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Eicke Latz MD

TitleAdjunct Professor
InstitutionUMass Chan Medical School
DepartmentMedicine
AddressUMass Chan Medical School
364 Plantation Street LRB
Worcester MA 01605
Phone508-856-5889
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    Other Positions
    InstitutionT.H. Chan School of Medicine
    DepartmentMedicine
    DivisionInfectious Diseases And Immunology


    Collapse Biography 
    Collapse education and training
    Free University of Berlin, Berlin, , GermanyMD

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Schneider KM, Mohs A, Gui W, Galvez EJC, Candels LS, Hoenicke L, Muthukumarasamy U, Holland CH, Elfers C, Kilic K, Schneider CV, Schierwagen R, Strnad P, Wirtz TH, Marschall HU, Latz E, Lelouvier B, Saez-Rodriguez J, de Vos W, Strowig T, Trebicka J, Trautwein C. Imbalanced gut microbiota fuels hepatocellular carcinoma development by shaping the hepatic inflammatory microenvironment. Nat Commun. 2022 07 08; 13(1):3964. PMID: 35803930.
      Citations:    Fields:    Translation:Animals
    2. Hosen MR, Goody PR, Zietzer A, Xiang X, Niepmann ST, Sedaghat A, Tiyerili V, Chennupati R, Moore JB, Boon RA, Uchida S, Sinning JM, Zimmer S, Latz E, Werner N, Nickenig G, Jansen F. Circulating MicroRNA-122-5p Is Associated With a Lack of Improvement in Left Ventricular Function After Transcatheter Aortic Valve Replacement and Regulates Viability of Cardiomyocytes Through Extracellular Vesicles. Circulation. 2022 Jul 08; 101161CIRCULATIONAHA122060258. PMID: 35862223.
      Citations:    Fields:    
    3. He W, Henne A, Lauterbach M, Geißmar E, Nikolka F, Kho C, Heinz A, Dostert C, Grusdat M, Cordes T, Härm J, Goldmann O, Ewen A, Verschueren C, Blay-Cadanet J, Geffers R, Garritsen H, Kneiling M, Holm CK, Metallo CM, Medina E, Abdullah Z, Latz E, Brenner D, Hiller K. Mesaconate is synthesized from itaconate and exerts immunomodulatory effects in macrophages. Nat Metab. 2022 05; 4(5):524-533. PMID: 35655024.
      Citations:    Fields:    Translation:AnimalsCells
    4. Li Q, Wang Y, Sun Q, Knopf J, Herrmann M, Lin L, Jiang J, Shao C, Li P, He X, Hua F, Niu Z, Ma C, Zhu Y, Ippolito G, Piacentini M, Estaquier J, Melino S, Weiss FD, Andreano E, Latz E, Schultze JL, Rappuoli R, Mantovani A, Mak TW, Melino G, Shi Y. Immune response in COVID-19: what is next? Cell Death Differ. 2022 06; 29(6):1107-1122. PMID: 35581387.
      Citations: 1     Fields:    Translation:HumansCellsPHPublic Health
    5. Rieke GJ, van Bremen K, Bischoff J, ToVinh M, Monin MB, Schlabe S, Raabe J, Kaiser KM, Finnemann C, Odainic A, Kudaliyanage A, Latz E, Strassburg CP, Boesecke C, Schmidt SV, Krämer B, Rockstroh JK, Nattermann J. Natural Killer Cell-Mediated Antibody-Dependent Cellular Cytotoxicity Against SARS-CoV-2 After Natural Infection Is More Potent Than After Vaccination. J Infect Dis. 2022 05 16; 225(10):1688-1693. PMID: 35323975.
      Citations: 1     Fields:    Translation:HumansCellsPHPublic Health
    6. Hochheiser IV, Behrmann H, Hagelueken G, Rodríguez-Alcázar JF, Kopp A, Latz E, Behrmann E, Geyer M. Directionality of PYD filament growth determined by the transition of NLRP3 nucleation seeds to ASC elongation. Sci Adv. 2022 May 13; 8(19):eabn7583. PMID: 35559676.
      Citations:    Fields:    
    7. Picon-Galindo E, Latz E, Wachten D. Primary cilia and their effects on immune cell functions and metabolism: a model. Trends Immunol. 2022 05; 43(5):366-378. PMID: 35361534.
      Citations:    Fields:    Translation:HumansCells
    8. Peukert K, Steinhagen F, Fox M, Feuerborn C, Schulz S, Seeliger B, Schuss P, Schneider M, Frede S, Sauer A, Putensen C, Latz E, Wilhelm C, Bode C. Tetracycline ameliorates silica-induced pulmonary inflammation and fibrosis via inhibition of caspase-1. Respir Res. 2022 Feb 07; 23(1):21. PMID: 35130879.
      Citations: 1     Fields:    Translation:Animals
    9. Hochheiser IV, Pilsl M, Hagelueken G, Moecking J, Marleaux M, Brinkschulte R, Latz E, Engel C, Geyer M. Structure of the NLRP3 decamer bound to the cytokine release inhibitor CRID3. Nature. 2022 04; 604(7904):184-189. PMID: 35114687.
      Citations: 8     Fields:    Translation:HumansCells
    10. Orecchioni M, Kobiyama K, Winkels H, Ghosheh Y, McArdle S, Mikulski Z, Kiosses WB, Fan Z, Wen L, Jung Y, Roy P, Ali AJ, Miyamoto Y, Mangan M, Makings J, Wang Z, Denn A, Vallejo J, Owens M, Durant CP, Braumann S, Mader N, Li L, Matsunami H, Eckmann L, Latz E, Wang Z, Hazen SL, Ley K. Olfactory receptor 2 in vascular macrophages drives atherosclerosis by NLRP3-dependent IL-1 production. Science. 2022 Jan 14; 375(6577):214-221. PMID: 35025664.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    11. Moeller MJ, Kramann R, Lammers T, Hoppe B, Latz E, Ludwig-Portugall I, Boor P, Floege J, Kurts C, Weiskirchen R, Ostendorf T. New Aspects of Kidney Fibrosis-From Mechanisms of Injury to Modulation of Disease. Front Med (Lausanne). 2021; 8:814497. PMID: 35096904.
      Citations:    
    12. Mainz RE, Albers S, Haque M, Sonntag R, Treichel NS, Clavel T, Latz E, Schneider KM, Trautwein C, Otto T. NLRP6 Inflammasome Modulates Disease Progression in a Chronic-Plus-Binge Mouse Model of Alcoholic Liver Disease. Cells. 2022 01 06; 11(2). PMID: 35053298.
      Citations:    Fields:    Translation:AnimalsCells
    13. Brosseron F, Maass A, Kleineidam L, Ravichandran KA, González PG, McManus RM, Ising C, Santarelli F, Kolbe CC, Häsler LM, Wolfsgruber S, Marquié M, Boada M, Orellana A, de Rojas I, Röske S, Peters O, Cosma NC, Cetindag A, Wang X, Priller J, Spruth EJ, Altenstein S, Schneider A, Fliessbach K, Wiltfang J, Schott BH, Bürger K, Janowitz D, Dichgans M, Perneczky R, Rauchmann BS, Teipel S, Kilimann I, Goerss D, Laske C, Munk MH, Düzel E, Yakupov R, Dobisch L, Metzger CD, Glanz W, Ewers M, Dechent P, Haynes JD, Scheffler K, Roy N, Rostamzadeh A, Teunissen CE, Marchant NL, Spottke A, Jucker M, Latz E, Wagner M, Mengel D, Synofzik M, Jessen F, Ramirez A, Ruiz A, Heneka MT. Soluble TAM receptors sAXL and sTyro3 predict structural and functional protection in Alzheimer's disease. Neuron. 2022 03 16; 110(6):1009-1022.e4. PMID: 34995486.
      Citations:    Fields:    Translation:Humans
    14. Kummer MP, Ising C, Kummer C, Sarlus H, Griep A, Vieira-Saecker A, Schwartz S, Halle A, Brückner M, Händler K, Schultze JL, Beyer M, Latz E, Heneka MT. Microglial PD-1 stimulation by astrocytic PD-L1 suppresses neuroinflammation and Alzheimer's disease pathology. EMBO J. 2021 12 15; 40(24):e108662. PMID: 34825707.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    15. Christ A, Latz E. Deciphering How NLRP3 Incites the Stromal Response in Kawasaki Vasculitis. Circ Res. 2021 10 15; 129(9):840-842. PMID: 34648364.
      Citations:    Fields:    Translation:Humans
    16. Verberk SGS, Kuiper KL, Lauterbach MA, Latz E, Van den Bossche J. The multifaceted therapeutic value of targeting ATP-citrate lyase in atherosclerosis. Trends Mol Med. 2021 12; 27(12):1095-1105. PMID: 34635427.
      Citations: 4     Fields:    Translation:Humans
    17. Latz E. The inflammasome: from bench to bedside. Nat Rev Immunol. 2021 10; 21(10):622-623. PMID: 34580455.
      Citations:    Fields:    
    18. Bittner ZA, Liu X, Mateo Tortola M, Tapia-Abellán A, Shankar S, Andreeva L, Mangan M, Spalinger M, Kalbacher H, Düwell P, Lovotti M, Bosch K, Dickhöfer S, Marcu A, Stevanovi? S, Herster F, Cardona Gloria Y, Chang TH, Bork F, Greve CL, Löffler MW, Wolz OO, Schilling NA, Kümmerle-Deschner JB, Wagner S, Delor A, Grimbacher B, Hantschel O, Scharl M, Wu H, Latz E, Weber ANR. BTK operates a phospho-tyrosine switch to regulate NLRP3 inflammasome activity. J Exp Med. 2021 11 01; 218(11). PMID: 34554188.
      Citations: 6     Fields:    Translation:Animals
    19. Scheiblich H, Dansokho C, Mercan D, Schmidt SV, Bousset L, Wischhof L, Eikens F, Odainic A, Spitzer J, Griep A, Schwartz S, Bano D, Latz E, Melki R, Heneka MT. Microglia jointly degrade fibrillar alpha-synuclein cargo by distribution through tunneling nanotubes. Cell. 2021 09 30; 184(20):5089-5106.e21. PMID: 34555357.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    20. Jiang S, Maphis NM, Binder J, Chisholm D, Weston L, Duran W, Peterson C, Zimmerman A, Mandell MA, Jett SD, Bigio E, Geula C, Mellios N, Weick JP, Rosenberg GA, Latz E, Heneka MT, Bhaskar K. Proteopathic tau primes and activates interleukin-1? via myeloid-cell-specific MyD88- and NLRP3-ASC-inflammasome pathway. Cell Rep. 2021 09 21; 36(12):109720. PMID: 34551296.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    21. Scheiblich H, Bousset L, Schwartz S, Griep A, Latz E, Melki R, Heneka MT. Microglial NLRP3 Inflammasome Activation upon TLR2 and TLR5 Ligation by Distinct ?-Synuclein Assemblies. J Immunol. 2021 10 15; 207(8):2143-2154. PMID: 34507948.
      Citations: 6     Fields:    Translation:AnimalsCells
    22. Thomas JM, Ling YH, Huuskes B, Jelinic M, Sharma P, Saini N, Ferens DM, Diep H, Krishnan SM, Kemp-Harper BK, O'Connor PM, Latz E, Arumugam TV, Guzik TJ, Hickey MJ, Mansell A, Sobey CG, Vinh A, Drummond GR. IL-18 (Interleukin-18) Produced by Renal Tubular Epithelial Cells Promotes Renal Inflammation and Injury During Deoxycorticosterone/Salt-Induced Hypertension in Mice. Hypertension. 2021 11; 78(5):1296-1309. PMID: 34488433.
      Citations: 2     Fields:    Translation:AnimalsCells
    23. Krämer B, Knoll R, Bonaguro L, ToVinh M, Raabe J, Astaburuaga-García R, Schulte-Schrepping J, Kaiser KM, Rieke GJ, Bischoff J, Monin MB, Hoffmeister C, Schlabe S, De Domenico E, Reusch N, Händler K, Reynolds G, Blüthgen N, Hack G, Finnemann C, Nischalke HD, Strassburg CP, Stephenson E, Su Y, Gardner L, Yuan D, Chen D, Goldman J, Rosenstiel P, Schmidt SV, Latz E, Hrusovsky K, Ball AJ, Johnson JM, Koenig PA, Schmidt FI, Haniffa M, Heath JR, Kümmerer BM, Keitel V, Jensen B, Stubbemann P, Kurth F, Sander LE, Sawitzki B, Aschenbrenner AC, Schultze JL, Nattermann J. Early IFN-? signatures and persistent dysfunction are distinguishing features of NK cells in severe COVID-19. Immunity. 2021 11 09; 54(11):2650-2669.e14. PMID: 34592166.
      Citations: 27     Fields:    Translation:HumansCells
    24. Liu K, Sato R, Shibata T, Hiranuma R, Reuter T, Fukui R, Zhang Y, Ichinohe T, Ozawa M, Yoshida N, Latz E, Miyake K. Skewed endosomal RNA responses from TLR7 to TLR3 in RNase T2-deficient macrophages. Int Immunol. 2021 08 23; 33(9):479-490. PMID: 34161582.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    25. Torres S, Brol MJ, Magdaleno F, Schierwagen R, Uschner FE, Klein S, Ortiz C, Tyc O, Bachtler N, Stunden J, Bertheloot D, Kitanovic A, Sanchez B, Schrum J, Roush WR, Franchi L, Byth K, Latz E, Trebicka J. The Specific NLRP3 Antagonist IFM-514 Decreases Fibrosis and Inflammation in Experimental Murine Non-Alcoholic Steatohepatitis. Front Mol Biosci. 2021; 8:715765. PMID: 34513923.
      Citations:    
    26. Budden CF, Gearing LJ, Kaiser R, Standke L, Hertzog PJ, Latz E. Inflammasome-induced extracellular vesicles harbour distinct RNA signatures and alter bystander macrophage responses. J Extracell Vesicles. 2021 08; 10(10):e12127. PMID: 34377374.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    27. Bonnekoh H, Vera C, Abad-Perez A, Radetzki S, Neuenschwander M, Specker E, Mahnke NA, Frischbutter S, Latz E, Nazaré M, Kries JV, Maurer M, Scheffel J, Krause K. Topical inflammasome inhibition with disulfiram prevents irritant contact dermatitis. Clin Transl Allergy. 2021 Jul; 11(5):e12045. PMID: 34322217.
      Citations:    
    28. Hepowit NL, Kolbe CC, Zelle SR, Latz E, MacGurn JA. Regulation of ubiquitin and ubiquitin-like modifiers by phosphorylation. FEBS J. 2022 08; 289(16):4797-4810. PMID: 34214249.
      Citations: 1     Fields:    
    29. Peukert K, Fox M, Schulz S, Feuerborn C, Frede S, Putensen C, Wrigge H, Kümmerer BM, David S, Seeliger B, Welte T, Latz E, Klinman D, Wilhelm C, Steinhagen F, Bode C. Inhibition of Caspase-1 with Tetracycline Ameliorates Acute Lung Injury. Am J Respir Crit Care Med. 2021 07 01; 204(1):53-63. PMID: 33760701.
      Citations: 10     Fields:    Translation:HumansAnimals
    30. Divangahi M, Aaby P, Khader SA, Barreiro LB, Bekkering S, Chavakis T, van Crevel R, Curtis N, DiNardo AR, Dominguez-Andres J, Duivenvoorden R, Fanucchi S, Fayad Z, Fuchs E, Hamon M, Jeffrey KL, Khan N, Joosten LAB, Kaufmann E, Latz E, Matarese G, van der Meer JWM, Mhlanga M, Moorlag SJCFM, Mulder WJM, Naik S, Novakovic B, O'Neill L, Ochando J, Ozato K, Riksen NP, Sauerwein R, Sherwood ER, Schlitzer A, Schultze JL, Sieweke MH, Benn CS, Stunnenberg H, Sun J, van de Veerdonk FL, Weis S, Williams DL, Xavier R, Netea MG. Author Correction: Trained immunity, tolerance, priming and differentiation: distinct immunological processes. Nat Immunol. 2021 Jul; 22(7):928. PMID: 34017127.
      Citations: 2     Fields:    
    31. Reif T, Dyckhoff G, Hohenberger R, Kolbe CC, Gruell H, Klein F, Latz E, Stolp B, Fackler OT. Contact-dependent inhibition of HIV-1 replication in ex vivo human tonsil cultures by polymorphonuclear neutrophils. Cell Rep Med. 2021 06 15; 2(6):100317. PMID: 34195682.
      Citations:    Fields:    Translation:HumansCells
    32. Hosen MR, Li Q, Liu Y, Zietzer A, Maus K, Goody P, Uchida S, Latz E, Werner N, Nickenig G, Jansen F. CAD increases the long noncoding RNA PUNISHER in small extracellular vesicles and regulates endothelial cell function via vesicular shuttling. Mol Ther Nucleic Acids. 2021 Sep 03; 25:388-405. PMID: 34484864.
      Citations:    
    33. Park MH, Suhalim JL, Elmastour F, Singha SK, Imafuku T, Venkatnarayan R, Christ A, Grebe A, Oppelt SA, Sviridov D, Bukrinsky M, Latz E, Potma EO, Fitzgerald ML. Non-linear optical imaging of atherosclerotic plaques in the context of SIV and HIV infection prominently detects crystalline cholesterol esters. PLoS One. 2021; 16(5):e0251599. PMID: 33984028.
      Citations:    Fields:    Translation:AnimalsCells
    34. Bode C, Poth JM, Fox M, Schulz S, Klinman DM, Latz E, Steinhagen F. Cytosolic d-type CpG-oligonucleotides induce a type I interferon response by activating the cGAS-STING signaling pathway. Eur J Immunol. 2021 07; 51(7):1686-1697. PMID: 33860535.
      Citations:    Fields:    Translation:HumansCells
    35. Keuler T, Gatterdam K, Akbal A, Lovotti M, Marleaux M, Geyer M, Latz E, Gütschow M. Development of Fluorescent and Biotin Probes Targeting NLRP3. Front Chem. 2021; 9:642273. PMID: 33996748.
      Citations:    
    36. Bertheloot D, Latz E, Franklin BS. Necroptosis, pyroptosis and apoptosis: an intricate game of cell death. Cell Mol Immunol. 2021 05; 18(5):1106-1121. PMID: 33785842.
      Citations: 70     Fields:    Translation:HumansAnimals
    37. Shan D, Johnson JM, Fernandes SC, Suib H, Hwang S, Wuelfing D, Mendes M, Holdridge M, Burke EM, Beauregard K, Zhang Y, Cleary M, Xu S, Yao X, Patel PP, Plavina T, Wilson DH, Chang L, Kaiser KM, Nattermann J, Schmidt SV, Latz E, Hrusovsky K, Mattoon D, Ball AJ. N-protein presents early in blood, dried blood and saliva during asymptomatic and symptomatic SARS-CoV-2 infection. Nat Commun. 2021 03 26; 12(1):1931. PMID: 33771993.
      Citations: 25     Fields:    Translation:HumansCellsPHPublic Health
    38. Frissen M, Liao L, Schneider KM, Djudjaj S, Haybaeck J, Wree A, Rolle-Kampczyk U, von Bergen M, Latz E, Boor P, Trautwein C. Bidirectional Role of NLRP3 During Acute and Chronic Cholestatic Liver Injury. Hepatology. 2021 05; 73(5):1836-1854. PMID: 32748971.
      Citations: 8     Fields:    Translation:HumansAnimals
    39. Braga TT, Davanso MR, Mendes D, de Souza TA, de Brito AF, Cruz MC, Hiyane MI, de Lima DS, Nunes V, de Fátima Giarola J, Souto DEP, Próchnicki T, Lauterbach M, Biscaia SMP, de Freitas RA, Curi R, Pontillo A, Latz E, Camara NOS. Sensing soluble uric acid by Naip1-Nlrp3 platform. Cell Death Dis. 2021 02 05; 12(2):158. PMID: 33547278.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    40. Thada S, Horvath GL, Müller MM, Dittrich N, Conrad ML, Sur S, Hussain A, Pelka K, Gaddam SL, Latz E, Slevogt H, Schumann RR, Burkert S. Interaction of TLR4 and TLR8 in the Innate Immune Response against Mycobacterium Tuberculosis. Int J Mol Sci. 2021 Feb 04; 22(4). PMID: 33557133.
      Citations: 2     Fields:    Translation:HumansCells
    41. Netea MG, Balkwill F, Chonchol M, Cominelli F, Donath MY, Giamarellos-Bourboulis EJ, Golenbock D, Gresnigt MS, Heneka MT, Hoffman HM, Hotchkiss R, Joosten LAB, Kastner DL, Korte M, Latz E, Libby P, Mandrup-Poulsen T, Mantovani A, Mills KHG, Nowak KL, O'Neill LA, Pickkers P, van der Poll T, Ridker PM, Schalkwijk J, Schwartz DA, Siegmund B, Steer CJ, Tilg H, van der Meer JWM, van de Veerdonk FL, Dinarello CA. Author Correction: A guiding map for inflammation. Nat Immunol. 2021 Feb; 22(2):254. PMID: 33288963.
      Citations: 2     Fields:    
    42. Davanso MR, Crisma AR, Braga TT, Masi LN, do Amaral CL, Leal VNC, de Lima DS, Patente TA, Barbuto JA, Corrêa-Giannella ML, Lauterbach M, Kolbe CC, Latz E, Camara NOS, Pontillo A, Curi R. Macrophage inflammatory state in Type 1 diabetes: triggered by NLRP3/iNOS pathway and attenuated by docosahexaenoic acid. Clin Sci (Lond). 2021 01 15; 135(1):19-34. PMID: 33399849.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    43. Divangahi M, Aaby P, Khader SA, Barreiro LB, Bekkering S, Chavakis T, van Crevel R, Curtis N, DiNardo AR, Dominguez-Andres J, Duivenvoorden R, Fanucchi S, Fayad Z, Fuchs E, Hamon M, Jeffrey KL, Khan N, Joosten LAB, Kaufmann E, Latz E, Matarese G, van der Meer JWM, Mhlanga M, Moorlag SJCFM, Mulder WJM, Naik S, Novakovic B, O'Neill L, Ochando J, Ozato K, Riksen NP, Sauerwein R, Sherwood ER, Schlitzer A, Schultze JL, Sieweke MH, Benn CS, Stunnenberg H, Sun J, van de Veerdonk FL, Weis S, Williams DL, Xavier R, Netea MG. Trained immunity, tolerance, priming and differentiation: distinct immunological processes. Nat Immunol. 2021 01; 22(1):2-6. PMID: 33293712.
      Citations: 72     Fields:    Translation:HumansAnimalsPHPublic Health
    44. Sato R, Reuter T, Hiranuma R, Shibata T, Fukui R, Motoi Y, Murakami Y, Tsukamoto H, Yamazaki S, Liu K, Saitoh SI, Latz E, Miyake K. The impact of cell maturation and tissue microenvironments on the expression of endosomal Toll-like receptors in monocytes and macrophages. Int Immunol. 2020 11 23; 32(12):785-798. PMID: 32840578.
      Citations: 6     Fields:    Translation:AnimalsCells
    45. Schneider KM, Elfers C, Ghallab A, Schneider CV, Galvez EJC, Mohs A, Gui W, Candels LS, Wirtz TH, Zuehlke S, Spiteller M, Myllys M, Roulet A, Ouzerdine A, Lelouvier B, Kilic K, Liao L, Nier A, Latz E, Bergheim I, Thaiss CA, Hengstler JG, Strowig T, Trautwein C. Intestinal Dysbiosis Amplifies Acetaminophen-Induced Acute Liver Injury. Cell Mol Gastroenterol Hepatol. 2021; 11(4):909-933. PMID: 33189892.
      Citations: 14     Fields:    Translation:HumansAnimals
    46. Brosseron F, Kleemann K, Kolbe CC, Santarelli F, Castro-Gomez S, Tacik P, Latz E, Jessen F, Heneka MT. Interrelations of Alzheimer´s disease candidate biomarkers neurogranin, fatty acid-binding protein 3 and ferritin to neurodegeneration and neuroinflammation. J Neurochem. 2021 06; 157(6):2210-2224. PMID: 32894885.
      Citations: 1     Fields:    Translation:Humans
    47. Niyonzima N, Bakke SS, Gregersen I, Holm S, Sandanger Ø, Orrem HL, Sporsheim B, Ryan L, Kong XY, Dahl TB, Skjelland M, Sørensen KK, Rokstad AM, Yndestad A, Latz E, Gullestad L, Andersen GØ, Damås JK, Aukrust P, Mollnes TE, Halvorsen B, Espevik T. Cholesterol crystals use complement to increase NLRP3 signaling pathways in coronary and carotid atherosclerosis. EBioMedicine. 2020 Oct; 60:102985. PMID: 32927275.
      Citations: 9     Fields:    Translation:HumansCells
    48. Lauterbach MA, Saavedra V, Mangan MSJ, Penno A, Thiele C, Latz E, Kuerschner L. 1-Deoxysphingolipids cause autophagosome and lysosome accumulation and trigger NLRP3 inflammasome activation. Autophagy. 2021 08; 17(8):1947-1961. PMID: 32835606.
      Citations: 6     Fields:    Translation:AnimalsCells
    49. Lauterbach MA, Latz E, Christ A. Metabolomic Profiling Reveals Distinct and Mutual Effects of Diet and Inflammation in Shaping Systemic Metabolism in Ldlr-/- Mice. Metabolites. 2020 Aug 19; 10(9). PMID: 32824900.
      Citations:    
    50. Balic JJ, Albargy H, Luu K, Kirby FJ, Jayasekara WSN, Mansell F, Garama DJ, De Nardo D, Baschuk N, Louis C, Humphries F, Fitzgerald K, Latz E, Gough DJ, Mansell A. STAT3 serine phosphorylation is required for TLR4 metabolic reprogramming and IL-1? expression. Nat Commun. 2020 07 30; 11(1):3816. PMID: 32732870.
      Citations: 23     Fields:    Translation:AnimalsCells
    51. Marleaux M, Anand K, Latz E, Geyer M. Crystal structure of the human NLRP9 pyrin domain suggests a distinct mode of inflammasome assembly. FEBS Lett. 2020 08; 594(15):2383-2395. PMID: 32542665.
      Citations: 7     Fields:    Translation:HumansCells
    52. Zietzer A, Hosen MR, Wang H, Goody PR, Sylvester M, Latz E, Nickenig G, Werner N, Jansen F. The RNA-binding protein hnRNPU regulates the sorting of microRNA-30c-5p into large extracellular vesicles. J Extracell Vesicles. 2020 Jul 02; 9(1):1786967. PMID: 32944175.
      Citations: 17     Fields:    
    53. Schmidt FI, Latz E. Jack of all trades inhibits inflammation (in sober people). Nat Immunol. 2020 07; 21(7):718-719. PMID: 32577009.
      Citations: 2     Fields:    Translation:Humans
    54. Selkrig J, Li N, Hausmann A, Mangan MSJ, Zietek M, Mateus A, Bobonis J, Sueki A, Imamura H, El Debs B, Sigismondo G, Florea BI, Overkleeft HS, Kopitar-Jerala N, Turk B, Beltrao P, Savitski MM, Latz E, Hardt WD, Krijgsveld J, Typas A. Spatiotemporal proteomics uncovers cathepsin-dependent macrophage cell death during Salmonella infection. Nat Microbiol. 2020 09; 5(9):1119-1133. PMID: 32514074.
      Citations: 14     Fields:    Translation:AnimalsCells
    55. Heneka MT, Golenbock D, Latz E, Morgan D, Brown R. Immediate and long-term consequences of COVID-19 infections for the development of neurological disease. Alzheimers Res Ther. 2020 06 04; 12(1):69. PMID: 32498691.
      Citations: 144     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    56. Beyer MMS, Lonnemann N, Remus A, Latz E, Heneka MT, Korte M. Enduring Changes in Neuronal Function upon Systemic Inflammation Are NLRP3 Inflammasome Dependent. J Neurosci. 2020 07 08; 40(28):5480-5494. PMID: 32499379.
      Citations: 11     Fields:    Translation:Animals
    57. Rolfes V, Ribeiro LS, Hawwari I, Böttcher L, Rosero N, Maasewerd S, Santos MLS, Próchnicki T, Silva CMS, Wanderley CWS, Rothe M, Schmidt SV, Stunden HJ, Bertheloot D, Rivas MN, Fontes CJ, Carvalho LH, Cunha FQ, Latz E, Arditi M, Franklin BS. Platelets Fuel the Inflammasome Activation of Innate Immune Cells. Cell Rep. 2020 05 12; 31(6):107615. PMID: 32402278.
      Citations: 26     Fields:    Translation:HumansCells
    58. Friker LL, Scheiblich H, Hochheiser IV, Brinkschulte R, Riedel D, Latz E, Geyer M, Heneka MT. ?-Amyloid Clustering around ASC Fibrils Boosts Its Toxicity in Microglia. Cell Rep. 2020 03 17; 30(11):3743-3754.e6. PMID: 32187546.
      Citations: 29     Fields:    Translation:HumansAnimalsCells
    59. Kleineidam L, Chouraki V, Próchnicki T, van der Lee SJ, Madrid-Márquez L, Wagner-Thelen H, Karaca I, Weinhold L, Wolfsgruber S, Boland A, Martino Adami PV, Lewczuk P, Popp J, Brosseron F, Jansen IE, Hulsman M, Kornhuber J, Peters O, Berr C, Heun R, Frölich L, Tzourio C, Dartigues JF, Hüll M, Espinosa A, Hernández I, de Rojas I, Orellana A, Valero S, Stringa N, van Schoor NM, Huisman M, Scheltens P, Rüther E, Deleuze JF, Wiltfang J, Tarraga L, Schmid M, Scherer M, Riedel-Heller S, Heneka MT, Amouyel P, Jessen F, Boada M, Maier W, Schneider A, González-Pérez A, van der Flier WM, Wagner M, Lambert JC, Holstege H, Sáez ME, Latz E, Ruiz A, Ramirez A. PLCG2 protective variant p.P522R modulates tau pathology and disease progression in patients with mild cognitive impairment. Acta Neuropathol. 2020 06; 139(6):1025-1044. PMID: 32166339.
      Citations: 14     Fields:    Translation:Humans
    60. Netea MG, Domínguez-Andrés J, Barreiro LB, Chavakis T, Divangahi M, Fuchs E, Joosten LAB, van der Meer JWM, Mhlanga MM, Mulder WJM, Riksen NP, Schlitzer A, Schultze JL, Stabell Benn C, Sun JC, Xavier RJ, Latz E. Defining trained immunity and its role in health and disease. Nat Rev Immunol. 2020 06; 20(6):375-388. PMID: 32132681.
      Citations: 417     Fields:    Translation:HumansAnimals
    61. Hupa KJ, Stein K, Schneider R, Lysson M, Schneiker B, Hornung V, Latz E, Iwakura Y, Kalff JC, Wehner S. Author Correction: AIM2 inflammasome-derived IL-1? induces postoperative ileus in mice. Sci Rep. 2020 Feb 21; 10(1):3457. PMID: 32081974.
      Citations:    Fields:    
    62. Brosseron F, Kolbe CC, Santarelli F, Carvalho S, Antonell A, Castro-Gomez S, Tacik P, Namasivayam AA, Mangone G, Schneider R, Latz E, Wüllner U, Svenningsson P, Sánchez-Valle R, Molinuevo JL, Corvol JC, Heneka MT. Multicenter Alzheimer's and Parkinson's disease immune biomarker verification study. Alzheimers Dement. 2020 02; 16(2):292-304. PMID: 31630996.
      Citations: 9     Fields:    Translation:Humans
    63. Lauterbach MA, Hanke JE, Serefidou M, Mangan MSJ, Kolbe CC, Hess T, Rothe M, Kaiser R, Hoss F, Gehlen J, Engels G, Kreutzenbeck M, Schmidt SV, Christ A, Imhof A, Hiller K, Latz E. Toll-like Receptor Signaling Rewires Macrophage Metabolism and Promotes Histone Acetylation via ATP-Citrate Lyase. Immunity. 2019 12 17; 51(6):997-1011.e7. PMID: 31851905.
      Citations: 68     Fields:    Translation:HumansAnimalsCells
    64. Zewinger S, Reiser J, Jankowski V, Alansary D, Hahm E, Triem S, Klug M, Schunk SJ, Schmit D, Kramann R, Körbel C, Ampofo E, Laschke MW, Selejan SR, Paschen A, Herter T, Schuster S, Silbernagel G, Sester M, Sester U, Aßmann G, Bals R, Kostner G, Jahnen-Dechent W, Menger MD, Rohrer L, März W, Böhm M, Jankowski J, Kopf M, Latz E, Niemeyer BA, Fliser D, Laufs U, Speer T. Apolipoprotein C3 induces inflammation and organ damage by alternative inflammasome activation. Nat Immunol. 2020 01; 21(1):30-41. PMID: 31819254.
      Citations: 54     Fields:    Translation:HumansAnimalsCells
    65. Ising C, Venegas C, Zhang S, Scheiblich H, Schmidt SV, Vieira-Saecker A, Schwartz S, Albasset S, McManus RM, Tejera D, Griep A, Santarelli F, Brosseron F, Opitz S, Stunden J, Merten M, Kayed R, Golenbock DT, Blum D, Latz E, Buée L, Heneka MT. NLRP3 inflammasome activation drives tau pathology. Nature. 2019 11; 575(7784):669-673. PMID: 31748742.
      Citations: 258     Fields:    Translation:HumansAnimalsCells
    66. Christ A, Lauterbach M, Latz E. Western Diet and the Immune System: An Inflammatory Connection. Immunity. 2019 11 19; 51(5):794-811. PMID: 31747581.
      Citations: 107     Fields:    Translation:HumansAnimals
    67. Khan NS, Lukason DP, Feliu M, Ward RA, Lord AK, Reedy JL, Ramirez-Ortiz ZG, Tam JM, Kasperkovitz PV, Negoro PE, Vyas TD, Xu S, Brinkmann MM, Acharaya M, Artavanis-Tsakonas K, Frickel EM, Becker CE, Dagher Z, Kim YM, Latz E, Ploegh HL, Mansour MK, Miranti CK, Levitz SM, Vyas JM. CD82 controls CpG-dependent TLR9 signaling. FASEB J. 2019 11; 33(11):12500-12514. PMID: 31408613.
      Citations: 6     Fields:    Translation:AnimalsCells
    68. Tejera D, Mercan D, Sanchez-Caro JM, Hanan M, Greenberg D, Soreq H, Latz E, Golenbock D, Heneka MT. Systemic inflammation impairs microglial A? clearance through NLRP3 inflammasome. EMBO J. 2019 09 02; 38(17):e101064. PMID: 31359456.
      Citations: 80     Fields:    Translation:HumansAnimalsCells
    69. Aftabizadeh M, Tatarek-Nossol M, Andreetto E, El Bounkari O, Kipp M, Beyer C, Latz E, Bernhagen J, Kapurniotu A. Blocking Inflammasome Activation Caused by ?-Amyloid Peptide (A?) and Islet Amyloid Polypeptide (IAPP) through an IAPP Mimic. ACS Chem Neurosci. 2019 08 21; 10(8):3703-3717. PMID: 31295403.
      Citations: 6     Fields:    Translation:AnimalsCells
    70. Taborda NA, Blanquiceth Y, Urcuqui-Inchima S, Latz E, Hernandez JC. High-Density Lipoproteins Decrease Proinflammatory Activity and Modulate the Innate Immune Response. J Interferon Cytokine Res. 2019 12; 39(12):760-770. PMID: 31335262.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    71. Hupa KJ, Stein K, Schneider R, Lysson M, Schneiker B, Hornung V, Latz E, Iwakura Y, Kalff JC, Wehner S. AIM2 inflammasome-derived IL-1? induces postoperative ileus in mice. Sci Rep. 2019 07 22; 9(1):10602. PMID: 31332247.
      Citations: 6     Fields:    Translation:Animals
    72. Hoss F, Mueller JL, Rojas Ringeling F, Rodriguez-Alcazar JF, Brinkschulte R, Seifert G, Stahl R, Broderick L, Putnam CD, Kolodner RD, Canzar S, Geyer M, Hoffman HM, Latz E. Alternative splicing regulates stochastic NLRP3 activity. Nat Commun. 2019 07 19; 10(1):3238. PMID: 31324763.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    73. Li T, Zehner M, He J, Próchnicki T, Horvath G, Latz E, Burgdorf S, Takeoka S. NLRP3 inflammasome-activating arginine-based liposomes promote antigen presentations in dendritic cells. Int J Nanomedicine. 2019; 14:3503-3516. PMID: 31190807.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    74. Christ A, Latz E. The Western lifestyle has lasting effects on metaflammation. Nat Rev Immunol. 2019 05; 19(5):267-268. PMID: 30911129.
      Citations: 33     Fields:    Translation:Humans
    75. He J, Li T, Próchnicki T, Horvath G, Latz E, Takeoka S. Membrane fusogenic lysine type lipid assemblies possess enhanced NLRP3 inflammasome activation potency. Biochem Biophys Rep. 2019 Jul; 18:100623. PMID: 31011633.
      Citations:    
    76. Civit L, Theodorou I, Frey F, Weber H, Lingnau A, Gröber C, Blank M, Dambrune C, Stunden J, Beyer M, Schultze J, Latz E, Ducongé F, Kubbutat MHG, Mayer G. Targeting hormone refractory prostate cancer by in vivo selected DNA libraries in an orthotopic xenograft mouse model. Sci Rep. 2019 03 21; 9(1):4976. PMID: 30899039.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    77. Krishnan SM, Ling YH, Huuskes BM, Ferens DM, Saini N, Chan CT, Diep H, Kett MM, Samuel CS, Kemp-Harper BK, Robertson AAB, Cooper MA, Peter K, Latz E, Mansell AS, Sobey CG, Drummond GR, Vinh A. Pharmacological inhibition of the NLRP3 inflammasome reduces blood pressure, renal damage, and dysfunction in salt-sensitive hypertension. Cardiovasc Res. 2019 03 15; 115(4):776-787. PMID: 30357309.
      Citations: 67     Fields:    Translation:AnimalsCells
    78. Heneka MT, McManus RM, Latz E. Author Correction: Inflammasome signalling in brain function and neurodegenerative disease. Nat Rev Neurosci. 2019 Mar; 20(3):187. PMID: 30742056.
      Citations: 1     Fields:    
    79. Wang L, Schmidt S, Larsen PP, Meyer JH, Roush WR, Latz E, Holz FG, Krohne TU. Efficacy of novel selective NLRP3 inhibitors in human and murine retinal pigment epithelial cells. J Mol Med (Berl). 2019 04; 97(4):523-532. PMID: 30739141.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    80. Alvarez-Silva C, Schierwagen R, Pohlmann A, Magdaleno F, Uschner FE, Ryan P, Vehreschild MJGT, Claria J, Latz E, Lelouvier B, Arumugam M, Trebicka J. Compartmentalization of Immune Response and Microbial Translocation in Decompensated Cirrhosis. Front Immunol. 2019; 10:69. PMID: 30800122.
      Citations: 16     Fields:    Translation:Humans
    81. Rodríguez-Alcázar JF, Ataide MA, Engels G, Schmitt-Mabmunyo C, Garbi N, Kastenmüller W, Latz E, Franklin BS. Charcot-Leyden Crystals Activate the NLRP3 Inflammasome and Cause IL-1? Inflammation in Human Macrophages. J Immunol. 2019 01 15; 202(2):550-558. PMID: 30559319.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    82. Porat A, Giat E, Kowal C, He M, Son M, Latz E, Ben-Zvi I, Al-Abed Y, Diamond B. DNA-Mediated Interferon Signature Induction by SLE Serum Occurs in Monocytes Through Two Pathways: A Mechanism to Inhibit Both Pathways. Front Immunol. 2018; 9:2824. PMID: 30619247.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    83. Heneka MT, McManus RM, Latz E. Inflammasome signalling in brain function and neurodegenerative disease. Nat Rev Neurosci. 2018 10; 19(10):610-621. PMID: 30206330.
      Citations: 184     Fields:    Translation:HumansAnimalsCells
    84. Latz E, Duewell P. NLRP3 inflammasome activation in inflammaging. Semin Immunol. 2018 12; 40:61-73. PMID: 30268598.
      Citations: 55     Fields:    Translation:HumansAnimalsCells
    85. Köppert S, Büscher A, Babler A, Ghallab A, Buhl EM, Latz E, Hengstler JG, Smith ER, Jahnen-Dechent W. Cellular Clearance and Biological Activity of Calciprotein Particles Depend on Their Maturation State and Crystallinity. Front Immunol. 2018; 9:1991. PMID: 30233585.
      Citations: 26     Fields:    Translation:HumansAnimalsCells
    86. Tzeng TC, Hasegawa Y, Iguchi R, Cheung A, Caffrey DR, Thatcher EJ, Mao W, Germain G, Tamburro ND, Okabe S, Heneka MT, Latz E, Futai K, Golenbock DT. Inflammasome-derived cytokine IL18 suppresses amyloid-induced seizures in Alzheimer-prone mice. Proc Natl Acad Sci U S A. 2018 09 04; 115(36):9002-9007. PMID: 30127003.
      Citations: 13     Fields:    Translation:AnimalsCells
    87. Mangan MSJ, Olhava EJ, Roush WR, Seidel HM, Glick GD, Latz E. Targeting the NLRP3 inflammasome in inflammatory diseases. Nat Rev Drug Discov. 2018 Sep; 17(9):688. PMID: 30116046.
      Citations: 91     Fields:    
    88. De Nardo D, Balka KR, Cardona Gloria Y, Rao VR, Latz E, Masters SL. Interleukin-1 receptor-associated kinase 4 (IRAK4) plays a dual role in myddosome formation and Toll-like receptor signaling. J Biol Chem. 2018 09 28; 293(39):15195-15207. PMID: 30076215.
      Citations: 24     Fields:    Translation:HumansAnimalsCells
    89. Wolf D, Latz E. ASC specks: a biomarker for myelodysplastic syndromes? Lancet Haematol. 2018 09; 5(9):e379-e380. PMID: 30072145.
      Citations: 2     Fields:    Translation:HumansCells
    90. Mangan MSJ, Olhava EJ, Roush WR, Seidel HM, Glick GD, Latz E. Targeting the NLRP3 inflammasome in inflammatory diseases. Nat Rev Drug Discov. 2018 08; 17(8):588-606. PMID: 30026524.
      Citations: 317     Fields:    
    91. Grebe A, Hoss F, Latz E. NLRP3 Inflammasome and the IL-1 Pathway in Atherosclerosis. Circ Res. 2018 06 08; 122(12):1722-1740. PMID: 29880500.
      Citations: 180     Fields:    Translation:HumansAnimals
    92. Rolfes V, Idel C, Pries R, Plötze-Martin K, Habermann J, Gemoll T, Bohnet S, Latz E, Ribbat-Idel J, Franklin BS, Wollenberg B. PD-L1 is expressed on human platelets and is affected by immune checkpoint therapy. Oncotarget. 2018 Jun 08; 9(44):27460-27470. PMID: 29937998.
      Citations: 23     Fields:    
    93. Pelka K, Bertheloot D, Reimer E, Phulphagar K, Schmidt SV, Christ A, Stahl R, Watson N, Miyake K, Hacohen N, Haas A, Brinkmann MM, Marshak-Rothstein A, Meissner F, Latz E. The Chaperone UNC93B1 Regulates Toll-like Receptor Stability Independently of Endosomal TLR Transport. Immunity. 2018 05 15; 48(5):911-922.e7. PMID: 29768176.
      Citations: 41     Fields:    Translation:HumansAnimalsCells
    94. Schierwagen R, Alvarez-Silva C, Madsen MSA, Kolbe CC, Meyer C, Thomas D, Uschner FE, Magdaleno F, Jansen C, Pohlmann A, Praktiknjo M, Hischebeth GT, Molitor E, Latz E, Lelouvier B, Trebicka J, Arumugam M. Circulating microbiome in blood of different circulatory compartments. Gut. 2019 03; 68(3):578-580. PMID: 29581241.
      Citations: 52     Fields:    Translation:Humans
    95. Mangan MS, Latz E. TAK1ng control: TAK1 restrains NLRP3 activation. J Exp Med. 2018 04 02; 215(4):1007-1008. PMID: 29507056.
      Citations: 5     Fields:    Translation:Cells
    96. Hoss F, Latz E. Inhibitory effects of colchicine on inflammasomes. Atherosclerosis. 2018 06; 273:153-154. PMID: 29526464.
      Citations: 4     Fields:    Translation:Humans
    97. Jansen C, Möller P, Meyer C, Kolbe CC, Bogs C, Pohlmann A, Schierwagen R, Praktiknjo M, Abdullah Z, Lehmann J, Thomas D, Strassburg CP, Latz E, Mueller S, Rössle M, Trebicka J. Increase in liver stiffness after transjugular intrahepatic portosystemic shunt is associated with inflammation and predicts mortality. Hepatology. 2018 04; 67(4):1472-1484. PMID: 29059466.
      Citations: 26     Fields:    Translation:Humans
    98. Ahmad F, Mishra N, Ahrenstorf G, Franklin BS, Latz E, Schmidt RE, Bossaller L. Evidence of inflammasome activation and formation of monocyte-derived ASC specks in HIV-1 positive patients. AIDS. 2018 01 28; 32(3):299-307. PMID: 29135573.
      Citations: 16     Fields:    Translation:HumansCells
    99. Christ A, Günther P, Lauterbach MAR, Duewell P, Biswas D, Pelka K, Scholz CJ, Oosting M, Haendler K, Baßler K, Klee K, Schulte-Schrepping J, Ulas T, Moorlag SJCFM, Kumar V, Park MH, Joosten LAB, Groh LA, Riksen NP, Espevik T, Schlitzer A, Li Y, Fitzgerald ML, Netea MG, Schultze JL, Latz E. Western Diet Triggers NLRP3-Dependent Innate Immune Reprogramming. Cell. 2018 01 11; 172(1-2):162-175.e14. PMID: 29328911.
      Citations: 297     Fields:    Translation:HumansAnimalsCells
    100. Cardona Gloria Y, Latz E, De Nardo D. Generation of Innate Immune Reporter Cells Using Retroviral Transduction. Methods Mol Biol. 2018; 1714:97-117. PMID: 29177858.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    101. De Nardo D, Kalvakolanu DV, Latz E. Immortalization of Murine Bone Marrow-Derived Macrophages. Methods Mol Biol. 2018; 1784:35-49. PMID: 29761386.
      Citations: 13     Fields:    Translation:AnimalsCells
    102. Franklin BS, Latz E, Schmidt FI. The intra- and extracellular functions of ASC specks. Immunol Rev. 2018 01; 281(1):74-87. PMID: 29247990.
      Citations: 31     Fields:    Translation:HumansAnimalsCells
    103. Steinhagen F, Zillinger T, Peukert K, Fox M, Thudium M, Barchet W, Putensen C, Klinman D, Latz E, Bode C. Suppressive oligodeoxynucleotides containing TTAGGG motifs inhibit cGAS activation in human monocytes. Eur J Immunol. 2018 04; 48(4):605-611. PMID: 29215161.
      Citations: 21     Fields:    Translation:HumansCells
    104. Venegas C, Kumar S, Franklin BS, Dierkes T, Brinkschulte R, Tejera D, Vieira-Saecker A, Schwartz S, Santarelli F, Kummer MP, Griep A, Gelpi E, Beilharz M, Riedel D, Golenbock DT, Geyer M, Walter J, Latz E, Heneka MT. Microglia-derived ASC specks cross-seed amyloid-? in Alzheimer's disease. Nature. 2017 12 20; 552(7685):355-361. PMID: 29293211.
      Citations: 276     Fields:    Translation:HumansAnimalsCells
    105. Sander J, Schmidt SV, Cirovic B, McGovern N, Papantonopoulou O, Hardt AL, Aschenbrenner AC, Kreer C, Quast T, Xu AM, Schmidleithner LM, Theis H, Thi Huong LD, Sumatoh HRB, Lauterbach MAR, Schulte-Schrepping J, Günther P, Xue J, Baßler K, Ulas T, Klee K, Katzmarski N, Herresthal S, Krebs W, Martin B, Latz E, Händler K, Kraut M, Kolanus W, Beyer M, Falk CS, Wiegmann B, Burgdorf S, Melosh NA, Newell EW, Ginhoux F, Schlitzer A, Schultze JL. Cellular Differentiation of Human Monocytes Is Regulated by Time-Dependent Interleukin-4 Signaling and the Transcriptional Regulator NCOR2. Immunity. 2017 12 19; 47(6):1051-1066.e12. PMID: 29262348.
      Citations: 51     Fields:    Translation:HumansCells
    106. Li T, He J, Horvath G, Próchnicki T, Latz E, Takeoka S. Lysine-containing cationic liposomes activate the NLRP3 inflammasome: Effect of a spacer between the head group and the hydrophobic moieties of the lipids. Nanomedicine. 2018 02; 14(2):279-288. PMID: 29127038.
      Citations: 6     Fields:    Translation:HumansCells
    107. Labzin LI, Heneka MT, Latz E. Innate Immunity and Neurodegeneration. Annu Rev Med. 2018 01 29; 69:437-449. PMID: 29106805.
      Citations: 107     Fields:    Translation:HumansCells
    108. Scheiblich H, Schlütter A, Golenbock DT, Latz E, Martinez-Martinez P, Heneka MT. Activation of the NLRP3 inflammasome in microglia: the role of ceramide. J Neurochem. 2017 12; 143(5):534-550. PMID: 28940479.
      Citations: 43     Fields:    Translation:AnimalsCells
    109. Civit L, Taghdisi SM, Jonczyk A, Haßel SK, Gröber C, Blank M, Stunden HJ, Beyer M, Schultze J, Latz E, Mayer G. Systematic evaluation of cell-SELEX enriched aptamers binding to breast cancer cells. Biochimie. 2018 Feb; 145:53-62. PMID: 29054799.
      Citations: 18     Fields:    Translation:HumansCells
    110. Schmidt FI, Latz E. CD14-New Tricks of an Old Acquaintance. Immunity. 2017 10 17; 47(4):606-608. PMID: 29045891.
      Citations: 1     Fields:    Translation:HumansCells
    111. Fülle L, Steiner N, Funke M, Gondorf F, Pfeiffer F, Siegl J, Opitz FV, Haßel SK, Erazo AB, Schanz O, Stunden HJ, Blank M, Gröber C, Händler K, Beyer M, Weighardt H, Latz E, Schultze JL, Mayer G, Förster I. RNA Aptamers Recognizing Murine CCL17 Inhibit T Cell Chemotaxis and Reduce Contact Hypersensitivity In Vivo. Mol Ther. 2018 01 03; 26(1):95-104. PMID: 29103909.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    112. Gaidt MM, Ebert TS, Chauhan D, Ramshorn K, Pinci F, Zuber S, O'Duill F, Schmid-Burgk JL, Hoss F, Buhmann R, Wittmann G, Latz E, Subklewe M, Hornung V. The DNA Inflammasome in Human Myeloid Cells Is Initiated by a STING-Cell Death Program Upstream of NLRP3. Cell. 2017 Nov 16; 171(5):1110-1124.e18. PMID: 29033128.
      Citations: 172     Fields:    Translation:HumansCells
    113. Hall J, Brault A, Vincent F, Weng S, Wang H, Dumlao D, Aulabaugh A, Aivazian D, Castro D, Chen M, Culp J, Dower K, Gardner J, Hawrylik S, Golenbock D, Hepworth D, Horn M, Jones L, Jones P, Latz E, Li J, Lin LL, Lin W, Lin D, Lovering F, Niljanskul N, Nistler R, Pierce B, Plotnikova O, Schmitt D, Shanker S, Smith J, Snyder W, Subashi T, Trujillo J, Tyminski E, Wang G, Wong J, Lefker B, Dakin L, Leach K. Discovery of PF-06928215 as a high affinity inhibitor of cGAS enabled by a novel fluorescence polarization assay. PLoS One. 2017; 12(9):e0184843. PMID: 28934246.
      Citations: 34     Fields:    Translation:HumansCells
    114. Quarta C, Clemmensen C, Zhu Z, Yang B, Joseph SS, Lutter D, Yi CX, Graf E, García-Cáceres C, Legutko B, Fischer K, Brommage R, Zizzari P, Franklin BS, Krueger M, Koch M, Vettorazzi S, Li P, Hofmann SM, Bakhti M, Bastidas-Ponce A, Lickert H, Strom TM, Gailus-Durner V, Bechmann I, Perez-Tilve D, Tuckermann J, Hrab? de Angelis M, Sandoval D, Cota D, Latz E, Seeley RJ, Müller TD, DiMarchi RD, Finan B, Tschöp MH. Molecular Integration of Incretin and Glucocorticoid Action Reverses Immunometabolic Dysfunction and Obesity. Cell Metab. 2017 Oct 03; 26(4):620-632.e6. PMID: 28943448.
      Citations: 31     Fields:    Translation:HumansAnimalsCells
    115. Bakke SS, Aune MH, Niyonzima N, Pilely K, Ryan L, Skjelland M, Garred P, Aukrust P, Halvorsen B, Latz E, Damås JK, Mollnes TE, Espevik T. Cyclodextrin Reduces Cholesterol Crystal-Induced Inflammation by Modulating Complement Activation. J Immunol. 2017 10 15; 199(8):2910-2920. PMID: 28855312.
      Citations: 10     Fields:    Translation:HumansCells
    116. Netea MG, Balkwill F, Chonchol M, Cominelli F, Donath MY, Giamarellos-Bourboulis EJ, Golenbock D, Gresnigt MS, Heneka MT, Hoffman HM, Hotchkiss R, Joosten LAB, Kastner DL, Korte M, Latz E, Libby P, Mandrup-Poulsen T, Mantovani A, Mills KHG, Nowak KL, O'Neill LA, Pickkers P, van der Poll T, Ridker PM, Schalkwijk J, Schwartz DA, Siegmund B, Steer CJ, Tilg H, van der Meer JWM, van de Veerdonk FL, Dinarello CA. A guiding map for inflammation. Nat Immunol. 2017 Jul 19; 18(8):826-831. PMID: 28722720.
      Citations: 165     Fields:    Translation:Humans
    117. Próchnicki T, Latz E. Inflammasomes on the Crossroads of Innate Immune Recognition and Metabolic Control. Cell Metab. 2017 Jul 05; 26(1):71-93. PMID: 28683296.
      Citations: 103     Fields:    Translation:HumansAnimalsCells
    118. Stutz A, Kolbe CC, Stahl R, Horvath GL, Franklin BS, van Ray O, Brinkschulte R, Geyer M, Meissner F, Latz E. NLRP3 inflammasome assembly is regulated by phosphorylation of the pyrin domain. J Exp Med. 2017 06 05; 214(6):1725-1736. PMID: 28465465.
      Citations: 118     Fields:    Translation:HumansAnimalsCells
    119. Choo MK, Sano Y, Kim C, Yasuda K, Li XD, Lin X, Stenzel-Poore M, Alexopoulou L, Ghosh S, Latz E, Rifkin IR, Chen ZJ, Stewart GC, Chong H, Park JM. TLR sensing of bacterial spore-associated RNA triggers host immune responses with detrimental effects. J Exp Med. 2017 05 01; 214(5):1297-1311. PMID: 28400473.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    120. Liu X, Pichulik T, Wolz OO, Dang TM, Stutz A, Dillen C, Delmiro Garcia M, Kraus H, Dickhöfer S, Daiber E, Münzenmayer L, Wahl S, Rieber N, Kümmerle-Deschner J, Yazdi A, Franz-Wachtel M, Macek B, Radsak M, Vogel S, Schulte B, Walz JS, Hartl D, Latz E, Stilgenbauer S, Grimbacher B, Miller L, Brunner C, Wolz C, Weber ANR. Human NACHT, LRR, and PYD domain-containing protein 3 (NLRP3) inflammasome activity is regulated by and potentially targetable through Bruton tyrosine kinase. J Allergy Clin Immunol. 2017 Oct; 140(4):1054-1067.e10. PMID: 28216434.
      Citations: 50     Fields:    Translation:HumansAnimalsCells
    121. Braga TT, Forni MF, Correa-Costa M, Ramos RN, Barbuto JA, Branco P, Castoldi A, Hiyane MI, Davanso MR, Latz E, Franklin BS, Kowaltowski AJ, Camara NO. Soluble Uric Acid Activates the NLRP3 Inflammasome. Sci Rep. 2017 01 13; 7:39884. PMID: 28084303.
      Citations: 102     Fields:    Translation:AnimalsCells
    122. Ling YH, Krishnan SM, Chan CT, Diep H, Ferens D, Chin-Dusting J, Kemp-Harper BK, Samuel CS, Hewitson TD, Latz E, Mansell A, Sobey CG, Drummond GR. Anakinra reduces blood pressure and renal fibrosis in one kidney/DOCA/salt-induced hypertension. Pharmacol Res. 2017 02; 116:77-86. PMID: 27986554.
      Citations: 18     Fields:    Translation:Animals
    123. Pinar A, Dowling JK, Bitto NJ, Robertson AA, Latz E, Stewart CR, Drummond GR, Cooper MA, McAuley JL, Tate MD, Mansell A. PB1-F2 Peptide Derived from Avian Influenza A Virus H7N9 Induces Inflammation via Activation of the NLRP3 Inflammasome. J Biol Chem. 2017 01 20; 292(3):826-836. PMID: 27913620.
      Citations: 36     Fields:    Translation:AnimalsCells
    124. Alecu I, Tedeschi A, Behler N, Wunderling K, Lamberz C, Lauterbach MA, Gaebler A, Ernst D, Van Veldhoven PP, Al-Amoudi A, Latz E, Othman A, Kuerschner L, Hornemann T, Bradke F, Thiele C, Penno A. Localization of 1-deoxysphingolipids to mitochondria induces mitochondrial dysfunction. J Lipid Res. 2017 01; 58(1):42-59. PMID: 27881717.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    125. Bertheloot D, Naumovski AL, Langhoff P, Horvath GL, Jin T, Xiao TS, Garbi N, Agrawal S, Kolbeck R, Latz E. RAGE Enhances TLR Responses through Binding and Internalization of RNA. J Immunol. 2016 11 15; 197(10):4118-4126. PMID: 27798148.
      Citations: 22     Fields:    Translation:HumansCells
    126. Hoss F, Rodriguez-Alcazar JF, Latz E. Assembly and regulation of ASC specks. Cell Mol Life Sci. 2017 04; 74(7):1211-1229. PMID: 27761594.
      Citations: 36     Fields:    Translation:HumansCells
    127. Hoss F, Budden CF, Latz E. IRGB10 Exposes Bacteria's Intimate Secrets. Dev Cell. 2016 10 10; 39(1):7-8. PMID: 27728782.
      Citations: 1     Fields:    Translation:Cells
    128. Pfeiler S, Khandagale AB, Magenau A, Nichols M, Heijnen HF, Rinninger F, Ziegler T, Seveau S, Schubert S, Zahler S, Verschoor A, Latz E, Massberg S, Gaus K, Engelmann B. Distinct surveillance pathway for immunopathology during acute infection via autophagy and SR-BI. Sci Rep. 2016 10 03; 6:34440. PMID: 27694929.
      Citations: 9     Fields:    Translation:AnimalsCells
    129. Schierwagen R, Maybüchen L, Hittatiya K, Klein S, Uschner FE, Braga TT, Franklin BS, Nickenig G, Strassburg CP, Plat J, Sauerbruch T, Latz E, Lütjohann D, Zimmer S, Trebicka J. Statins improve NASH via inhibition of RhoA and Ras. Am J Physiol Gastrointest Liver Physiol. 2016 10 01; 311(4):G724-G733. PMID: 27634010.
      Citations: 17     Fields:    Translation:AnimalsCells
    130. Montenegro Raudales JL, Yoshimura A, Sm Z, Kaneko T, Ozaki Y, Ukai T, Miyazaki T, Latz E, Hara Y. Dental Calculus Stimulates Interleukin-1? Secretion by Activating NLRP3 Inflammasome in Human and Mouse Phagocytes. PLoS One. 2016; 11(9):e0162865. PMID: 27632566.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    131. von Kolontaj K, Horvath GL, Latz E, Büscher M. Automated nanoscale flow cytometry for assessing protein-protein interactions. Cytometry A. 2016 09; 89(9):835-43. PMID: 27584593.
      Citations: 2     Fields:    Translation:HumansCells
    132. Bertheloot D, Latz E. HMGB1, IL-1?, IL-33 and S100 proteins: dual-function alarmins. Cell Mol Immunol. 2017 01; 14(1):43-64. PMID: 27569562.
      Citations: 171     Fields:    Translation:HumansAnimals
    133. Primiano MJ, Lefker BA, Bowman MR, Bree AG, Hubeau C, Bonin PD, Mangan M, Dower K, Monks BG, Cushing L, Wang S, Guzova J, Jiao A, Lin LL, Latz E, Hepworth D, Hall JP. Efficacy and Pharmacology of the NLRP3 Inflammasome Inhibitor CP-456,773 (CRID3) in Murine Models of Dermal and Pulmonary Inflammation. J Immunol. 2016 09 15; 197(6):2421-33. PMID: 27521339.
      Citations: 53     Fields:    Translation:HumansAnimalsCells
    134. Bode N, Grebe A, Kerksiek A, Lütjohann D, Werner N, Nickenig G, Latz E, Zimmer S. Ursodeoxycholic acid impairs atherogenesis and promotes plaque regression by cholesterol crystal dissolution in mice. Biochem Biophys Res Commun. 2016 09 09; 478(1):356-362. PMID: 27416761.
      Citations: 8     Fields:    Translation:AnimalsCells
    135. Bossaller L, Christ A, Pelka K, Nündel K, Chiang PI, Pang C, Mishra N, Busto P, Bonegio RG, Schmidt RE, Latz E, Marshak-Rothstein A. TLR9 Deficiency Leads to Accelerated Renal Disease and Myeloid Lineage Abnormalities in Pristane-Induced Murine Lupus. J Immunol. 2016 08 15; 197(4):1044-53. PMID: 27354219.
      Citations: 22     Fields:    Translation:AnimalsCells
    136. Tzeng TC, Schattgen S, Monks B, Wang D, Cerny A, Latz E, Fitzgerald K, Golenbock DT. A Fluorescent Reporter Mouse for Inflammasome Assembly Demonstrates an Important Role for Cell-Bound and Free ASC Specks during In Vivo Infection. Cell Rep. 2016 07 12; 16(2):571-582. PMID: 27346360.
      Citations: 41     Fields:    Translation:AnimalsCells
    137. Próchnicki T, Mangan MS, Latz E. Recent insights into the molecular mechanisms of the NLRP3 inflammasome activation. F1000Res. 2016; 5. PMID: 27508077.
      Citations: 62     Fields:    
    138. Tate MD, Ong JDH, Dowling JK, McAuley JL, Robertson AB, Latz E, Drummond GR, Cooper MA, Hertzog PJ, Mansell A. Reassessing the role of the NLRP3 inflammasome during pathogenic influenza A virus infection via temporal inhibition. Sci Rep. 2016 06 10; 6:27912. PMID: 27283237.
      Citations: 68     Fields:    Translation:AnimalsCells
    139. Ludwig-Portugall I, Bartok E, Dhana E, Evers BD, Primiano MJ, Hall JP, Franklin BS, Knolle PA, Hornung V, Hartmann G, Boor P, Latz E, Kurts C. An NLRP3-specific inflammasome inhibitor attenuates crystal-induced kidney fibrosis in mice. Kidney Int. 2016 09; 90(3):525-39. PMID: 27262364.
      Citations: 59     Fields:    Translation:HumansAnimalsCells
    140. Labzin LI, Lauterbach MA, Latz E. Interferons and inflammasomes: Cooperation and counterregulation in disease. J Allergy Clin Immunol. 2016 07; 138(1):37-46. PMID: 27373324.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    141. Christ A, Bekkering S, Latz E, Riksen NP. Long-term activation of the innate immune system in atherosclerosis. Semin Immunol. 2016 08; 28(4):384-93. PMID: 27113267.
      Citations: 38     Fields:    Translation:HumansAnimals
    142. Netea MG, Joosten LA, Latz E, Mills KH, Natoli G, Stunnenberg HG, O'Neill LA, Xavier RJ. Trained immunity: A program of innate immune memory in health and disease. Science. 2016 Apr 22; 352(6284):aaf1098. PMID: 27102489.
      Citations: 784     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    143. Zimmer S, Grebe A, Bakke SS, Bode N, Halvorsen B, Ulas T, Skjelland M, De Nardo D, Labzin LI, Kerksiek A, Hempel C, Heneka MT, Hawxhurst V, Fitzgerald ML, Trebicka J, Björkhem I, Gustafsson JÅ, Westerterp M, Tall AR, Wright SD, Espevik T, Schultze JL, Nickenig G, Lütjohann D, Latz E. Cyclodextrin promotes atherosclerosis regression via macrophage reprogramming. Sci Transl Med. 2016 Apr 06; 8(333):333ra50. PMID: 27053774.
      Citations: 88     Fields:    Translation:HumansAnimalsCells
    144. Franklin BS, Mangan MS, Latz E. Crystal Formation in Inflammation. Annu Rev Immunol. 2016 05 20; 34:173-202. PMID: 26772211.
      Citations: 44     Fields:    Translation:HumansAnimalsCells
    145. Sun J, Li N, Oh KS, Dutta B, Vayttaden SJ, Lin B, Ebert TS, De Nardo D, Davis J, Bagirzadeh R, Lounsbury NW, Pasare C, Latz E, Hornung V, Fraser ID. Comprehensive RNAi-based screening of human and mouse TLR pathways identifies species-specific preferences in signaling protein use. Sci Signal. 2016 Jan 05; 9(409):ra3. PMID: 26732763.
      Citations: 30     Fields:    Translation:HumansAnimalsCells
    146. Horvath GL, Langhoff P, Latz E. Toll-Like Receptor Interactions Measured by Microscopic and Flow Cytometric FRET. Methods Mol Biol. 2016; 1390:41-64. PMID: 26803621.
      Citations: 1     Fields:    Translation:HumansCells
    147. Beilharz M, De Nardo D, Latz E, Franklin BS. Measuring NLR Oligomerization II: Detection of ASC Speck Formation by Confocal Microscopy and Immunofluorescence. Methods Mol Biol. 2016; 1417:145-58. PMID: 27221487.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    148. Pelka K, Shibata T, Miyake K, Latz E. Nucleic acid-sensing TLRs and autoimmunity: novel insights from structural and cell biology. Immunol Rev. 2016 Jan; 269(1):60-75. PMID: 26683145.
      Citations: 42     Fields:    Translation:HumansAnimalsCells
    149. Beilharz M, De Nardo D, Latz E, Franklin BS. Erratum to: Measuring NLR Oligomerization II: Detection of ASC Speck Formation by Confocal Microscopy and Immunofluorescence. Methods Mol Biol. 2016; 1417:E1. PMID: 27699711.
      Citations: 1     Fields:    
    150. Levy M, Thaiss CA, Zeevi D, Dohnalová L, Zilberman-Schapira G, Mahdi JA, David E, Savidor A, Korem T, Herzig Y, Pevsner-Fischer M, Shapiro H, Christ A, Harmelin A, Halpern Z, Latz E, Flavell RA, Amit I, Segal E, Elinav E. Microbiota-Modulated Metabolites Shape the Intestinal Microenvironment by Regulating NLRP6 Inflammasome Signaling. Cell. 2015 Dec 03; 163(6):1428-43. PMID: 26638072.
      Citations: 335     Fields:    Translation:AnimalsCells
    151. Labzin LI, Schmidt SV, Masters SL, Beyer M, Krebs W, Klee K, Stahl R, Lütjohann D, Schultze JL, Latz E, De Nardo D. ATF3 Is a Key Regulator of Macrophage IFN Responses. J Immunol. 2015 Nov 01; 195(9):4446-55. PMID: 26416280.
      Citations: 43     Fields:    Translation:HumansAnimalsCells
    152. Schneider KM, Bieghs V, Heymann F, Hu W, Dreymueller D, Liao L, Frissen M, Ludwig A, Gassler N, Pabst O, Latz E, Sellge G, Penders J, Tacke F, Trautwein C. CX3CR1 is a gatekeeper for intestinal barrier integrity in mice: Limiting steatohepatitis by maintaining intestinal homeostasis. Hepatology. 2015 Nov; 62(5):1405-16. PMID: 26178698.
      Citations: 37     Fields:    Translation:AnimalsCells
    153. Walenbergh SM, Houben T, Hendrikx T, Jeurissen ML, van Gorp PJ, Vaes N, Olde Damink SW, Verheyen F, Koek GH, Lütjohann D, Grebe A, Latz E, Shiri-Sverdlov R. Weekly Treatment of 2-Hydroxypropyl-?-cyclodextrin Improves Intracellular Cholesterol Levels in LDL Receptor Knockout Mice. Int J Mol Sci. 2015 Sep 02; 16(9):21056-69. PMID: 26404254.
      Citations: 7     Fields:    Translation:AnimalsCells
    154. Netea MG, Latz E, Mills KH, O'Neill LA. Innate immune memory: a paradigm shift in understanding host defense. Nat Immunol. 2015 Jul; 16(7):675-9. PMID: 26086132.
      Citations: 91     Fields:    Translation:Humans
    155. Eigenbrod T, Pelka K, Latz E, Kreikemeyer B, Dalpke AH. TLR8 Senses Bacterial RNA in Human Monocytes and Plays a Nonredundant Role for Recognition of Streptococcus pyogenes. J Immunol. 2015 Aug 01; 195(3):1092-9. PMID: 26101323.
      Citations: 29     Fields:    Translation:HumansAnimalsCells
    156. Niyonzima N, Samstad EO, Aune MH, Ryan L, Bakke SS, Rokstad AM, Wright SD, Damås JK, Mollnes TE, Latz E, Espevik T. Reconstituted High-Density Lipoprotein Attenuates Cholesterol Crystal-Induced Inflammatory Responses by Reducing Complement Activation. J Immunol. 2015 Jul 01; 195(1):257-64. PMID: 26026058.
      Citations: 14     Fields:    Translation:HumansCells
    157. Hirschfeld J, Dommisch H, Skora P, Horvath G, Latz E, Hoerauf A, Waller T, Kawai T, Jepsen S, Deschner J, Bekeredjian-Ding I. Neutrophil extracellular trap formation in supragingival biofilms. Int J Med Microbiol. 2015 Jun-Aug; 305(4-5):453-63. PMID: 25959370.
      Citations: 25     Fields:    Translation:HumansCells
    158. Schultze JL, Freeman T, Hume DA, Latz E. A transcriptional perspective on human macrophage biology. Semin Immunol. 2015 Feb; 27(1):44-50. PMID: 25843246.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    159. Heneka MT, Carson MJ, El Khoury J, Landreth GE, Brosseron F, Feinstein DL, Jacobs AH, Wyss-Coray T, Vitorica J, Ransohoff RM, Herrup K, Frautschy SA, Finsen B, Brown GC, Verkhratsky A, Yamanaka K, Koistinaho J, Latz E, Halle A, Petzold GC, Town T, Morgan D, Shinohara ML, Perry VH, Holmes C, Bazan NG, Brooks DJ, Hunot S, Joseph B, Deigendesch N, Garaschuk O, Boddeke E, Dinarello CA, Breitner JC, Cole GM, Golenbock DT, Kummer MP. Neuroinflammation in Alzheimer's disease. Lancet Neurol. 2015 Apr; 14(4):388-405. PMID: 25792098.
      Citations: 1639     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    160. Brandstetter C, Mohr LK, Latz E, Holz FG, Krohne TU. Light induces NLRP3 inflammasome activation in retinal pigment epithelial cells via lipofuscin-mediated photooxidative damage. J Mol Med (Berl). 2015 Aug; 93(8):905-16. PMID: 25783493.
      Citations: 36     Fields:    Translation:HumansCells
    161. Heneka MT, Golenbock DT, Latz E. Innate immunity in Alzheimer's disease. Nat Immunol. 2015 Mar; 16(3):229-36. PMID: 25689443.
      Citations: 295     Fields:    Translation:HumansAnimals
    162. Coll RC, Robertson AA, Chae JJ, Higgins SC, Muñoz-Planillo R, Inserra MC, Vetter I, Dungan LS, Monks BG, Stutz A, Croker DE, Butler MS, Haneklaus M, Sutton CE, Núñez G, Latz E, Kastner DL, Mills KH, Masters SL, Schroder K, Cooper MA, O'Neill LA. A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases. Nat Med. 2015 Mar; 21(3):248-55. PMID: 25686105.
      Citations: 812     Fields:    Translation:HumansAnimals
    163. Geyer M, Pelka K, Latz E. Synergistic activation of Toll-like receptor 8 by two RNA degradation products. Nat Struct Mol Biol. 2015 Feb; 22(2):99-101. PMID: 25650902.
      Citations: 10     Fields:    Translation:HumansAnimals
    164. Zimmer S, Grebe A, Latz E. Danger signaling in atherosclerosis. Circ Res. 2015 Jan 16; 116(2):323-40. PMID: 25593277.
      Citations: 28     Fields:    Translation:HumansAnimalsCells
    165. Mizushina Y, Shirasuna K, Usui F, Karasawa T, Kawashima A, Kimura H, Kobayashi M, Komada T, Inoue Y, Mato N, Yamasawa H, Latz E, Iwakura Y, Kasahara T, Bando M, Sugiyama Y, Takahashi M. NLRP3 protein deficiency exacerbates hyperoxia-induced lethality through Stat3 protein signaling independent of interleukin-1?. J Biol Chem. 2015 Feb 20; 290(8):5065-5077. PMID: 25548278.
      Citations: 22     Fields:    Translation:AnimalsCells
    166. Sarvestani ST, Stunden HJ, Behlke MA, Forster SC, McCoy CE, Tate MD, Ferrand J, Lennox KA, Latz E, Williams BR, Gantier MP. Sequence-dependent off-target inhibition of TLR7/8 sensing by synthetic microRNA inhibitors. Nucleic Acids Res. 2015 Jan; 43(2):1177-88. PMID: 25539920.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    167. Fassl SK, Austermann J, Papantonopoulou O, Riemenschneider M, Xue J, Bertheloot D, Freise N, Spiekermann C, Witten A, Viemann D, Kirschnek S, Stoll M, Latz E, Schultze JL, Roth J, Vogl T. Transcriptome assessment reveals a dominant role for TLR4 in the activation of human monocytes by the alarmin MRP8. J Immunol. 2015 Jan 15; 194(2):575-83. PMID: 25505274.
      Citations: 30     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
    168. Broderick L, De Nardo D, Franklin BS, Hoffman HM, Latz E. The inflammasomes and autoinflammatory syndromes. Annu Rev Pathol. 2015; 10:395-424. PMID: 25423351.
      Citations: 111     Fields:    Translation:HumansAnimals
    169. Krebs W, Schmidt SV, Goren A, De Nardo D, Labzin L, Bovier A, Ulas T, Theis H, Kraut M, Latz E, Beyer M, Schultze JL. Optimization of transcription factor binding map accuracy utilizing knockout-mouse models. Nucleic Acids Res. 2014 Dec 01; 42(21):13051-60. PMID: 25378309.
      Citations: 11     Fields:    Translation:AnimalsCells
    170. Kono H, Kimura Y, Latz E. Inflammasome activation in response to dead cells and their metabolites. Curr Opin Immunol. 2014 Oct; 30:91-8. PMID: 25282339.
      Citations: 23     Fields:    Translation:HumansAnimals
    171. Latz E, Miyake K. Editorial overview: Special section: effects of endogenous immune stimulants: from a defence system against infection to a homeostatic mechanism linking metabolism with inflammation. Curr Opin Immunol. 2014 Oct; 30:viii-ix. PMID: 25224931.
      Citations: 1     Fields:    
    172. Schmid-Burgk JL, Schmidt T, Gaidt MM, Pelka K, Latz E, Ebert TS, Hornung V. OutKnocker: a web tool for rapid and simple genotyping of designer nuclease edited cell lines. Genome Res. 2014 Oct; 24(10):1719-23. PMID: 25186908.
      Citations: 53     Fields:    Translation:HumansCells
    173. Pelka K, Phulphagar K, Zimmermann J, Stahl R, Schmid-Burgk JL, Schmidt T, Spille JH, Labzin LI, Agrawal S, Kandimalla ER, Casanova JL, Hornung V, Marshak-Rothstein A, Höning S, Latz E. Cutting edge: the UNC93B1 tyrosine-based motif regulates trafficking and TLR responses via separate mechanisms. J Immunol. 2014 Oct 01; 193(7):3257-61. PMID: 25187660.
      Citations: 17     Fields:    Translation:HumansCells
    174. Christ A, Latz E. LOX-1 and mitochondria: an inflammatory relationship. Cardiovasc Res. 2014 Sep 01; 103(4):435-7. PMID: 25114006.
      Citations: 3     Fields:    Translation:HumansCells
    175. Heneka MT, Kummer MP, Latz E. Innate immune activation in neurodegenerative disease. Nat Rev Immunol. 2014 Jul; 14(7):463-77. PMID: 24962261.
      Citations: 472     Fields:    Translation:HumansCells
    176. Franklin BS, Bossaller L, De Nardo D, Ratter JM, Stutz A, Engels G, Brenker C, Nordhoff M, Mirandola SR, Al-Amoudi A, Mangan MS, Zimmer S, Monks BG, Fricke M, Schmidt RE, Espevik T, Jones B, Jarnicki AG, Hansbro PM, Busto P, Marshak-Rothstein A, Hornemann S, Aguzzi A, Kastenmüller W, Latz E. The adaptor ASC has extracellular and 'prionoid' activities that propagate inflammation. Nat Immunol. 2014 Aug; 15(8):727-37. PMID: 24952505.
      Citations: 318     Fields:    Translation:HumansAnimalsCells
    177. Schmidt-Lauber C, Bossaller L, Abujudeh HH, Vladimer GI, Christ A, Fitzgerald KA, Latz E, Gravallese EM, Marshak-Rothstein A, Kay J. Gadolinium-based compounds induce NLRP3-dependent IL-1? production and peritoneal inflammation. Ann Rheum Dis. 2015 Nov; 74(11):2062-9. PMID: 24914072.
      Citations: 13     Fields:    Translation:AnimalsCells
    178. Verstak B, Stack J, Ve T, Mangan M, Hjerrild K, Jeon J, Stahl R, Latz E, Gay N, Kobe B, Bowie AG, Mansell A. The TLR signaling adaptor TRAM interacts with TRAF6 to mediate activation of the inflammatory response by TLR4. J Leukoc Biol. 2014 Sep; 96(3):427-36. PMID: 24812060.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    179. Mangan MS, Latz E. NLRC3 puts the brakes on STING. Immunity. 2014 Mar 20; 40(3):305-6. PMID: 24656040.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    180. Wilson NS, Duewell P, Yang B, Li Y, Marsters S, Koernig S, Latz E, Maraskovsky E, Morelli AB, Schnurr M, Ashkenazi A. Inflammasome-dependent and -independent IL-18 production mediates immunity to the ISCOMATRIX adjuvant. J Immunol. 2014 Apr 01; 192(7):3259-68. PMID: 24610009.
      Citations: 28     Fields:    Translation:HumansAnimalsCells
    181. Samstad EO, Niyonzima N, Nymo S, Aune MH, Ryan L, Bakke SS, Lappegård KT, Brekke OL, Lambris JD, Damås JK, Latz E, Mollnes TE, Espevik T. Cholesterol crystals induce complement-dependent inflammasome activation and cytokine release. J Immunol. 2014 Mar 15; 192(6):2837-45. PMID: 24554772.
      Citations: 98     Fields:    Translation:HumansCells
    182. Xue J, Schmidt SV, Sander J, Draffehn A, Krebs W, Quester I, De Nardo D, Gohel TD, Emde M, Schmidleithner L, Ganesan H, Nino-Castro A, Mallmann MR, Labzin L, Theis H, Kraut M, Beyer M, Latz E, Freeman TC, Ulas T, Schultze JL. Transcriptome-based network analysis reveals a spectrum model of human macrophage activation. Immunity. 2014 Feb 20; 40(2):274-88. PMID: 24530056.
      Citations: 815     Fields:    Translation:HumansAnimalsCells
    183. Kalantari P, DeOliveira RB, Chan J, Corbett Y, Rathinam V, Stutz A, Latz E, Gazzinelli RT, Golenbock DT, Fitzgerald KA. Dual engagement of the NLRP3 and AIM2 inflammasomes by plasmodium-derived hemozoin and DNA during malaria. Cell Rep. 2014 Jan 16; 6(1):196-210. PMID: 24388751.
      Citations: 79     Fields:    Translation:HumansAnimalsCells
    184. Lamphier M, Zheng W, Latz E, Spyvee M, Hansen H, Rose J, Genest M, Yang H, Shaffer C, Zhao Y, Shen Y, Liu C, Liu D, Mempel TR, Rowbottom C, Chow J, Twine NC, Yu M, Gusovsky F, Ishizaka ST. Novel small molecule inhibitors of TLR7 and TLR9: mechanism of action and efficacy in vivo. Mol Pharmacol. 2014 Mar; 85(3):429-40. PMID: 24342772.
      Citations: 46     Fields:    Translation:AnimalsCells
    185. De Nardo D, Labzin LI, Kono H, Seki R, Schmidt SV, Beyer M, Xu D, Zimmer S, Lahrmann C, Schildberg FA, Vogelhuber J, Kraut M, Ulas T, Kerksiek A, Krebs W, Bode N, Grebe A, Fitzgerald ML, Hernandez NJ, Williams BR, Knolle P, Kneilling M, Röcken M, Lütjohann D, Wright SD, Schultze JL, Latz E. High-density lipoprotein mediates anti-inflammatory reprogramming of macrophages via the transcriptional regulator ATF3. Nat Immunol. 2014 Feb; 15(2):152-60. PMID: 24317040.
      Citations: 145     Fields:    Translation:HumansAnimalsCells
    186. Rubartelli A, Lotze MT, Latz E, Manfredi A. Mechanisms of sterile inflammation. Front Immunol. 2013; 4:398. PMID: 24319446.
      Citations: 20     Fields:    
    187. De Nardo D, De Nardo CM, Latz E. New insights into mechanisms controlling the NLRP3 inflammasome and its role in lung disease. Am J Pathol. 2014 Jan; 184(1):42-54. PMID: 24183846.
      Citations: 86     Fields:    Translation:HumansAnimals
    188. Sirois CM, Jin T, Miller AL, Bertheloot D, Nakamura H, Horvath GL, Mian A, Jiang J, Schrum J, Bossaller L, Pelka K, Garbi N, Brewah Y, Tian J, Chang C, Chowdhury PS, Sims GP, Kolbeck R, Coyle AJ, Humbles AA, Xiao TS, Latz E. RAGE is a nucleic acid receptor that promotes inflammatory responses to DNA. J Exp Med. 2013 Oct 21; 210(11):2447-63. PMID: 24081950.
      Citations: 84     Fields:    Translation:HumansAnimalsCells
    189. Ablasser A, Schmid-Burgk JL, Hemmerling I, Horvath GL, Schmidt T, Latz E, Hornung V. Cell intrinsic immunity spreads to bystander cells via the intercellular transfer of cGAMP. Nature. 2013 Nov 28; 503(7477):530-4. PMID: 24077100.
      Citations: 244     Fields:    Translation:HumansAnimalsCells
    190. Hernandez JC, Latz E, Urcuqui-Inchima S. HIV-1 induces the first signal to activate the NLRP3 inflammasome in monocyte-derived macrophages. Intervirology. 2014; 57(1):36-42. PMID: 24008203.
      Citations: 34     Fields:    Translation:HumansCells
    191. Bossaller L, Rathinam VA, Bonegio R, Chiang PI, Busto P, Wespiser AR, Caffrey DR, Li QZ, Mohan C, Fitzgerald KA, Latz E, Marshak-Rothstein A. Overexpression of membrane-bound fas ligand (CD95L) exacerbates autoimmune disease and renal pathology in pristane-induced lupus. J Immunol. 2013 Sep 01; 191(5):2104-14. PMID: 23918976.
      Citations: 12     Fields:    Translation:AnimalsCells
    192. Pelka K, Latz E. IRF5, IRF8, and IRF7 in human pDCs - the good, the bad, and the insignificant? Eur J Immunol. 2013 Jul; 43(7):1693-7. PMID: 23828296.
      Citations: 17     Fields:    Translation:HumansCells
    193. Sheedy FJ, Grebe A, Rayner KJ, Kalantari P, Ramkhelawon B, Carpenter SB, Becker CE, Ediriweera HN, Mullick AE, Golenbock DT, Stuart LM, Latz E, Fitzgerald KA, Moore KJ. CD36 coordinates NLRP3 inflammasome activation by facilitating intracellular nucleation of soluble ligands into particulate ligands in sterile inflammation. Nat Immunol. 2013 Aug; 14(8):812-20. PMID: 23812099.
      Citations: 361     Fields:    Translation:Animals
    194. Latz E, Xiao TS, Stutz A. Activation and regulation of the inflammasomes. Nat Rev Immunol. 2013 Jun; 13(6):397-411. PMID: 23702978.
      Citations: 1144     Fields:    Translation:HumansCells
    195. McAuley JL, Tate MD, MacKenzie-Kludas CJ, Pinar A, Zeng W, Stutz A, Latz E, Brown LE, Mansell A. Activation of the NLRP3 inflammasome by IAV virulence protein PB1-F2 contributes to severe pathophysiology and disease. PLoS Pathog. 2013; 9(5):e1003392. PMID: 23737748.
      Citations: 120     Fields:    Translation:HumansAnimalsCells
    196. Hett EC, Slater LH, Mark KG, Kawate T, Monks BG, Stutz A, Latz E, Hung DT. Chemical genetics reveals a kinase-independent role for protein kinase R in pyroptosis. Nat Chem Biol. 2013 Jun; 9(6):398-405. PMID: 23603659.
      Citations: 45     Fields:    Translation:AnimalsCells
    197. Grebe A, Latz E. Cholesterol crystals and inflammation. Curr Rheumatol Rep. 2013 Mar; 15(3):313. PMID: 23412688.
      Citations: 55     Fields:    Translation:HumansCells
    198. Bartok E, Bauernfeind F, Khaminets MG, Jakobs C, Monks B, Fitzgerald KA, Latz E, Hornung V. iGLuc: a luciferase-based inflammasome and protease activity reporter. Nat Methods. 2013 Feb; 10(2):147-154. PMID: 23291722.
      Citations: 24     Fields:    Translation:HumansAnimalsCells
    199. Duewell P, Latz E. Assessment and quantification of crystal-induced lysosomal damage. Methods Mol Biol. 2013; 1040:19-27. PMID: 23852594.
      Citations: 6     Fields:    Translation:AnimalsCells
    200. Stutz A, Horvath GL, Monks BG, Latz E. ASC speck formation as a readout for inflammasome activation. Methods Mol Biol. 2013; 1040:91-101. PMID: 23852599.
      Citations: 102     Fields:    Translation:HumansAnimalsCells
    201. Heneka MT, Kummer MP, Stutz A, Delekate A, Schwartz S, Vieira-Saecker A, Griep A, Axt D, Remus A, Tzeng TC, Gelpi E, Halle A, Korte M, Latz E, Golenbock DT. NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 mice. Nature. 2013 Jan 31; 493(7434):674-8. PMID: 23254930.
      Citations: 925     Fields:    Translation:HumansAnimals
    202. Henault J, Martinez J, Riggs JM, Tian J, Mehta P, Clarke L, Sasai M, Latz E, Brinkmann MM, Iwasaki A, Coyle AJ, Kolbeck R, Green DR, Sanjuan MA. Noncanonical autophagy is required for type I interferon secretion in response to DNA-immune complexes. Immunity. 2012 Dec 14; 37(6):986-997. PMID: 23219390.
      Citations: 188     Fields:    Translation:HumansAnimalsCells
    203. Bossaller L, Chiang PI, Schmidt-Lauber C, Ganesan S, Kaiser WJ, Rathinam VA, Mocarski ES, Subramanian D, Green DR, Silverman N, Fitzgerald KA, Marshak-Rothstein A, Latz E. Cutting edge: FAS (CD95) mediates noncanonical IL-1? and IL-18 maturation via caspase-8 in an RIP3-independent manner. J Immunol. 2012 Dec 15; 189(12):5508-12. PMID: 23144495.
      Citations: 137     Fields:    Translation:AnimalsCells
    204. Stunden HJ, Latz E. PKR stirs up inflammasomes. Cell Res. 2013 Feb; 23(2):168-70. PMID: 22945351.
      Citations: 2     Fields:    Translation:HumansAnimals
    205. Jansen F, Yang X, Hoyer FF, Paul K, Heiermann N, Becher MU, Abu Hussein N, Kebschull M, Bedorf J, Franklin BS, Latz E, Nickenig G, Werner N. Endothelial microparticle uptake in target cells is annexin I/phosphatidylserine receptor dependent and prevents apoptosis. Arterioscler Thromb Vasc Biol. 2012 Aug; 32(8):1925-35. PMID: 22701020.
      Citations: 67     Fields:    Translation:HumansCells
    206. Franklin BS, Latz E. For gut's sake: NLRC4 inflammasomes distinguish friend from foe. Nat Immunol. 2012 Apr 18; 13(5):429-31. PMID: 22513324.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    207. Jin T, Perry A, Jiang J, Smith P, Curry JA, Unterholzner L, Jiang Z, Horvath G, Rathinam VA, Johnstone RW, Hornung V, Latz E, Bowie AG, Fitzgerald KA, Xiao TS. Structures of the HIN domain:DNA complexes reveal ligand binding and activation mechanisms of the AIM2 inflammasome and IFI16 receptor. Immunity. 2012 Apr 20; 36(4):561-71. PMID: 22483801.
      Citations: 240     Fields:    Translation:HumansCells
    208. Grebe A, Latz E. IL-1, quo vadis? Atherosclerosis. 2012 Jun; 222(2):324-5. PMID: 22513052.
      Citations: 1     Fields:    Translation:HumansAnimals
    209. Brockschmidt A, Trost D, Peterziel H, Zimmermann K, Ehrler M, Grassmann H, Pfenning PN, Waha A, Wohlleber D, Brockschmidt FF, Jugold M, Hoischen A, Kalla C, Waha A, Seifert G, Knolle PA, Latz E, Hans VH, Wick W, Pfeifer A, Angel P, Weber RG. KIAA1797/FOCAD encodes a novel focal adhesion protein with tumour suppressor function in gliomas. Brain. 2012 Apr; 135(Pt 4):1027-41. PMID: 22427331.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    210. Hernández JC, Stevenson M, Latz E, Urcuqui-Inchima S. HIV type 1 infection up-regulates TLR2 and TLR4 expression and function in vivo and in vitro. AIDS Res Hum Retroviruses. 2012 Oct; 28(10):1313-28. PMID: 22280204.
      Citations: 35     Fields:    Translation:HumansCells
    211. Klein DC, Øvrebø KM, Latz E, Espevik T, Stokke BT. Direct measurement of the interaction force between immunostimulatory CpG-DNA and TLR9 fusion protein. J Mol Recognit. 2012 Feb; 25(2):74-81. PMID: 22290768.
      Citations: 1     Fields:    Translation:HumansCellsPHPublic Health
    212. Horvath GL, Schrum JE, De Nardo CM, Latz E. Intracellular sensing of microbes and danger signals by the inflammasomes. Immunol Rev. 2011 Sep; 243(1):119-35. PMID: 21884172.
      Citations: 46     Fields:    Translation:HumansAnimalsCells
    213. Schlaweck S, Zimmer S, Struck R, Bartok E, Werner N, Bauernfeind F, Latz E, Nickenig G, Hornung V, Ghanem A. Critical role of nucleotide-binding oligomerization domain-like receptor 3 in vascular repair. Biochem Biophys Res Commun. 2011 Aug 05; 411(3):627-31. PMID: 21777570.
      Citations: 2     Fields:    Translation:Animals
    214. De Nardo D, Latz E. NLRP3 inflammasomes link inflammation and metabolic disease. Trends Immunol. 2011 Aug; 32(8):373-9. PMID: 21733753.
      Citations: 157     Fields:    Translation:HumansAnimals
    215. Masters SL, Latz E, O'Neill LA. The inflammasome in atherosclerosis and type 2 diabetes. Sci Transl Med. 2011 May 04; 3(81):81ps17. PMID: 21543720.
      Citations: 67     Fields:    Translation:HumansAnimals
    216. Pelka K, Latz E. Getting closer to the dirty little secret. Immunity. 2011 Apr 22; 34(4):455-8. PMID: 21511178.
      Citations: 10     Fields:    
    217. Hernández JC, Arteaga J, Paul S, Kumar A, Latz E, Urcuqui-Inchima S. Up-regulation of TLR2 and TLR4 in dendritic cells in response to HIV type 1 and coinfection with opportunistic pathogens. AIDS Res Hum Retroviruses. 2011 Oct; 27(10):1099-109. PMID: 21406030.
      Citations: 26     Fields:    Translation:HumansAnimalsCells
    218. Ashman RF, Goeken JA, Latz E, Lenert P. Optimal oligonucleotide sequences for TLR9 inhibitory activity in human cells: lack of correlation with TLR9 binding. Int Immunol. 2011 Mar; 23(3):203-14. PMID: 21393636.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    219. Nagpal K, Plantinga TS, Sirois CM, Monks BG, Latz E, Netea MG, Golenbock DT. Natural loss-of-function mutation of myeloid differentiation protein 88 disrupts its ability to form Myddosomes. J Biol Chem. 2011 Apr 01; 286(13):11875-82. PMID: 21325272.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    220. Kim TW, Febbraio M, Robinet P, Dugar B, Greene D, Cerny A, Latz E, Gilmour R, Staschke K, Chisolm G, Fox PL, DiCorleto PE, Smith JD, Li X. The critical role of IL-1 receptor-associated kinase 4-mediated NF-?B activation in modified low-density lipoprotein-induced inflammatory gene expression and atherosclerosis. J Immunol. 2011 Mar 01; 186(5):2871-80. PMID: 21278342.
      Citations: 24     Fields:    Translation:AnimalsCells
    221. Stutz A, Bertheloot D, Latz E. Innate immune receptors for nucleic acids. Methods Mol Biol. 2011; 748:69-82. PMID: 21701967.
      Citations:    Fields:    Translation:HumansCells
    222. Husebye H, Aune MH, Stenvik J, Samstad E, Skjeldal F, Halaas O, Nilsen NJ, Stenmark H, Latz E, Lien E, Mollnes TE, Bakke O, Espevik T. The Rab11a GTPase controls Toll-like receptor 4-induced activation of interferon regulatory factor-3 on phagosomes. Immunity. 2010 Oct 29; 33(4):583-96. PMID: 20933442.
      Citations: 102     Fields:    Translation:HumansCells
    223. Unterholzner L, Keating SE, Baran M, Horan KA, Jensen SB, Sharma S, Sirois CM, Jin T, Latz E, Xiao TS, Fitzgerald KA, Paludan SR, Bowie AG. IFI16 is an innate immune sensor for intracellular DNA. Nat Immunol. 2010 Nov; 11(11):997-1004. PMID: 20890285.
      Citations: 784     Fields:    Translation:HumansAnimalsCells
    224. Latz E. NOX-free inflammasome activation. Blood. 2010 Sep 02; 116(9):1393-4. PMID: 20813905.
      Citations: 19     Fields:    
    225. Kumpf O, Giamarellos-Bourboulis EJ, Koch A, Hamann L, Mouktaroudi M, Oh DY, Latz E, Lorenz E, Schwartz DA, Ferwerda B, Routsi C, Skalioti C, Kullberg BJ, van der Meer JW, Schlag PM, Netea MG, Zacharowski K, Schumann RR. Influence of genetic variations in TLR4 and TIRAP/Mal on the course of sepsis and pneumonia and cytokine release: an observational study in three cohorts. Crit Care. 2010; 14(3):R103. PMID: 20525286.
      Citations: 33     Fields:    Translation:Humans
    226. Kim S, Bauernfeind F, Ablasser A, Hartmann G, Fitzgerald KA, Latz E, Hornung V. Listeria monocytogenes is sensed by the NLRP3 and AIM2 inflammasome. Eur J Immunol. 2010 Jun; 40(6):1545-51. PMID: 20333626.
      Citations: 126     Fields:    Translation:AnimalsCells
    227. Bauer C, Duewell P, Mayer C, Lehr HA, Fitzgerald KA, Dauer M, Tschopp J, Endres S, Latz E, Schnurr M. Colitis induced in mice with dextran sulfate sodium (DSS) is mediated by the NLRP3 inflammasome. Gut. 2010 Sep; 59(9):1192-9. PMID: 20442201.
      Citations: 278     Fields:    Translation:AnimalsCells
    228. Gray P, Michelsen KS, Sirois CM, Lowe E, Shimada K, Crother TR, Chen S, Brikos C, Bulut Y, Latz E, Underhill D, Arditi M. Identification of a novel human MD-2 splice variant that negatively regulates Lipopolysaccharide-induced TLR4 signaling. J Immunol. 2010 Jun 01; 184(11):6359-66. PMID: 20435923.
      Citations: 19     Fields:    Translation:HumansCells
    229. Duewell P, Kono H, Rayner KJ, Sirois CM, Vladimer G, Bauernfeind FG, Abela GS, Franchi L, Nuñez G, Schnurr M, Espevik T, Lien E, Fitzgerald KA, Rock KL, Moore KJ, Wright SD, Hornung V, Latz E. NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals. Nature. 2010 Apr 29; 464(7293):1357-61. PMID: 20428172.
      Citations: 1399     Fields:    Translation:HumansAnimalsCells
    230. Rathinam VA, Jiang Z, Waggoner SN, Sharma S, Cole LE, Waggoner L, Vanaja SK, Monks BG, Ganesan S, Latz E, Hornung V, Vogel SN, Szomolanyi-Tsuda E, Fitzgerald KA. The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses. Nat Immunol. 2010 May; 11(5):395-402. PMID: 20351692.
      Citations: 622     Fields:    Translation:HumansAnimalsCells
    231. Hornung V, Latz E. Critical functions of priming and lysosomal damage for NLRP3 activation. Eur J Immunol. 2010 Mar; 40(3):620-3. PMID: 20201015.
      Citations: 125     Fields:    Translation:HumansAnimalsCells
    232. Klein DC, Latz E, Espevik T, Stokke BT. Higher order structure of short immunostimulatory oligonucleotides studied by atomic force microscopy. Ultramicroscopy. 2010 May; 110(6):689-93. PMID: 20202756.
      Citations: 11     Fields:    Translation:Cells
    233. Gantier MP, Tong S, Behlke MA, Irving AT, Lappas M, Nilsson UW, Latz E, McMillan NA, Williams BR. Rational design of immunostimulatory siRNAs. Mol Ther. 2010 Apr; 18(4):785-95. PMID: 20125126.
      Citations: 30     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    234. Hornung V, Latz E. Intracellular DNA recognition. Nat Rev Immunol. 2010 Feb; 10(2):123-30. PMID: 20098460.
      Citations: 171     Fields:    Translation:HumansAnimalsCells
    235. Juliana C, Fernandes-Alnemri T, Wu J, Datta P, Solorzano L, Yu JW, Meng R, Quong AA, Latz E, Scott CP, Alnemri ES. Anti-inflammatory compounds parthenolide and Bay 11-7082 are direct inhibitors of the inflammasome. J Biol Chem. 2010 Mar 26; 285(13):9792-9802. PMID: 20093358.
      Citations: 210     Fields:    Translation:HumansAnimalsCells
    236. Latz E. The inflammasomes: mechanisms of activation and function. Curr Opin Immunol. 2010 Feb; 22(1):28-33. PMID: 20060699.
      Citations: 185     Fields:    Translation:HumansAnimalsCells
    237. Rock KL, Latz E, Ontiveros F, Kono H. The sterile inflammatory response. Annu Rev Immunol. 2010; 28:321-42. PMID: 20307211.
      Citations: 327     Fields:    Translation:HumansAnimalsCells
    238. Stutz A, Golenbock DT, Latz E. Inflammasomes: too big to miss. J Clin Invest. 2009 Dec; 119(12):3502-11. PMID: 19955661.
      Citations: 149     Fields:    Translation:HumansAnimalsCells
    239. Liehl P, França AR, Prudêncio M, Latz E, Zaidman-Rémy A, Mota MM. Phosphothioate oligodeoxynucleotides inhibit Plasmodium sporozoite gliding motility. Cell Microbiol. 2010 Apr 01; 12(4):506-15. PMID: 19912239.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    240. Avalos AM, Latz E, Mousseau B, Christensen SR, Shlomchik MJ, Lund F, Marshak-Rothstein A. Differential cytokine production and bystander activation of autoreactive B cells in response to CpG-A and CpG-B oligonucleotides. J Immunol. 2009 Nov 15; 183(10):6262-8. PMID: 19864612.
      Citations: 21     Fields:    Translation:AnimalsCells
    241. Hamm S, Latz E, Hangel D, Müller T, Yu P, Golenbock D, Sparwasser T, Wagner H, Bauer S. Alternating 2'-O-ribose methylation is a universal approach for generating non-stimulatory siRNA by acting as TLR7 antagonist. Immunobiology. 2010 Jul; 215(7):559-69. PMID: 19854535.
      Citations: 38     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    242. Ablasser A, Bauernfeind F, Hartmann G, Latz E, Fitzgerald KA, Hornung V. RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III-transcribed RNA intermediate. Nat Immunol. 2009 Oct; 10(10):1065-72. PMID: 19609254.
      Citations: 425     Fields:    Translation:HumansAnimalsCells
    243. Motshwene PG, Moncrieffe MC, Grossmann JG, Kao C, Ayaluru M, Sandercock AM, Robinson CV, Latz E, Gay NJ. An oligomeric signaling platform formed by the Toll-like receptor signal transducers MyD88 and IRAK-4. J Biol Chem. 2009 Sep 11; 284(37):25404-11. PMID: 19592493.
      Citations: 159     Fields:    Translation:HumansCells
    244. Schlee M, Roth A, Hornung V, Hagmann CA, Wimmenauer V, Barchet W, Coch C, Janke M, Mihailovic A, Wardle G, Juranek S, Kato H, Kawai T, Poeck H, Fitzgerald KA, Takeuchi O, Akira S, Tuschl T, Latz E, Ludwig J, Hartmann G. Recognition of 5' triphosphate by RIG-I helicase requires short blunt double-stranded RNA as contained in panhandle of negative-strand virus. Immunity. 2009 Jul 17; 31(1):25-34. PMID: 19576794.
      Citations: 356     Fields:    Translation:HumansAnimalsCells
    245. Bauernfeind FG, Horvath G, Stutz A, Alnemri ES, MacDonald K, Speert D, Fernandes-Alnemri T, Wu J, Monks BG, Fitzgerald KA, Hornung V, Latz E. Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression. J Immunol. 2009 Jul 15; 183(2):787-91. PMID: 19570822.
      Citations: 1052     Fields:    Translation:HumansAnimalsCells
    246. Hornung V, Ablasser A, Charrel-Dennis M, Bauernfeind F, Horvath G, Caffrey DR, Latz E, Fitzgerald KA. AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC. Nature. 2009 Mar 26; 458(7237):514-8. PMID: 19158675.
      Citations: 1088     Fields:    Translation:HumansAnimalsCells
    247. Horvath G, Young S, Latz E. Toll-like receptor interactions imaged by FRET microscopy and GFP fragment reconstitution. Methods Mol Biol. 2009; 517:33-54. PMID: 19378018.
      Citations: 2     Fields:    Translation:AnimalsCells
    248. Charrel-Dennis M, Latz E, Halmen KA, Trieu-Cuot P, Fitzgerald KA, Kasper DL, Golenbock DT. TLR-independent type I interferon induction in response to an extracellular bacterial pathogen via intracellular recognition of its DNA. Cell Host Microbe. 2008 Dec 11; 4(6):543-54. PMID: 19064255.
      Citations: 77     Fields:    Translation:AnimalsCells
    249. Bartholomeu DC, Ropert C, Melo MB, Parroche P, Junqueira CF, Teixeira SM, Sirois C, Kasperkovitz P, Knetter CF, Lien E, Latz E, Golenbock DT, Gazzinelli RT. Recruitment and endo-lysosomal activation of TLR9 in dendritic cells infected with Trypanosoma cruzi. J Immunol. 2008 Jul 15; 181(2):1333-44. PMID: 18606688.
      Citations: 34     Fields:    Translation:HumansAnimalsCells
    250. Halle A, Hornung V, Petzold GC, Stewart CR, Monks BG, Reinheckel T, Fitzgerald KA, Latz E, Moore KJ, Golenbock DT. The NALP3 inflammasome is involved in the innate immune response to amyloid-beta. Nat Immunol. 2008 Aug; 9(8):857-65. PMID: 18604209.
      Citations: 1005     Fields:    
    251. Hornung V, Bauernfeind F, Halle A, Samstad EO, Kono H, Rock KL, Fitzgerald KA, Latz E. Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization. Nat Immunol. 2008 Aug; 9(8):847-56. PMID: 18604214.
      Citations: 1220     Fields:    Translation:AnimalsCells
    252. Tamehiro N, Zhou S, Okuhira K, Benita Y, Brown CE, Zhuang DZ, Latz E, Hornemann T, von Eckardstein A, Xavier RJ, Freeman MW, Fitzgerald ML. SPTLC1 binds ABCA1 to negatively regulate trafficking and cholesterol efflux activity of the transporter. Biochemistry. 2008 Jun 10; 47(23):6138-47. PMID: 18484747.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    253. Williams B, Vanags D, Hall S, McCormack C, Foley P, Weiss J, Johnson B, Latz E, Feeney D. Efficacy and safety of chaperonin 10 in patients with moderate to severe plaque psoriasis: evidence of utility beyond a single indication. Arch Dermatol. 2008 May; 144(5):683-5. PMID: 18490603.
      Citations: 9     Fields:    Translation:Humans
    254. Haas T, Metzger J, Schmitz F, Heit A, Müller T, Latz E, Wagner H. The DNA sugar backbone 2' deoxyribose determines toll-like receptor 9 activation. Immunity. 2008 Mar; 28(3):315-23. PMID: 18342006.
      Citations: 119     Fields:    Translation:HumansAnimalsCells
    255. Asagiri M, Hirai T, Kunigami T, Kamano S, Gober HJ, Okamoto K, Nishikawa K, Latz E, Golenbock DT, Aoki K, Ohya K, Imai Y, Morishita Y, Miyazono K, Kato S, Saftig P, Takayanagi H. Cathepsin K-dependent toll-like receptor 9 signaling revealed in experimental arthritis. Science. 2008 Feb 01; 319(5863):624-7. PMID: 18239127.
      Citations: 121     Fields:    Translation:AnimalsCells
    256. Latz E, Verma A, Visintin A, Gong M, Sirois CM, Klein DC, Monks BG, McKnight CJ, Lamphier MS, Duprex WP, Espevik T, Golenbock DT. Ligand-induced conformational changes allosterically activate Toll-like receptor 9. Nat Immunol. 2007 Jul; 8(7):772-9. PMID: 17572678.
      Citations: 154     Fields:    Translation:HumansCells
    257. Tian J, Avalos AM, Mao SY, Chen B, Senthil K, Wu H, Parroche P, Drabic S, Golenbock D, Sirois C, Hua J, An LL, Audoly L, La Rosa G, Bierhaus A, Naworth P, Marshak-Rothstein A, Crow MK, Fitzgerald KA, Latz E, Kiener PA, Coyle AJ. Toll-like receptor 9-dependent activation by DNA-containing immune complexes is mediated by HMGB1 and RAGE. Nat Immunol. 2007 May; 8(5):487-96. PMID: 17417641.
      Citations: 602     Fields:    Translation:AnimalsCells
    258. Parroche P, Lauw FN, Goutagny N, Latz E, Monks BG, Visintin A, Halmen KA, Lamphier M, Olivier M, Bartholomeu DC, Gazzinelli RT, Golenbock DT. Malaria hemozoin is immunologically inert but radically enhances innate responses by presenting malaria DNA to Toll-like receptor 9. Proc Natl Acad Sci U S A. 2007 Feb 06; 104(6):1919-24. PMID: 17261807.
      Citations: 242     Fields:    Translation:HumansAnimals
    259. Wang JP, Liu P, Latz E, Golenbock DT, Finberg RW, Libraty DH. Flavivirus activation of plasmacytoid dendritic cells delineates key elements of TLR7 signaling beyond endosomal recognition. J Immunol. 2006 Nov 15; 177(10):7114-21. PMID: 17082628.
      Citations: 88     Fields:    Translation:HumansAnimalsCells
    260. Lamphier MS, Sirois CM, Verma A, Golenbock DT, Latz E. TLR9 and the recognition of self and non-self nucleic acids. Ann N Y Acad Sci. 2006 Oct; 1082:31-43. PMID: 17145922.
      Citations: 45     Fields:    Translation:HumansCells
    261. Yu M, Wang H, Ding A, Golenbock DT, Latz E, Czura CJ, Fenton MJ, Tracey KJ, Yang H. HMGB1 signals through toll-like receptor (TLR) 4 and TLR2. Shock. 2006 Aug; 26(2):174-9. PMID: 16878026.
      Citations: 365     Fields:    Translation:HumansAnimalsCells
    262. Rowe DC, McGettrick AF, Latz E, Monks BG, Gay NJ, Yamamoto M, Akira S, O'Neill LA, Fitzgerald KA, Golenbock DT. The myristoylation of TRIF-related adaptor molecule is essential for Toll-like receptor 4 signal transduction. Proc Natl Acad Sci U S A. 2006 Apr 18; 103(16):6299-304. PMID: 16603631.
      Citations: 85     Fields:    Translation:HumansAnimalsCells
    263. Mansour MK, Latz E, Levitz SM. Cryptococcus neoformans glycoantigens are captured by multiple lectin receptors and presented by dendritic cells. J Immunol. 2006 Mar 01; 176(5):3053-61. PMID: 16493064.
      Citations: 58     Fields:    Translation:HumansAnimalsCells
    264. Husebye H, Halaas Ø, Stenmark H, Tunheim G, Sandanger Ø, Bogen B, Brech A, Latz E, Espevik T. Endocytic pathways regulate Toll-like receptor 4 signaling and link innate and adaptive immunity. EMBO J. 2006 Feb 22; 25(4):683-92. PMID: 16467847.
      Citations: 196     Fields:    Translation:HumansCells
    265. Mann PB, Wolfe D, Latz E, Golenbock D, Preston A, Harvill ET. Comparative toll-like receptor 4-mediated innate host defense to Bordetella infection. Infect Immun. 2005 Dec; 73(12):8144-52. PMID: 16299309.
      Citations: 37     Fields:    Translation:HumansAnimalsCells
    266. Visintin A, Halmen KA, Latz E, Monks BG, Golenbock DT. Pharmacological inhibition of endotoxin responses is achieved by targeting the TLR4 coreceptor, MD-2. J Immunol. 2005 Nov 15; 175(10):6465-72. PMID: 16272300.
      Citations: 50     Fields:    Translation:HumansCells
    267. Means TK, Latz E, Hayashi F, Murali MR, Golenbock DT, Luster AD. Human lupus autoantibody-DNA complexes activate DCs through cooperation of CD32 and TLR9. J Clin Invest. 2005 Feb; 115(2):407-17. PMID: 15668740.
      Citations: 284     Fields:    Translation:HumansCells
    268. Schoenemeyer A, Barnes BJ, Mancl ME, Latz E, Goutagny N, Pitha PM, Fitzgerald KA, Golenbock DT. The interferon regulatory factor, IRF5, is a central mediator of toll-like receptor 7 signaling. J Biol Chem. 2005 Apr 29; 280(17):17005-12. PMID: 15695821.
      Citations: 165     Fields:    Translation:HumansCells
    269. DiPerna G, Stack J, Bowie AG, Boyd A, Kotwal G, Zhang Z, Arvikar S, Latz E, Fitzgerald KA, Marshall WL. Poxvirus protein N1L targets the I-kappaB kinase complex, inhibits signaling to NF-kappaB by the tumor necrosis factor superfamily of receptors, and inhibits NF-kappaB and IRF3 signaling by toll-like receptors. J Biol Chem. 2004 Aug 27; 279(35):36570-8. PMID: 15215253.
      Citations: 124     Fields:    Translation:HumansCells
    270. Latz E, Franko J, Golenbock DT, Schreiber JR. Haemophilus influenzae type b-outer membrane protein complex glycoconjugate vaccine induces cytokine production by engaging human toll-like receptor 2 (TLR2) and requires the presence of TLR2 for optimal immunogenicity. J Immunol. 2004 Feb 15; 172(4):2431-8. PMID: 14764714.
      Citations: 44     Fields:    Translation:HumansAnimalsCells
    271. Latz E, Schoenemeyer A, Visintin A, Fitzgerald KA, Monks BG, Knetter CF, Lien E, Nilsen NJ, Espevik T, Golenbock DT. TLR9 signals after translocating from the ER to CpG DNA in the lysosome. Nat Immunol. 2004 Feb; 5(2):190-8. PMID: 14716310.
      Citations: 462     Fields:    Translation:HumansAnimalsCells
    272. Latz E, Visintin A, Espevik T, Golenbock DT. Mechanisms of TLR9 activation. J Endotoxin Res. 2004; 10(6):406-12. PMID: 15588423.
      Citations: 22     Fields:    Translation:HumansCells
    273. Latz E, Golenbock DT. Receptor "cross talk" in innate immunity. J Clin Invest. 2003 Oct; 112(8):1136-7. PMID: 14561697.
      Citations: 5     Fields:    Translation:AnimalsCells
    274. Fitzgerald KA, Rowe DC, Barnes BJ, Caffrey DR, Visintin A, Latz E, Monks B, Pitha PM, Golenbock DT. LPS-TLR4 signaling to IRF-3/7 and NF-kappaB involves the toll adapters TRAM and TRIF. J Exp Med. 2003 Oct 06; 198(7):1043-55. PMID: 14517278.
      Citations: 393     Fields:    Translation:HumansAnimalsCells
    275. Sandor F, Latz E, Re F, Mandell L, Repik G, Golenbock DT, Espevik T, Kurt-Jones EA, Finberg RW. Importance of extra- and intracellular domains of TLR1 and TLR2 in NFkappa B signaling. J Cell Biol. 2003 Sep 15; 162(6):1099-110. PMID: 12975352.
      Citations: 36     Fields:    Translation:HumansCells
    276. Visintin A, Latz E, Monks BG, Espevik T, Golenbock DT. Lysines 128 and 132 enable lipopolysaccharide binding to MD-2, leading to Toll-like receptor-4 aggregation and signal transduction. J Biol Chem. 2003 Nov 28; 278(48):48313-20. PMID: 12960171.
      Citations: 63     Fields:    Translation:HumansCells
    277. Sau K, Mambula SS, Latz E, Henneke P, Golenbock DT, Levitz SM. The antifungal drug amphotericin B promotes inflammatory cytokine release by a Toll-like receptor- and CD14-dependent mechanism. J Biol Chem. 2003 Sep 26; 278(39):37561-8. PMID: 12860979.
      Citations: 61     Fields:    Translation:HumansCells
    278. Hohenberger P, Latz E, Kettelhack C, Rezaei AH, Schumann R, Schlag PM. Pentoxifyllin attenuates the systemic inflammatory response induced during isolated limb perfusion with recombinant human tumor necrosis factor-alpha and melphalan. Ann Surg Oncol. 2003 Jun; 10(5):562-8. PMID: 12794024.
      Citations: 5     Fields:    Translation:HumansCTClinical Trials
    279. Fitzgerald KA, McWhirter SM, Faia KL, Rowe DC, Latz E, Golenbock DT, Coyle AJ, Liao SM, Maniatis T. IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway. Nat Immunol. 2003 May; 4(5):491-6. PMID: 12692549.
      Citations: 1031     Fields:    Translation:HumansCells
    280. Compton T, Kurt-Jones EA, Boehme KW, Belko J, Latz E, Golenbock DT, Finberg RW. Human cytomegalovirus activates inflammatory cytokine responses via CD14 and Toll-like receptor 2. J Virol. 2003 Apr; 77(8):4588-96. PMID: 12663765.
      Citations: 258     Fields:    Translation:HumansAnimalsCells
    281. Espevik T, Latz E, Lien E, Monks B, Golenbock DT. Cell distributions and functions of Toll-like receptor 4 studied by fluorescent gene constructs. Scand J Infect Dis. 2003; 35(9):660-4. PMID: 14620151.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    282. Latz E, Visintin A, Lien E, Fitzgerald KA, Espevik T, Golenbock DT. The LPS receptor generates inflammatory signals from the cell surface. J Endotoxin Res. 2003; 9(6):375-80. PMID: 14733724.
      Citations: 16     Fields:    Translation:HumansCells
    283. van der Kleij D, Latz E, Brouwers JF, Kruize YC, Schmitz M, Kurt-Jones EA, Espevik T, de Jong EC, Kapsenberg ML, Golenbock DT, Tielens AG, Yazdanbakhsh M. A novel host-parasite lipid cross-talk. Schistosomal lyso-phosphatidylserine activates toll-like receptor 2 and affects immune polarization. J Biol Chem. 2002 Dec 13; 277(50):48122-9. PMID: 12359728.
      Citations: 190     Fields:    Translation:HumansAnimalsCells
    284. Latz E, Visintin A, Lien E, Fitzgerald KA, Monks BG, Kurt-Jones EA, Golenbock DT, Espevik T. Lipopolysaccharide rapidly traffics to and from the Golgi apparatus with the toll-like receptor 4-MD-2-CD14 complex in a process that is distinct from the initiation of signal transduction. J Biol Chem. 2002 Dec 06; 277(49):47834-43. PMID: 12324469.
      Citations: 150     Fields:    Translation:HumansCells
    285. Flo TH, Ryan L, Latz E, Takeuchi O, Monks BG, Lien E, Halaas Ø, Akira S, Skjåk-Braek G, Golenbock DT, Espevik T. Involvement of toll-like receptor (TLR) 2 and TLR4 in cell activation by mannuronic acid polymers. J Biol Chem. 2002 Sep 20; 277(38):35489-95. PMID: 12089142.
      Citations: 42     Fields:    Translation:HumansAnimalsCells
    286. Massari P, Henneke P, Ho Y, Latz E, Golenbock DT, Wetzler LM. Cutting edge: Immune stimulation by neisserial porins is toll-like receptor 2 and MyD88 dependent. J Immunol. 2002 Feb 15; 168(4):1533-7. PMID: 11823477.
      Citations: 107     Fields:    Translation:HumansAnimalsCells
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