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John P Mordes MD

TitleProfessor
InstitutionUniversity of Massachusetts Medical School
DepartmentMedicine
AddressUniversity of Massachusetts Medical School
364 Plantation Street, LRB-222
Worcester MA 01605
Phone508-856-3166
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    Other Positions
    InstitutionUMMS - School of Medicine
    DepartmentMedicine
    DivisionEndocrinology & Metabolism

    InstitutionUMMS - Graduate School of Biomedical Sciences
    DepartmentBiochemistry and Molecular Pharmacology

    InstitutionUMMS - Graduate School of Biomedical Sciences
    DepartmentInterdisciplinary Graduate Program


    Collapse Biography 
    Collapse education and training
    Harvard University, Cambridge, MA, United StatesABSocial Relations
    Harvard Medical School, Boston, MA, United StatesMD

    Collapse Overview 
    Collapse overview
    John Morder, MDBoard CertificationAmerican Board of Internal Medicine
    American Board of IM-Endocrinology, Diabetes, Meta
    Medical DegreeHarvard Medical School
    Boston Massachusetts
    Residency/TrainingBrigham & Women's Hospital
    Massachusetts Mental Health Center
    FellowshipUMass Memorial Medical Center

    Research

    Our laboratory conducts basic and clinical research in the area of type 1 diabetes. Basic research is currently focused on the genetics and pathophysiology of diabetes in rat models of the disease with particular emphasis on the T cell receptor beta chain and the diubiquitin gene. We are also in the early stages of a program designed to understand the mechanisms underlying type 1 diabetes following viral infection. Another program is studying the susceptibility of certain rats to multiple disorders including diabetes, arthritis, and thyroiditis. Finally, we are also participating in clinical studies of otelixizumab, an anti-CD3 monoclonal antibody currently in phase 3 trials in adolescents and adults with new onset type 1 diabetes and in clinical studies of non-invasive methods for measuring glucose concentration.




    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Yuan X, Dai X, Liu L, Hsue C, Miller JD, Fang Z, Li J, Feng J, Huang Y, Liu C, Shen J, Chen T, Liu Y, Mordes J, Lou Q. Comparing the Effects of Six-Month Aerobic Exercise and Resistance Training on Metabolic Control and Beta Cell Function in Chinese Patients with Prediabetes: A multicenter randomized controlled trial. J Diabetes. 2019 May 29. PMID: 31141300.
      View in: PubMed
    2. Aydemir Ö, Noble JA, Bailey J, Lernmark Å, Marsh P, Svärd AA, Bearoff F, Blankenhorn EP, Mordes JP. Genetic Variation Within the HLA-DRA1 Gene Modulates Susceptibility to Type 1 Diabetes in HLA-DR3 Homozygotes. Diabetes. 2019 Apr 08. PMID: 30962219.
      View in: PubMed
    3. Qaisar N, Lin S, Ryan G, Yang C, Oikemus SR, Brodsky MH, Bortell R, Mordes JP, Wang JP. A Critical Role for the Type I Interferon Receptor in Virus-Induced Autoimmune Diabetes in Rats. Diabetes. 2017 Jan; 66(1):145-157. PMID: 27999109.
      View in: PubMed
    4. Liu L, Lou Q, Guo X, Yuan L, Shen L, Sun Z, Zhao F, Dai X, Huang J, Yang H, Mordes JP. Management status and its predictive factors in patients with type 2 diabetes in China: A Nationwide Multicenter Study: A Nationwide Multicenter Study. Diabetes Metab Res Rev. 2015 Nov; 31(8):811-6. PMID: 26455830.
      View in: PubMed
    5. Mordes JP, Liu C, Xu S. Medications for weight loss. Curr Opin Endocrinol Diabetes Obes. 2015 Apr; 22(2):91-7. PMID: 25692921.
      View in: PubMed
    6. Mordes JP, Alonso LC. Evaluation, Medical Therapy, and Course of Adult Persistent Hyperinsulinemic Hypoglycemia After Roux-en-Y Gastric Bypass Surgery: A Case Series. Endocr Pract. 2015 Mar; 21(3):237-46. PMID: 25100376.
      View in: PubMed
    7. Cort L, Habib M, Eberwine RA, Hessner MJ, Mordes JP, Blankenhorn EP. Diubiquitin (Ubd) is a susceptibility gene for virus-triggered autoimmune diabetes in rats. Genes Immun. 2014 Apr-May; 15(3):168-75. PMID: 24452267.
      View in: PubMed
    8. Eberwine RA, Cort L, Habib M, Mordes JP, Blankenhorn EP. Autoantigen-induced focusing of Vß13+ T cells precedes onset of autoimmune diabetes in the LEW.1WR1 rat. Diabetes. 2014 Feb; 63(2):596-604. PMID: 24150607.
      View in: PubMed
    9. Chen YG, Mordes JP, Blankenhorn EP, Kashmiri H, Kaldunski ML, Jia S, Geoffrey R, Wang X, Hessner MJ. Temporal induction of immunoregulatory processes coincides with age-dependent resistance to viral-induced type 1 diabetes. Genes Immun. 2013 Sep; 14(6):387-400. PMID: 23739610.
      View in: PubMed
    10. Pierce BG, Eberwine R, Noble JA, Habib M, Shulha HP, Weng Z, Blankenhorn EP, Mordes JP. The Missing Heritability in T1D and Potential New Targets for Prevention. J Diabetes Res. 2013; 2013:737485. PMID: 23691517.
      View in: PubMed
    11. Liu Z, Cort L, Eberwine R, Herrmann T, Leif JH, Greiner DL, Yahalom B, Blankenhorn EP, Mordes JP. Prevention of type 1 diabetes in the rat with an allele-specific anti-T-cell receptor antibody: Vß13 as a therapeutic target and biomarker. Diabetes. 2012 May; 61(5):1160-8. PMID: 22368175.
      View in: PubMed
    12. Ockene IS, Tellez TL, Rosal MC, Reed GW, Mordes J, Merriam PA, Olendzki BC, Handelman G, Nicolosi R, Ma Y. Outcomes of a Latino community-based intervention for the prevention of diabetes: the Lawrence Latino Diabetes Prevention Project. Am J Public Health. 2012 Feb; 102(2):336-42. PMID: 22390448.
      View in: PubMed
    13. Malkani S, Mordes JP. Implications of using hemoglobin A1C for diagnosing diabetes mellitus. Am J Med. 2011 May; 124(5):395-401. PMID: 21531226.
      View in: PubMed
    14. Kruger AJ, Yang C, Tam SW, Hinerfeld D, Evans JE, Green KM, Leszyk J, Yang K, Guberski DL, Mordes JP, Greiner DL, Rossini AA, Bortell R. Haptoglobin as an early serum biomarker of virus-induced autoimmune type 1 diabetes in biobreeding diabetes resistant and LEW1.WR1 rats. Exp Biol Med (Maywood). 2010 Nov; 235(11):1328-37. PMID: 20975081.
      View in: PubMed
    15. Kaldunski M, Jia S, Geoffrey R, Basken J, Prosser S, Kansra S, Mordes JP, Lernmark A, Wang X, Hessner MJ. Identification of a serum-induced transcriptional signature associated with type 1 diabetes in the BioBreeding rat. Diabetes. 2010 Oct; 59(10):2375-85. PMID: 20682698.
      View in: PubMed
    16. Jurczyk A, Pino SC, O'Sullivan-Murphy B, Addorio M, Lidstone EA, Diiorio P, Lipson KL, Standley C, Fogarty K, Lifshitz L, Urano F, Mordes JP, Greiner DL, Rossini AA, Bortell R. A novel role for the centrosomal protein, pericentrin, in regulation of insulin secretory vesicle docking in mouse pancreatic beta-cells. PLoS One. 2010 Jul 27; 5(7):e11812. PMID: 20676397.
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    17. Guseva N, Phillips D, Mordes JP. Successful treatment of persistent hyperinsulinemic hypoglycemia with nifedipine in an adult patient. Endocr Pract. 2010 Jan-Feb; 16(1):107-11. PMID: 19625246.
      View in: PubMed
    18. Tirabassi RS, Guberski DL, Blankenhorn EP, Leif JH, Woda BA, Liu Z, Winans D, Greiner DL, Mordes JP. Infection with viruses from several families triggers autoimmune diabetes in LEW*1WR1 rats: prevention of diabetes by maternal immunization. Diabetes. 2010 Jan; 59(1):110-8. PMID: 19794063.
      View in: PubMed
    19. Blankenhorn EP, Cort L, Greiner DL, Guberski DL, Mordes JP. Virus-induced autoimmune diabetes in the LEW.1WR1 rat requires Iddm14 and a genetic locus proximal to the major histocompatibility complex. Diabetes. 2009 Dec; 58(12):2930-8. PMID: 19720792.
      View in: PubMed
    20. Pino SC, O'Sullivan-Murphy B, Lidstone EA, Yang C, Lipson KL, Jurczyk A, diIorio P, Brehm MA, Mordes JP, Greiner DL, Rossini AA, Bortell R. CHOP mediates endoplasmic reticulum stress-induced apoptosis in Gimap5-deficient T cells. PLoS One. 2009; 4(5):e5468. PMID: 19424493.
      View in: PubMed
    21. Fuller JM, Bogdani M, Tupling TD, Jensen RA, Pefley R, Manavi S, Cort L, Blankenhorn EP, Mordes JP, Lernmark A, Kwitek AE. Genetic dissection reveals diabetes loci proximal to the gimap5 lymphopenia gene. Physiol Genomics. 2009 Jun 10; 38(1):89-97. PMID: 19351909.
      View in: PubMed
    22. Chopra P, Diiorio P, Pino SC, Wilson SB, Phillips NE, Mordes JP, Rossini AA, Greiner DL, Shultz LD, Bortell R. Failure of alpha-galactosylceramide to prevent diabetes in virus-inducible models of type 1 diabetes in the rat. In Vivo. 2009 Mar-Apr; 23(2):195-201. PMID: 19414403.
      View in: PubMed
    23. Bishop KD, Harris JE, Mordes JP, Greiner DL, Rossini AA, Czech MP, Phillips NE. Depletion of the programmed death-1 receptor completely reverses established clonal anergy in CD4(+) T lymphocytes via an interleukin-2-dependent mechanism. Cell Immunol. 2009; 256(1-2):86-91. PMID: 19230866.
      View in: PubMed
    24. Mordes JP, Cort L, Norowski E, Leif J, Fuller JM, Lernmark A, Greiner DL, Blankenhorn EP. Analysis of the rat Iddm14 diabetes susceptibility locus in multiple rat strains: identification of a susceptibility haplotype in the Tcrb-V locus. Mamm Genome. 2009 Mar; 20(3):162-9. PMID: 19205800.
      View in: PubMed
    25. Pino SC, O'Sullivan-Murphy B, Lidstone EA, Thornley TB, Jurczyk A, Urano F, Greiner DL, Mordes JP, Rossini AA, Bortell R. Protein kinase C signaling during T cell activation induces the endoplasmic reticulum stress response. Cell Stress Chaperones. 2008 Dec; 13(4):421-34. PMID: 18418732.
      View in: PubMed
    26. Thornley TB, Phillips NE, Beaudette-Zlatanova BC, Markees TG, Bahl K, Brehm MA, Shultz LD, Kurt-Jones EA, Mordes JP, Welsh RM, Rossini AA, Greiner DL. Type 1 IFN mediates cross-talk between innate and adaptive immunity that abrogates transplantation tolerance. J Immunol. 2007 Nov 15; 179(10):6620-9. PMID: 17982052.
      View in: PubMed
    27. Yamazaki M, Pearson T, Brehm MA, Miller DM, Mangada JA, Markees TG, Shultz LD, Mordes JP, Rossini AA, Greiner DL. Different mechanisms control peripheral and central tolerance in hematopoietic chimeric mice. Am J Transplant. 2007 Jul; 7(7):1710-21. PMID: 17564635.
      View in: PubMed
    28. Wallis RH, Wang K, Dabrowski D, Marandi L, Ning T, Hsieh E, Paterson AD, Mordes JP, Blankenhorn EP, Poussier P. A novel susceptibility locus on rat chromosome 8 affects spontaneous but not experimentally induced type 1 diabetes. Diabetes. 2007 Jun; 56(6):1731-6. PMID: 17389329.
      View in: PubMed
    29. Blankenhorn EP, Descipio C, Rodemich L, Cort L, Leif JH, Greiner DL, Mordes JP. Refinement of the Iddm4 diabetes susceptibility locus reveals TCRVbeta4 as a candidate gene. Ann N Y Acad Sci. 2007 Apr; 1103:128-31. PMID: 17376830.
      View in: PubMed
    30. King M, Pearson T, Shultz LD, Leif J, Bottino R, Trucco M, Atkinson M, Wasserfall C, Herold K, Mordes JP, Rossini AA, Greiner DL. Development of new-generation HU-PBMC-NOD/SCID mice to study human islet alloreactivity. Ann N Y Acad Sci. 2007 Apr; 1103:90-3. PMID: 17376822.
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    31. Zipris D, Lien E, Nair A, Xie JX, Greiner DL, Mordes JP, Rossini AA. TLR9-signaling pathways are involved in Kilham rat virus-induced autoimmune diabetes in the biobreeding diabetes-resistant rat. J Immunol. 2007 Jan 15; 178(2):693-701. PMID: 17202329.
      View in: PubMed
    32. Hillebrands JL, Whalen B, Visser JT, Koning J, Bishop KD, Leif J, Rozing J, Mordes JP, Greiner DL, Rossini AA. A regulatory CD4+ T cell subset in the BB rat model of autoimmune diabetes expresses neither CD25 nor Foxp3. J Immunol. 2006 Dec 1; 177(11):7820-32. PMID: 17114453.
      View in: PubMed
    33. Phillips NE, Greiner DL, Mordes JP, Rossini AA. Costimulatory blockade induces hyporesponsiveness in T cells that recognize alloantigen via indirect antigen presentation. Transplantation. 2006 Oct 27; 82(8):1085-92. PMID: 17060858.
      View in: PubMed
    34. Autoimmunity after islet-cell allotransplantation. N Engl J Med. 2006 09 28; 355(13):1397-9. PMID: 17005967.
      View in: PubMed
    35. Morrison AR, Moss J, Stevens LA, Evans JE, Farrell C, Merithew E, Lambright DG, Greiner DL, Mordes JP, Rossini AA, Bortell R. ART2, a T cell surface mono-ADP-ribosyltransferase, generates extracellular poly(ADP-ribose). J Biol Chem. 2006 Nov 3; 281(44):33363-72. PMID: 16931513.
      View in: PubMed
    36. Masaki H, Appel MC, Leahy L, Leif J, Paquin L, Shultz LD, Mordes JP, Greiner DL, Rossini AA. Anti-mouse CD154 antibody treatment facilitates generation of mixed xenogeneic rat hematopoietic chimerism, prevents wasting disease and prolongs xenograft survival in mice. Xenotransplantation. 2006 May; 13(3):224-32. PMID: 16756565.
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    37. Beaudette-Zlatanova BC, Whalen B, Zipris D, Yagita H, Rozing J, Groen H, Benjamin CD, Hunig T, Drexhage HA, Ansari MJ, Leif J, Mordes JP, Greiner DL, Sayegh MH, Rossini AA. Costimulation and autoimmune diabetes in BB rats. Am J Transplant. 2006 May; 6(5 Pt 1):894-902. PMID: 16611325.
      View in: PubMed
    38. Thornley TB, Brehm MA, Markees TG, Shultz LD, Mordes JP, Welsh RM, Rossini AA, Greiner DL. TLR agonists abrogate costimulation blockade-induced prolongation of skin allografts. J Immunol. 2006 Feb 1; 176(3):1561-70. PMID: 16424185.
      View in: PubMed
    39. Mordes JP, Guberski DL, Leif JH, Woda BA, Flanagan JF, Greiner DL, Kislauskis EH, Tirabassi RS. LEW.1WR1 rats develop autoimmune diabetes spontaneously and in response to environmental perturbation. Diabetes. 2005 Sep; 54(9):2727-33. PMID: 16123363.
      View in: PubMed
    40. Blankenhorn EP, Rodemich L, Martin-Fernandez C, Leif J, Greiner DL, Mordes JP. The rat diabetes susceptibility locus Iddm4 and at least one additional gene are required for autoimmune diabetes induced by viral infection. Diabetes. 2005 Apr; 54(4):1233-7. PMID: 15793267.
      View in: PubMed
    41. Gordon EJ, Wicker LS, Peterson LB, Serreze DV, Markees TG, Shultz LD, Rossini AA, Greiner DL, Mordes JP. Autoimmune diabetes and resistance to xenograft transplantation tolerance in NOD mice. Diabetes. 2005 Jan; 54(1):107-15. PMID: 15616017.
      View in: PubMed
    42. Zipris D, Lien E, Xie JX, Greiner DL, Mordes JP, Rossini AA. TLR activation synergizes with Kilham rat virus infection to induce diabetes in BBDR rats. J Immunol. 2005 Jan 1; 174(1):131-42. PMID: 15611235.
      View in: PubMed
    43. Harris JE, Bishop KD, Phillips NE, Mordes JP, Greiner DL, Rossini AA, Czech MP. Early growth response gene-2, a zinc-finger transcription factor, is required for full induction of clonal anergy in CD4+ T cells. J Immunol. 2004 Dec 15; 173(12):7331-8. PMID: 15585857.
      View in: PubMed
    44. Markees TG, Pearson T, Cuthbert A, Pearson AL, Shultz LD, Leif J, Phillips NE, Mordes JP, Greiner DL, Rossini AA. Evaluation of donor-specific transfusion sources: unique failure of bone marrow cells to induce prolonged skin allograft survival with anti-CD154 monoclonal antibody. Transplantation. 2004 Dec 15; 78(11):1601-8. PMID: 15591948.
      View in: PubMed
    45. Banuelos SJ, Markees TG, Phillips NE, Appel MC, Cuthbert A, Leif J, Mordes JP, Shultz LD, Rossini AA, Greiner DL. Regulation of skin and islet allograft survival in mice treated with costimulation blockade is mediated by different CD4+ cell subsets and different mechanisms. Transplantation. 2004 Sep 15; 78(5):660-7. PMID: 15371665.
      View in: PubMed
    46. Pearson T, Weiser P, Markees TG, Serreze DV, Wicker LS, Peterson LB, Cumisky AM, Shultz LD, Mordes JP, Rossini AA, Greiner DL. Islet allograft survival induced by costimulation blockade in NOD mice is controlled by allelic variants of Idd3. Diabetes. 2004 Aug; 53(8):1972-8. PMID: 15277375.
      View in: PubMed
    47. Appel MC, Banuelos SJ, Greiner DL, Shultz LD, Mordes JP, Rossini AA. Prolonged survival of neonatal porcine islet xenografts in mice treated with a donor-specific transfusion and anti-CD154 antibody. Transplantation. 2004 May 15; 77(9):1341-9. PMID: 15167588.
      View in: PubMed
    48. Todd DJ, Forsberg EM, Greiner DL, Mordes JP, Rossini AA, Bortell R. Deficiencies in gut NK cell number and function precede diabetes onset in BB rats. J Immunol. 2004 May 1; 172(9):5356-62. PMID: 15100275.
      View in: PubMed
    49. Hornum L, DeScipio C, Markholst H, Troutman SA, Novak S, Leif J, Greiner D, Mordes JP, Blankenhorn EP. Comparative mapping of rat Iddm4 to segments on HSA7 and MMU6. Mamm Genome. 2004 Jan; 15(1):53-61. PMID: 14727142.
      View in: PubMed
    50. Mordes JP, Bortell R, Blankenhorn EP, Rossini AA, Greiner DL. Rat models of type 1 diabetes: genetics, environment, and autoimmunity. ILAR J. 2004; 45(3):278-91. PMID: 15229375.
      View in: PubMed
    51. Pearson T, Markees TG, Serreze DV, Pierce MA, Wicker LS, Peterson LB, Shultz LD, Mordes JP, Rossini AA, Greiner DL. Islet cell autoimmunity and transplantation tolerance: two distinct mechanisms? Ann N Y Acad Sci. 2003 Nov; 1005:148-56. PMID: 14679049.
      View in: PubMed
    52. Turgeon NA, Banuelos SJ, Shultz LD, Lyons BL, Iwakoshi N, Greiner DL, Mordes JP, Rossini AA, Appel MC. Alloimmune injury and rejection of human skin grafts on human peripheral blood lymphocyte-reconstituted non-obese diabetic severe combined immunodeficient beta2-microglobulin-null mice. Exp Biol Med (Maywood). 2003 Oct; 228(9):1096-104. PMID: 14530522.
      View in: PubMed
    53. Seung E, Mordes JP, Rossini AA, Greiner DL. Hematopoietic chimerism and central tolerance created by peripheral-tolerance induction without myeloablative conditioning. J Clin Invest. 2003 Sep; 112(5):795-808. PMID: 12952928.
      View in: PubMed
    54. Pearson T, Markees TG, Serreze DV, Pierce MA, Wicker LS, Peterson LB, Shultz LD, Mordes JP, Rossini AA, Greiner DL. Genetic separation of the transplantation tolerance and autoimmune phenotypes in NOD mice. Rev Endocr Metab Disord. 2003 Sep; 4(3):255-61. PMID: 14501176.
      View in: PubMed
    55. Pandarpurkar M, Wilson-Fritch L, Corvera S, Markholst H, Hornum L, Greiner DL, Mordes JP, Rossini AA, Bortell R. Ian4 is required for mitochondrial integrity and T cell survival. Proc Natl Acad Sci U S A. 2003 Sep 2; 100(18):10382-7. PMID: 12930893.
      View in: PubMed
    56. Seung E, Mordes JP, Greiner DL, Rossini AA. Induction of tolerance for islet transplantation for type 1 diabetes. Curr Diab Rep. 2003 Aug; 3(4):329-35. PMID: 12866997.
      View in: PubMed
    57. Pearson T, Markees TG, Serreze DV, Pierce MA, Marron MP, Wicker LS, Peterson LB, Shultz LD, Mordes JP, Rossini AA, Greiner DL. Genetic disassociation of autoimmunity and resistance to costimulation blockade-induced transplantation tolerance in nonobese diabetic mice. J Immunol. 2003 Jul 1; 171(1):185-95. PMID: 12816997.
      View in: PubMed
    58. Zipris D, Hillebrands JL, Welsh RM, Rozing J, Xie JX, Mordes JP, Greiner DL, Rossini AA. Infections that induce autoimmune diabetes in BBDR rats modulate CD4+CD25+ T cell populations. J Immunol. 2003 Apr 1; 170(7):3592-602. PMID: 12646622.
      View in: PubMed
    59. Phillips NE, Markees TG, Mordes JP, Greiner DL, Rossini AA. Blockade of CD40-mediated signaling is sufficient for inducing islet but not skin transplantation tolerance. J Immunol. 2003 Mar 15; 170(6):3015-23. PMID: 12626555.
      View in: PubMed
    60. Pearson T, Markees TG, Wicker LS, Serreze DV, Peterson LB, Mordes JP, Rossini AA, Greiner DL. NOD congenic mice genetically protected from autoimmune diabetes remain resistant to transplantation tolerance induction. Diabetes. 2003 Feb; 52(2):321-6. PMID: 12540603.
      View in: PubMed
    61. Whalen BJ, Marounek J, Mordes JP, Rossini AA, Greiner DL. Type 1 cytokines polarize thymocytes during T cell development in adult thymus organ cultures. J Autoimmun. 2003 Feb; 20(1):27-42. PMID: 12604310.
      View in: PubMed
    62. Mordes JP, Leif J, Novak S, DeScipio C, Greiner DL, Blankenhorn EP. The iddm4 locus segregates with diabetes susceptibility in congenic WF.iddm4 rats. Diabetes. 2002 Nov; 51(11):3254-62. PMID: 12401717.
      View in: PubMed
    63. Waegell W, Babineau M, Hart M, Dixon K, McRae B, Wallace C, Leach M, Ratnofsky S, Belanger A, Hirst G, Rossini A, Appel M, Mordes J, Greiner D, Banerjee S. A420983, a novel, small molecule inhibitor of LCK prevents allograft rejection. Transplant Proc. 2002 Aug; 34(5):1411-7. PMID: 12176420.
      View in: PubMed
    64. Forman D, Welsh RM, Markees TG, Woda BA, Mordes JP, Rossini AA, Greiner DL. Viral abrogation of stem cell transplantation tolerance causes graft rejection and host death by different mechanisms. J Immunol. 2002 Jun 15; 168(12):6047-56. PMID: 12055213.
      View in: PubMed
    65. Iwakoshi NN, Markees TG, Turgeon N, Thornley T, Cuthbert A, Leif J, Phillips NE, Mordes JP, Greiner DL, Rossini AA. Skin allograft maintenance in a new synchimeric model system of tolerance. J Immunol. 2001 Dec 1; 167(11):6623-30. PMID: 11714833.
      View in: PubMed
    66. Rossini AA, Mordes JP, Greiner DL, Stoff JS. Islet cell transplantation tolerance. Transplantation. 2001 Oct 27; 72(8 Suppl):S43-6. PMID: 11888156.
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    67. Todd DJ, Greiner DL, Rossini AA, Mordes JP, Bortell R. An atypical population of NK cells that spontaneously secrete IFN-gamma and IL-4 is present in the intraepithelial lymphoid compartment of the rat. J Immunol. 2001 Oct 1; 167(7):3600-9. PMID: 11564772.
      View in: PubMed
    68. Whitmarsh AJ, Kuan CY, Kennedy NJ, Kelkar N, Haydar TF, Mordes JP, Appel M, Rossini AA, Jones SN, Flavell RA, Rakic P, Davis RJ. Requirement of the JIP1 scaffold protein for stress-induced JNK activation. Genes Dev. 2001 Sep 15; 15(18):2421-32. PMID: 11562351.
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    69. Bortell R, Moss J, McKenna RC, Rigby MR, Niedzwiecki D, Stevens LA, Patton WA, Mordes JP, Greiner DL, Rossini AA. Nicotinamide adenine dinucleotide (NAD) and its metabolites inhibit T lymphocyte proliferation: role of cell surface NAD glycohydrolase and pyrophosphatase activities. J Immunol. 2001 Aug 15; 167(4):2049-59. PMID: 11489987.
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    70. Greiner DL, Rossini AA, Mordes JP. Translating data from animal models into methods for preventing human autoimmune diabetes mellitus: caveat emptor and primum non nocere. Clin Immunol. 2001 Aug; 100(2):134-43. PMID: 11465941.
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    71. Whalen BJ, Marounek J, Weiser P, Appel MC, Greiner DL, Mordes JP, Rossini AA. BB rat thymocytes cultured in the presence of islets lose their ability to transfer autoimmune diabetes. Diabetes. 2001 May; 50(5):972-9. PMID: 11334440.
      View in: PubMed
    72. Whalen BJ, Mordes JP, Rossini AA. The BB rat as a model of human insulin-dependent diabetes mellitus. Curr Protoc Immunol. 2001 May; Chapter 15:Unit 15.3. PMID: 18432735.
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    73. Bortel R, Waite DJ, Whalen BJ, Todd D, Leif JH, Lesma E, Moss J, Mordes JP, Rossini AA, Greiner DL. Levels of Art2+ cells but not soluble Art2 protein correlate with expression of autoimmune diabetes in the BB rat. Autoimmunity. 2001 May; 33(3):199-211. PMID: 11683379.
      View in: PubMed
    74. Zipris D, Leif J, Deluca D, Lin MY, Mordes JP, Rossini AA, Greiner DL, Whalen BJ. Fetal thymi from diabetes-prone but not diabetes-resistant BB/Wor rats fail to generate mature ART2+ T-cells in organ culture. Cell Mol Biol (Noisy-le-grand). 2001 Feb; 47(1):65-74. PMID: 11292261.
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    75. Gordon EJ, Woda BA, Shultz LD, Rossini AA, Greiner DL, Mordes JP. Rat xenograft survival in mice treated with donor-specific transfusion and anti-CD154 antibody is enhanced by elimination of host CD4+ cells. Transplantation. 2001 Jan 27; 71(2):319-27. PMID: 11213080.
      View in: PubMed
    76. Turgeon NA, Iwakoshi NN, Phillips NE, Meyers WC, Welsh RM, Greiner DL, Mordes JP, Rossini AA. Viral infection abrogates CD8(+) T-cell deletion induced by costimulation blockade. J Surg Res. 2000 Sep; 93(1):63-9. PMID: 10945944.
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    77. Seung E, Iwakoshi N, Woda BA, Markees TG, Mordes JP, Rossini AA, Greiner DL. Allogeneic hematopoietic chimerism in mice treated with sublethal myeloablation and anti-CD154 antibody: absence of graft-versus-host disease, induction of skin allograft tolerance, and prevention of recurrent autoimmunity in islet-allografted NOD/Lt mice. Blood. 2000 Mar 15; 95(6):2175-82. PMID: 10706892.
      View in: PubMed
    78. Welsh RM, Markees TG, Woda BA, Daniels KA, Brehm MA, Mordes JP, Greiner DL, Rossini AA. Virus-induced abrogation of transplantation tolerance induced by donor-specific transfusion and anti-CD154 antibody. J Virol. 2000 Mar; 74(5):2210-8. PMID: 10666251.
      View in: PubMed
    79. Iwakoshi NN, Mordes JP, Markees TG, Phillips NE, Rossini AA, Greiner DL. Treatment of allograft recipients with donor-specific transfusion and anti-CD154 antibody leads to deletion of alloreactive CD8+ T cells and prolonged graft survival in a CTLA4-dependent manner. J Immunol. 2000 Jan 1; 164(1):512-21. PMID: 10605049.
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    80. Martin AM, Maxson MN, Leif J, Mordes JP, Greiner DL, Blankenhorn EP. Diabetes-prone and diabetes-resistant BB rats share a common major diabetes susceptibility locus, iddm4: additional evidence for a "universal autoimmunity locus" on rat chromosome 4. Diabetes. 1999 Nov; 48(11):2138-44. PMID: 10535446.
      View in: PubMed
    81. Whalen BJ, Love LC, Mordes JP, Rossini AA, Greiner DL. Intravital dye-labeled diabetogenic rat T cells retain dye, home to the pancreas, and induce diabetes. Transplant Proc. 1999 May; 31(3):1611-4. PMID: 10331021.
      View in: PubMed
    82. Markees TG, Serreze DV, Phillips NE, Sorli CH, Gordon EJ, Shultz LD, Noelle RJ, Woda BA, Greiner DL, Mordes JP, Rossini AA. NOD mice have a generalized defect in their response to transplantation tolerance induction. Diabetes. 1999 May; 48(5):967-74. PMID: 10331399.
      View in: PubMed
    83. Todd D, Singh AJ, Greiner DL, Mordes JP, Rossini AA, Bortell R. A new isolation method for rat intraepithelial lymphocytes. J Immunol Methods. 1999 Apr 22; 224(1-2):111-27. PMID: 10357212.
      View in: PubMed
    84. Zheng XX, Markees TG, Hancock WW, Li Y, Greiner DL, Li XC, Mordes JP, Sayegh MH, Rossini AA, Strom TB. CTLA4 signals are required to optimally induce allograft tolerance with combined donor-specific transfusion and anti-CD154 monoclonal antibody treatment. J Immunol. 1999 Apr 15; 162(8):4983-90. PMID: 10202046.
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    85. Whalen BJ, Weiser P, Marounek J, Rossini AA, Mordes JP, Greiner DL. Recapitulation of normal and abnormal BioBreeding rat T cell development in adult thymus organ culture. J Immunol. 1999 Apr 1; 162(7):4003-12. PMID: 10201921.
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    86. Bortell R, Kanaitsuka T, Stevens LA, Moss J, Mordes JP, Rossini AA, Greiner DL. The RT6 (Art2) family of ADP-ribosyltransferases in rat and mouse. Mol Cell Biochem. 1999 Mar; 193(1-2):61-8. PMID: 10331639.
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    87. Rossini AA, Mordes JP, Markees TG, Phillips NE, Gordon EJ, Greiner DL. Induction of islet transplantation tolerance using donor specific transfusion and anti-CD154 monoclonal antibody. Transplant Proc. 1999 Feb-Mar; 31(1-2):629-32. PMID: 10083269.
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    88. Markees TG, Phillips NE, Gordon EJ, Noelle RJ, Maliszewski C, Mordes JP, Greiner DL, Rossini AA. Prolonged skin allograft survival in mice treated with Flt3-ligand-induced dendritic cells and anti-CD154 monoclonal antibody. Transplant Proc. 1999 Feb-Mar; 31(1-2):884-5. PMID: 10083387.
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    89. Iwakoshi NN, Greiner DL, Rossini AA, Mordes JP. Diabetes prone BB rats are severely deficient in natural killer T cells. Autoimmunity. 1999; 31(1):1-14. PMID: 10593564.
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    90. Rossini AA, Greiner DL, Mordes JP. Induction of immunologic tolerance for transplantation. Physiol Rev. 1999 Jan; 79(1):99-141. PMID: 9922369.
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    91. Martin AM, Blankenhorn EP, Maxson MN, Zhao M, Leif J, Mordes JP, Greiner DL. Non-major histocompatibility complex-linked diabetes susceptibility loci on chromosomes 4 and 13 in a backcross of the DP-BB/Wor rat to the WF rat. Diabetes. 1999 Jan; 48(1):50-8. PMID: 9892222.
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    92. Markees T, Phillips N, Gordon E, Noelle RJ, Mordes JP, Greiner DL, Rossini AA. Improved skin allograft tolerance induced by treatment with donor splenocytes and an extended course of anti-CD154 monoclonal antibody. Transplant Proc. 1998 Aug; 30(5):2444-6. PMID: 9723531.
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    93. Gordon EJ, Markees TG, Phillips NE, Noelle RJ, Shultz LD, Mordes JP, Rossini AA, Greiner DL. Prolonged survival of rat islet and skin xenografts in mice treated with donor splenocytes and anti-CD154 monoclonal antibody. Diabetes. 1998 Aug; 47(8):1199-206. PMID: 9703317.
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    94. Lesma E, Moss J, Brewer HB, Bortell R, Greiner D, Mordes J, Rossini AA. Characterization of high density lipoprotein-bound and soluble RT6 released following administration of anti-RT6.1 monoclonal antibody. J Immunol. 1998 Aug 1; 161(3):1212-9. PMID: 9686581.
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    95. Iwakoshi NN, Goldschneider I, Tausche F, Mordes JP, Rossini AA, Greiner DL. High frequency apoptosis of recent thymic emigrants in the liver of lymphopenic diabetes-prone BioBreeding rats. J Immunol. 1998 Jun 15; 160(12):5838-50. PMID: 9637495.
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    96. Markees TG, Phillips NE, Gordon EJ, Noelle RJ, Shultz LD, Mordes JP, Greiner DL, Rossini AA. Long-term survival of skin allografts induced by donor splenocytes and anti-CD154 antibody in thymectomized mice requires CD4(+) T cells, interferon-gamma, and CTLA4. J Clin Invest. 1998 Jun 1; 101(11):2446-55. PMID: 9616216.
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    97. Kanaitsuka T, Bortell R, Stevens LA, Moss J, Sardinha D, Rajan TV, Zipris D, Mordes JP, Greiner DL, Rossini AA. Expression in BALB/c and C57BL/6 mice of Rt6-1 and Rt6-2 ADP-ribosyltransferases that differ in enzymatic activity: C57BL/6 Rt6-1 is a natural transferase knockout. J Immunol. 1997 Sep 15; 159(6):2741-9. PMID: 9300695.
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    98. Markees TG, Phillips NE, Noelle RJ, Shultz LD, Mordes JP, Greiner DL, Rossini AA. Prolonged survival of mouse skin allografts in recipients treated with donor splenocytes and antibody to CD40 ligand. Transplantation. 1997 Jul 27; 64(2):329-35. PMID: 9256196.
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    99. Malkani S, Nompleggi D, Hansen JW, Greiner DL, Mordes JP, Rossini AA. Dietary cow's milk protein does not alter the frequency of diabetes in the BB rat. Diabetes. 1997 Jul; 46(7):1133-40. PMID: 9200647.
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    100. Whalen BJ, Doukas J, Mordes JP, Rossini AA, Greiner DL. Induction of insulin-dependent diabetes mellitus in PVG.RT1u rats. Transplant Proc. 1997 May; 29(3):1684-5. PMID: 9142232.
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    101. Moss J, Stevens LA, Cavanaugh E, Okazaki IJ, Bortell R, Kanaitsuka T, Mordes JP, Greiner DL, Rossini AA. Characterization of mouse Rt6.1 NAD:arginine ADP-ribosyltransferase. J Biol Chem. 1997 Feb 14; 272(7):4342-6. PMID: 9020154.
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    102. Bortell R, Rigby M, Stevens L, Moss J, Kanaitsuka T, Mordes J, Greiner D, Rossini A. Mouse RT6 locus 1 and rat RT6.2 are NAD+. Arginine ADP-ribosyltransferases with auto-ADP-ribosylation activity. Adv Exp Med Biol. 1997; 419:169-73. PMID: 9193650.
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    103. Greiner DL, Malkani S, Kanaitsuka T, Bortell R, Doukas J, Rigby M, Whalen B, Stevens LA, Moss J, Mordes JP, Rossini AA. The T cell marker RT6 in a rat model of autoimmune diabetes. Adv Exp Med Biol. 1997; 419:209-16. PMID: 9193656.
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    104. Rigby MR, Bortell R, Greiner DL, Czech MP, Klarlund JK, Mordes JP, Rossini AA. The rat T-cell surface protein RT6 is associated with src family tyrosine kinases and generates an activation signal. Diabetes. 1996 Oct; 45(10):1419-26. PMID: 8826980.
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    105. Doukas J, Majno G, Mordes JP. Anti-endothelial cell autoantibodies in BB rats with spontaneous and induced IDDM. Diabetes. 1996 Sep; 45(9):1209-16. PMID: 8772724.
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    106. Mordes JP, Bortell R, Doukas J, Rigby M, Whalen B, Zipris D, Greiner DL, Rossini AA. The BB/Wor rat and the balance hypothesis of autoimmunity. Diabetes Metab Rev. 1996 Jul; 12(2):103-9. PMID: 8877279.
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    107. Rigby MR, Bortell R, Stevens LA, Moss J, Kanaitsuka T, Shigeta H, Mordes JP, Greiner DL, Rossini AA. Rat RT6.2 and mouse Rt6 locus 1 are NAD+: arginine ADP ribosyltransferases with auto-ADP ribosylation activity. J Immunol. 1996 Jun 1; 156(11):4259-65. PMID: 8666796.
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    108. Waite DJ, Appel MC, Handler ES, Mordes JP, Rossini AA, Greiner DL. Ontogeny and immunohistochemical localization of thymus-dependent and thymus-independent RT6+ cells in the rat. Am J Pathol. 1996 Jun; 148(6):2043-56. PMID: 8669488.
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    109. Markees TG, Appel MC, Noelle RJ, Mordes JP, Greiner DL, Rossini AA. Tolerance to islet xenografts induced by dual manipulation of antigen presentation and co-stimulation. Transplant Proc. 1996 Apr; 28(2):814-5. PMID: 8623413.
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    110. Mordes JP, Schirf B, Roipko D, Greiner DL, Weiner H, Nelson P, Rossini AA. Oral insulin does not prevent insulin-dependent diabetes mellitus in BB rats. Ann N Y Acad Sci. 1996 Feb 13; 778:418-21. PMID: 8611008.
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    111. Zipris D, Greiner DL, Malkani S, Whalen B, Mordes JP, Rossini AA. Cytokine gene expression in islets and thyroids of BB rats. IFN-gamma and IL-12p40 mRNA increase with age in both diabetic and insulin-treated nondiabetic BB rats. J Immunol. 1996 Feb 1; 156(3):1315-21. PMID: 8558012.
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    112. Rossini AA, Parker DC, Phillips NE, Durie FH, Noelle RJ, Mordes JP, Greiner DL. Induction of immunological tolerance to islet allografts. Cell Transplant. 1996 Jan-Feb; 5(1):49-52. PMID: 8665076.
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    113. Parker DC, Greiner DL, Phillips NE, Appel MC, Steele AW, Durie FH, Noelle RJ, Mordes JP, Rossini AA. Survival of mouse pancreatic islet allografts in recipients treated with allogeneic small lymphocytes and antibody to CD40 ligand. Proc Natl Acad Sci U S A. 1995 Oct 10; 92(21):9560-4. PMID: 7568172.
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    114. Hesselton RM, Greiner DL, Mordes JP, Rajan TV, Sullivan JL, Shultz LD. High levels of human peripheral blood mononuclear cell engraftment and enhanced susceptibility to human immunodeficiency virus type 1 infection in NOD/LtSz-scid/scid mice. J Infect Dis. 1995 Oct; 172(4):974-82. PMID: 7561218.
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    115. Whalen BJ, Rossini AA, Mordes JP, Greiner DL. DR-BB rat thymus contains thymocyte populations predisposed to autoreactivity. Diabetes. 1995 Aug; 44(8):963-7. PMID: 7622003.
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    116. Rossini AA, Handler ES, Mordes JP, Greiner DL. Human autoimmune diabetes mellitus: lessons from BB rats and NOD mice--Caveat emptor. Clin Immunol Immunopathol. 1995 Jan; 74(1):2-9. PMID: 7994922.
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    117. Whalen BJ, Greiner DL, Mordes JP, Rossini AA. Adoptive transfer of autoimmune diabetes mellitus to athymic rats: synergy of CD4+ and CD8+ T cells and prevention by RT6+ T cells. J Autoimmun. 1994 Dec; 7(6):819-31. PMID: 7888038.
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    118. Doukas J, Mordes JP, Swymer C, Niedzwiecki D, Mason R, Rozing J, Rossini AA, Greiner DL. Thymic epithelial defects and predisposition to autoimmune disease in BB rats. Am J Pathol. 1994 Dec; 145(6):1517-25. PMID: 7992854.
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    119. Doukas J, Cutler AH, Mordes JP. Polyinosinic:polycytidylic acid is a potent activator of endothelial cells. Am J Pathol. 1994 Jul; 145(1):137-47. PMID: 7518192.
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    120. Battan R, Mordes JP, Abreau S, Greiner DL, Handler ES, Rossini AA. Evidence that intrathymic islet transplantation does not prevent diabetes or subsequent islet graft destruction in RT6-depleted, diabetes-resistant BioBreeding/Worcester rats. Transplantation. 1994 Mar 15; 57(5):731-6. PMID: 8140636.
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    121. Jiang Z, Makowiecki J, Mordes JP, Woda BA. Cytolysin gene expression in the islets of diabetic BioBreeding/Worcester rats. J Immunol. 1994 Jan 1; 152(1):322-9. PMID: 8254201.
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    122. Sarkar P, Crisá L, McKeever U, Bortell R, Handler E, Mordes JP, Waite D, Schoenbaum A, Haag F, Koch-Nolte F, et al. Loss of RT6 message and most circulating T cells after thymectomy of diabetes prone BB rats. Autoimmunity. 1994; 18(1):15-22. PMID: 7999952.
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    123. Waite DJ, Handler ES, Mordes JP, Rossini AA, Greiner DL. The RT6 rat lymphocyte alloantigen circulates in soluble form. Cell Immunol. 1993 Nov; 152(1):82-95. PMID: 8242775.
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    124. Kitagawa Y, Desemone J, Mordes JP. Pancreas-specific venular labeling by monastral blue B in the BB rat: modulation by prostaglandins and their inhibitors. Immunopharmacology. 1993 May-Jun; 25(3):229-38. PMID: 8354639.
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    125. Crisá L, Sarkar P, Waite DJ, Friedrich FH, et al. An RT6a gene is transcribed and translated in lymphopenic diabetes-prone BB rats. Diabetes. 1993 May; 42(5):688-95. PMID: 7683289.
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    126. Tafuri A, Bowers WE, Handler ES, Appel M, Lew R, Greiner D, Mordes JP, Rossini AA. High stimulatory activity of dendritic cells from diabetes-prone BioBreeding/Worcester rats exposed to macrophage-derived factors. J Clin Invest. 1993 May; 91(5):2040-8. PMID: 8486773.
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    127. Doukas J, Mordes JP. T lymphocytes capable of activating endothelial cells in vitro are present in rats with autoimmune diabetes. J Immunol. 1993 Feb 1; 150(3):1036-46. PMID: 8423330.
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    128. Crisá L, Mordes JP, Rossini AA. Autoimmune diabetes mellitus in the BB rat. Diabetes Metab Rev. 1992 Apr; 8(1):4-37. PMID: 1633738.
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    129. Kitagawa Y, Greiner DL, Reynolds CW, Ortaldo JR, Toccafondi R, Handler ES, van der Meide PH, Mordes JP, Rossini AA. Islet cells but not thyrocytes are susceptible to lysis by NK cells. J Autoimmun. 1991 Oct; 4(5):703-16. PMID: 1797021.
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    130. Greiner DL, Shultz LD, Rossini AA, Mordes JP, Handler ES, Rajan TV. Recapitulation of normal and abnormal BB rat immune system development in scid mouse/rat lymphohemopoietic chimeras. J Clin Invest. 1991 Aug; 88(2):717-9. PMID: 1864981.
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    131. Gottlieb PA, Handler ES, Appel MC, Greiner DL, Mordes JP, Rossini AA. Insulin treatment prevents diabetes mellitus but not thyroiditis in RT6-depleted diabetes resistant BB/Wor rats. Diabetologia. 1991 May; 34(5):296-300. PMID: 1864483.
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    132. Woda BA, Handler ES, Greiner DL, Reynolds C, Mordes JP, Rossini AA. T-lymphocyte requirement for diabetes in RT6-depleted diabetes-resistant BB rats. Diabetes. 1991 Apr; 40(4):423-8. PMID: 1707018.
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    133. Thomas VA, Woda BA, Handler ES, Greiner DL, Mordes JP, Rossini AA. Altered expression of diabetes in BB/Wor rats by exposure to viral pathogens. Diabetes. 1991 Feb; 40(2):255-8. PMID: 1703973.
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    134. Rossini AA, Handler ES, Greiner DL, Mordes JP. Insulin dependent diabetes mellitus hypothesis of autoimmunity. Autoimmunity. 1991; 8(3):221-35. PMID: 1932509.
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    135. Crisá L, Greiner DL, Mordes JP, MacDonald RG, Handler ES, Czech MP, Rossini AA. Biochemical studies of RT6 alloantigens in BB/Wor and normal rats. Evidence for intact unexpressed RT6a structural gene in diabetes-prone BB rats. Diabetes. 1990 Oct; 39(10):1279-88. PMID: 2210079.
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    136. McKeever U, Mordes JP, Greiner DL, Appel MC, Rozing J, Handler ES, Rossini AA. Adoptive transfer of autoimmune diabetes and thyroiditis to athymic rats. Proc Natl Acad Sci U S A. 1990 Oct; 87(19):7618-22. PMID: 2217193.
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    137. Nakamura N, Woda BA, Tafuri A, Greiner DL, Reynolds CW, Ortaldo J, Chick W, Handler ES, Mordes JP, Rossini AA. Intrinsic cytotoxicity of natural killer cells to pancreatic islets in vitro. Diabetes. 1990 Jul; 39(7):836-43. PMID: 2191887.
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    138. Markholst H, Klaff LJ, Klöppel G, Lernmark A, Mordes JP, Palmer J. Lack of systematically found insulin autoantibodies in spontaneously diabetic BB rats. Diabetes. 1990 Jun; 39(6):720-7. PMID: 2189763.
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    139. Abend S, Cormier J, Appel MC, Lueprasitsakul W, Alex S, Mordes JP, Usadel KH, Handler ES, Rossini AA, Braverman LE. The effect of ciamexone on lymphocytic thyroiditis and insulin-dependent diabetes mellitus in the BB/Wor rat. Immunopharmacology. 1990 May-Jun; 19(3):163-8. PMID: 2394579.
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    140. Gottlieb PA, Berrios JP, Mariani G, Handler ES, Greiner D, Mordes JP, Rossini AA. Autoimmune destruction of islets transplanted into RT6-depleted diabetes-resistant BB/Wor rats. Diabetes. 1990 May; 39(5):643-5. PMID: 1970541.
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    141. Lefkowith J, Schreiner G, Cormier J, Handler ES, Driscoll HK, Greiner D, Mordes JP, Rossini AA. Prevention of diabetes in the BB rat by essential fatty acid deficiency. Relationship between physiological and biochemical changes. J Exp Med. 1990 Mar 1; 171(3):729-43. PMID: 2307932.
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    142. Desemone J, Majno G, Joris I, Handler ES, Rossini AA, Mordes JP. Morphological and physiological characteristics of pancreas-specific venular permeability induced by Monastral blue B. Exp Mol Pathol. 1990 Feb; 52(1):141-53. PMID: 1689667.
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    143. Driscoll HK, Gottlieb PA, Mordes JP, Matschinsky FM, Rossini AA. Plasma from BB/Wor rats increases insulin secretion by perfused rat pancreas. Endocrinology. 1990 Feb; 126(2):1241-9. PMID: 2404744.
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    144. Handler ES, Mordes JP, McKeever U, Nakamura N, Bernhard J, Greiner DL, Rossini AA. Effects of irradiation on diabetes in the BB/Wor rat. Autoimmunity. 1989; 4(1-2):21-30. PMID: 2491639.
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    145. Burstein D, Mordes JP, Greiner DL, Stein D, Nakamura N, Handler ES, Rossini AA. Prevention of diabetes in BB/Wor rat by single transfusion of spleen cells. Parameters that affect degree of protection. Diabetes. 1989 Jan; 38(1):24-30. PMID: 2642432.
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    146. Rossini AA, Mordes JP, Greiner DL. The pathogenesis of autoimmune diabetes mellitus. Curr Opin Immunol. 1989-1990 Apr; 2(4):598-603. PMID: 2700903.
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    147. Angelillo M, Greiner DL, Mordes JP, Handler ES, Nakamura N, McKeever U, Rossini A. Absence of RT6+ T cells in diabetes-prone biobreeding/Worcester rats is due to genetic and cell developmental defects. J Immunol. 1988 Dec 15; 141(12):4146-51. PMID: 3058800.
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    148. Gottlieb PA, Rossini AA, Mordes JP. Approaches to prevention and treatment of IDDM in animal models. Diabetes Care. 1988 Nov-Dec; 11 Suppl 1:29-36. PMID: 3069388.
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    149. Nakano K, Mordes JP, Handler ES, Greiner DL, Rossini AA. Role of host immune system in BB/Wor rat. Predisposition to diabetes resides in bone marrow. Diabetes. 1988 May; 37(5):520-5. PMID: 3282942.
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    150. Rossini AA, Mordes JP, Handler ES. Speculations on etiology of diabetes mellitus. Tumbler hypothesis. Diabetes. 1988 Mar; 37(3):257-61. PMID: 3371561.
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    151. Greiner DL, Angelillo M, Mordes JP, Handler ES, Mojcik CF, Nakamura N, Rossini AA. Regulatory T cell control of autoimmune destruction of beta cells in the BB rat. Adv Exp Med Biol. 1988; 246:379-85. PMID: 3266909.
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    152. Majno G, Joris I, Handler ES, Desemone J, Mordes JP, Rossini AA. A pancreatic venular defect in the BB/Wor rat. Am J Pathol. 1987 Aug; 128(2):210-5. PMID: 3618725.
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    153. Burstein D, Handler ES, Schindler J, Seals J, Mordes JP, Rossini AA. Effect of interleukin-2 on diabetes in the BB/Wor rat. Diabetes Res. 1987 Aug; 5(4):163-7. PMID: 3499282.
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    154. Greiner DL, Mordes JP, Handler ES, Angelillo M, Nakamura N, Rossini AA. Depletion of RT6.1+ T lymphocytes induces diabetes in resistant biobreeding/Worcester (BB/W) rats. J Exp Med. 1987 Aug 1; 166(2):461-75. PMID: 3496416.
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    155. Mordes JP, Desemone J, Rossini AA. The BB rat. Diabetes Metab Rev. 1987 Jul; 3(3):725-50. PMID: 3301238.
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    156. Orczyk GP, Mordes JP, Longcope C. Aromatase activity in a rat Leydig cell tumor. Endocrinology. 1987 Apr; 120(4):1482-9. PMID: 3030702.
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    157. Greiner DL, Mordes JP, Handler ES, Nakamura N, Angelillo M, Rossini AA. Prothymocyte development in diabetes-prone BB rats: description of a defect that predisposes to immune abnormalities. Transplant Proc. 1987 Feb; 19(1 Pt 2):976-8. PMID: 3274436.
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    158. Mordes JP, Gallina DL, Handler ES, Greiner DL, Nakamura N, Pelletier A, Rossini AA. Transfusions enriched for W3/25+ helper/inducer T lymphocytes prevent spontaneous diabetes in the BB/W rat. Diabetologia. 1987 Jan; 30(1):22-6. PMID: 2952538.
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    159. Mordes JP, Handler ES, Like AA, Nakano K, Rossini AA. Irradiated lymphocytes do not adoptively transfer diabetes or prevent spontaneous disease in the BB/W rat. Metabolism. 1986 Jun; 35(6):552-4. PMID: 3713516.
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    160. Rossini AA, Mordes JP, Greiner DL, Nakano K, Appel MC, Handler ES. Spleen cell transfusion in the Bio-Breeding/Worcester rat. Prevention of diabetes, major histocompatibility complex restriction, and long-term persistence of transfused cells. J Clin Invest. 1986 Apr; 77(4):1399-401. PMID: 3958191.
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    161. Greiner DL, Handler ES, Nakano K, Mordes JP, Rossini AA. Absence of the RT-6 T cell subset in diabetes-prone BB/W rats. J Immunol. 1986 Jan; 136(1):148-51. PMID: 3079605.
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    162. Malhotra A, Mordes JP, McDermott L, Schaible TF. Abnormal cardiac biochemistry in spontaneously diabetic Bio-Breeding/Worcester rat. Am J Physiol. 1985 Nov; 249(5 Pt 2):H1051-5. PMID: 2932920.
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    163. Handler ES, Mordes JP, Seals J, Koevary S, Like AA, Nakano K, Rossini AA. Diabetes in the Bio-Breeding/Worcester rat. Induction and acceleration by spleen cell-conditioned media. J Clin Invest. 1985 Oct; 76(4):1692-4. PMID: 4056046.
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    164. Rossini AA, Mordes JP, Like AA. Immunology of insulin-dependent diabetes mellitus. Annu Rev Immunol. 1985; 3:289-320. PMID: 3904771.
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    165. Rajatanavin R, Safran M, Stoller WA, Mordes JP, Braverman LE. Five patients with iodine-induced hyperthyroidism. Am J Med. 1984 Aug; 77(2):378-84. PMID: 6235747.
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    166. Blume FD, Boyer SJ, Braverman LE, Cohen A, Dirkse J, Mordes JP. Impaired osmoregulation at high altitude. Studies on Mt Everest. JAMA. 1984 Jul 27; 252(4):524-6. PMID: 6429358.
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    167. Mordes JP, Longcope C, Flatt JP, MacLean DB, Rossini AA. The rat LTW(m) Leydig cell tumor: cancer anorexia due to estrogen. Endocrinology. 1984 Jul; 115(1):167-73. PMID: 6587964.
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    168. Rossini AA, Faustman D, Woda BA, Like AA, Szymanski I, Mordes JP. Lymphocyte transfusions prevent diabetes in the Bio-Breeding/Worcester rat. J Clin Invest. 1984 Jul; 74(1):39-46. PMID: 6610693.
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    169. Rossini AA, Slavin S, Woda BA, Geisberg M, Like AA, Mordes JP. Total lymphoid irradiation prevents diabetes mellitus in the Bio-Breeding/Worcester (BB/W) rat. Diabetes. 1984 Jun; 33(6):543-7. PMID: 6373460.
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    170. Rossini AA, Mordes JP, Gallina DL, Like AA. Hormonal and environmental factors in the pathogenesis of BB rat diabetes. Metabolism. 1983 Jul; 32(7 Suppl 1):33-6. PMID: 6223195.
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    171. Rossini AA, Mordes JP, Williams RM, Pelletier AM, Like AA. Failure to transfer insulitis to athymic recipients using BB/W rat lymphoid tissue transplants. Metabolism. 1983 Jul; 32(7 Suppl 1):80-2. PMID: 6345997.
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    172. Mordes JP, Blume FD, Boyer S, Zheng MR, Braverman LE. High-altitude pituitary-thyroid dysfunction on Mount Everest. N Engl J Med. 1983 May 12; 308(19):1135-8. PMID: 6835338.
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    173. Rossini AA, Mordes JP, Pelletier AM, Like AA. Transfusions of whole blood prevent spontaneous diabetes mellitus in the BB/W rat. Science. 1983 Feb 25; 219(4587):975-7. PMID: 6823559.
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    174. Gallina DL, Mordes JP, Rossini AA. Surgery in the diabetic patient. Compr Ther. 1983 Feb; 9(2):8-16. PMID: 6340941.
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    175. Mordes JP, Eastwood GL, Loo S, Rossini AA. Pancreatic polypeptide causes diarrhea and weight loss in obese mice but not in lean littermates. Peptides. 1982 Sep-Oct; 3(5):873-5. PMID: 7177927.
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    176. Mordes JP, Rossini AA. Tumor-induced anorexia in the Wistar rat. Science. 1981 Jul 31; 213(4507):565-7. PMID: 6941477.
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    177. Mordes JP, Rossini AA. Animal models of diabetes. Am J Med. 1981 Feb; 70(2):353-60. PMID: 6451172.
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    178. Mordes JP, Johnson MW, Soter NA. Possible naproxen-associated vasculitis. Arch Intern Med. 1980 Jul; 140(7):985. PMID: 7387310.
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    179. Rossini AA, Williams RM, Mordes JP, Appel MC, Like AA. Spontaneous diabetes in the gnotobiotic BB/W rat. Diabetes. 1979 Nov; 28(11):1031-2. PMID: 488543.
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    180. Mordes JP, el Lozy M, Herrera MG, Silen W. Effects of vagotomy with and without pyloroplasty on weight and food intake in rats. Am J Physiol. 1979 Jan; 236(1):R61-6. PMID: 434188.
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    181. Foote WE, Holmes P, Pritchard A, Hatcher C, Mordes J. Neurophysiological and pharmacodynamic studies on caffeine and on interactions between caffeine and nicotinic acid in the rat. Neuropharmacology. 1978 Jan; 17(1):7-12. PMID: 652133.
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    182. Mordes JP, Wacker WE. Excess magnesium. Pharmacol Rev. 1977 Dec; 29(4):273-300. PMID: 364497.
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    183. Mordes JP, Guillermo Herrera M, Silen W. Decreased weight gain and food intake in vagotomized rats. Proc Soc Exp Biol Med. 1977 Nov; 156(2):257-60. PMID: 928397.
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    184. Foote WE, Mordes JP, Colby CL, Harrison TA. Differential effect of midbrain stimulation on X-sustained and Y-transient neurons in the lateral geniculate nucleus of the cat. Brain Res. 1977 May 20; 127(1):153-8. PMID: 861748.
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    185. Mordes JP, Swartz R, Arky RA. Extreme hypermagnesemia as a cause of refractory hypotension. Ann Intern Med. 1975 Nov; 83(5):657-8. PMID: 1200497.
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    186. Foote WE, Maciewicz RJ, Mordes JP. Effect of midbrain raphe and lateral mesencephalic stimulation on spontaneous and evoked activity in the lateral geniculate of the cat. Exp Brain Res. 1974 Jan 31; 19(2):124-30. PMID: 4361031.
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