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Katherine A Fitzgerald PhD

Endowed TitleWorcester Foundation for Biomedical Research Chair III
InstitutionUMass Chan Medical School
AddressUMass Chan Medical School
364 Plantation Street LRB
Worcester MA 01605
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    Other Positions
    InstitutionT.H. Chan School of Medicine
    DivisionInfectious Diseases And Immunology

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentImmunology and Microbiology Program

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentInterdisciplinary Graduate Program

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentMD/PhD Program

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentPostbaccalaureate Research Education Program

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentTranslational Science

    Collapse Biography 
    Collapse education and training
    University College, Cork, Cork, , IrelandB SCBiochemistry
    Trinity College, Dublin, , IrelandPHDBiochemistry
    Collapse awards and honors
    2014BD-Investigator Award, American Association of Immunologists
    2014Eli Lilly and Elanco Company Award, American Association of Microbiologists
    2014The Milstein Award for Excellence in Interferon and Cytokine research , International Cytokine and Interferon Society
    2015Saint Patricks Day Medal, Irish Government and Science Foundation Ireland
    2018Alumni Achievement Award, University College Cork, Ireland
    2018Women in Science and Health Achievement Award, University of Massachusetts Medical School
    2020Elected Fellow, American Academy of Microbiology
    2020Elected member, Royal Irish Academy
    2021Elected Member, National Academy of Sciences
    2021Elected member, National Academy of Medicine
    2022Thermofischer Meritorious Career Award, American Association of Immunologists

    Collapse Overview 
    Collapse overview


    Dr. Fitzgerald is Professor and Vice Chair of Medicine, Chief of the Division of Innate Immunity, and the Worcester Foundation in Biomedical Sciences Research Chair. Dr. Fitzgerald completed all of her education in Ireland. She received her B.Sc. in Biochemistry in 1995 from University College Cork, Ireland and her PhD in Biochemistry in 1999 from Trinity College Dublin, Ireland. After pursing a post-doctoral fellowship at Trinity College Dublin, she joined UMass Chan as Instructor and is currently a tenured Professor.

    Dr. Fitzgerald is an elected fellow of the American Society of Microbiology and an elected member of the Royal Irish Academy, the National Academy of Sciences (USA) and the National Academy of Medicine (USA). She is the recipient of several awards including the  Thermo-Fischer Meritorious Career Award (from the American Association of Immunology), the Saint Patrick’s Day Medal (from the Irish Government and Science Foundation Ireland) and the Milstein Award for Excellence in Interferon and Cytokine research (from the International Cytokine and Interferon Society), amongst others.

    She has extensive service both locally at UMass Chan and nationally including service on local and national advisory boards (e.g., Massachusetts Center For Pathogen Readiness, NIAID Board of Scientific Councillors, Burroughs Wellcome Fund Pathogenesis of Infectious Diseases and the Cancer Research Institute). She was also the recent past President of the International Cytokine and Interferon Society.

    Research Information  Katherine PhotoHer work is focused on the innate immune system aimed at understanding the molecular basis of the inflammatory response during Infection and in inflammatory diseases. In particular her group studies nucleic acid sensors, inflammasomes as well as long non-coding RNAs in immunity and inflammation. The long-term goal of her work is to determine how innate immune sensing and signaling contribute to infectious, inflammatory, and autoimmune diseases in humans.


    Collapse Rotation Projects
    Please email Kate.Fitzgerald@umassmed.edu if you are interested in rotations.

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Shmuel-Galia L, Humphries F, Vierbuchen T, Jiang Z, Santos N, Johnson J, Shklyar B, Joannas L, Mustone N, Sherman S, Ward D, Houghton J, Baer CE, O'Hara A, Henao-Mejia J, Hoebe K, Fitzgerald KA. The lncRNA HOXA11os regulates mitochondrial function in myeloid cells to maintain intestinal homeostasis. Cell Metab. 2023 08 08; 35(8):1441-1456.e9. PMID: 37494932.
      Citations:    Fields:    Translation:AnimalsCells
    2. Gao KM, Fitzgerald KA. ERADication of STING limits inflammation. Nat Cell Biol. 2023 05; 25(5):635-636. PMID: 37142792.
      Citations:    Fields:    Translation:HumansCells
    3. MacLauchlan S, Kushwaha P, Tai A, Chen S, Manning C, Swarnkar G, Abu-Amer Y, Fitzgerald KA, Sharma S, Gravallese EM. STING-dependent interferon signatures restrict osteoclast differentiation and bone loss in mice. Proc Natl Acad Sci U S A. 2023 04 11; 120(15):e2210409120. PMID: 37023130.
      Citations: 1     Fields:    Translation:AnimalsCells
    4. Hariharan VN, Shin M, Chang CW, O'Reilly D, Biscans A, Yamada K, Guo Z, Somasundaran M, Tang Q, Monopoli K, Krishnamurthy PM, Devi G, McHugh N, Cooper DA, Echeverria D, Cruz J, Chan IL, Liu P, Lim SY, McConnell J, Singh SP, Hildebrand S, Sousa J, Davis SM, Kennedy Z, Ferguson C, Godinho BMDC, Thillier Y, Caiazzi J, Ly S, Muhuri M, Kelly K, Humphries F, Cousineau A, Parsi KM, Li Q, Wang Y, Maehr R, Gao G, Korkin D, McDougall WM, Finberg RW, Fitzgerald KA, Wang JP, Watts JK, Khvorova A. Divalent siRNAs are bioavailable in the lung and efficiently block SARS-CoV-2 infection. Proc Natl Acad Sci U S A. 2023 03 14; 120(11):e2219523120. PMID: 36893269.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    5. Lei X, Chen Y, Lien E, Fitzgerald KA. MLKL-Driven Inflammasome Activation and Caspase-8 Mediate Inflammatory Cell Death in Influenza A Virus Infection. mBio. 2023 04 25; 14(2):e0011023. PMID: 36852999.
      Citations: 2     Fields:    Translation:HumansCells
    6. Kelliher MA, Fitzgerald KA. TBK1 inhibition unleashes RIPK1, resensitizing tumors to immunotherapy. Trends Immunol. 2023 03; 44(3):156-158. PMID: 36740513.
      Citations:    Fields:    Translation:Humans
    7. Zhou JY, Sarkar MK, Okamura K, Harris JE, Gudjonsson JE, Fitzgerald KA. Activation of the NLRP1 inflammasome in human keratinocytes by the dsDNA mimetic poly(dA:dT). Proc Natl Acad Sci U S A. 2023 01 31; 120(5):e2213777120. PMID: 36693106.
      Citations: 3     Fields:    Translation:HumansCells
    8. Gao KM, Marshak-Rothstein A, Fitzgerald KA. Type-1 interferon-dependent and -independent mechanisms in cyclic GMP-AMP synthase-stimulator of interferon genes-driven auto-inflammation. Curr Opin Immunol. 2023 02; 80:102280. PMID: 36638547.
      Citations: 1     Fields:    Translation:Animals
    9. Collins CC, Hahn P, Jiang Z, Fitzgerald KA, Xiao TS, Budd RC. Regulation of Synovial ?d T Cell Ligand Expression by Mitochondrial Reactive Oxygen Species and Gasdermin-D. J Immunol. 2023 01 01; 210(1):61-71. PMID: 36445376.
      Citations: 1     Fields:    Translation:HumansCells
    10. Vierbuchen T, Agarwal S, Johnson JL, Galia L, Lei X, Stein K, Olagnier D, Gaede KI, Herzmann C, Holm CK, Heine H, Pai A, O'Hara Hall A, Hoebe K, Fitzgerald KA. The lncRNA LUCAT1 is elevated in inflammatory disease and restrains inflammation by regulating the splicing and stability of NR4A2. Proc Natl Acad Sci U S A. 2023 01 03; 120(1):e2213715120. PMID: 36577072.
      Citations: 3     Fields:    Translation:HumansCells
    11. Mondal S, Chen Y, Lockbaum GJ, Sen S, Chaudhuri S, Reyes AC, Lee JM, Kaur AN, Sultana N, Cameron MD, Shaffer SA, Schiffer CA, Fitzgerald KA, Thompson PR. Dual Inhibitors of Main Protease (MPro) and Cathepsin L as Potent Antivirals against SARS-CoV2. J Am Chem Soc. 2022 11 23; 144(46):21035-21045. PMID: 36356199.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    12. Li Z, Zhou P, Kwon E, Fitzgerald KA, Weng Z, Zhou C. Flnc: Machine Learning Improves the Identification of Novel Long Noncoding RNAs from Stand-Alone RNA-Seq Data. Noncoding RNA. 2022 Oct 13; 8(5). PMID: 36287122.
    13. MacLauchlan S, Fitzgerald KA, Gravallese EM. Intracellular Sensing of DNA in Autoinflammation and Autoimmunity. Arthritis Rheumatol. 2022 10; 74(10):1615-1624. PMID: 35656967.
      Citations: 2     Fields:    Translation:HumansAnimals
    14. Foley SE, Dente MJ, Lei X, Sallis BF, Loew EB, Meza-Segura M, Fitzgerald KA, McCormick BA. Microbial Metabolites Orchestrate a Distinct Multi-Tiered Regulatory Network in the Intestinal Epithelium That Directs P-Glycoprotein Expression. mBio. 2022 08 30; 13(4):e0199322. PMID: 35968955.
      Citations: 3     Fields:    Translation:Animals
    15. Zhou JY, Fitzgerald KA. Hold your horses! Reining in your fastest pores with caspase-7. Immunity. 2022 08 09; 55(8):1340-1342. PMID: 35947978.
      Citations:    Fields:    Translation:Cells
    16. Lei X, Ketelut-Carneiro N, Shmuel-Galia L, Xu W, Wilson R, Vierbuchen T, Chen Y, Reboldi A, Kang J, Edelblum KL, Ward D, Fitzgerald KA. Epithelial HNF4A shapes the intraepithelial lymphocyte compartment via direct regulation of immune signaling molecules. J Exp Med. 2022 08 01; 219(8). PMID: 35792863.
      Citations: 6     Fields:    Translation:AnimalsCells
    17. Gao KM, Motwani M, Tedder T, Marshak-Rothstein A, Fitzgerald KA. Radioresistant cells initiate lymphocyte-dependent lung inflammation and IFN?-dependent mortality in STING gain-of-function mice. Proc Natl Acad Sci U S A. 2022 06 21; 119(25):e2202327119. PMID: 35696583.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    18. Crabtree JN, Caffrey DR, de Souza Silva L, Kurt-Jones EA, Dobbs K, Dent A, Fitzgerald KA, Golenbock DT. Lymphocyte crosstalk is required for monocyte-intrinsic trained immunity to Plasmodium falciparum. J Clin Invest. 2022 06 01; 132(11). PMID: 35642634.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    19. Jabara HH, McDonald DR, Janssen E, Massaad MJ, Ramesh N, Borzutzky A, Rauter I, Benson H, Schneider L, Baxi S, Recher M, Notarangelo LD, Wakim R, Dbaibo G, Dasouki M, Al-Herz W, Barlan I, Baris S, Kutukculer N, Ochs HD, Plebani A, Kanariou M, Lefranc G, Reisli I, Fitzgerald KA, Golenbock D, Manis J, Keles S, Ceja R, Chatila TA, Geha RS. Author Correction: DOCK8 functions as an adaptor that links TLR-MyD88 signaling to B cell activation. Nat Immunol. 2022 May; 23(5):815. PMID: 35332329.
      Citations:    Fields:    
    20. Ketelut-Carneiro N, Fitzgerald KA. Apoptosis, Pyroptosis, and Necroptosis-Oh My! The Many Ways a Cell Can Die. J Mol Biol. 2022 02 28; 434(4):167378. PMID: 34838807.
      Citations: 27     Fields:    Translation:HumansAnimals
    21. Kiritsy MC, Ankley LM, Trombley J, Huizinga GP, Lord AE, Orning P, Elling R, Fitzgerald KA, Olive AJ. A genetic screen in macrophages identifies new regulators of IFN?-inducible MHCII that contribute to T cell activation. Elife. 2021 11 08; 10. PMID: 34747695.
      Citations: 8     Fields:    Translation:AnimalsCells
    22. Humphries F, Fitzgerald KA. Igniting the firestorm: The inflammasome in autoinflammatory syndromes. J Allergy Clin Immunol. 2021 12; 148(6):1470-1472. PMID: 34403657.
      Citations:    Fields:    Translation:HumansAnimalsCells
    23. Fukuda K, Okamura K, Riding RL, Fan X, Afshari K, Haddadi NS, McCauley SM, Guney MH, Luban J, Funakoshi T, Yaguchi T, Kawakami Y, Khvorova A, Fitzgerald KA, Harris JE. AIM2 regulates anti-tumor immunity and is a viable therapeutic target for melanoma. J Exp Med. 2021 09 06; 218(9). PMID: 34325468.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    24. Chen Y, Lei X, Jiang Z, Fitzgerald KA. Cellular nucleic acid-binding protein is essential for type I interferon-mediated immunity to RNA virus infection. Proc Natl Acad Sci U S A. 2021 06 29; 118(26). PMID: 34168080.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    25. Shmuel-Galia L, Humphries F, Lei X, Ceglia S, Wilson R, Jiang Z, Ketelut-Carneiro N, Foley SE, Pechhold S, Houghton J, Muneeruddin K, Shaffer SA, McCormick BA, Reboldi A, Ward D, Marshak-Rothstein A, Fitzgerald KA. Dysbiosis exacerbates colitis by promoting ubiquitination and accumulation of the innate immune adaptor STING in myeloid cells. Immunity. 2021 06 08; 54(6):1137-1153.e8. PMID: 34051146.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    26. Motwani M, McGowan J, Antonovitch J, Gao KM, Jiang Z, Sharma S, Baltus GA, Nickerson KM, Marshak-Rothstein A, Fitzgerald KA. cGAS-STING Pathway Does Not Promote Autoimmunity in Murine Models of SLE. Front Immunol. 2021; 12:605930. PMID: 33854495.
      Citations: 17     Fields:    Translation:AnimalsCells
    27. Muhuri M, Maeda Y, Ma H, Ram S, Fitzgerald KA, Tai PW, Gao G. Overcoming innate immune barriers that impede AAV gene therapy vectors. J Clin Invest. 2021 01 04; 131(1). PMID: 33393506.
      Citations: 33     Fields:    Translation:HumansAnimalsCells
    28. Agarwal S, Vierbuchen T, Ghosh S, Chan J, Jiang Z, Kandasamy RK, Ricci E, Fitzgerald KA. The long non-coding RNA LUCAT1 is a negative feedback regulator of interferon responses in humans. Nat Commun. 2020 12 11; 11(1):6348. PMID: 33311506.
      Citations: 33     Fields:    Translation:HumansAnimalsCells
    29. Humphries F, Fitzgerald KA. Loosening the grip on nuclear cGAS. Nat Genet. 2020 12; 52(12):1269-1270. PMID: 33230301.
      Citations:    Fields:    Translation:Cells
    30. Pereira LMN, Assis PA, de Ara?jo NM, Durso DF, Junqueira C, Ata?de MA, Pereira DB, Lien E, Fitzgerald KA, Zamboni DS, Golenbock DT, Gazzinelli RT. Author Correction: Caspase-8 mediates inflammation and disease in rodent malaria. Nat Commun. 2020 Nov 03; 11(1):5673. PMID: 33144583.
      Citations: 1     Fields:    
    31. Magupalli VG, Negro R, Tian Y, Hauenstein AV, Di Caprio G, Skillern W, Deng Q, Orning P, Alam HB, Maliga Z, Sharif H, Hu JJ, Evavold CL, Kagan JC, Schmidt FI, Fitzgerald KA, Kirchhausen T, Li Y, Wu H. HDAC6 mediates an aggresome-like mechanism for NLRP3 and pyrin inflammasome activation. Science. 2020 09 18; 369(6510). PMID: 32943500.
      Citations: 95     Fields:    Translation:HumansAnimalsCells
    32. Pereira LMN, Assis PA, de Ara?jo NM, Durso DF, Junqueira C, Ata?de MA, Pereira DB, Lien E, Fitzgerald KA, Zamboni DS, Golenbock DT, Gazzinelli RT. Caspase-8 mediates inflammation and disease in rodent malaria. Nat Commun. 2020 09 14; 11(1):4596. PMID: 32929083.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    33. Humphries F, Shmuel-Galia L, Ketelut-Carneiro N, Li S, Wang B, Nemmara VV, Wilson R, Jiang Z, Khalighinejad F, Muneeruddin K, Shaffer SA, Dutta R, Ionete C, Pesiridis S, Yang S, Thompson PR, Fitzgerald KA. Succination inactivates gasdermin D and blocks pyroptosis. Science. 2020 09 25; 369(6511):1633-1637. PMID: 32820063.
      Citations: 164     Fields:    Translation:HumansAnimalsCells
    34. Balic JJ, Albargy H, Luu K, Kirby FJ, Jayasekara WSN, Mansell F, Garama DJ, De Nardo D, Baschuk N, Louis C, Humphries F, Fitzgerald K, Latz E, Gough DJ, Mansell A. STAT3 serine phosphorylation is required for TLR4 metabolic reprogramming and IL-1? expression. Nat Commun. 2020 07 30; 11(1):3816. PMID: 32732870.
      Citations: 37     Fields:    Translation:AnimalsCells
    35. Vierbuchen T, Fitzgerald KA. Long non-coding RNAs in antiviral immunity. Semin Cell Dev Biol. 2021 03; 111:126-134. PMID: 32580911.
      Citations: 12     Fields:    Translation:HumansCells
    36. Yang G, Lee HE, Moon SJ, Ko KM, Koh JH, Seok JK, Min JK, Heo TH, Kang HC, Cho YY, Lee HS, Fitzgerald KA, Lee JY. Direct Binding to NLRP3 Pyrin Domain as a Novel Strategy to Prevent NLRP3-Driven Inflammation and Gouty Arthritis. Arthritis Rheumatol. 2020 07; 72(7):1192-1202. PMID: 32134203.
      Citations: 37     Fields:    Translation:HumansAnimalsCells
    37. Fitzgerald KA, Kagan JC. Toll-like Receptors and the Control of Immunity. Cell. 2020 03 19; 180(6):1044-1066. PMID: 32164908.
      Citations: 516     Fields:    Translation:HumansAnimalsCells
    38. Agliano F, Fitzgerald KA, Vella AT, Rathinam VA, Medvedev AE. Long Non-coding RNA LincRNA-EPS Inhibits Host Defense Against Listeria monocytogenes Infection. Front Cell Infect Microbiol. 2019; 9:481. PMID: 32039056.
      Citations: 12     Fields:    Translation:AnimalsCells
    39. Gross-Vered M, Shmuel-Galia L, Zarmi B, Humphries F, Thaiss C, Salame TM, David E, Chappell-Maor L, Fitzgerald KA, Shai Y, Jung S. TLR2 Dimerization Blockade Allows Generation of Homeostatic Intestinal Macrophages under Acute Colitis Challenge. J Immunol. 2020 02 01; 204(3):707-717. PMID: 31882517.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    40. Bhatta A, Atianand M, Jiang Z, Crabtree J, Blin J, Fitzgerald KA. A Mitochondrial Micropeptide Is Required for Activation of the Nlrp3 Inflammasome. J Immunol. 2020 01 15; 204(2):428-437. PMID: 31836654.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    41. Humphries F, Fitzgerald KA. hnRNPA2B1: Fueling Antiviral Immunity from the Nucleus. Mol Cell. 2019 10 03; 76(1):8-10. PMID: 31585104.
      Citations: 1     Fields:    Translation:Cells
    42. Orning P, Lien E, Fitzgerald KA. Gasdermins and their role in immunity and inflammation. J Exp Med. 2019 11 04; 216(11):2453-2465. PMID: 31548300.
      Citations: 95     Fields:    Translation:Humans
    43. Humphries F, Fitzgerald KA. Assembling the Inflammasome, Piece by Piece. J Immunol. 2019 09 01; 203(5):1093-1094. PMID: 31427397.
      Citations: 1     Fields:    Translation:Humans
    44. Motwani M, Pesiridis S, Fitzgerald KA. DNA sensing by the cGAS-STING pathway in health and disease. Nat Rev Genet. 2019 11; 20(11):657-674. PMID: 31358977.
      Citations: 386     Fields:    Translation:HumansAnimalsCells
    45. Mumbach MR, Granja JM, Flynn RA, Roake CM, Satpathy AT, Rubin AJ, Qi Y, Jiang Z, Shams S, Louie BH, Guo JK, Gennert DG, Corces MR, Khavari PA, Atianand MK, Artandi SE, Fitzgerald KA, Greenleaf WJ, Chang HY. HiChIRP reveals RNA-associated chromosome conformation. Nat Methods. 2019 06; 16(6):489-492. PMID: 31133759.
      Citations: 42     Fields:    Translation:AnimalsCells
    46. Carty M, Kearney J, Shanahan KA, Hams E, Sugisawa R, Connolly D, Doran CG, Mu?oz-Wolf N, G?rtler C, Fitzgerald KA, Lavelle EC, Fallon PG, Bowie AG. Cell Survival and Cytokine Release after Inflammasome Activation Is Regulated by the Toll-IL-1R Protein SARM. Immunity. 2019 06 18; 50(6):1412-1424.e6. PMID: 31076360.
      Citations: 55     Fields:    Translation:AnimalsCells
    47. Chen Y, Sharma S, Assis PA, Jiang Z, Elling R, Olive AJ, Hang S, Bernier J, Huh JR, Sassetti CM, Knipe DM, Gazzinelli RT, Fitzgerald KA. CNBP controls IL-12 gene transcription and Th1 immunity. J Exp Med. 2018 12 03; 215(12):3136-3150. PMID: 30442645.
      Citations: 21     Fields:    Translation:AnimalsCells
    48. Elling R, Robinson EK, Shapleigh B, Liapis SC, Covarrubias S, Katzman S, Groff AF, Jiang Z, Agarwal S, Motwani M, Chan J, Sharma S, Hennessy EJ, FitzGerald GA, McManus MT, Rinn JL, Fitzgerald KA, Carpenter S. Genetic Models Reveal cis and trans Immune-Regulatory Activities for lincRNA-Cox2. Cell Rep. 2018 11 06; 25(6):1511-1524.e6. PMID: 30404006.
      Citations: 42     Fields:    Translation:HumansAnimalsCells
    49. Orning P, Weng D, Starheim K, Ratner D, Best Z, Lee B, Brooks A, Xia S, Wu H, Kelliher MA, Berger SB, Gough PJ, Bertin J, Proulx MM, Goguen JD, Kayagaki N, Fitzgerald KA, Lien E. Pathogen blockade of TAK1 triggers caspase-8-dependent cleavage of gasdermin D and cell death. Science. 2018 11 30; 362(6418):1064-1069. PMID: 30361383.
      Citations: 364     Fields:    Translation:HumansAnimalsCells
    50. Mansouri S, Patel S, Katikaneni DS, Blaauboer SM, Wang W, Schattgen S, Fitzgerald K, Jin L. Immature lung TNFR2- conventional DC 2 subpopulation activates moDCs to promote cyclic di-GMP mucosal adjuvant responses in vivo. Mucosal Immunol. 2019 01; 12(1):277-289. PMID: 30327534.
      Citations: 15     Fields:    Translation:AnimalsCells
    51. Banerjee I, Behl B, Mendonca M, Shrivastava G, Russo AJ, Menoret A, Ghosh A, Vella AT, Vanaja SK, Sarkar SN, Fitzgerald KA, Rathinam VAK. Gasdermin D Restrains Type I Interferon Response to Cytosolic DNA by Disrupting Ionic Homeostasis. Immunity. 2018 09 18; 49(3):413-426.e5. PMID: 30170814.
      Citations: 99     Fields:    Translation:HumansAnimalsCells
    52. Mande P, Zirak B, Ko WC, Taravati K, Bride KL, Brodeur TY, Deng A, Dresser K, Jiang Z, Ettinger R, Fitzgerald KA, Rosenblum MD, Harris JE, Marshak-Rothstein A. Fas ligand promotes an inducible TLR-dependent model of cutaneous lupus-like inflammation. J Clin Invest. 2018 07 02; 128(7):2966-2978. PMID: 29889098.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    53. Carpenter S, Fitzgerald KA. Cytokines and Long Noncoding RNAs. Cold Spring Harb Perspect Biol. 2018 06 01; 10(6). PMID: 28716885.
      Citations: 44     Fields:    Translation:HumansAnimals
    54. Sarhan J, Liu BC, Muendlein HI, Weindel CG, Smirnova I, Tang AY, Ilyukha V, Sorokin M, Buzdin A, Fitzgerald KA, Poltorak A. Constitutive interferon signaling maintains critical threshold of MLKL expression to license necroptosis. Cell Death Differ. 2019 01; 26(2):332-347. PMID: 29786074.
      Citations: 70     Fields:    Translation:HumansAnimalsCells
    55. Papinska J, Bagavant H, Gmyrek GB, Sroka M, Tummala S, Fitzgerald KA, Deshmukh US. Activation of Stimulator of Interferon Genes (STING) and Sj?gren Syndrome. J Dent Res. 2018 07; 97(8):893-900. PMID: 29505322.
      Citations: 15     Fields:    Translation:AnimalsCells
    56. Schrum JE, Crabtree JN, Dobbs KR, Kiritsy MC, Reed GW, Gazzinelli RT, Netea MG, Kazura JW, Dent AE, Fitzgerald KA, Golenbock DT. Cutting Edge: Plasmodium falciparum Induces Trained Innate Immunity. J Immunol. 2018 02 15; 200(4):1243-1248. PMID: 29330325.
      Citations: 55     Fields:    Translation:Humans
    57. Ketelut-Carneiro N, Ghosh S, Levitz SM, Fitzgerald KA, da Silva JS. A Dectin-1-Caspase-8 Pathway Licenses Canonical Caspase-1 Inflammasome Activation and Interleukin-1? Release in Response to a Pathogenic Fungus. J Infect Dis. 2018 01 04; 217(2):329-339. PMID: 29099934.
      Citations: 10     Fields:    Translation:AnimalsCells
    58. O'Donnell JA, Lehman J, Roderick JE, Martinez-Marin D, Zelic M, Doran C, Hermance N, Lyle S, Pasparakis M, Fitzgerald KA, Marshak-Rothstein A, Kelliher MA. Dendritic Cell RIPK1 Maintains Immune Homeostasis by Preventing Inflammation and Autoimmunity. J Immunol. 2018 01 15; 200(2):737-748. PMID: 29212904.
      Citations: 17     Fields:    Translation:AnimalsCells
    59. Gallego-Marin C, Schrum JE, Andrade WA, Shaffer SA, Giraldo LF, Lasso AM, Kurt-Jones EA, Fitzgerald KA, Golenbock DT. Cyclic GMP-AMP Synthase Is the Cytosolic Sensor of Plasmodium falciparum Genomic DNA and Activates Type I IFN in Malaria. J Immunol. 2018 01 15; 200(2):768-774. PMID: 29212905.
      Citations: 30     Fields:    Translation:HumansAnimalsCells
    60. Kerur N, Fukuda S, Banerjee D, Kim Y, Fu D, Apicella I, Varshney A, Yasuma R, Fowler BJ, Baghdasaryan E, Marion KM, Huang X, Yasuma T, Hirano Y, Serbulea V, Ambati M, Ambati VL, Kajiwara Y, Ambati K, Hirahara S, Bastos-Carvalho A, Ogura Y, Terasaki H, Oshika T, Kim KB, Hinton DR, Leitinger N, Cambier JC, Buxbaum JD, Kenney MC, Jazwinski SM, Nagai H, Hara I, West AP, Fitzgerald KA, Sadda SR, Gelfand BD, Ambati J. cGAS drives noncanonical-inflammasome activation in age-related macular degeneration. Nat Med. 2018 01; 24(1):50-61. PMID: 29176737.
      Citations: 115     Fields:    Translation:HumansAnimalsCells
    61. King KR, Aguirre AD, Ye YX, Sun Y, Roh JD, Ng RP, Kohler RH, Arlauckas SP, Iwamoto Y, Savol A, Sadreyev RI, Kelly M, Fitzgibbons TP, Fitzgerald KA, Mitchison T, Libby P, Nahrendorf M, Weissleder R. IRF3 and type I interferons fuel a fatal response to myocardial infarction. Nat Med. 2017 Dec; 23(12):1481-1487. PMID: 29106401.
      Citations: 181     Fields:    Translation:AnimalsCells
    62. Motwani M, Fitzgerald KA. cGAS Micro-Manages Genotoxic Stress. Immunity. 2017 10 17; 47(4):616-617. PMID: 29045895.
      Citations: 7     Fields:    Translation:Cells
    63. Ghosh S, Wallerath C, Covarrubias S, Hornung V, Carpenter S, Fitzgerald KA. The PYHIN Protein p205 Regulates the Inflammasome by Controlling Asc Expression. J Immunol. 2017 11 01; 199(9):3249-3260. PMID: 28931603.
      Citations: 9     Fields:    Translation:AnimalsCells
    64. Saleh D, Najjar M, Zelic M, Shah S, Nogusa S, Polykratis A, Paczosa MK, Gough PJ, Bertin J, Whalen M, Fitzgerald KA, Slavov N, Pasparakis M, Balachandran S, Kelliher M, Mecsas J, Degterev A. Kinase Activities of RIPK1 and RIPK3 Can Direct IFN-? Synthesis Induced by Lipopolysaccharide. J Immunol. 2017 06 01; 198(11):4435-4447. PMID: 28461567.
      Citations: 31     Fields:    Translation:AnimalsCells
    65. Kalantari P, Harandi OF, Agarwal S, Rus F, Kurt-Jones EA, Fitzgerald KA, Caffrey DR, Golenbock DT. miR-718 represses proinflammatory cytokine production through targeting phosphatase and tensin homolog (PTEN). J Biol Chem. 2017 04 07; 292(14):5634-5644. PMID: 28209713.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    66. Atianand MK, Caffrey DR, Fitzgerald KA. Immunobiology of Long Noncoding RNAs. Annu Rev Immunol. 2017 04 26; 35:177-198. PMID: 28125358.
      Citations: 227     Fields:    Translation:HumansAnimals
    67. Hu B, Jin C, Li HB, Tong J, Ouyang X, Cetinbas NM, Zhu S, Strowig T, Lam FC, Zhao C, Henao-Mejia J, Yilmaz O, Fitzgerald KA, Eisenbarth SC, Elinav E, Flavell RA. The DNA-sensing AIM2 inflammasome controls radiation-induced cell death and tissue injury. Science. 2016 11 11; 354(6313):765-768. PMID: 27846608.
      Citations: 146     Fields:    Translation:AnimalsPHPublic Health
    68. Reinert LS, Lopu?n? K, Winther H, Sun C, Thomsen MK, Nandakumar R, Mogensen TH, Meyer M, V?gter C, Nyengaard JR, Fitzgerald KA, Paludan SR. Sensing of HSV-1 by the cGAS-STING pathway in microglia orchestrates antiviral defence in the CNS. Nat Commun. 2016 11 10; 7:13348. PMID: 27830700.
      Citations: 150     Fields:    Translation:HumansAnimalsCells
    69. Iracheta-Vellve A, Petrasek J, Gyongyosi B, Satishchandran A, Lowe P, Kodys K, Catalano D, Calenda CD, Kurt-Jones EA, Fitzgerald KA, Szabo G. Endoplasmic Reticulum Stress-induced Hepatocellular Death Pathways Mediate Liver Injury and Fibrosis via Stimulator of Interferon Genes. J Biol Chem. 2016 Dec 23; 291(52):26794-26805. PMID: 27810900.
      Citations: 62     Fields:    Translation:AnimalsCells
    70. Pawaria S, Sharma S, Baum R, N?ndel K, Busto P, Gravallese EM, Fitzgerald KA, Marshak-Rothstein A. Taking the STING out of TLR-driven autoimmune diseases: good, bad, or indifferent? J Leukoc Biol. 2017 01; 101(1):121-126. PMID: 27531928.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    71. Andrade WA, Firon A, Schmidt T, Hornung V, Fitzgerald KA, Kurt-Jones EA, Trieu-Cuot P, Golenbock DT, Kaminski PA. Group B Streptococcus Degrades Cyclic-di-AMP to Modulate STING-Dependent Type I Interferon Production. Cell Host Microbe. 2016 Jul 13; 20(1):49-59. PMID: 27414497.
      Citations: 61     Fields:    Translation:Cells
    72. Tzeng TC, Schattgen S, Monks B, Wang D, Cerny A, Latz E, Fitzgerald K, Golenbock DT. A Fluorescent Reporter Mouse for Inflammasome Assembly Demonstrates an Important Role for Cell-Bound and Free ASC Specks during In?Vivo Infection. Cell Rep. 2016 07 12; 16(2):571-582. PMID: 27346360.
      Citations: 55     Fields:    Translation:AnimalsCells
    73. Atianand MK, Hu W, Satpathy AT, Shen Y, Ricci EP, Alvarez-Dominguez JR, Bhatta A, Schattgen SA, McGowan JD, Blin J, Braun JE, Gandhi P, Moore MJ, Chang HY, Lodish HF, Caffrey DR, Fitzgerald KA. A Long Noncoding RNA lincRNA-EPS Acts as a Transcriptional Brake to Restrain Inflammation. Cell. 2016 Jun 16; 165(7):1672-1685. PMID: 27315481.
      Citations: 227     Fields:    Translation:HumansAnimalsCells
    74. Akula MK, Shi M, Jiang Z, Foster CE, Miao D, Li AS, Zhang X, Gavin RM, Forde SD, Germain G, Carpenter S, Rosadini CV, Gritsman K, Chae JJ, Hampton R, Silverman N, Gravallese EM, Kagan JC, Fitzgerald KA, Kastner DL, Golenbock DT, Bergo MO, Wang D. Control of the innate immune response by the mevalonate pathway. Nat Immunol. 2016 08; 17(8):922-9. PMID: 27270400.
      Citations: 84     Fields:    Translation:HumansAnimalsCells
    75. Andrade WA, Agarwal S, Mo S, Shaffer SA, Dillard JP, Schmidt T, Hornung V, Fitzgerald KA, Kurt-Jones EA, Golenbock DT. Type I Interferon Induction by Neisseria gonorrhoeae: Dual Requirement of Cyclic GMP-AMP Synthase and Toll-like Receptor 4. Cell Rep. 2016 06 14; 15(11):2438-48. PMID: 27264171.
      Citations: 36     Fields:    Translation:HumansCells
    76. Rathinam VA, Fitzgerald KA. Inflammasome Complexes: Emerging Mechanisms and Effector Functions. Cell. 2016 May 05; 165(4):792-800. PMID: 27153493.
      Citations: 394     Fields:    Translation:HumansAnimalsCells
    77. Atianand MK, Fitzgerald KA. IMMUNOLOGY. An RNA twist to T(H)17 cells. Science. 2016 Mar 04; 351(6277):1032. PMID: 26941307.
      Citations: 2     Fields:    Translation:HumansCells
    78. Carroll EC, Jin L, Mori A, Mu?oz-Wolf N, Oleszycka E, Moran HBT, Mansouri S, McEntee CP, Lambe E, Agger EM, Andersen P, Cunningham C, Hertzog P, Fitzgerald KA, Bowie AG, Lavelle EC. The Vaccine Adjuvant Chitosan Promotes Cellular Immunity via DNA Sensor cGAS-STING-Dependent Induction of Type I Interferons. Immunity. 2016 Mar 15; 44(3):597-608. PMID: 26944200.
      Citations: 168     Fields:    Translation:HumansAnimalsCells
    79. Elling R, Chan J, Fitzgerald KA. Emerging role of long noncoding RNAs as regulators of innate immune cell development and inflammatory gene expression. Eur J Immunol. 2016 Mar; 46(3):504-12. PMID: 26820238.
      Citations: 67     Fields:    Translation:Cells
    80. Baum R, N?ndel K, Pawaria S, Sharma S, Busto P, Fitzgerald KA, Gravallese EM, Marshak-Rothstein A. Synergy between Hematopoietic and Radioresistant Stromal Cells Is Required for Autoimmune Manifestations of DNase II-/-IFNaR-/- Mice. J Immunol. 2016 Feb 01; 196(3):1348-54. PMID: 26729810.
      Citations: 7     Fields:    Translation:AnimalsCells
    81. Surpris G, Chan J, Thompson M, Ilyukha V, Liu BC, Atianand M, Sharma S, Volkova T, Smirnova I, Fitzgerald KA, Poltorak A. Cutting Edge: Novel Tmem173 Allele Reveals Importance of STING N Terminus in Trafficking and Type I IFN Production. J Immunol. 2016 Jan 15; 196(2):547-52. PMID: 26685207.
      Citations: 8     Fields:    Translation:Animals
    82. Suschak JJ, Wang S, Fitzgerald KA, Lu S. A cGAS-Independent STING/IRF7 Pathway Mediates the Immunogenicity of DNA Vaccines. J Immunol. 2016 Jan 01; 196(1):310-6. PMID: 26590319.
      Citations: 44     Fields:    Translation:AnimalsCells
    83. Schattgen SA, Gao G, Kurt-Jones EA, Fitzgerald KA. Cutting Edge: DNA in the Lung Microenvironment during Influenza Virus Infection Tempers Inflammation by Engaging the DNA Sensor AIM2. J Immunol. 2016 Jan 01; 196(1):29-33. PMID: 26590313.
      Citations: 22     Fields:    Translation:AnimalsCells
    84. Barrat FJ, Elkon KB, Fitzgerald KA. Importance of Nucleic Acid Recognition in Inflammation and Autoimmunity. Annu Rev Med. 2016; 67:323-36. PMID: 26526766.
      Citations: 71     Fields:    Translation:HumansAnimalsCells
    85. Pawaria S, Moody KL, Busto P, N?ndel K, Baum R, Sharma S, Gravallese EM, Fitzgerald KA, Marshak-Rothstein A. An unexpected role for RNA-sensing toll-like receptors in a murine model of DNA accrual. Clin Exp Rheumatol. 2015 Jul-Aug; 33(4 Suppl 92):S70-3. PMID: 26457825.
      Citations: 3     Fields:    Translation:AnimalsCells
    86. Bronner DN, Abuaita BH, Chen X, Fitzgerald KA, Nu?ez G, He Y, Yin XM, O'Riordan MX. Endoplasmic Reticulum Stress Activates the Inflammasome via NLRP3- and Caspase-2-Driven Mitochondrial Damage. Immunity. 2015 Sep 15; 43(3):451-62. PMID: 26341399.
      Citations: 168     Fields:    Translation:HumansAnimalsCells
    87. Chan J, Atianand M, Jiang Z, Carpenter S, Aiello D, Elling R, Fitzgerald KA, Caffrey DR. Cutting Edge: A Natural Antisense Transcript, AS-IL1a, Controls Inducible Transcription of the Proinflammatory Cytokine IL-1a. J Immunol. 2015 Aug 15; 195(4):1359-63. PMID: 26179904.
      Citations: 56     Fields:    Translation:AnimalsCells
    88. Kang S, Fernandes-Alnemri T, Rogers C, Mayes L, Wang Y, Dillon C, Roback L, Kaiser W, Oberst A, Sagara J, Fitzgerald KA, Green DR, Zhang J, Mocarski ES, Alnemri ES. Caspase-8 scaffolding function and MLKL regulate NLRP3 inflammasome activation downstream of TLR3. Nat Commun. 2015 Jun 24; 6:7515. PMID: 26104484.
      Citations: 125     Fields:    Translation:AnimalsCells
    89. Iracheta-Vellve A, Petrasek J, Satishchandran A, Gyongyosi B, Saha B, Kodys K, Fitzgerald KA, Kurt-Jones EA, Szabo G. Inhibition of sterile danger signals, uric acid and ATP, prevents inflammasome activation and protects from alcoholic steatohepatitis in mice. J Hepatol. 2015 Nov; 63(5):1147-55. PMID: 26100496.
      Citations: 60     Fields:    Translation:AnimalsCells
    90. Fitzgerald KA. Paula Pitha-Rowe 1937-2015. Nat Immunol. 2015 Jun; 16(6):591. PMID: 25988897.
      Citations:    Fields:    
    91. Petrasek J, Iracheta-Vellve A, Saha B, Satishchandran A, Kodys K, Fitzgerald KA, Kurt-Jones EA, Szabo G. Metabolic danger signals, uric acid and ATP, mediate inflammatory cross-talk between hepatocytes and immune cells in alcoholic liver disease. J Leukoc Biol. 2015 Aug; 98(2):249-56. PMID: 25934928.
      Citations: 67     Fields:    Translation:HumansAnimalsCells
    92. Fitzgerald KA, Rathinam VA. GBPs take AIM at Francisella. Nat Immunol. 2015 May; 16(5):443-4. PMID: 25898190.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    93. Sharma S, Campbell AM, Chan J, Schattgen SA, Orlowski GM, Nayar R, Huyler AH, N?ndel K, Mohan C, Berg LJ, Shlomchik MJ, Marshak-Rothstein A, Fitzgerald KA. Suppression of systemic autoimmunity by the innate immune adaptor STING. Proc Natl Acad Sci U S A. 2015 Feb 17; 112(7):E710-7. PMID: 25646421.
      Citations: 84     Fields:    Translation:AnimalsCells
    94. Vanaja SK, Rathinam VA, Fitzgerald KA. Mechanisms of inflammasome activation: recent advances and novel insights. Trends Cell Biol. 2015 May; 25(5):308-15. PMID: 25639489.
      Citations: 211     Fields:    Translation:HumansAnimalsCells
    95. Sun C, Schattgen SA, Pisitkun P, Jorgensen JP, Hilterbrand AT, Wang LJ, West JA, Hansen K, Horan KA, Jakobsen MR, O'Hare P, Adler H, Sun R, Ploegh HL, Damania B, Upton JW, Fitzgerald KA, Paludan SR. Evasion of innate cytosolic DNA sensing by a gammaherpesvirus facilitates establishment of latent infection. J Immunol. 2015 Feb 15; 194(4):1819-31. PMID: 25595793.
      Citations: 65     Fields:    Translation:HumansAnimalsCells
    96. Baum R, Sharma S, Carpenter S, Li QZ, Busto P, Fitzgerald KA, Marshak-Rothstein A, Gravallese EM. Cutting edge: AIM2 and endosomal TLRs differentially regulate arthritis and autoantibody production in DNase II-deficient mice. J Immunol. 2015 Feb 01; 194(3):873-7. PMID: 25548216.
      Citations: 57     Fields:    Translation:AnimalsCells
    97. Nilsen NJ, Vladimer GI, Stenvik J, Orning MP, Zeid-Kilani MV, Bugge M, Bergstroem B, Conlon J, Husebye H, Hise AG, Fitzgerald KA, Espevik T, Lien E. A role for the adaptor proteins TRAM and TRIF in toll-like receptor 2 signaling. J Biol Chem. 2015 Feb 06; 290(6):3209-22. PMID: 25505250.
      Citations: 46     Fields:    Translation:HumansAnimalsCells
    98. Suschak JJ, Wang S, Fitzgerald KA, Lu S. Identification of Aim2 as a sensor for DNA vaccines. J Immunol. 2015 Jan 15; 194(2):630-6. PMID: 25488991.
      Citations: 37     Fields:    Translation:HumansAnimals
    99. Corbett Y, Parapini S, D'Alessandro S, Scaccabarozzi D, Rocha BC, Egan TJ, Omar A, Galastri L, Fitzgerald KA, Golenbock DT, Taramelli D, Basilico N. Involvement of Nod2 in the innate immune response elicited by malarial pigment hemozoin. Microbes Infect. 2015 Mar; 17(3):184-94. PMID: 25462568.
      Citations: 12     Fields:    Translation:HumansAnimals
    100. Woo SR, Fuertes MB, Corrales L, Spranger S, Furdyna MJ, Leung MY, Duggan R, Wang Y, Barber GN, Fitzgerald KA, Alegre ML, Gajewski TF. STING-dependent cytosolic DNA sensing mediates innate immune recognition of immunogenic tumors. Immunity. 2014 Nov 20; 41(5):830-42. PMID: 25517615.
      Citations: 690     Fields:    Translation:AnimalsCells
    101. Gazzinelli RT, Kalantari P, Fitzgerald KA, Golenbock DT. Innate sensing of malaria parasites. Nat Rev Immunol. 2014 Nov; 14(11):744-57. PMID: 25324127.
      Citations: 140     Fields:    Translation:HumansAnimalsCells
    102. Martin BN, Wang C, Willette-Brown J, Herjan T, Gulen MF, Zhou H, Bulek K, Franchi L, Sato T, Alnemri ES, Narla G, Zhong XP, Thomas J, Klinman D, Fitzgerald KA, Karin M, Nu?ez G, Dubyak G, Hu Y, Li X. IKKa negatively regulates ASC-dependent inflammasome activation. Nat Commun. 2014 Sep 30; 5:4977. PMID: 25266676.
      Citations: 56     Fields:    Translation:AnimalsCells
    103. Atianand MK, Fitzgerald KA. Long non-coding RNAs and control of gene expression in the immune system. Trends Mol Med. 2014 Nov; 20(11):623-31. PMID: 25262537.
      Citations: 115     Fields:    Translation:HumansAnimals
    104. Carpenter S, Fitzgerald KA. Transcription of inflammatory genes: long noncoding RNA and beyond. J Interferon Cytokine Res. 2015 Feb; 35(2):79-88. PMID: 25250698.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    105. Collins JW, Keeney KM, Crepin VF, Rathinam VA, Fitzgerald KA, Finlay BB, Frankel G. Citrobacter rodentium: infection, inflammation and the microbiota. Nat Rev Microbiol. 2014 Sep; 12(9):612-23. PMID: 25088150.
      Citations: 234     Fields:    Translation:AnimalsCells
    106. Ganesan S, Rathinam VAK, Bossaller L, Army K, Kaiser WJ, Mocarski ES, Dillon CP, Green DR, Mayadas TN, Levitz SM, Hise AG, Silverman N, Fitzgerald KA. Caspase-8 modulates dectin-1 and complement receptor 3-driven IL-1? production in response to ?-glucans and the fungal pathogen, Candida albicans. J Immunol. 2014 Sep 01; 193(5):2519-2530. PMID: 25063877.
      Citations: 66     Fields:    Translation:HumansAnimalsCells
    107. Wochal P, Rathinam VA, Dunne A, Carlson T, Kuang W, Seidl KJ, Hall JP, Lin LL, Collins M, Schattgen SA, MacKay CR, Fagundes CT, Carpenter S, Fitzgerald KA, O'Neill LA. TRIL is involved in cytokine production in the brain following Escherichia coli infection. J Immunol. 2014 Aug 15; 193(4):1911-9. PMID: 25015823.
      Citations: 11     Fields:    Translation:AnimalsCells
    108. Narayan K, Waggoner L, Pham ST, Hendricks GL, Waggoner SN, Conlon J, Wang JP, Fitzgerald KA, Kang J. TRIM13 is a negative regulator of MDA5-mediated type I interferon production. J Virol. 2014 Sep; 88(18):10748-57. PMID: 25008915.
      Citations: 41     Fields:    Translation:HumansAnimalsCells
    109. Thompson MR, Sharma S, Atianand M, Jensen SB, Carpenter S, Knipe DM, Fitzgerald KA, Kurt-Jones EA. Interferon ?-inducible protein (IFI) 16 transcriptionally regulates type i interferons and other interferon-stimulated genes and controls the interferon response to both DNA and RNA viruses. J Biol Chem. 2014 Aug 22; 289(34):23568-81. PMID: 25002588.
      Citations: 69     Fields:    Translation:HumansCells
    110. Schmidt-Lauber C, Bossaller L, Abujudeh HH, Vladimer GI, Christ A, Fitzgerald KA, Latz E, Gravallese EM, Marshak-Rothstein A, Kay J. Gadolinium-based compounds induce NLRP3-dependent IL-1? production and peritoneal inflammation. Ann Rheum Dis. 2015 Nov; 74(11):2062-9. PMID: 24914072.
      Citations: 13     Fields:    Translation:AnimalsCells
    111. Carpenter S, Ricci EP, Mercier BC, Moore MJ, Fitzgerald KA. Post-transcriptional regulation of gene expression in innate immunity. Nat Rev Immunol. 2014 Jun; 14(6):361-76. PMID: 24854588.
      Citations: 172     Fields:    Translation:HumansAnimalsCells
    112. Kailasan Vanaja S, Rathinam VA, Atianand MK, Kalantari P, Skehan B, Fitzgerald KA, Leong JM. Bacterial RNA:DNA hybrids are activators of the NLRP3 inflammasome. Proc Natl Acad Sci U S A. 2014 May 27; 111(21):7765-70. PMID: 24828532.
      Citations: 53     Fields:    Translation:AnimalsCells
    113. Weng D, Marty-Roix R, Ganesan S, Proulx MK, Vladimer GI, Kaiser WJ, Mocarski ES, Pouliot K, Chan FK, Kelliher MA, Harris PA, Bertin J, Gough PJ, Shayakhmetov DM, Goguen JD, Fitzgerald KA, Silverman N, Lien E. Caspase-8 and RIP kinases regulate bacteria-induced innate immune responses and cell death. Proc Natl Acad Sci U S A. 2014 May 20; 111(20):7391-6. PMID: 24799678.
      Citations: 157     Fields:    Translation:AnimalsCells
    114. Davaro F, Forde SD, Garfield M, Jiang Z, Halmen K, Tamburro ND, Kurt-Jones E, Fitzgerald KA, Golenbock DT, Wang D. 3-Hydroxyl-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor (statin)-induced 28-kDa interleukin-1? interferes with mature IL-1? signaling. J Biol Chem. 2014 Jun 06; 289(23):16214-22. PMID: 24790079.
      Citations: 13     Fields:    Translation:AnimalsCells
    115. Gupta R, Ghosh S, Monks B, DeOliveira RB, Tzeng TC, Kalantari P, Nandy A, Bhattacharjee B, Chan J, Ferreira F, Rathinam V, Sharma S, Lien E, Silverman N, Fitzgerald K, Firon A, Trieu-Cuot P, Henneke P, Golenbock DT. RNA and ?-hemolysin of group B Streptococcus induce interleukin-1? (IL-1?) by activating NLRP3 inflammasomes in mouse macrophages. J Biol Chem. 2014 May 16; 289(20):13701-5. PMID: 24692555.
      Citations: 45     Fields:    Translation:HumansAnimalsCells
    116. Lu A, Magupalli VG, Ruan J, Yin Q, Atianand MK, Vos MR, Schr?der GF, Fitzgerald KA, Wu H, Egelman EH. Unified polymerization mechanism for the assembly of ASC-dependent inflammasomes. Cell. 2014 Mar 13; 156(6):1193-1206. PMID: 24630722.
      Citations: 579     Fields:    Translation:HumansCells
    117. Zhang L, Mo J, Swanson KV, Wen H, Petrucelli A, Gregory SM, Zhang Z, Schneider M, Jiang Y, Fitzgerald KA, Ouyang S, Liu ZJ, Damania B, Shu HB, Duncan JA, Ting JP. NLRC3, a member of the NLR family of proteins, is a negative regulator of innate immune signaling induced by the DNA sensor STING. Immunity. 2014 Mar 20; 40(3):329-41. PMID: 24560620.
      Citations: 127     Fields:    Translation:HumansAnimalsCells
    118. Janssen E, Ozcan E, Liadaki K, Jabara HH, Manis J, Ullas S, Akira S, Fitzgerald KA, Golenbock DT, Geha RS. TRIF signaling is essential for TLR4-driven IgE class switching. J Immunol. 2014 Mar 15; 192(6):2651-8. PMID: 24532577.
      Citations: 7     Fields:    Translation:AnimalsCells
    119. Severa M, Islam SA, Waggoner SN, Jiang Z, Kim ND, Ryan G, Kurt-Jones E, Charo I, Caffrey DR, Boyartchuk VL, Luster AD, Fitzgerald KA. The transcriptional repressor BLIMP1 curbs host defenses by suppressing expression of the chemokine CCL8. J Immunol. 2014 Mar 01; 192(5):2291-304. PMID: 24477914.
      Citations: 19     Fields:    Translation:AnimalsCells
    120. Ataide MA, Andrade WA, Zamboni DS, Wang D, Souza Mdo C, Franklin BS, Elian S, Martins FS, Pereira D, Reed G, Fitzgerald KA, Golenbock DT, Gazzinelli RT. Malaria-induced NLRP12/NLRP3-dependent caspase-1 activation mediates inflammation and hypersensitivity to bacterial superinfection. PLoS Pathog. 2014 Jan; 10(1):e1003885. PMID: 24453977.
      Citations: 87     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
    121. Bhat N, Fitzgerald KA. Recognition of cytosolic DNA by cGAS and other STING-dependent sensors. Eur J Immunol. 2014 Mar; 44(3):634-40. PMID: 24356864.
      Citations: 59     Fields:    Translation:HumansAnimalsCells
    122. Kalantari P, DeOliveira RB, Chan J, Corbett Y, Rathinam V, Stutz A, Latz E, Gazzinelli RT, Golenbock DT, Fitzgerald KA. Dual engagement of the NLRP3 and AIM2 inflammasomes by plasmodium-derived hemozoin and DNA during malaria. Cell Rep. 2014 Jan 16; 6(1):196-210. PMID: 24388751.
      Citations: 90     Fields:    Translation:HumansAnimalsCells
    123. Moy RH, Gold B, Molleston JM, Schad V, Yanger K, Salzano MV, Yagi Y, Fitzgerald KA, Stanger BZ, Soldan SS, Cherry S. Antiviral autophagy restrictsRift Valley fever virus infection and is conserved from flies to mammals. Immunity. 2014 Jan 16; 40(1):51-65. PMID: 24374193.
      Citations: 85     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    124. Liehl P, Zuzarte-Lu?s V, Chan J, Zillinger T, Baptista F, Carapau D, Konert M, Hanson KK, Carret C, Lassnig C, M?ller M, Kalinke U, Saeed M, Chora AF, Golenbock DT, Strobl B, Prud?ncio M, Coelho LP, Kappe SH, Superti-Furga G, Pichlmair A, Vig?rio AM, Rice CM, Fitzgerald KA, Barchet W, Mota MM. Host-cell sensors for Plasmodium activate innate immunity against liver-stage infection. Nat Med. 2014 Jan; 20(1):47-53. PMID: 24362933.
      Citations: 145     Fields:    Translation:AnimalsCells
    125. Fitzgerald KA, Caffrey DR. Long noncoding RNAs in innate and adaptive immunity. Curr Opin Immunol. 2014 Feb; 26:140-6. PMID: 24556411.
      Citations: 105     Fields:    Translation:HumansAnimalsCells
    126. Kim HY, Lee HJ, Chang YJ, Pichavant M, Shore SA, Fitzgerald KA, Iwakura Y, Israel E, Bolger K, Faul J, DeKruyff RH, Umetsu DT. Interleukin-17-producing innate lymphoid cells and the NLRP3 inflammasome facilitate obesity-associated airway hyperreactivity. Nat Med. 2014 Jan; 20(1):54-61. PMID: 24336249.
      Citations: 275     Fields:    Translation:AnimalsCells
    127. Ermler ME, Traylor Z, Patel K, Schattgen SA, Vanaja SK, Fitzgerald KA, Hise AG. Rift Valley fever virus infection induces activation of the NLRP3 inflammasome. Virology. 2014 Jan 20; 449:174-80. PMID: 24418550.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    128. Man SM, Tourlomousis P, Hopkins L, Monie TP, Fitzgerald KA, Bryant CE. Salmonella infection induces recruitment of Caspase-8 to the inflammasome to modulate IL-1? production. J Immunol. 2013 Nov 15; 191(10):5239-46. PMID: 24123685.
      Citations: 127     Fields:    Translation:AnimalsCells
    129. Petrasek J, Iracheta-Vellve A, Csak T, Satishchandran A, Kodys K, Kurt-Jones EA, Fitzgerald KA, Szabo G. STING-IRF3 pathway links endoplasmic reticulum stress with hepatocyte apoptosis in early alcoholic liver disease. Proc Natl Acad Sci U S A. 2013 Oct 08; 110(41):16544-9. PMID: 24052526.
      Citations: 183     Fields:    Translation:AnimalsCells
    130. Fernandes-Alnemri T, Kang S, Anderson C, Sagara J, Fitzgerald KA, Alnemri ES. Cutting edge: TLR signaling licenses IRAK1 for rapid activation of the NLRP3 inflammasome. J Immunol. 2013 Oct 15; 191(8):3995-9. PMID: 24043892.
      Citations: 112     Fields:    Translation:AnimalsCells
    131. Abdul-Sater AA, Tattoli I, Jin L, Grajkowski A, Levi A, Koller BH, Allen IC, Beaucage SL, Fitzgerald KA, Ting JP, Cambier JC, Girardin SE, Schindler C. Cyclic-di-GMP and cyclic-di-AMP activate the NLRP3 inflammasome. EMBO Rep. 2013 Oct; 14(10):900-6. PMID: 24008845.
      Citations: 40     Fields:    Translation:HumansAnimalsCells
    132. Rathinam VA, Fitzgerald KA. Immunology: Lipopolysaccharide sensing on the inside. Nature. 2013 Sep 12; 501(7466):173-5. PMID: 24005321.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    133. Shah S, Bohsali A, Ahlbrand SE, Srinivasan L, Rathinam VA, Vogel SN, Fitzgerald KA, Sutterwala FS, Briken V. Cutting edge: Mycobacterium tuberculosis but not nonvirulent mycobacteria inhibits IFN-? and AIM2 inflammasome-dependent IL-1? production via its ESX-1 secretion system. J Immunol. 2013 Oct 01; 191(7):3514-8. PMID: 23997220.
      Citations: 58     Fields:    Translation:AnimalsCells
    134. Kaminski JJ, Schattgen SA, Tzeng TC, Bode C, Klinman DM, Fitzgerald KA. Synthetic oligodeoxynucleotides containing suppressive TTAGGG motifs inhibit AIM2 inflammasome activation. J Immunol. 2013 Oct 01; 191(7):3876-83. PMID: 23986531.
      Citations: 51     Fields:    Translation:HumansAnimalsCells
    135. Bossaller L, Rathinam VA, Bonegio R, Chiang PI, Busto P, Wespiser AR, Caffrey DR, Li QZ, Mohan C, Fitzgerald KA, Latz E, Marshak-Rothstein A. Overexpression of membrane-bound fas ligand (CD95L) exacerbates autoimmune disease and renal pathology in pristane-induced lupus. J Immunol. 2013 Sep 01; 191(5):2104-14. PMID: 23918976.
      Citations: 12     Fields:    Translation:AnimalsCells
    136. Carpenter S, Aiello D, Atianand MK, Ricci EP, Gandhi P, Hall LL, Byron M, Monks B, Henry-Bezy M, Lawrence JB, O'Neill LA, Moore MJ, Caffrey DR, Fitzgerald KA. A long noncoding RNA mediates both activation and repression of immune response genes. Science. 2013 Aug 16; 341(6147):789-92. PMID: 23907535.
      Citations: 510     Fields:    Translation:AnimalsCells
    137. Sheedy FJ, Grebe A, Rayner KJ, Kalantari P, Ramkhelawon B, Carpenter SB, Becker CE, Ediriweera HN, Mullick AE, Golenbock DT, Stuart LM, Latz E, Fitzgerald KA, Moore KJ. CD36 coordinates NLRP3 inflammasome activation by facilitating intracellular nucleation of soluble ligands into particulate ligands in sterile inflammation. Nat Immunol. 2013 Aug; 14(8):812-20. PMID: 23812099.
      Citations: 409     Fields:    Translation:Animals
    138. Sokolovska A, Becker CE, Ip WK, Rathinam VA, Brudner M, Paquette N, Tanne A, Vanaja SK, Moore KJ, Fitzgerald KA, Lacy-Hulbert A, Stuart LM. Activation of caspase-1 by the NLRP3 inflammasome regulates the NADPH oxidase NOX2 to control phagosome function. Nat Immunol. 2013 Jun; 14(6):543-53. PMID: 23644505.
      Citations: 107     Fields:    Translation:HumansAnimalsCells
    139. Conlon J, Burdette DL, Sharma S, Bhat N, Thompson M, Jiang Z, Rathinam VA, Monks B, Jin T, Xiao TS, Vogel SN, Vance RE, Fitzgerald KA. Mouse, but not human STING, binds and signals in response to the vascular disrupting agent 5,6-dimethylxanthenone-4-acetic acid. J Immunol. 2013 May 15; 190(10):5216-25. PMID: 23585680.
      Citations: 171     Fields:    Translation:HumansAnimalsCells
    140. Sandanger ?, Ranheim T, Vinge LE, Bliks?en M, Alfsnes K, Finsen AV, Dahl CP, Askevold ET, Florholmen G, Christensen G, Fitzgerald KA, Lien E, Valen G, Espevik T, Aukrust P, Yndestad A. The NLRP3 inflammasome is up-regulated in cardiac fibroblasts and mediates myocardial ischaemia-reperfusion injury. Cardiovasc Res. 2013 Jul 01; 99(1):164-74. PMID: 23580606.
      Citations: 205     Fields:    Translation:AnimalsCells
    141. Atianand MK, Rathinam VA, Fitzgerald KA. SnapShot: inflammasomes. Cell. 2013 Mar 28; 153(1):272-272.e1. PMID: 23540703.
      Citations: 17     Fields:    Translation:HumansAnimals
    142. Atianand MK, Fitzgerald KA. Molecular basis of DNA recognition in the immune system. J Immunol. 2013 Mar 01; 190(5):1911-8. PMID: 23417527.
      Citations: 58     Fields:    Translation:HumansAnimalsCells
    143. Souza-Fonseca-Guimaraes F, Parlato M, de Oliveira RB, Golenbock D, Fitzgerald K, Shalova IN, Biswas SK, Cavaillon JM, Adib-Conquy M. Interferon-? and granulocyte/monocyte colony-stimulating factor production by natural killer cells involves different signaling pathways and the adaptor stimulator of interferon genes (STING). J Biol Chem. 2013 Apr 12; 288(15):10715-21. PMID: 23443666.
      Citations: 13     Fields:    Translation:AnimalsCells
    144. Ermler ME, Yerukhim E, Schriewer J, Schattgen S, Traylor Z, Wespiser AR, Caffrey DR, Chen ZJ, King CH, Gale M, Colonna M, Fitzgerald KA, Buller RM, Hise AG. RNA helicase signaling is critical for type i interferon production and protection against Rift Valley fever virus during mucosal challenge. J Virol. 2013 May; 87(9):4846-60. PMID: 23408632.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    145. Wang D, H?ing S, Patterson HC, Ahmad UM, Rathinam VA, Rajewsky K, Fitzgerald KA, Golenbock DT. Inflammation in mice ectopically expressing human Pyogenic Arthritis, Pyoderma Gangrenosum, and Acne (PAPA) Syndrome-associated PSTPIP1 A230T mutant proteins. J Biol Chem. 2013 Feb 15; 288(7):4594-601. PMID: 23293022.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    146. Ramirez A, Rathinam V, Fitzgerald KA, Golenbock DT, Mathew A. Defective pro-IL-1? responses in macrophages from aged mice. Immun Ageing. 2012 Dec 11; 9(1):27. PMID: 23228123.
    147. Mishra BB, Rathinam VA, Martens GW, Martinot AJ, Kornfeld H, Fitzgerald KA, Sassetti CM. Nitric oxide controls the immunopathology of tuberculosis by inhibiting NLRP3 inflammasome-dependent processing of IL-1?. Nat Immunol. 2013 Jan; 14(1):52-60. PMID: 23160153.
      Citations: 291     Fields:    Translation:HumansAnimalsCells
    148. Bossaller L, Chiang PI, Schmidt-Lauber C, Ganesan S, Kaiser WJ, Rathinam VA, Mocarski ES, Subramanian D, Green DR, Silverman N, Fitzgerald KA, Marshak-Rothstein A, Latz E. Cutting edge: FAS (CD95) mediates noncanonical IL-1? and IL-18 maturation via caspase-8 in an RIP3-independent manner. J Immunol. 2012 Dec 15; 189(12):5508-12. PMID: 23144495.
      Citations: 155     Fields:    Translation:AnimalsCells
    149. Prantner D, Perkins DJ, Lai W, Williams MS, Sharma S, Fitzgerald KA, Vogel SN. 5,6-Dimethylxanthenone-4-acetic acid (DMXAA) activates stimulator of interferon gene (STING)-dependent innate immune pathways and is regulated by mitochondrial membrane potential. J Biol Chem. 2012 Nov 16; 287(47):39776-88. PMID: 23027866.
      Citations: 96     Fields:    Translation:AnimalsCells
    150. Hafner-Bratkovic I, Bencina M, Fitzgerald KA, Golenbock D, Jerala R. NLRP3 inflammasome activation in macrophage cell lines by prion protein fibrils as the source of IL-1? and neuronal toxicity. Cell Mol Life Sci. 2012 Dec; 69(24):4215-28. PMID: 22926439.
      Citations: 46     Fields:    Translation:AnimalsCells
    151. Zhou S, Cerny AM, Fitzgerald KA, Kurt-Jones EA, Finberg RW. Role of interferon regulatory factor 7 in T cell responses during acute lymphocytic choriomeningitis virus infection. J Virol. 2012 Oct; 86(20):11254-65. PMID: 22875973.
      Citations: 20     Fields:    Translation:AnimalsCells
    152. Vladimer GI, Weng D, Paquette SW, Vanaja SK, Rathinam VA, Aune MH, Conlon JE, Burbage JJ, Proulx MK, Liu Q, Reed G, Mecsas JC, Iwakura Y, Bertin J, Goguen JD, Fitzgerald KA, Lien E. The NLRP12 inflammasome recognizes Yersinia pestis. Immunity. 2012 Jul 27; 37(1):96-107. PMID: 22840842.
      Citations: 173     Fields:    Translation:AnimalsCells
    153. Rathinam VA, Vanaja SK, Waggoner L, Sokolovska A, Becker C, Stuart LM, Leong JM, Fitzgerald KA. TRIF licenses caspase-11-dependent NLRP3 inflammasome activation by gram-negative bacteria. Cell. 2012 Aug 03; 150(3):606-19. PMID: 22819539.
      Citations: 390     Fields:    Translation:AnimalsCells
    154. Paquette N, Conlon J, Sweet C, Rus F, Wilson L, Pereira A, Rosadini CV, Goutagny N, Weber AN, Lane WS, Shaffer SA, Maniatis S, Fitzgerald KA, Stuart L, Silverman N. Serine/threonine acetylation of TGF?-activated kinase (TAK1) by Yersinia pestis YopJ inhibits innate immune signaling. Proc Natl Acad Sci U S A. 2012 Jul 31; 109(31):12710-5. PMID: 22802624.
      Citations: 93     Fields:    Translation:HumansAnimalsCells
    155. Holm CK, Jensen SB, Jakobsen MR, Cheshenko N, Horan KA, Moeller HB, Gonzalez-Dosal R, Rasmussen SB, Christensen MH, Yarovinsky TO, Rixon FJ, Herold BC, Fitzgerald KA, Paludan SR. Virus-cell fusion as a trigger of innate immunity dependent on the adaptor STING. Nat Immunol. 2012 Jun 17; 13(8):737-43. PMID: 22706339.
      Citations: 135     Fields:    Translation:HumansAnimalsCells
    156. Jabara HH, McDonald DR, Janssen E, Massaad MJ, Ramesh N, Borzutzky A, Rauter I, Benson H, Schneider L, Baxi S, Recher M, Notarangelo LD, Wakim R, Dbaibo G, Dasouki M, Al-Herz W, Barlan I, Baris S, Kutukculer N, Ochs HD, Plebani A, Kanariou M, Lefranc G, Reisli I, Fitzgerald KA, Golenbock D, Manis J, Keles S, Ceja R, Chatila TA, Geha RS. DOCK8 functions as an adaptor that links TLR-MyD88 signaling to B cell activation. Nat Immunol. 2012 May 13; 13(6):612-20. PMID: 22581261.
      Citations: 104     Fields:    Translation:HumansAnimalsCells
    157. Caffrey DR, Fitzgerald KA. Immunology. Select inflammasome assembly. Science. 2012 Apr 27; 336(6080):420-1. PMID: 22539706.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    158. Jin T, Perry A, Jiang J, Smith P, Curry JA, Unterholzner L, Jiang Z, Horvath G, Rathinam VA, Johnstone RW, Hornung V, Latz E, Bowie AG, Fitzgerald KA, Xiao TS. Structures of the HIN domain:DNA complexes reveal ligand binding and activation mechanisms of the AIM2 inflammasome and IFI16 receptor. Immunity. 2012 Apr 20; 36(4):561-71. PMID: 22483801.
      Citations: 265     Fields:    Translation:HumansCells
    159. Rathinam VA, Vanaja SK, Fitzgerald KA. Regulation of inflammasome signaling. Nat Immunol. 2012 Mar 19; 13(4):333-42. PMID: 22430786.
      Citations: 457     Fields:    Translation:HumansAnimalsCells
    160. Shimada K, Crother TR, Karlin J, Dagvadorj J, Chiba N, Chen S, Ramanujan VK, Wolf AJ, Vergnes L, Ojcius DM, Rentsendorj A, Vargas M, Guerrero C, Wang Y, Fitzgerald KA, Underhill DM, Town T, Arditi M. Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis. Immunity. 2012 Mar 23; 36(3):401-14. PMID: 22342844.
      Citations: 901     Fields:    Translation:AnimalsCells
    161. Shi CS, Shenderov K, Huang NN, Kabat J, Abu-Asab M, Fitzgerald KA, Sher A, Kehrl JH. Activation of autophagy by inflammatory signals limits IL-1? production by targeting ubiquitinated inflammasomes for destruction. Nat Immunol. 2012 Jan 29; 13(3):255-63. PMID: 22286270.
      Citations: 658     Fields:    Translation:HumansAnimalsCells
    162. Conrady CD, Zheng M, Fitzgerald KA, Liu C, Carr DJ. Resistance to HSV-1 infection in the epithelium resides with the novel innate sensor, IFI-16. Mucosal Immunol. 2012 Mar; 5(2):173-83. PMID: 22236996.
      Citations: 72     Fields:    Translation:AnimalsCells
    163. Tomalka J, Ganesan S, Azodi E, Patel K, Majmudar P, Hall BA, Fitzgerald KA, Hise AG. A novel role for the NLRC4 inflammasome in mucosal defenses against the fungal pathogen Candida albicans. PLoS Pathog. 2011 Dec; 7(12):e1002379. PMID: 22174673.
      Citations: 100     Fields:    Translation:Animals
    164. Rathinam VA, Fitzgerald KA. Cytosolic surveillance and antiviral immunity. Curr Opin Virol. 2011 Dec; 1(6):455-62. PMID: 22440909.
      Citations: 45     Fields:    Translation:HumansAnimalsCells
    165. Schattgen SA, Fitzgerald KA. The PYHIN protein family as mediators of host defenses. Immunol Rev. 2011 Sep; 243(1):109-18. PMID: 21884171.
      Citations: 121     Fields:    Translation:HumansAnimals
    166. Dai P, Cao H, Merghoub T, Avogadri F, Wang W, Parikh T, Fang CM, Pitha PM, Fitzgerald KA, Rahman MM, McFadden G, Hu X, Houghton AN, Shuman S, Deng L. Myxoma virus induces type I interferon production in murine plasmacytoid dendritic cells via a TLR9/MyD88-, IRF5/IRF7-, and IFNAR-dependent pathway. J Virol. 2011 Oct; 85(20):10814-25. PMID: 21835795.
      Citations: 26     Fields:    Translation:AnimalsCells
    167. Sharma S, DeOliveira RB, Kalantari P, Parroche P, Goutagny N, Jiang Z, Chan J, Bartholomeu DC, Lauw F, Hall JP, Barber GN, Gazzinelli RT, Fitzgerald KA, Golenbock DT. Innate immune recognition of an AT-rich stem-loop DNA motif in the Plasmodium falciparum genome. Immunity. 2011 Aug 26; 35(2):194-207. PMID: 21820332.
      Citations: 148     Fields:    Translation:HumansAnimalsCells
    168. Thompson MR, Kaminski JJ, Kurt-Jones EA, Fitzgerald KA. Pattern recognition receptors and the innate immune response to viral infection. Viruses. 2011 06; 3(6):920-40. PMID: 21994762.
      Citations: 337     Fields:    Translation:HumansAnimalsCells
    169. Ather JL, Ckless K, Martin R, Foley KL, Suratt BT, Boyson JE, Fitzgerald KA, Flavell RA, Eisenbarth SC, Poynter ME. Serum amyloid A activates the NLRP3 inflammasome and promotes Th17 allergic asthma in mice. J Immunol. 2011 Jul 01; 187(1):64-73. PMID: 21622869.
      Citations: 124     Fields:    Translation:AnimalsCells
    170. Parker D, Martin FJ, Soong G, Harfenist BS, Aguilar JL, Ratner AJ, Fitzgerald KA, Schindler C, Prince A. Streptococcus pneumoniae DNA initiates type I interferon signaling in the respiratory tract. mBio. 2011; 2(3):e00016-11. PMID: 21586648.
      Citations: 89     Fields:    Translation:AnimalsCells
    171. Panchanathan R, Shen H, Duan X, Rathinam VA, Erickson LD, Fitzgerald KA, Choubey D. Aim2 deficiency in mice suppresses the expression of the inhibitory Fcgamma receptor (FcgammaRIIB) through the induction of the IFN-inducible p202, a lupus susceptibility protein. J Immunol. 2011 Jun 15; 186(12):6762-70. PMID: 21551362.
      Citations: 18     Fields:    Translation:Animals
    172. Sharma S, Fitzgerald KA. Innate immune sensing of DNA. PLoS Pathog. 2011 Apr; 7(4):e1001310. PMID: 21533068.
      Citations: 42     Fields:    Translation:HumansAnimals
    173. Wang L, Trebicka E, Fu Y, Waggoner L, Akira S, Fitzgerald KA, Kagan JC, Cherayil BJ. Regulation of lipopolysaccharide-induced translation of tumor necrosis factor-alpha by the toll-like receptor 4 adaptor protein TRAM. J Innate Immun. 2011; 3(5):437-46. PMID: 21494017.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    174. Rathinam VA, Fitzgerald KA. Innate immune sensing of DNA viruses. Virology. 2011 Mar 15; 411(2):153-62. PMID: 21334037.
      Citations: 63     Fields:    Translation:HumansCells
    175. Paludan SR, Bowie AG, Horan KA, Fitzgerald KA. Recognition of herpesviruses by the innate immune system. Nat Rev Immunol. 2011 02; 11(2):143-54. PMID: 21267015.
      Citations: 185     Fields:    Translation:HumansCells
    176. Siednienko J, Gajanayake T, Fitzgerald KA, Moynagh P, Miggin SM. Absence of MyD88 results in enhanced TLR3-dependent phosphorylation of IRF3 and increased IFN-? and RANTES production. J Immunol. 2011 Feb 15; 186(4):2514-22. PMID: 21248248.
      Citations: 32     Fields:    Translation:HumansAnimalsCells
    177. Harris J, Hartman M, Roche C, Zeng SG, O'Shea A, Sharp FA, Lambe EM, Creagh EM, Golenbock DT, Tschopp J, Kornfeld H, Fitzgerald KA, Lavelle EC. Autophagy controls IL-1beta secretion by targeting pro-IL-1beta for degradation. J Biol Chem. 2011 Mar 18; 286(11):9587-97. PMID: 21228274.
      Citations: 403     Fields:    Translation:AnimalsCells
    178. Fitzgerald KA. The interferon inducible gene: Viperin. J Interferon Cytokine Res. 2011 Jan; 31(1):131-5. PMID: 21142818.
      Citations: 74     Fields:    Translation:HumansAnimalsCells
    179. Nakahira K, Haspel JA, Rathinam VA, Lee SJ, Dolinay T, Lam HC, Englert JA, Rabinovitch M, Cernadas M, Kim HP, Fitzgerald KA, Ryter SW, Choi AM. Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome. Nat Immunol. 2011 Mar; 12(3):222-30. PMID: 21151103.
      Citations: 1374     Fields:    Translation:Animals
    180. McNeela EA, Burke A, Neill DR, Baxter C, Fernandes VE, Ferreira D, Smeaton S, El-Rachkidy R, McLoughlin RM, Mori A, Moran B, Fitzgerald KA, Tschopp J, P?trilli V, Andrew PW, Kadioglu A, Lavelle EC. Pneumolysin activates the NLRP3 inflammasome and promotes proinflammatory cytokines independently of TLR4. PLoS Pathog. 2010 Nov 11; 6(11):e1001191. PMID: 21085613.
      Citations: 179     Fields:    Translation:AnimalsCells
    181. Panchanathan R, Duan X, Shen H, Rathinam VA, Erickson LD, Fitzgerald KA, Choubey D. Aim2 deficiency stimulates the expression of IFN-inducible Ifi202, a lupus susceptibility murine gene within the Nba2 autoimmune susceptibility locus. J Immunol. 2010 Dec 15; 185(12):7385-93. PMID: 21057088.
      Citations: 41     Fields:    Translation:AnimalsCells
    182. van Lint AL, Murawski MR, Goodbody RE, Severa M, Fitzgerald KA, Finberg RW, Knipe DM, Kurt-Jones EA. Herpes simplex virus immediate-early ICP0 protein inhibits Toll-like receptor 2-dependent inflammatory responses and NF-kappaB signaling. J Virol. 2010 Oct; 84(20):10802-11. PMID: 20686034.
      Citations: 92     Fields:    Translation:HumansAnimalsCells
    183. Rathinam VA, Fitzgerald KA. Inflammasomes and anti-viral immunity. J Clin Immunol. 2010 Sep; 30(5):632-7. PMID: 20665097.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    184. Zhou S, Cerny AM, Zacharia A, Fitzgerald KA, Kurt-Jones EA, Finberg RW. Induction and inhibition of type I interferon responses by distinct components of lymphocytic choriomeningitis virus. J Virol. 2010 Sep; 84(18):9452-62. PMID: 20592086.
      Citations: 90     Fields:    Translation:HumansAnimalsCells
    185. Kim S, Bauernfeind F, Ablasser A, Hartmann G, Fitzgerald KA, Latz E, Hornung V. Listeria monocytogenes is sensed by the NLRP3 and AIM2 inflammasome. Eur J Immunol. 2010 Jun; 40(6):1545-51. PMID: 20333626.
      Citations: 130     Fields:    Translation:AnimalsCells
    186. Rathinam VA, Sharma S, Fitzgerald KA. Catenin' on to nucleic acid sensing. Nat Immunol. 2010 Jun; 11(6):466-8. PMID: 20485273.
      Citations: 5     Fields:    Translation:HumansCells
    187. Sharma S, Fitzgerald KA. Viral defense: it takes two MAVS to Tango. Cell. 2010 May 14; 141(4):570-2. PMID: 20478250.
      Citations: 7     Fields:    
    188. Bauer C, Duewell P, Mayer C, Lehr HA, Fitzgerald KA, Dauer M, Tschopp J, Endres S, Latz E, Schnurr M. Colitis induced in mice with dextran sulfate sodium (DSS) is mediated by the NLRP3 inflammasome. Gut. 2010 Sep; 59(9):1192-9. PMID: 20442201.
      Citations: 340     Fields:    Translation:AnimalsCells
    189. Duewell P, Kono H, Rayner KJ, Sirois CM, Vladimer G, Bauernfeind FG, Abela GS, Franchi L, Nu?ez G, Schnurr M, Espevik T, Lien E, Fitzgerald KA, Rock KL, Moore KJ, Wright SD, Hornung V, Latz E. NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals. Nature. 2010 Apr 29; 464(7293):1357-61. PMID: 20428172.
      Citations: 1563     Fields:    Translation:HumansAnimalsCells
    190. He X, Mekasha S, Mavrogiorgos N, Fitzgerald KA, Lien E, Ingalls RR. Inflammation and fibrosis during Chlamydia pneumoniae infection is regulated by IL-1 and the NLRP3/ASC inflammasome. J Immunol. 2010 May 15; 184(10):5743-54. PMID: 20393140.
      Citations: 84     Fields:    Translation:AnimalsCells
    191. Zhao H, Leu SW, Shi L, Dedaj R, Zhao G, Garg HG, Shen L, Lien E, Fitzgerald KA, Shiedlin A, Shen H, Quinn DA, Hales CA. TLR4 is a negative regulator in noninfectious lung inflammation. J Immunol. 2010 May 01; 184(9):5308-14. PMID: 20357263.
      Citations: 27     Fields:    Translation:AnimalsCells
    192. Nguyen TT, Johnsen IB, Knetter CF, Drabl?s F, Fitzgerald KA, Lien E, Anthonsen MW. Differential gene expression downstream of Toll-like receptors (TLRs): role of c-Src and activating transcription factor 3 (ATF3). J Biol Chem. 2010 May 28; 285(22):17011-9. PMID: 20351107.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    193. Rathinam VA, Jiang Z, Waggoner SN, Sharma S, Cole LE, Waggoner L, Vanaja SK, Monks BG, Ganesan S, Latz E, Hornung V, Vogel SN, Szomolanyi-Tsuda E, Fitzgerald KA. The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses. Nat Immunol. 2010 May; 11(5):395-402. PMID: 20351692.
      Citations: 665     Fields:    Translation:HumansAnimalsCells
    194. Fitzgerald KA. NLR-containing inflammasomes: central mediators of host defense and inflammation. Eur J Immunol. 2010 Mar; 40(3):595-8. PMID: 20201007.
      Citations: 10     Fields:    Translation:HumansAnimals
    195. Goutagny N, Jiang Z, Tian J, Parroche P, Schickli J, Monks BG, Ulbrandt N, Ji H, Kiener PA, Coyle AJ, Fitzgerald KA. Cell type-specific recognition of human metapneumoviruses (HMPVs) by retinoic acid-inducible gene I (RIG-I) and TLR7 and viral interference of RIG-I ligand recognition by HMPV-B1 phosphoprotein. J Immunol. 2010 Feb 01; 184(3):1168-79. PMID: 20042593.
      Citations: 45     Fields:    Translation:HumansAnimalsCells
    196. Cole LE, Laird MH, Seekatz A, Santiago A, Jiang Z, Barry E, Shirey KA, Fitzgerald KA, Vogel SN. Phagosomal retention of Francisella tularensis results in TIRAP/Mal-independent TLR2 signaling. J Leukoc Biol. 2010 Feb; 87(2):275-81. PMID: 19889726.
      Citations: 24     Fields:    Translation:HumansAnimalsCells
    197. Woo CW, Cui D, Arellano J, Dorweiler B, Harding H, Fitzgerald KA, Ron D, Tabas I. Adaptive suppression of the ATF4-CHOP branch of the unfolded protein response by toll-like receptor signalling. Nat Cell Biol. 2009 Dec; 11(12):1473-80. PMID: 19855386.
      Citations: 144     Fields:    Translation:HumansAnimalsCells
    198. Balkhi MY, Fitzgerald KA, Pitha PM. IKKalpha negatively regulates IRF-5 function in a MyD88-TRAF6 pathway. Cell Signal. 2010 Jan; 22(1):117-27. PMID: 19786094.
      Citations: 19     Fields:    Translation:HumansCells
    199. Piao W, Song C, Chen H, Diaz MA, Wahl LM, Fitzgerald KA, Li L, Medvedev AE. Endotoxin tolerance dysregulates MyD88- and Toll/IL-1R domain-containing adapter inducing IFN-beta-dependent pathways and increases expression of negative regulators of TLR signaling. J Leukoc Biol. 2009 Oct; 86(4):863-75. PMID: 19656901.
      Citations: 68     Fields:    Translation:HumansCells
    200. McWhirter SM, Barbalat R, Monroe KM, Fontana MF, Hyodo M, Joncker NT, Ishii KJ, Akira S, Colonna M, Chen ZJ, Fitzgerald KA, Hayakawa Y, Vance RE. A host type I interferon response is induced by cytosolic sensing of the bacterial second messenger cyclic-di-GMP. J Exp Med. 2009 Aug 31; 206(9):1899-911. PMID: 19652017.
      Citations: 146     Fields:    Translation:AnimalsCells
    201. Fitzgerald KA. Integr-ating IL-1 alpha in antiviral host defenses. Immunity. 2009 Jul 17; 31(1):7-9. PMID: 19604487.
      Citations: 4     Fields:    Translation:AnimalsCells
    202. Pandey AK, Yang Y, Jiang Z, Fortune SM, Coulombe F, Behr MA, Fitzgerald KA, Sassetti CM, Kelliher MA. NOD2, RIP2 and IRF5 play a critical role in the type I interferon response to Mycobacterium tuberculosis. PLoS Pathog. 2009 Jul; 5(7):e1000500. PMID: 19578435.
      Citations: 142     Fields:    Translation:AnimalsCells
    203. Schlee M, Roth A, Hornung V, Hagmann CA, Wimmenauer V, Barchet W, Coch C, Janke M, Mihailovic A, Wardle G, Juranek S, Kato H, Kawai T, Poeck H, Fitzgerald KA, Takeuchi O, Akira S, Tuschl T, Latz E, Ludwig J, Hartmann G. Recognition of 5' triphosphate by RIG-I helicase requires short blunt double-stranded RNA as contained in panhandle of negative-strand virus. Immunity. 2009 Jul 17; 31(1):25-34. PMID: 19576794.
      Citations: 383     Fields:    Translation:HumansAnimalsCells
    204. Bauernfeind FG, Horvath G, Stutz A, Alnemri ES, MacDonald K, Speert D, Fernandes-Alnemri T, Wu J, Monks BG, Fitzgerald KA, Hornung V, Latz E. Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression. J Immunol. 2009 Jul 15; 183(2):787-91. PMID: 19570822.
      Citations: 1209     Fields:    Translation:HumansAnimalsCells
    205. Nagpal K, Plantinga TS, Wong J, Monks BG, Gay NJ, Netea MG, Fitzgerald KA, Golenbock DT. A TIR domain variant of MyD88 adapter-like (Mal)/TIRAP results in loss of MyD88 binding and reduced TLR2/TLR4 signaling. J Biol Chem. 2009 Sep 18; 284(38):25742-8. PMID: 19509286.
      Citations: 31     Fields:    Translation:HumansCells
    206. Hise AG, Tomalka J, Ganesan S, Patel K, Hall BA, Brown GD, Fitzgerald KA. An essential role for the NLRP3 inflammasome in host defense against the human fungal pathogen Candida albicans. Cell Host Microbe. 2009 May 08; 5(5):487-97. PMID: 19454352.
      Citations: 293     Fields:    Translation:HumansAnimalsCells
    207. Kenzel S, Santos-Sierra S, Deshmukh SD, Moeller I, Ergin B, Fitzgerald KA, Lien E, Akira S, Golenbock DT, Henneke P. Role of p38 and early growth response factor 1 in the macrophage response to group B streptococcus. Infect Immun. 2009 Jun; 77(6):2474-81. PMID: 19332535.
      Citations: 14     Fields:    Translation:AnimalsCells
    208. Hornung V, Ablasser A, Charrel-Dennis M, Bauernfeind F, Horvath G, Caffrey DR, Latz E, Fitzgerald KA. AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC. Nature. 2009 Mar 26; 458(7237):514-8. PMID: 19158675.
      Citations: 1193     Fields:    Translation:HumansAnimalsCells
    209. Sun Y, Ishibashi M, Seimon T, Lee M, Sharma SM, Fitzgerald KA, Samokhin AO, Wang Y, Sayers S, Aikawa M, Jerome WG, Ostrowski MC, Bromme D, Libby P, Tabas IA, Welch CL, Tall AR. Free cholesterol accumulation in macrophage membranes activates Toll-like receptors and p38 mitogen-activated protein kinase and induces cathepsin K. Circ Res. 2009 Feb 27; 104(4):455-65. PMID: 19122179.
      Citations: 93     Fields:    Translation:HumansAnimalsCells
    210. Charrel-Dennis M, Latz E, Halmen KA, Trieu-Cuot P, Fitzgerald KA, Kasper DL, Golenbock DT. TLR-independent type I interferon induction in response to an extracellular bacterial pathogen via intracellular recognition of its DNA. Cell Host Microbe. 2008 Dec 11; 4(6):543-54. PMID: 19064255.
      Citations: 78     Fields:    Translation:AnimalsCells
    211. Chessler AD, Ferreira LR, Chang TH, Fitzgerald KA, Burleigh BA. A novel IFN regulatory factor 3-dependent pathway activated by trypanosomes triggers IFN-beta in macrophages and fibroblasts. J Immunol. 2008 Dec 01; 181(11):7917-24. PMID: 19017982.
      Citations: 28     Fields:    Translation:HumansAnimalsCells
    212. El Kasmi KC, Qualls JE, Pesce JT, Smith AM, Thompson RW, Henao-Tamayo M, Basaraba RJ, K?nig T, Schleicher U, Koo MS, Kaplan G, Fitzgerald KA, Tuomanen EI, Orme IM, Kanneganti TD, Bogdan C, Wynn TA, Murray PJ. Toll-like receptor-induced arginase 1 in macrophages thwarts effective immunity against intracellular pathogens. Nat Immunol. 2008 Dec; 9(12):1399-406. PMID: 18978793.
      Citations: 335     Fields:    Translation:AnimalsCells
    213. Chen W, Lam SS, Srinath H, Jiang Z, Correia JJ, Schiffer CA, Fitzgerald KA, Lin K, Royer WE. Insights into interferon regulatory factor activation from the crystal structure of dimeric IRF5. Nat Struct Mol Biol. 2008 Nov; 15(11):1213-20. PMID: 18836453.
      Citations: 66     Fields:    Translation:HumansCells
    214. Balkhi MY, Fitzgerald KA, Pitha PM. Functional regulation of MyD88-activated interferon regulatory factor 5 by K63-linked polyubiquitination. Mol Cell Biol. 2008 Dec; 28(24):7296-308. PMID: 18824541.
      Citations: 60     Fields:    Translation:HumansAnimalsCells
    215. Halle A, Hornung V, Petzold GC, Stewart CR, Monks BG, Reinheckel T, Fitzgerald KA, Latz E, Moore KJ, Golenbock DT. The NALP3 inflammasome is involved in the innate immune response to amyloid-beta. Nat Immunol. 2008 Aug; 9(8):857-65. PMID: 18604209.
      Citations: 1117     Fields:    
    216. Hornung V, Bauernfeind F, Halle A, Samstad EO, Kono H, Rock KL, Fitzgerald KA, Latz E. Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization. Nat Immunol. 2008 Aug; 9(8):847-56. PMID: 18604214.
      Citations: 1355     Fields:    Translation:AnimalsCells
    217. Piao W, Song C, Chen H, Wahl LM, Fitzgerald KA, O'Neill LA, Medvedev AE. Tyrosine phosphorylation of MyD88 adapter-like (Mal) is critical for signal transduction and blocked in endotoxin tolerance. J Biol Chem. 2008 Feb 08; 283(6):3109-3119. PMID: 18070880.
      Citations: 37     Fields:    Translation:HumansCells
    218. Fitzgerald KA, Golenbock DT. Immunology. The shape of things to come. Science. 2007 Jun 15; 316(5831):1574-6. PMID: 17569850.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    219. Roberts ZJ, Goutagny N, Perera PY, Kato H, Kumar H, Kawai T, Akira S, Savan R, van Echo D, Fitzgerald KA, Young HA, Ching LM, Vogel SN. The chemotherapeutic agent DMXAA potently and specifically activates the TBK1-IRF-3 signaling axis. J Exp Med. 2007 Jul 09; 204(7):1559-69. PMID: 17562815.
      Citations: 91     Fields:    Translation:AnimalsCells
    220. Cook P, T?temeyer S, Stevenson C, Fitzgerald KA, Yamamoto M, Akira S, Maskell DJ, Bryant CE. Salmonella-induced SipB-independent cell death requires Toll-like receptor-4 signalling via the adapter proteins Tram and Trif. Immunology. 2007 Oct; 122(2):222-9. PMID: 17490432.
      Citations: 12     Fields:    Translation:AnimalsCells
    221. Zhou S, Kurt-Jones EA, Fitzgerald KA, Wang JP, Cerny AM, Chan M, Finberg RW. Role of MyD88 in route-dependent susceptibility to vesicular stomatitis virus infection. J Immunol. 2007 Apr 15; 178(8):5173-81. PMID: 17404300.
      Citations: 20     Fields:    Translation:AnimalsCells
    222. Tian J, Avalos AM, Mao SY, Chen B, Senthil K, Wu H, Parroche P, Drabic S, Golenbock D, Sirois C, Hua J, An LL, Audoly L, La Rosa G, Bierhaus A, Naworth P, Marshak-Rothstein A, Crow MK, Fitzgerald KA, Latz E, Kiener PA, Coyle AJ. Toll-like receptor 9-dependent activation by DNA-containing immune complexes is mediated by HMGB1 and RAGE. Nat Immunol. 2007 May; 8(5):487-96. PMID: 17417641.
      Citations: 637     Fields:    Translation:AnimalsCells
    223. Miggin SM, P?lsson-McDermott E, Dunne A, Jefferies C, Pinteaux E, Banahan K, Murphy C, Moynagh P, Yamamoto M, Akira S, Rothwell N, Golenbock D, Fitzgerald KA, O'Neill LA. NF-kappaB activation by the Toll-IL-1 receptor domain protein MyD88 adapter-like is regulated by caspase-1. Proc Natl Acad Sci U S A. 2007 Feb 27; 104(9):3372-7. PMID: 17360653.
      Citations: 56     Fields:    Translation:HumansCells
    224. Hise AG, Daehnel K, Gillette-Ferguson I, Cho E, McGarry HF, Taylor MJ, Golenbock DT, Fitzgerald KA, Kazura JW, Pearlman E. Innate immune responses to endosymbiotic Wolbachia bacteria in Brugia malayi and Onchocerca volvulus are dependent on TLR2, TLR6, MyD88, and Mal, but not TLR4, TRIF, or TRAM. J Immunol. 2007 Jan 15; 178(2):1068-76. PMID: 17202370.
      Citations: 54     Fields:    Translation:HumansAnimalsCells
    225. Severa M, Fitzgerald KA. TLR-mediated activation of type I IFN during antiviral immune responses: fighting the battle to win the war. Curr Top Microbiol Immunol. 2007; 316:167-92. PMID: 17969448.
      Citations: 23     Fields:    Translation:HumansAnimals
    226. Severa M, Coccia EM, Fitzgerald KA. Toll-like receptor-dependent and -independent viperin gene expression and counter-regulation by PRDI-binding factor-1/BLIMP1. J Biol Chem. 2006 Sep 08; 281(36):26188-95. PMID: 16849320.
      Citations: 65     Fields:    Translation:HumansAnimalsCells
    227. Goutagny N, Fitzgerald KA. Pattern recognition receptors: an update. Expert Rev Clin Immunol. 2006 Jul; 2(4):569-83. PMID: 20477614.
      Citations: 3     Fields:    
    228. Mitchell JA, Fitzgerald KA, Coyle A, Silverman N, Cartwright N. TOLLing away in Brazil. Nat Immunol. 2006 Jul; 7(7):675-9. PMID: 16785880.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    229. McGettrick AF, Brint EK, Palsson-McDermott EM, Rowe DC, Golenbock DT, Gay NJ, Fitzgerald KA, O'Neill LA. Trif-related adapter molecule is phosphorylated by PKC{epsilon} during Toll-like receptor 4 signaling. Proc Natl Acad Sci U S A. 2006 Jun 13; 103(24):9196-201. PMID: 16757566.
      Citations: 44     Fields:    Translation:HumansAnimalsCells
    230. Fitzgerald KA, Chen ZJ. Sorting out Toll signals. Cell. 2006 Jun 02; 125(5):834-6. PMID: 16751092.
      Citations: 39     Fields:    Translation:HumansAnimalsCells
    231. Rowe DC, McGettrick AF, Latz E, Monks BG, Gay NJ, Yamamoto M, Akira S, O'Neill LA, Fitzgerald KA, Golenbock DT. The myristoylation of TRIF-related adaptor molecule is essential for Toll-like receptor 4 signal transduction. Proc Natl Acad Sci U S A. 2006 Apr 18; 103(16):6299-304. PMID: 16603631.
      Citations: 93     Fields:    Translation:HumansAnimalsCells
    232. Rothenfusser S, Goutagny N, DiPerna G, Gong M, Monks BG, Schoenemeyer A, Yamamoto M, Akira S, Fitzgerald KA. The RNA helicase Lgp2 inhibits TLR-independent sensing of viral replication by retinoic acid-inducible gene-I. J Immunol. 2005 Oct 15; 175(8):5260-8. PMID: 16210631.
      Citations: 283     Fields:    Translation:HumansAnimalsCells
    233. Jefferies CA, Fitzgerald KA. Interferon gene regulation: not all roads lead to Tolls. Trends Mol Med. 2005 Sep; 11(9):403-11. PMID: 16095970.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    234. Youn HS, Lee JY, Fitzgerald KA, Young HA, Akira S, Hwang DH. Specific inhibition of MyD88-independent signaling pathways of TLR3 and TLR4 by resveratrol: molecular targets are TBK1 and RIP1 in TRIF complex. J Immunol. 2005 Sep 01; 175(5):3339-46. PMID: 16116226.
      Citations: 83     Fields:    Translation:AnimalsCells
    235. Medin CL, Fitzgerald KA, Rothman AL. Dengue virus nonstructural protein NS5 induces interleukin-8 transcription and secretion. J Virol. 2005 Sep; 79(17):11053-61. PMID: 16103156.
      Citations: 44     Fields:    Translation:HumansCells
    236. Cusson-Hermance N, Khurana S, Lee TH, Fitzgerald KA, Kelliher MA. Rip1 mediates the Trif-dependent toll-like receptor 3- and 4-induced NF-{kappa}B activation but does not contribute to interferon regulatory factor 3 activation. J Biol Chem. 2005 Nov 04; 280(44):36560-6. PMID: 16115877.
      Citations: 141     Fields:    Translation:HumansAnimalsCells
    237. Stack J, Haga IR, Schr?der M, Bartlett NW, Maloney G, Reading PC, Fitzgerald KA, Smith GL, Bowie AG. Vaccinia virus protein A46R targets multiple Toll-like-interleukin-1 receptor adaptors and contributes to virulence. J Exp Med. 2005 Mar 21; 201(6):1007-18. PMID: 15767367.
      Citations: 162     Fields:    Translation:HumansAnimalsCells
    238. Schoenemeyer A, Barnes BJ, Mancl ME, Latz E, Goutagny N, Pitha PM, Fitzgerald KA, Golenbock DT. The interferon regulatory factor, IRF5, is a central mediator of toll-like receptor 7 signaling. J Biol Chem. 2005 Apr 29; 280(17):17005-12. PMID: 15695821.
      Citations: 176     Fields:    Translation:HumansCells
    239. Fitzgerald KA, Rowe DC, Golenbock DT. Endotoxin recognition and signal transduction by the TLR4/MD2-complex. Microbes Infect. 2004 Dec; 6(15):1361-7. PMID: 15596121.
      Citations: 111     Fields:    Translation:AnimalsCells
    240. Silverman N, Fitzgerald K. DUBbing down innate immunity. Nat Immunol. 2004 Oct; 5(10):1010-2. PMID: 15454928.
      Citations: 2     Fields:    Translation:Animals
    241. Bj?rkbacka H, Fitzgerald KA, Huet F, Li X, Gregory JA, Lee MA, Ordija CM, Dowley NE, Golenbock DT, Freeman MW. The induction of macrophage gene expression by LPS predominantly utilizes Myd88-independent signaling cascades. Physiol Genomics. 2004 Nov 17; 19(3):319-30. PMID: 15367722.
      Citations: 93     Fields:    Translation:HumansAnimalsCells
    242. DiPerna G, Stack J, Bowie AG, Boyd A, Kotwal G, Zhang Z, Arvikar S, Latz E, Fitzgerald KA, Marshall WL. Poxvirus protein N1L targets the I-kappaB kinase complex, inhibits signaling to NF-kappaB by the tumor necrosis factor superfamily of receptors, and inhibits NF-kappaB and IRF3 signaling by toll-like receptors. J Biol Chem. 2004 Aug 27; 279(35):36570-8. PMID: 15215253.
      Citations: 129     Fields:    Translation:HumansCells
    243. Liberati NT, Fitzgerald KA, Kim DH, Feinbaum R, Golenbock DT, Ausubel FM. Requirement for a conserved Toll/interleukin-1 resistance domain protein in the Caenorhabditis elegans immune response. Proc Natl Acad Sci U S A. 2004 Apr 27; 101(17):6593-8. PMID: 15123841.
      Citations: 101     Fields:    Translation:AnimalsCells
    244. Lee JY, Zhao L, Youn HS, Weatherill AR, Tapping R, Feng L, Lee WH, Fitzgerald KA, Hwang DH. Saturated fatty acid activates but polyunsaturated fatty acid inhibits Toll-like receptor 2 dimerized with Toll-like receptor 6 or 1. J Biol Chem. 2004 Apr 23; 279(17):16971-9. PMID: 14966134.
      Citations: 192     Fields:    Translation:HumansAnimalsCells
    245. Latz E, Schoenemeyer A, Visintin A, Fitzgerald KA, Monks BG, Knetter CF, Lien E, Nilsen NJ, Espevik T, Golenbock DT. TLR9 signals after translocating from the ER to CpG DNA in the lysosome. Nat Immunol. 2004 Feb; 5(2):190-8. PMID: 14716310.
      Citations: 491     Fields:    Translation:HumansAnimalsCells
    246. McWhirter SM, Fitzgerald KA, Rosains J, Rowe DC, Golenbock DT, Maniatis T. IFN-regulatory factor 3-dependent gene expression is defective in Tbk1-deficient mouse embryonic fibroblasts. Proc Natl Acad Sci U S A. 2004 Jan 06; 101(1):233-8. PMID: 14679297.
      Citations: 209     Fields:    Translation:AnimalsCells
    247. Vogel SN, Fitzgerald KA, Fenton MJ. TLRs: differential adapter utilization by toll-like receptors mediates TLR-specific patterns of gene expression. Mol Interv. 2003 Dec; 3(8):466-77. PMID: 14993454.
      Citations: 82     Fields:    Translation:HumansCells
    248. Fitzgerald KA, Rowe DC, Barnes BJ, Caffrey DR, Visintin A, Latz E, Monks B, Pitha PM, Golenbock DT. LPS-TLR4 signaling to IRF-3/7 and NF-kappaB involves the toll adapters TRAM and TRIF. J Exp Med. 2003 Oct 06; 198(7):1043-55. PMID: 14517278.
      Citations: 415     Fields:    Translation:HumansAnimalsCells
    249. O'Neill LA, Fitzgerald KA, Bowie AG. The Toll-IL-1 receptor adaptor family grows to five members. Trends Immunol. 2003 Jun; 24(6):286-90. PMID: 12810098.
      Citations: 114     Fields:    Translation:HumansAnimalsCells
    250. Fitzgerald KA, McWhirter SM, Faia KL, Rowe DC, Latz E, Golenbock DT, Coyle AJ, Liao SM, Maniatis T. IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway. Nat Immunol. 2003 May; 4(5):491-6. PMID: 12692549.
      Citations: 1109     Fields:    Translation:HumansCells
    251. Fitzgerald KA, Palsson-McDermott EM, Bowie AG, Jefferies CA, Mansell AS, Brady G, Brint E, Dunne A, Gray P, Harte MT, McMurray D, Smith DE, Sims JE, Bird TA, O'Neill LA. Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction. Nature. 2001 Sep 06; 413(6851):78-83. PMID: 11544529.
      Citations: 354     Fields:    Translation:HumansAnimalsCells
    252. Fitzgerald KA, O'Neill LA. The role of the interleukin-1/Toll-like receptor superfamily in inflammation and host defence. Microbes Infect. 2000 Jul; 2(8):933-43. PMID: 10962277.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    253. Meuer SC, Hussey RE, Fabbi M, Fox D, Acuto O, Fitzgerald KA, Hodgdon JC, Protentis JP, Schlossman SF, Reinherz EL. An alternative pathway of T-cell activation: a functional role for the 50 kd T11 sheep erythrocyte receptor protein. Cell. 1984 Apr; 36(4):897-906. PMID: 6231105.
      Citations: 260     Fields:    Translation:HumansAnimalsCells
    254. Acuto O, Hussey RE, Fitzgerald KA, Protentis JP, Meuer SC, Schlossman SF, Reinherz EL. The human T cell receptor: appearance in ontogeny and biochemical relationship of alpha and beta subunits on IL-2 dependent clones and T cell tumors. Cell. 1983 Oct; 34(3):717-26. PMID: 6605197.
      Citations: 85     Fields:    Translation:HumansCells
    255. Reinherz EL, Meuer S, Fitzgerald KA, Hussey RE, Levine H, Schlossman SF. Antigen recognition by human T lymphocytes is linked to surface expression of the T3 molecular complex. Cell. 1982 Oct; 30(3):735-43. PMID: 6982759.
      Citations: 114     Fields:    Translation:HumansCells
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