville D, Carroll J, Yu WM, Goodrich LV, Harlan DM, Grove KL, Roberts CT, Powers AC, Gu G, Stein R. The MAFB transcription factor impacts islet a-cell function in rodents and represents a unique signature of primate islet ?-cells. Am J Physiol Endocrinol Metab. 2016 Jan 01; 310(1):E91-E102. PMID: 26554594.
      Citations: 33     Fields:    Translation:HumansAnimalsCells
    34. Jurczyk A, Nowosielska A, Przewozniak N, Aryee KE, DiIorio P, Blodgett D, Yang C, Campbell-Thompson M, Atkinson M, Shultz L, Rittenhouse A, Harlan D, Greiner D, Bortell R. Beyond the brain: disrupted in schizophrenia 1 regulates pancreatic ?-cell function via glycogen synthase kinase-3?. FASEB J. 2016 Feb; 30(2):983-93. PMID: 26546129.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    35. Yang C, Loehn M, Jurczyk A, Przewozniak N, Leehy L, Herrera PL, Shultz LD, Greiner DL, Harlan DM, Bortell R. Lixisenatide accelerates restoration of normoglycemia and improves human beta-cell function and survival in diabetic immunodeficient NOD-scid IL-2rg(null) RIP-DTR mice engrafted with human islets. Diabetes Metab Syndr Obes. 2015; 8:387-98. PMID: 26316789.
    36. Blodgett DM, Nowosielska A, Afik S, Pechhold S, Cura AJ, Kennedy NJ, Kim S, Kucukural A, Davis RJ, Kent SC, Greiner DL, Garber MG, Harlan DM, diIorio P. Novel Observations from Next Generation RNA Sequencing of Highly Purified Human Adult and Fetal Islet Cell Subsets. 2015; Diabetes.
    37. Blau JE, Abegg MR, Flegel WA, Zhao X, Harlan DM, Rother KI. Long-term immunosuppression after solitary islet transplantation is associated with preserved C-peptide secretion for more than a decade. Am J Transplant. 2015 Nov; 15(11):2995-3001. PMID: 26184712.
      Citations: 8     Fields:    Translation:Humans
    38. Blodgett DM, Nowosielska A, Afik S, Pechhold S, Cura AJ, Kennedy NJ, Kim S, Kucukural A, Davis RJ, Kent SC, Greiner DL, Garber MG, Harlan DM, diIorio P. Novel Observations From Next-Generation RNA Sequencing of Highly Purified Human Adult and Fetal Islet Cell Subsets. Diabetes. 2015 Sep; 64(9):3172-81. PMID: 25931473.
      Citations: 162     Fields:    Translation:HumansCells
    39. Harlan DM. Editorial: diabetes and the endocrine pancreas I. Curr Opin Endocrinol Diabetes Obes. 2015 Apr; 22(2):75-6. PMID: 25692919.
      Citations:    Fields:    Translation:HumansAnimals
    40. Sarkar G, Alattar M, Brown RJ, Quon MJ, Harlan DM, Rother KI. Response to comment on Sarkar et al. Exenatide treatment for 6 months improves insulin sensitivity in adults with type 1 diabetes. Diabetes care 2014;37:666-670. Diabetes Care. 2014 Oct; 37(10):e219-20. PMID: 25249681.
      Citations:    Fields:    Translation:Humans
    41. Fuchs YF, Adler K, Lindner A, Karasinsky A, Wilhelm C, Weigelt M, Balke H, F?rtsch K, Mortler-Hildebrandt LF, Harlan DM, Pechhold K, Ziegler AG, Bonifacio E. IGRP and insulin vaccination induce CD8+ T cell-mediated autoimmune diabetes in the RIP-CD80GP mouse. Clin Exp Immunol. 2014 May; 176(2):199-206. PMID: 24387268.
      Citations: 3     Fields:    Translation:AnimalsCellsPHPublic Health
    42. Blodgett DM, Cura AJ, Harlan DM. The pancreatic ?-cell transcriptome and integrated-omics. Curr Opin Endocrinol Diabetes Obes. 2014 Apr; 21(2):83-8. PMID: 24526012.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    43. Miao F, Chen Z, Genuth S, Paterson A, Zhang L, Wu X, Li SM, Cleary P, Riggs A, Harlan DM, Lorenzi G, Kolterman O, Sun W, Lachin JM, Natarajan R. Evaluating the role of epigenetic histone modifications in the metabolic memory of type 1 diabetes. Diabetes. 2014 May; 63(5):1748-62. PMID: 24458354.
      Citations: 108     Fields:    Translation:Humans
    44. Jurczyk A, Diiorio P, Brostowin D, Leehy L, Yang C, Urano F, Harlan DM, Shultz LD, Greiner DL, Bortell R. Improved function and proliferation of adult human beta cells engrafted in diabetic immunodeficient NOD-scid IL2r?(null) mice treated with alogliptin. Diabetes Metab Syndr Obes. 2013; 6:493-9. PMID: 24376359.
    45. Sarkar G, Alattar M, Brown RJ, Quon MJ, Harlan DM, Rother KI. Exenatide treatment for 6 months improves insulin sensitivity in adults with type 1 diabetes. Diabetes Care. 2014; 37(3):666-70. PMID: 24194508.
      Citations: 23     Fields:    Translation:Humans
    46. Adler RN, Harlan DM. Diabetes: 8 strategies to put into practice. J Fam Pract. 2013 Oct; 62(10):542-7. PMID: 24143345.
      Citations: 1     Fields:    Translation:HumansPHPublic Health
    47. Simmons JH, Chen V, Miller KM, McGill JB, Bergenstal RM, Goland RS, Harlan DM, Largay JF, Massaro EM, Beck RW. Differences in the management of type 1 diabetes among adults under excellent control compared with those under poor control in the T1D Exchange Clinic Registry. Diabetes Care. 2013 Nov; 36(11):3573-7. PMID: 24026543.
      Citations: 40     Fields:    Translation:Humans
    48. Burbelo PD, Lebovitz EE, Bren KE, Bayat A, Paviol S, Wenzlau JM, Barriga KJ, Rewers M, Harlan DM, Iadarola MJ. Extrapancreatic autoantibody profiles in type I diabetes. PLoS One. 2012; 7(9):e45216. PMID: 23028856.
      Citations: 15     Fields:    Translation:Humans
    49. Feigenbaum K, Brooks PG, Chamberlain CE, Cochran E, Adams-McLean A, Malek R, Harlan DM. The Clinical Center's blood glucose management service: a story in quality integrated care. Diabetes Educ. 2012 Mar-Apr; 38(2):194-206. PMID: 22190644.
      Citations:    Fields:    Translation:Humans
    50. Greiner DL, Brehm MA, Hosur V, Harlan DM, Powers AC, Shultz LD. Humanized mice for the study of type 1 and type 2 diabetes. Ann N Y Acad Sci. 2011 Dec; 1245:55-8. PMID: 22211980.
      Citations: 22     Fields:    Translation:HumansAnimals
    51. Soleimanpour SA, Hirshberg B, Bunnell DJ, Sumner AE, Ader M, Remaley AT, Rother KI, Rickels MR, Harlan DM. Metabolic function of a suboptimal transplanted islet mass in nonhuman primates on rapamycin monotherapy. Cell Transplant. 2012; 21(6):1297-304. PMID: 22080915.
      Citations: 5     Fields:    Translation:AnimalsCells
    52. Brown RJ, Wijewickrama RC, Harlan DM, Rother KI. Uncoupling intensive insulin therapy from weight gain and hypoglycemia in type 1 diabetes. Diabetes Technol Ther. 2011 Apr; 13(4):457-60. PMID: 21355723.
      Citations: 9     Fields:    Translation:Humans
    53. Rother KI, Harlan DM. Comment on: Keenan et al. (2010) residual insulin production and pancreatic ?-Cell turnover after 50 years of diabetes: Joslin Medalist Study. Diabetes 2010;59:2846-2853. Diabetes. 2010 Dec; 59(12):e26; author reply e27. PMID: 21115779.
      Citations: 1     Fields:    Translation:HumansCells
    54. Harlan DM, Lee MM. Infant formula, autoimmune triggers, and type 1 diabetes. N Engl J Med. 2010 Nov 11; 363(20):1961-3. PMID: 21067389.
      Citations:    Fields:    Translation:HumansCells
    55. Perl S, Kushner JA, Buchholz BA, Meeker AK, Stein GM, Hsieh M, Kirby M, Pechhold S, Liu EH, Harlan DM, Tisdale JF. Significant human beta-cell turnover is limited to the first three decades of life as determined by in vivo thymidine analog incorporation and radiocarbon dating. J Clin Endocrinol Metab. 2010 Oct; 95(10):E234-9. PMID: 20660050.
      Citations: 130     Fields:    Translation:HumansCells
    56. Giovannucci E, Harlan DM, Archer MC, Bergenstal RM, Gapstur SM, Habel LA, Pollak M, Regensteiner JG, Yee D. Diabetes and cancer: a consensus report. Diabetes Care. 2010 Jul; 33(7):1674-85. PMID: 20587728.
      Citations: 799     Fields:    Translation:Humans
    57. Giovannucci E, Harlan DM, Archer MC, Bergenstal RM, Gapstur SM, Habel LA, Pollak M, Regensteiner JG, Yee D. Diabetes and cancer: a consensus report. CA Cancer J Clin. 2010 Jul-Aug; 60(4):207-21. PMID: 20554718.
      Citations: 376     Fields:    Translation:Humans
    58. Pechhold S, Stouffer M, Walker G, Martel R, Seligmann B, Hang Y, Stein R, Harlan DM, Pechhold K. Transcriptional analysis of intracytoplasmically stained, FACS-purified cells by high-throughput, quantitative nuclease protection. Nat Biotechnol. 2009 Nov; 27(11):1038-42. PMID: 19838197.
      Citations: 28     Fields:    Translation:AnimalsCells
    59. Rother KI, Spain LM, Wesley RA, Digon BJ, Baron A, Chen K, Nelson P, Dosch HM, Palmer JP, Brooks-Worrell B, Ring M, Harlan DM. Effects of exenatide alone and in combination with daclizumab on beta-cell function in long-standing type 1 diabetes. Diabetes Care. 2009 Dec; 32(12):2251-7. PMID: 19808924.
      Citations: 45     Fields:    Translation:HumansCells
    60. Harlan DM, Kenyon NS, Korsgren O, Roep BO. Current advances and travails in islet transplantation. Diabetes. 2009 Oct; 58(10):2175-84. PMID: 19794074.
      Citations: 76     Fields:    Translation:HumansCells
    61. Khan MH, Harlan DM. Counterpoint: clinical islet transplantation: not ready for prime time. Diabetes Care. 2009 Aug; 32(8):1570-4. PMID: 19638528.
      Citations: 4     Fields:    Translation:Humans
    62. Rother KI, Brown RJ, Morales MM, Wright E, Duan Z, Campbell C, Hardin DS, Popovic J, McEvoy RC, Harlan DM, Orlander PR, Brod SA. Effect of ingested interferon-alpha on beta-cell function in children with new-onset type 1 diabetes. Diabetes Care. 2009 Jul; 32(7):1250-5. PMID: 19564474.
      Citations: 15     Fields:    Translation:HumansCells
    63. Craig AT, Gavrilova O, Dwyer NK, Jou W, Pack S, Liu E, Pechhold K, Schmidt M, McAlister VJ, Chiorini JA, Blanchette-Mackie EJ, Harlan DM, Owens RA. Transduction of rat pancreatic islets with pseudotyped adeno-associated virus vectors. Virol J. 2009 May 18; 6:61. PMID: 19450275.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    64. Liu EH, Digon BJ, Hirshberg B, Chang R, Wood BJ, Neeman Z, Kam A, Wesley RA, Polly SM, Hofmann RM, Rother KI, Harlan DM. Pancreatic beta cell function persists in many patients with chronic type 1 diabetes, but is not dramatically improved by prolonged immunosuppression and euglycaemia from a beta cell allograft. Diabetologia. 2009 Jul; 52(7):1369-80. PMID: 19418039.
      Citations: 38     Fields:    Translation:HumansCellsCTClinical Trials
    65. Shen HC, Adem A, Ylaya K, Wilson A, He M, Lorang D, Hewitt SM, Pechhold K, Harlan DM, Lubensky IA, Schmidt LS, Linehan WM, Libutti SK. Deciphering von Hippel-Lindau (VHL/Vhl)-associated pancreatic manifestations by inactivating Vhl in specific pancreatic cell populations. PLoS One. 2009; 4(4):e4897. PMID: 19340311.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    66. Pechhold K, Koczwara K, Zhu X, Harrison VS, Walker G, Lee J, Harlan DM. Blood glucose levels regulate pancreatic beta-cell proliferation during experimentally-induced and spontaneous autoimmune diabetes in mice. PLoS One. 2009; 4(3):e4827. PMID: 19287497.
      Citations: 22     Fields:    Translation:Animals
    67. Lin HM, Lee JH, Yadav H, Kamaraju AK, Liu E, Zhigang D, Vieira A, Kim SJ, Collins H, Matschinsky F, Harlan DM, Roberts AB, Rane SG. Transforming growth factor-beta/Smad3 signaling regulates insulin gene transcription and pancreatic islet beta-cell function. J Biol Chem. 2009 May 01; 284(18):12246-57. PMID: 19265200.
      Citations: 95     Fields:    Translation:HumansAnimalsCells
    68. Pechhold K, Zhu X, Harrison VS, Lee J, Chakrabarty S, Koczwara K, Gavrilova O, Harlan DM. Dynamic changes in pancreatic endocrine cell abundance, distribution, and function in antigen-induced and spontaneous autoimmune diabetes. Diabetes. 2009 May; 58(5):1175-84. PMID: 19228810.
      Citations: 22     Fields:    Translation:AnimalsCells
    69. Pechhold K, Chakrabarty S, Harlan DM. Cytotoxic T cell-mediated diabetes in RIP-CD80 transgenic mice: autoantigen peptide sensitivity and fine specificity. Ann N Y Acad Sci. 2007 Apr; 1103:132-42. PMID: 17376836.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    70. Perl S, Hirshberg B, Harlan DM, Tisdale JF. How much insulin is enough? A quantitative assessment of the transdifferentiaton potential of liver. Diabetologia. 2007 Mar; 50(3):690-2. PMID: 17221213.
      Citations: 1     Fields:    Translation:HumansAnimals
    71. Ren J, Jin P, Wang E, Liu E, Harlan DM, Li X, Stroncek DF. Pancreatic islet cell therapy for type I diabetes: understanding the effects of glucose stimulation on islets in order to produce better islets for transplantation. J Transl Med. 2007 Jan 03; 5:1. PMID: 17201925.
      Citations: 10     Fields:    Translation:HumansAnimals
    72. Liu EH, Siegel RM, Harlan DM, O'Shea JJ. T cell-directed therapies: lessons learned and future prospects. Nat Immunol. 2007 Jan; 8(1):25-30. PMID: 17179969.
      Citations: 20     Fields:    Translation:HumansCells
    73. Taylor-Fishwick DA, Bowman A, Hamblet N, Bernard P, Harlan DM, Vinik AI. Islet neogenesis associated protein transgenic mice are resistant to hyperglycemia induced by streptozotocin. J Endocrinol. 2006 Sep; 190(3):729-37. PMID: 17003274.
      Citations: 9     Fields:    Translation:AnimalsCells
    74. Neeman Z, Hirshberg B, Harlan D, Wood BJ. Radiologic aspects of islet cell transplantation. Curr Diab Rep. 2006 Aug; 6(4):310-5. PMID: 16879784.
      Citations: 2     Fields:    Translation:Humans
    75. Dy EC, Harlan DM, Rother KI. Assessment of islet function following islet and pancreas transplantation. Curr Diab Rep. 2006 Aug; 6(4):316-22. PMID: 16879785.
      Citations: 2     Fields:    Translation:Humans
    76. Bagenstose LM, Agarwal RK, Silver PB, Harlan DM, Hoffmann SC, Kampen RL, Chan CC, Caspi RR. Disruption of CD40/CD40-ligand interactions in a retinal autoimmunity model results in protection without tolerance. J Immunol. 2005 Jul 01; 175(1):124-30. PMID: 15972638.
      Citations: 17     Fields:    Translation:HumansAnimalsPHPublic Health
    77. Harlan DM, von Herrath M. Immune intervention with anti-CD3 in diabetes. Nat Med. 2005 Jul; 11(7):716-8. PMID: 16015359.
      Citations: 2     Fields:    Translation:HumansCells
    78. Herold KC, Gitelman SE, Masharani U, Hagopian W, Bisikirska B, Donaldson D, Rother K, Diamond B, Harlan DM, Bluestone JA. A single course of anti-CD3 monoclonal antibody hOKT3gamma1(Ala-Ala) results in improvement in C-peptide responses and clinical parameters for at least 2 years after onset of type 1 diabetes. Diabetes. 2005 Jun; 54(6):1763-9. PMID: 15919798.
      Citations: 239     Fields:    Translation:HumansCTClinical Trials
    79. Kang EM, Zickler PP, Burns S, Langemeijer SM, Brenner S, Phang OA, Patterson N, Harlan D, Tisdale JF. Hematopoietic stem cell transplantation prevents diabetes in NOD mice but does not contribute to significant islet cell regeneration once disease is established. Exp Hematol. 2005 Jun; 33(6):699-705. PMID: 15911094.
      Citations: 14     Fields:    Translation:Animals
    80. Brissova M, Fowler MJ, Nicholson WE, Chu A, Hirshberg B, Harlan DM, Powers AC. Assessment of human pancreatic islet architecture and composition by laser scanning confocal microscopy. J Histochem Cytochem. 2005 Sep; 53(9):1087-97. PMID: 15923354.
      Citations: 359     Fields:    Translation:HumansAnimals
    81. Fowler M, Virostko J, Chen Z, Poffenberger G, Radhika A, Brissova M, Shiota M, Nicholson WE, Shi Y, Hirshberg B, Harlan DM, Jansen ED, Powers AC. Assessment of pancreatic islet mass after islet transplantation using in vivo bioluminescence imaging. Transplantation. 2005 Apr 15; 79(7):768-76. PMID: 15818318.
      Citations: 32     Fields:    Translation:HumansAnimals
    82. Liu EH, Rother KI, Harlan DM. Islet transplantation and the challenges of treating type 1 diabetes. Discov Med. 2005 Feb; 5(25):43-9. PMID: 20704922.
      Citations:    Fields:    
    83. Naftanel MA, Harlan DM. Pancreatic islet transplantation. PLoS Med. 2004 Dec; 1(3):e58; quiz e75. PMID: 15630467.
      Citations: 34     Fields:    Translation:Humans
    84. Minn AH, Lan H, Rabaglia ME, Harlan DM, Peculis BA, Attie AD, Shalev A. Increased insulin translation from an insulin splice-variant overexpressed in diabetes, obesity, and insulin resistance. Mol Endocrinol. 2005 Mar; 19(3):794-803. PMID: 15550470.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    85. Neeman Z, Hirshberg B, Tal MG, Wood BJ, Harlan DM. Pulmonary angiography for the diagnosis of thromboembolic events in the non-human primate. Transplantation. 2004 Oct 15; 78(7):1025-9. PMID: 15480169.
      Citations: 1     Fields:    Translation:HumansAnimals
    86. Ferrant JL, Benjamin CD, Cutler AH, Kalled SL, Hsu YM, Garber EA, Hess DM, Shapiro RI, Kenyon NS, Harlan DM, Kirk AD, Burkly LC, Taylor FR. The contribution of Fc effector mechanisms in the efficacy of anti-CD154 immunotherapy depends on the nature of the immune challenge. Int Immunol. 2004 Nov; 16(11):1583-94. PMID: 15466914.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    87. Rother KI, Harlan DM. Challenges facing islet transplantation for the treatment of type 1 diabetes mellitus. J Clin Invest. 2004 Oct; 114(7):877-83. PMID: 15467822.
      Citations: 75     Fields:    Translation:Humans
    88. Harlan DM, Rother KI. Islet transplantation as a treatment for diabetes. N Engl J Med. 2004 May 13; 350(20):2104; author reply 2104. PMID: 15141057.
      Citations: 4     Fields:    Translation:Humans
    89. Shalev A, Patterson NB, Hirshberg B, Rother KI, Harlan DM. Resistin serum levels in type 1 diabetes pre- and post-islet transplantation. Metabolism. 2004 Apr; 53(4):403-4. PMID: 15045683.
      Citations: 6     Fields:    Translation:Humans
    90. Steele C, Hagopian WA, Gitelman S, Masharani U, Cavaghan M, Rother KI, Donaldson D, Harlan DM, Bluestone J, Herold KC. Insulin secretion in type 1 diabetes. Diabetes. 2004 Feb; 53(2):426-33. PMID: 14747294.
      Citations: 66     Fields:    Translation:HumansCTClinical Trials
    91. Harlan DM. Gene-altered islets for transplant: giant leap or small step? Endocrinology. 2004 Feb; 145(2):463-6. PMID: 14739150.
      Citations: 2     Fields:    Translation:HumansAnimals
    92. Minn AH, Kayton M, Lorang D, Hoffmann SC, Harlan DM, Libutti SK, Shalev A. Insulinomas and expression of an insulin splice variant. Lancet. 2004 Jan 31; 363(9406):363-7. PMID: 15070567.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    93. Tal MG, Hirshberg B, Neeman Z, Bunnell D, Soleimanpour S, Bacher J, Patterson N, Chang R, Harlan DM. Induction of diabetes in nonhuman primates by means of temporary arterial embolization and selective arterial injection of streptozotocin. Radiology. 2004 Jan; 230(1):163-8. PMID: 14695391.
      Citations: 9     Fields:    Translation:Animals
    94. Venstrom JM, McBride MA, Rother KI, Hirshberg B, Orchard TJ, Harlan DM. Survival after pancreas transplantation in patients with diabetes and preserved kidney function. JAMA. 2003 Dec 03; 290(21):2817-23. PMID: 14657065.
      Citations: 65     Fields:    Translation:Humans
    95. Hirshberg B, Rother KI, Digon III BJ, Venstrom J, Harlan DM. State of the art: islet transplantation for the cure of type 1 diabetes mellitus. Rev Endocr Metab Disord. 2003 Dec; 4(4):381-9. PMID: 14618023.
      Citations: 8     Fields:    Translation:Humans
    96. Hirshberg B, Rother KI, Digon BJ, Lee J, Gaglia JL, Hines K, Read EJ, Chang R, Wood BJ, Harlan DM. Benefits and risks of solitary islet transplantation for type 1 diabetes using steroid-sparing immunosuppression: the National Institutes of Health experience. Diabetes Care. 2003 Dec; 26(12):3288-95. PMID: 14633816.
      Citations: 49     Fields:    Translation:HumansCTClinical Trials
    97. Kayton ML, Costouros NG, Lorang D, Alexander HR, Hewitt SM, Cochran C, Shalev A, Harlan D, Skarulis MC, Gorden P, Libutti SK. Peak stimulated insulin secretion is associated with specific changes in gene expression profiles in sporadic insulinomas. Surgery. 2003 Dec; 134(6):982-7; discussion 987-8. PMID: 14668731.
      Citations: 1     Fields:    Translation:HumansCells
    98. Xu H, Elster EA, Blair PJ, Burkly LC, Tadaki DK, Harlan DM, Kirk AD. Effects of combined treatment with CD25- and CD154-specific monoclonal antibodies in non-human primate allotransplantation. Am J Transplant. 2003 Nov; 3(11):1350-4. PMID: 14525594.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    99. Digon BJ, Rother KI, Hirshberg B, Harlan DM. Sirolimus-induced interstitial pneumonitis in an islet transplant recipient. Diabetes Care. 2003 Nov; 26(11):3191. PMID: 14578266.
      Citations: 10     Fields:    Translation:Humans
    100. Minn AH, Patterson NB, Pack S, Hoffmann SC, Gavrilova O, Vinson C, Harlan DM, Shalev A. Resistin is expressed in pancreatic islets. Biochem Biophys Res Commun. 2003 Oct 17; 310(2):641-5. PMID: 14521959.
      Citations: 26     Fields:    Translation:HumansAnimalsCells
    101. Farilla L, Bulotta A, Hirshberg B, Li Calzi S, Khoury N, Noushmehr H, Bertolotto C, Di Mario U, Harlan DM, Perfetti R. Glucagon-like peptide 1 inhibits cell apoptosis and improves glucose responsiveness of freshly isolated human islets. Endocrinology. 2003 Dec; 144(12):5149-58. PMID: 12960095.
      Citations: 194     Fields:    Translation:HumansCells
    102. Hirshberg B, Preston EH, Xu H, Tal MG, Neeman Z, Bunnell D, Soleimanpour S, Hale DA, Kirk AD, Harlan DM. Rabbit antithymocyte globulin induction and sirolimus monotherapy supports prolonged islet allograft function in a nonhuman primate islet transplantation model. Transplantation. 2003 Jul 15; 76(1):55-60. PMID: 12865786.
      Citations: 6     Fields:    Translation:Animals
    103. Kirk AD, Hale DA, Mannon RB, Kleiner DE, Hoffmann SC, Kampen RL, Cendales LK, Tadaki DK, Harlan DM, Swanson SJ. Results from a human renal allograft tolerance trial evaluating the humanized CD52-specific monoclonal antibody alemtuzumab (CAMPATH-1H). Transplantation. 2003 Jul 15; 76(1):120-9. PMID: 12865797.
      Citations: 113     Fields:    Translation:HumansCellsCTClinical Trials
    104. Hirshberg B, Rother KI, Harlan DM. Islet transplantation: where do we stand now? Diabetes Metab Res Rev. 2003 May-Jun; 19(3):175-8; discussion 175. PMID: 12789649.
      Citations: 5     Fields:    Translation:Humans
    105. Tadaki DK, Williams A, Lee KP, Kirk AD, Harlan DM. Porcine CD80: cloning, characterization, and evidence for its role in direct human T-cell activation. Xenotransplantation. 2003 May; 10(3):252-8. PMID: 12694545.
      Citations:    Fields:    Translation:HumansAnimalsCells
    106. Xu H, Montgomery SP, Preston EH, Tadaki DK, Hale DA, Harlan DM, Kirk AD. Studies investigating pretransplant donor-specific blood transfusion, rapamycin, and the CD154-specific antibody IDEC-131 in a nonhuman primate model of skin allotransplantation. J Immunol. 2003 Mar 01; 170(5):2776-82. PMID: 12594309.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    107. Pechhold K, Karges W, Blum C, Boehm BO, Harlan DM. Beta cell-specific CD80 (B7-1) expression disrupts tissue protection from autoantigen-specific CTL-mediated diabetes. J Autoimmun. 2003 Feb; 20(1):1-13. PMID: 12604308.
      Citations: 7     Fields:    Translation:AnimalsCells
    108. Hirshberg B, Mog S, Patterson N, Leconte J, Harlan DM. Histopathological study of intrahepatic islets transplanted in the nonhuman primate model using edmonton protocol immunosuppression. J Clin Endocrinol Metab. 2002 Dec; 87(12):5424-9. PMID: 12466330.
      Citations: 17     Fields:    Translation:Animals
    109. Montgomery SP, Xu H, Tadaki DK, Celniker A, Burkly LC, Berning JD, Cruzata F, Elster EA, Gray G, Kampen RL, Swanson SJ, Harlan DM, Kirk AD. Combination induction therapy with monoclonal antibodies specific for CD80, CD86, and CD154 in nonhuman primate renal transplantation. Transplantation. 2002 Nov 27; 74(10):1365-9. PMID: 12451232.
      Citations: 10     Fields:    Translation:HumansAnimals
    110. Swanson SJ, Hale DA, Mannon RB, Kleiner DE, Cendales LC, Chamberlain CE, Polly SM, Harlan DM, Kirk AD. Kidney transplantation with rabbit antithymocyte globulin induction and sirolimus monotherapy. Lancet. 2002 Nov 23; 360(9346):1662-4. PMID: 12457792.
      Citations: 27     Fields:    Translation:HumansAnimalsCTClinical Trials
    111. Xu H, Tadaki DK, Elster EA, Burkly LC, Berning JD, Cruzata F, Kampen RL, Montgomery SP, Patterson NB, Harlan DM, Kirk AD. Humanized anti-CD154 antibody therapy for the treatment of allograft rejection in nonhuman primates. Transplantation. 2002 Oct 15; 74(7):940-3. PMID: 12394834.
      Citations: 10     Fields:    Translation:HumansAnimals
    112. Shalev A, Pise-Masison CA, Radonovich M, Hoffmann SC, Hirshberg B, Brady JN, Harlan DM. Oligonucleotide microarray analysis of intact human pancreatic islets: identification of glucose-responsive genes and a highly regulated TGFbeta signaling pathway. Endocrinology. 2002 Sep; 143(9):3695-8. PMID: 12193586.
      Citations: 95     Fields:    Translation:HumansCells
    113. Chute JP, Saini AA, Chute DJ, Wells MR, Clark WB, Harlan DM, Park J, Stull MK, Civin C, Davis TA. Ex vivo culture with human brain endothelial cells increases the SCID-repopulating capacity of adult human bone marrow. Blood. 2002 Dec 15; 100(13):4433-9. PMID: 12393435.
      Citations: 36     Fields:    Translation:HumansAnimalsCells
    114. Shalev A, Blair PJ, Hoffmann SC, Hirshberg B, Peculis BA, Harlan DM. A proinsulin gene splice variant with increased translation efficiency is expressed in human pancreatic islets. Endocrinology. 2002 Jul; 143(7):2541-7. PMID: 12072386.
      Citations: 22     Fields:    Translation:HumansCells
    115. Hirshberg B, Montgomery S, Wysoki MG, Xu H, Tadaki D, Lee J, Hines K, Gaglia J, Patterson N, Leconte J, Hale D, Chang R, Kirk AD, Harlan DM. Pancreatic islet transplantation using the nonhuman primate (rhesus) model predicts that the portal vein is superior to the celiac artery as the islet infusion site. Diabetes. 2002 Jul; 51(7):2135-40. PMID: 12086943.
      Citations: 17     Fields:    Translation:Animals
    116. Hoffmann SC, Stanley EM, Cox ED, DiMercurio BS, Koziol DE, Harlan DM, Kirk AD, Blair PJ. Ethnicity greatly influences cytokine gene polymorphism distribution. Am J Transplant. 2002 Jul; 2(6):560-7. PMID: 12118901.
      Citations: 87     Fields:    Translation:Humans
    117. Harlan DM. Islet cell allotransplantation as a model system for a bioengineering approach to reparative medicine: immunological concerns. Ann N Y Acad Sci. 2002 Jun; 961:331-4. PMID: 12081931.
      Citations:    Fields:    Translation:Animals
    118. Harlan DM, Metzger DW, Karp CL, Matzinger P, Munn DH, Ransohoff RM. Immune response to engineered tissues and cells: breakout session summary. Ann N Y Acad Sci. 2002 Jun; 961:350-1. PMID: 12081937.
      Citations:    Fields:    Translation:HumansAnimalsCells
    119. Harlan DM, Karp CL, Matzinger P, Munn DH, Ransohoff RM, Metzger DW. Immunological concerns with bioengineering approaches. Ann N Y Acad Sci. 2002 Jun; 961:323-30. PMID: 12081930.
      Citations: 2     Fields:    Translation:HumansAnimals
    120. Herold KC, Hagopian W, Auger JA, Poumian-Ruiz E, Taylor L, Donaldson D, Gitelman SE, Harlan DM, Xu D, Zivin RA, Bluestone JA. Anti-CD3 monoclonal antibody in new-onset type 1 diabetes mellitus. N Engl J Med. 2002 May 30; 346(22):1692-8. PMID: 12037148.
      Citations: 450     Fields:    Translation:HumansCTClinical Trials
    121. Montgomery SP, Mog SR, Xu H, Tadaki DK, Hirshberg B, Berning JD, Leconte J, Harlan DM, Hale D, Kirk AD. Efficacy and toxicity of a protocol using sirolimus, tacrolimus and daclizumab in a nonhuman primate renal allotransplant model. Am J Transplant. 2002 Apr; 2(4):381-5. PMID: 12118862.
      Citations: 8     Fields:    Translation:Animals
    122. Chute JP, Clark W, Saini A, Wells M, Harlan D. Rescue of hematopoietic stem cells following high-dose radiation injury using ex vivo culture on endothelial monolayers. Mil Med. 2002 Feb; 167(2 Suppl):74-7. PMID: 11878265.
      Citations: 3     Fields:    Translation:AnimalsCellsPHPublic Health
    123. Xu H, Arnaud F, Tadaki DK, Burkly LC, Harlan DM, Kirk AD. Human platelets activate porcine endothelial cells through a CD154-dependent pathway. Transplantation. 2001 Dec 15; 72(11):1858-61. PMID: 11740405.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    124. Elster EA, Xu H, Tadaki DK, Montgomery S, Burkly LC, Berning JD, Baumgartner RE, Cruzata F, Marx R, Harlan DM, Kirk AD. Treatment with the humanized CD154-specific monoclonal antibody, hu5C8, prevents acute rejection of primary skin allografts in nonhuman primates. Transplantation. 2001 Nov 15; 72(9):1473-8. PMID: 11707732.
      Citations: 25     Fields:    Translation:HumansAnimals
    125. Hoffmann SC, Stanley EM, Darrin Cox E, Craighead N, DiMercurio BS, Koziol DE, Harlan DM, Kirk AD, Blair PJ. Association of cytokine polymorphic inheritance and in vitro cytokine production in anti-CD3/CD28-stimulated peripheral blood lymphocytes. Transplantation. 2001 Oct 27; 72(8):1444-50. PMID: 11685118.
      Citations: 79     Fields:    Translation:HumansCells
    126. Montgomery SP, Hale DA, Hirshberg B, Harlan DM, Kirk AD. Preclinical evaluation of tolerance induction protocols and islet transplantation in non-human primates. Immunol Rev. 2001 Oct; 183:214-22. PMID: 11782259.
      Citations: 3     Fields:    Translation:Animals
    127. Cox ED, Hoffmann SC, DiMercurio BS, Wesley RA, Harlan DM, Kirk AD, Blair PJ. Cytokine polymorphic analyses indicate ethnic differences in the allelic distribution of interleukin-2 and interleukin-6. Transplantation. 2001 Aug 27; 72(4):720-6. PMID: 11544437.
      Citations: 46     Fields:    Translation:Humans
    128. Kirk AD, Tadaki DK, Celniker A, Batty DS, Berning JD, Colonna JO, Cruzata F, Elster EA, Gray GS, Kampen RL, Patterson NB, Szklut P, Swanson J, Xu H, Harlan DM. Induction therapy with monoclonal antibodies specific for CD80 and CD86 delays the onset of acute renal allograft rejection in non-human primates. Transplantation. 2001 Aug 15; 72(3):377-84. PMID: 11502964.
      Citations: 26     Fields:    Translation:HumansAnimalsCells
    129. Kirk AD, Blair PJ, Tadaki DK, Xu H, Harlan DM. The role of CD154 in organ transplant rejection and acceptance. Philos Trans R Soc Lond B Biol Sci. 2001 May 29; 356(1409):691-702. PMID: 11375072.
      Citations: 13     Fields:    Translation:HumansAnimals
    130. Pechhold K, Patterson NB, Blum C, Fleischacker CL, Boehm BO, Harlan DM. Low dose streptozotocin-induced diabetes in rat insulin promoter-mCD80-transgenic mice is T cell autoantigen-specific and CD28 dependent. J Immunol. 2001 Feb 15; 166(4):2531-9. PMID: 11160314.
      Citations: 5     Fields:    Translation:AnimalsCells
    131. Elster EA, Xu H, Tadaki DK, Burkly LC, Berning JD, Baumgartner RE, Cruzata F, Patterson NB, Harlan DM, Kirk AD. Primate skin allotransplantation with anti-CD154 monotherapy. Transplant Proc. 2001 Feb-Mar; 33(1-2):675-6. PMID: 11267012.
      Citations: 6     Fields:    Translation:Animals
    132. Xu H, Elster E, Batty D, Berning J, Burkly L, Kampen R, Swanson S, Tadaki D, Harlan D, Kirk A. Effects of dose and duration of anti-CD154 antibody therapy in preventing renal allograft rejection in a nonhuman primate model. Transplant Proc. 2001 Feb-Mar; 33(1-2):223-4. PMID: 11266788.
      Citations: 6     Fields:    Translation:Animals
    133. Gaglia JL, Harlan DM. Transplantation tolerance. Curr Dir Autoimmun. 2001; 4:283-307. PMID: 11569407.
      Citations:    Fields:    Translation:HumansAnimalsCells
    134. Chute JP, Saini A, Wells M, Clark W, Wu A, St Louis D, Blair P, Harlan D, Kaushal S. Preincubation with endothelial cell monolayers increases gene transfer efficiency into human bone marrow CD34(+)CD38(-) progenitor cells. Hum Gene Ther. 2000 Dec 10; 11(18):2515-28. PMID: 11119422.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    135. Tadaki DK, Craighead N, Saini A, Celniker A, Burkly LC, Lee KP, Chute JP, Harlan DM, Kirk AD. Costimulatory molecules are active in the human xenoreactive T-cell response but not in natural killer-mediated cytotoxicity. Transplantation. 2000 Jul 15; 70(1):162-7. PMID: 10919595.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    136. Blair PJ, Riley JL, Harlan DM, Abe R, Tadaki DK, Hoffmann SC, White L, Francomano T, Perfetto SJ, Kirk AD, June CH. CD40 ligand (CD154) triggers a short-term CD4(+) T cell activation response that results in secretion of immunomodulatory cytokines and apoptosis. J Exp Med. 2000 Feb 21; 191(4):651-60. PMID: 10684857.
      Citations: 43     Fields:    Translation:HumansCells
    137. Herrera PL, Harlan DM, Vassalli P. A mouse CD8 T cell-mediated acute autoimmune diabetes independent of the perforin and Fas cytotoxic pathways: possible role of membrane TNF. Proc Natl Acad Sci U S A. 2000 Jan 04; 97(1):279-84. PMID: 10618409.
      Citations: 9     Fields:    Translation:AnimalsCells
    138. Harlan DM, Kirk AD. The future of organ and tissue transplantation: can T-cell costimulatory pathway modifiers revolutionize the prevention of graft rejection? JAMA. 1999 Sep 15; 282(11):1076-82. PMID: 10493208.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    139. Kenyon NS, Chatzipetrou M, Masetti M, Ranuncoli A, Oliveira M, Wagner JL, Kirk AD, Harlan DM, Burkly LC, Ricordi C. Long-term survival and function of intrahepatic islet allografts in rhesus monkeys treated with humanized anti-CD154. Proc Natl Acad Sci U S A. 1999 Jul 06; 96(14):8132-7. PMID: 10393960.
      Citations: 78     Fields:    Translation:HumansAnimals
    140. Saha B, Saini A, Germond R, Perrin PJ, Harlan DM, Davis TA. Susceptibility or resistance to Leishmania infection is dictated by the macrophages evolved under the influence of IL-3 or GM-CSF. Eur J Immunol. 1999 07; 29(7):2319-29. PMID: 10427995.
      Citations: 17     Fields:    Translation:AnimalsCellsPHPublic Health
    141. Kenyon NS, Fernandez LA, Lehmann R, Masetti M, Ranuncoli A, Chatzipetrou M, Iaria G, Han D, Wagner JL, Ruiz P, Berho M, Inverardi L, Alejandro R, Mintz DH, Kirk AD, Harlan DM, Burkly LC, Ricordi C. Long-term survival and function of intrahepatic islet allografts in baboons treated with humanized anti-CD154. Diabetes. 1999 Jul; 48(7):1473-81. PMID: 10389857.
      Citations: 44     Fields:    Translation:HumansAnimals
    142. Kirk AD, Burkly LC, Batty DS, Baumgartner RE, Berning JD, Buchanan K, Fechner JH, Germond RL, Kampen RL, Patterson NB, Swanson SJ, Tadaki DK, TenHoor CN, White L, Knechtle SJ, Harlan DM. Treatment with humanized monoclonal antibody against CD154 prevents acute renal allograft rejection in nonhuman primates. Nat Med. 1999 Jun; 5(6):686-93. PMID: 10371508.
      Citations: 137     Fields:    Translation:HumansAnimalsCells
    143. Knechtle SJ, Kirk AD, Fechner JH, Hong X, Dong Y, Hamawy MM, Harlan DM. Inducing unresponsiveness by the use of anti-CD3 immunotoxin, CTLA4-Ig, and anti-CD40 ligand. Transplant Proc. 1999 May; 31(3B Suppl):27S-28S. PMID: 10330966.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    144. St Louis DC, Woodcock JB, Franzoso G, Blair PJ, Carlson LM, Murillo M, Wells MR, Williams AJ, Smoot DS, Kaushal S, Grimes JL, Harlan DM, Chute JP, June CH, Siebenlist U, Lee KP, Fransozo G. Evidence for distinct intracellular signaling pathways in CD34+ progenitor to dendritic cell differentiation from a human cell line model. J Immunol. 1999 Mar 15; 162(6):3237-48. PMID: 10092775.
      Citations: 26     Fields:    Translation:HumansCells
    145. Saha B, Chattopadhyay S, Germond R, Harlan DM, Perrin PJ. CTLA4 (CD152) modulates the Th subset response and alters the course of experimental Leishmania major infection. Eur J Immunol. 1998 12; 28(12):4213-20. PMID: 9862358.
      Citations: 6     Fields:    Translation:AnimalsCells
    146. Sobel DO, Goyal D, Ahvazi B, Yoon JW, Chung YH, Bagg A, Harlan DM. Low dose poly I:C prevents diabetes in the diabetes prone BB rat. J Autoimmun. 1998 Aug; 11(4):343-52. PMID: 9776712.
      Citations: 14     Fields:    Translation:AnimalsCells
    147. Davis TA, Saini AA, Blair PJ, Levine BL, Craighead N, Harlan DM, June CH, Lee KP. Phorbol esters induce differentiation of human CD34+ hemopoietic progenitors to dendritic cells: evidence for protein kinase C-mediated signaling. J Immunol. 1998 Apr 15; 160(8):3689-97. PMID: 9558069.
      Citations: 19     Fields:    Translation:HumansCells
    148. Horspool JH, Perrin PJ, Woodcock JB, Cox JH, King CL, June CH, Harlan DM, St Louis DC, Lee KP. Nucleic acid vaccine-induced immune responses require CD28 costimulation and are regulated by CTLA4. J Immunol. 1998 Mar 15; 160(6):2706-14. PMID: 9510170.
      Citations: 7     Fields:    Translation:AnimalsCellsPHPublic Health
    149. Kirk AD, Harlan DM, Armstrong NN, Davis TA, Dong Y, Gray GS, Hong X, Thomas D, Fechner JH, Knechtle SJ. CTLA4-Ig and anti-CD40 ligand prevent renal allograft rejection in primates. Proc Natl Acad Sci U S A. 1997 Aug 05; 94(16):8789-94. PMID: 9238056.
      Citations: 178     Fields:    Translation:HumansAnimals
    150. Pechhold K, Patterson NB, Craighead N, Lee KP, June CH, Harlan DM. Inflammatory cytokines IFN-gamma plus TNF-alpha induce regulated expression of CD80 (B7-1) but not CD86 (B7-2) on murine fibroblasts. J Immunol. 1997 May 15; 158(10):4921-9. PMID: 9144510.
      Citations: 18     Fields:    Translation:AnimalsCells
    151. Blair PJ, Riley JL, Carroll RG, St Louis DC, Levine BL, Saha B, Lee KP, Perrin PJ, Harlan DM, June CH. CD28 co-receptor signal transduction in T-cell activation. Biochem Soc Trans. 1997 May; 25(2):651-7. PMID: 9191174.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    152. Saha B, Jaklic B, Harlan DM, Gray GS, June CH, Abe R. Toxic shock syndrome toxin-1-induced death is prevented by CTLA4Ig. J Immunol. 1996 Nov 01; 157(9):3869-75. PMID: 8892617.
      Citations: 17     Fields:    Translation:AnimalsCells
    153. Saha B, Harlan DM, Lee KP, June CH, Abe R. Protection against lethal toxic shock by targeted disruption of the CD28 gene. J Exp Med. 1996 Jun 01; 183(6):2675-80. PMID: 8676089.
      Citations: 24     Fields:    Translation:AnimalsCells
    154. Imagawa A, Hanafusa T, Itoh N, Miyagawa J, Nakajima H, Namba M, Kuwajima M, Tamura S, Kawata S, Matsuzawa Y, Harlan DM. Islet-infiltrating t lymphocytes in insulin-dependent diabetic patients express CD80 (B7-1) and CD86 (B7-2). J Autoimmun. 1996 Jun; 9(3):391-6. PMID: 8816976.
      Citations: 11     Fields:    Translation:HumansCells
    155. Harlan DM, Barnett MA, Abe R, Pechhold K, Patterson NB, Gray GS, June CH. Very-low-dose streptozotocin induces diabetes in insulin promoter-mB7-1 transgenic mice. Diabetes. 1995 Jul; 44(7):816-23. PMID: 7540575.
      Citations: 10     Fields:    Translation:AnimalsCells
    156. Harlan DM, Abe R, Lee KP, June CH. Potential roles of the B7 and CD28 receptor families in autoimmunity and immune evasion. Clin Immunol Immunopathol. 1995 May; 75(2):99-111. PMID: 7535672.
      Citations: 8     Fields:    Translation:HumansAnimals
    157. Herrera PL, Harlan DM, Fossati L, Izui S, Huarte J, Orci L, Vassalli JD, Vassalli P. A CD8+ T-lymphocyte-mediated and CD4+ T-lymphocyte-independent autoimmune diabetes of early onset in transgenic mice. Diabetologia. 1994 Dec; 37(12):1277-9. PMID: 7534735.
      Citations: 5     Fields:    Translation:AnimalsCells
    158. Harlan DM, Hengartner H, Huang ML, Kang YH, Abe R, Moreadith RW, Pircher H, Gray GS, Ohashi PS, Freeman GJ, et al. Mice expressing both B7-1 and viral glycoprotein on pancreatic beta cells along with glycoprotein-specific transgenic T cells develop diabetes due to a breakdown of T-lymphocyte unresponsiveness. Proc Natl Acad Sci U S A. 1994 Apr 12; 91(8):3137-41. PMID: 7512724.
      Citations: 35     Fields:    Translation:AnimalsCells
    159. Harlan DM, Graff JM, Stumpo DJ, Eddy RL, Shows TB, Boyle JM, Blackshear PJ. The human myristoylated alanine-rich C kinase substrate (MARCKS) gene (MACS). Analysis of its gene product, promoter, and chromosomal localization. J Biol Chem. 1991 Aug 05; 266(22):14399-405. PMID: 1860846.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    Harlan's Networks
    Click the
    buttons for more information and interactive visualizations!
    Concepts (589)
    Co-Authors (26)
    Similar People (60)
    Same Department Expand Description
    Physical Neighbors