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Hassan H Fakih PhD

TitleInstructor
InstitutionUMass Chan Medical School
DepartmentRNA Therapeutics Institute
AddressUMass Chan Medical School
55 Lake Avenue North
Worcester MA 01655
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    Other Positions
    InstitutionT.H. Chan School of Medicine
    DepartmentRNA Therapeutics Institute


    Collapse Biography 
    Collapse education and training
    American University of Beirut, Beirut, , LebanonBSPremedical Chemistry
    McGill University, Montreal, QC, CanadaPHDChemistry and Chemical Biology

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Hariharan VN, Summers A, Clipperton-Allen AE, Caiazzi J, Hildebrand SR, O' Reilly D, Tang Q, Kennedy Z, Echeverria D, McHugh N, Cooper D, Sousa J, Ferguson C, Fakih HH, Bogdanik L, Coenraads M, Khvorova A. Single-dose administration of therapeutic divalent siRNA targeting MECP2 prevents lethality in an MECP2 duplication mouse model. Nat Commun. 2026 Jul 21. PMID: 42481469.
      Citations:    
    2. Belgrad J, Greco TM, Sapp E, Summers A, O'Reilly D, Luu E, Hutton JE, Yamada N, Fakih HH, Furgal R, Echeverria D, McHugh N, Bramato B, Furguson C, Hildebrand S, Allen S, Gaston N, Cooper D, Maebius A, Gross KY, Vogt TF, Finley M, Prasad B, DiFiglia M, Cristea IM, Aronin N, Khvorova A. Mismatch repair dissection by in vivo RNAi reveals dose-dependent modulators of somatic instability and proteome remodeling in Huntington's disease. bioRxiv. 2026 Jun 24. PMID: 42395360.
      Citations:    
    3. Yang YS, Gross KY, Cooper D, Chaugule S, Kim MJ, Dahlke C, Mayer E, Kercher EM, Kim JW, Ormsby T, Yamada N, Caiazzi J, Jackson SO, Rachid MO, Echiverria D, Fakih HH, Yamada K, Lee FY, Khvorova A, Alterman JF, Shim JH. Precision RNAi for Fibrodysplasia Ossificans Progressiva: a combinatorial, unimolecular, allele selective approach. Res Sq. 2026 Jun 15. PMID: 42370290.
      Citations:    
    4. Blitek M, Le Coz O, Ogor V, Fakih HH, Khvorova A, Goyenvalle A. Efficient Downregulation of Flt-1 Mediated by Splice Switching ASO in Murine Endothelial Cells. Nucleic Acid Ther. 2026 Jun; 36(3):147-157. PMID: 41933450.
      Citations:    
    5. Fakih HH, Zain Ui Abideen M, Rachid MO, Gross KY, Ormsby TJR, Ross VM, Gagnon R, Dahlke C, Furgal RC, Lochmann C, Summers A, Sleiman HF, F?rst SM, Jackson SN, Gordilho JO, Bouix-Peter C, Portal T, Tang Q, Harris JE, Khvorova A, Blanchard C, Alterman JF. Intradermal delivery of lipophilic siRNAs enables prolonged skin retention and sustained gene silencing in a porcine model. Nat Commun. 2026 Feb 03; 17(1). PMID: 41634015.
      Citations:    
    6. Tocheny CE, Buchwald JE, Dahlke CD, Fakih HH, Morgan JS, Summers A, Silva CA, Jackson SO, Lee JS, Card MA, Echeverria D, Peterson C, Mercurio AM, Khvorova A, Shaw LM. Therapeutic delivery of albumin-binding siRNA targeting IRS2 to diverse cell types reduces mammary tumor growth. Mol Ther. 2026 May 06; 34(5):2963-2982. PMID: 41612694.
      Citations:    
    7. O'Reilly D, Furgal RC, Ross VM, Luu E, Gross KY, Hariharan V, Summers A, Cooper D, Allen S, Dahlke C, Rachid MO, Chan IL, Fakih HH, Alterman JF, Echeverria D, Watts JK, Khvorova A. Presence of phosphodiester backbone, but not nucleobases, in the guide's 3' terminal region is necessary for RISC loading and target cleavage in vitro and in vivo. Nucleic Acids Res. 2026 Jan 05; 54(1). PMID: 41521659.
      Citations:    
    8. Fakih HH, Ohara M, Summers A, Sarli SL, Kelly K, Gagnon R, Maru B, Bramato B, Khvorova A, Watts JK. Albumin-binding dendrimer-conjugated siRNA enables safe and effective gene silencing throughout the central nervous system. bioRxiv. 2025 Dec 18. PMID: 41473322.
      Citations:    
    9. Fakih HH, Lochmann C, Gagnon R, Summers A, Caiazzi J, Buchwald JE, Tang Q, Maru B, Hildebrand SR, Abideen MZUI, Furgal RC, Gross KY, Yang YS, Cooper D, Monopoli KR, Echeverria D, Shim JH, Yamada K, Alterman JF, Khvorova A. Potent and durable gene modulation in heart and muscle with chemically defined lipophilic siRNAs. Nucleic Acids Res. 2025 Nov 26; 53(22). PMID: 41432033.
      Citations:    
    10. Tocheny CE, Buchwald JE, Dahlke CD, Fakih HH, Morgan JS, Summers A, Wisniewski CA, Jackson SO, Lee JS, Card MA, Echeverria D, Peterson C, Mercurio AM, Khvorova A, Shaw LM. Therapeutic delivery of albumin-binding siRNA targeting IRS2 to diverse cell types reduces mammary tumor growth. bioRxiv. 2025 Aug 01. PMID: 40766531.
      Citations:    
    11. Fakih HH, Tang Q, Summers A, Gross KY, Rachid MO, Okamura K, Martinez N, Sleiman HF, Harris JE, Khvorova A. Albumin-binding dendritic siRNA improves delivery and efficacy to solid tumors in a melanoma model. Mol Ther Nucleic Acids. 2025 Sep 09; 36(3):102579. PMID: 40606645.
      Citations:    
    12. Tang Q, Fakih HH, Gross KY, Winter SJ, Bramato BM, Yildiz-Altay ?, Chang BK, Echeverria D, Jackson SO, McHugh N, Srnka A, Alterman JF, Almela RM, Kudej RK, London CA, Richmond JM, Harris JE, Khvorova A. A Therapeutic Small-Interfering RNA Potentiates Janus Kinase 1 Modulation for the Treatment of Dog Inflammatory Diseases. ACS Pharmacol Transl Sci. 2025 Jun 13; 8(6):1526-1535. PMID: 40534660.
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    13. Rafique MG, Laurent Q, Dore MD, Fakih HH, Trinh T, Rizzuto FJ, Sleiman HF. Sequence-Defined DNA Polymers: New Tools for DNA Nanotechnology and Nucleic Acid Therapy. Acc Chem Res. 2025 01 21; 58(2):177-188. PMID: 39772484.
      Citations:    
    14. Yamada K, Hariharan VN, Caiazzi J, Miller R, Ferguson CM, Sapp E, Fakih HH, Tang Q, Yamada N, Furgal RC, Paquette JD, Biscans A, Bramato BM, McHugh N, Summers A, Lochmann C, Godinho BMDC, Hildebrand S, Jackson SO, Echeverria D, Hassler MR, Alterman JF, DiFiglia M, Aronin N, Khvorova A. Enhancing siRNA efficacy in vivo with extended nucleic acid backbones. Nat Biotechnol. 2025 Jun; 43(6):904-913. PMID: 39090305.
      Citations:    
    15. Sarli SL, Fakih HH, Kelly K, Devi G, Rembetsy-Brown JM, McEachern HR, Ferguson CM, Echeverria D, Lee J, Sousa J, Sleiman HF, Khvorova A, Watts JK. Quantifying the activity profile of ASO and siRNA conjugates in glioblastoma xenograft tumors in vivo. Nucleic Acids Res. 2024 05 22; 52(9):4799-4817. PMID: 38613388.
      Citations:    
    16. Belgrad J, Fakih HH, Khvorova A. Nucleic Acid Therapeutics: Successes, Milestones, and Upcoming Innovation. Nucleic Acid Ther. 2024 04; 34(2):52-72. PMID: 38507678.
      Citations:    
    17. Belgrad J, Fakih HH, Johnson KC, Corey DR. Editorial: Nucleic Acids Research virtual issue dedicated to nucleic acid therapeutics, 2018-2023. Nucleic Acids Res. 2024 01 25; 52(2):511-512. PMID: 38035373.
      Citations:    
    18. Asohan J, Fakih HH, Das T, Sleiman HF. Control of the Assembly and Disassembly of Spherical Nucleic Acids Is Critical for Enhanced Gene Silencing. ACS Nano. 2024 02 06; 18(5):3996-4007. PMID: 38265027.
      Citations:    
    19. Tang Q, Gross KY, Fakih HH, Jackson SO, Zain U I Abideen M, Monopoli KR, Blanchard C, Bouix-Peter C, Portal T, Harris JE, Khvorova A, Alterman JF. Multispecies-targeting siRNAs for the modulation of JAK1 in the skin. Mol Ther Nucleic Acids. 2024 Mar 12; 35(1):102117. PMID: 38304729.
      Citations:    
    20. Fakih HH, Tang Q, Summers A, Shin M, Buchwald JE, Gagnon R, Hariharan VN, Echeverria D, Cooper DA, Watts JK, Khvorova A, Sleiman HF. Dendritic amphiphilic siRNA: Selective albumin binding, in?vivo efficacy, and low toxicity. Mol Ther Nucleic Acids. 2023 Dec 12; 34:102080. PMID: 38089931.
      Citations:    
    21. Tang Q, Fakih HH, Zain Ui Abideen M, Hildebrand SR, Afshari K, Gross KY, Sousa J, Maebius AS, Bartholdy C, S?gaard PP, Jackerott M, Hariharan V, Summers A, Fan X, Okamura K, Monopoli KR, Cooper DA, Echeverria D, Bramato B, McHugh N, Furgal RC, Dresser K, Winter SJ, Biscans A, Chuprin J, Haddadi NS, Sherman S, Yildiz-Altay ?, Rashighi M, Richmond JM, Bouix-Peter C, Blanchard C, Clauss A, Alterman JF, Khvorova A, Harris JE. Rational design of a JAK1-selective siRNA inhibitor for the modulation of autoimmunity in the skin. Nat Commun. 2023 11 04; 14(1):7099. PMID: 37925520.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    22. Hariharan VN, Caiazzi J, Miller R, Ferguson C, Sapp E, Fakih H, Tang Q, Yamada N, Furgal R, Paquette J, Bramato B, McHugh N, Summers A, Lochmann C, Godinho B, Hildebrand S, Echeverria D, Hassler M, Alterman J, DiFiglia M, Aronin N, Khvorova A, Yamada K. Extended Nucleic Acid (exNA): A Novel, Biologically Compatible Backbone that Significantly Enhances Oligonucleotide Efficacy in vivo. Res Sq. 2023 Jun 01. PMID: 37398145.
      Citations:    
    23. Yamada K, Hariharan VN, Caiazzi J, Miller R, Furguson C, Sapp E, Fakih H, Tan Q, Yamada N, Furgal RC, Paquette J, Bramato B, McHugh N, Summers A, Lochmann C, Godinho BMDC, Hildebrand S, Echeverria D, Hassler MR, Alterman JF, DiFiglia M, Aronin N, Khvorova A. Extended Nucleic Acid (exNA): A Novel, Biologically Compatible Backbone that Significantly Enhances Oligonucleotide Efficacy in vivo. bioRxiv. 2023 May 26. PMID: 37292886.
      Citations:    
    24. Kaviani S, Fakih HH, Asohan J, Katolik A, Damha MJ, Sleiman HF. Sequence-Controlled Spherical Nucleic Acids: Gene Silencing, Encapsulation, and Cellular Uptake. Nucleic Acid Ther. 2023 08; 33(4):265-276. PMID: 37196168.
      Citations:    
    25. Brown TM, Fakih HH, Saliba D, Asohan J, Sleiman HF. Stabilization of Functional DNA Structures with Mild Photochemical Methods. J Am Chem Soc. 2023 02 01; 145(4):2142-2151. PMID: 36651186.
      Citations:    
    26. Fakih HH, Katolik A, Malek-Adamian E, Fakhoury JJ, Kaviani S, Damha MJ, Sleiman HF. Design and enhanced gene silencing activity of spherical 2'-fluoroarabinose nucleic acids (FANA-SNAs). Chem Sci. 2021 Jan 15; 12(8):2993-3003. PMID: 34164068.
      Citations:    
    27. Habibian M, Harikrishna S, Fakhoury J, Barton M, Ageely EA, Cencic R, Fakih HH, Katolik A, Takahashi M, Rossi J, Pelletier J, Gagnon KT, Pradeepkumar PI, Damha MJ. Effect of 2'-5'/3'-5' phosphodiester linkage heterogeneity on RNA interference. Nucleic Acids Res. 2020 05 21; 48(9):4643-4657. PMID: 32282904.
      Citations:    
    28. Lacroix A, Fakih HH, Sleiman HF. Detailed cellular assessment of albumin-bound oligonucleotides: Increased stability and lower non-specific cell uptake. J Control Release. 2020 08 10; 324:34-46. PMID: 32330572.
      Citations:    
    29. Fakih HH, Fakhoury JJ, Bousmail D, Sleiman HF. Minimalist Design of a Stimuli-Responsive Spherical Nucleic Acid for Conditional Delivery of Oligonucleotide Therapeutics. ACS Appl Mater Interfaces. 2019 Apr 17; 11(15):13912-13920. PMID: 30720262.
      Citations:    
    30. Bujold KE, Fakih HH, Sleiman HF. Design Strategy to Access siRNA-Encapsulating DNA "Nanosuitcases" That Can Conditionally Release Their Cargo. Methods Mol Biol. 2019; 1974:69-81. PMID: 31098996.
      Citations:    
    31. Bousmail D, Amrein L, Fakhoury JJ, Fakih HH, Hsu JCC, Panasci L, Sleiman HF. Precision spherical nucleic acids for delivery of anticancer drugs. Chem Sci. 2017 Sep 01; 8(9):6218-6229. PMID: 28989655.
      Citations:    
    32. Darwish GH, Fakih HH, Karam P. Temperature Mapping in Hydrogel Matrices Using Unmodified Digital Camera. J Phys Chem B. 2017 02 09; 121(5):1033-1040. PMID: 28072912.
      Citations:    
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