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Roger J Davis PhD, FRS

TitleChair and Professor
Endowed TitleH. Arthur Smith Chair in Cancer Research
InstitutionUMass Chan Medical School
DepartmentProgram in Molecular Medicine
AddressUMass Chan Medical School
373 Plantation Street Two Biotech Suite 309
Worcester MA 01605
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    Other Positions
    InstitutionT.H. Chan School of Medicine
    DepartmentBiochemistry and Molecular Biotechnology

    InstitutionT.H. Chan School of Medicine
    DepartmentNeuroNexus Institute

    InstitutionT.H. Chan School of Medicine
    DepartmentProgram in Molecular Medicine

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentBiochemistry and Molecular Biotechnology

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentCancer Biology

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentInterdisciplinary Graduate Program

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentMD/PhD Program

    InstitutionMorningside Graduate School of Biomedical Sciences

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentTranslational Science

    Collapse Biography 
    Collapse education and training
    Queens' College Cambridge, Cambridge, , United KingdomBABiochemistry
    Queens' College Cambridge, Cambridge, , United KingdomMAArts
    Queens' College Cambridge, Cambridge, , United KingdomPHMBiochemistry
    Queens' College Cambridge, Cambridge, , United KingdomPHDBiochemistry
    Collapse awards and honors
    2002Fellow, The Royal Society
    2010Member, European Molecular Biology Organization (EMBO)
    2012Fellow, American Academy of Microbiology (AAM)
    2012Fellow, American Association for the Advancement of Science (AAAS)
    2012Member, National Academy of Inventors (NAI)
    2018Member, National Academy of Sciences (NAS)

    Collapse Overview 
    Collapse overview

    Academic Background

    Dr. Roger J. Davis is an Investigator of the Howard Hughes Medical Institute and is the H. Arthur Smith Professor and Chair, Program in Molecular Medicine at the University of Massachusetts Medical School. He received his initial training as a student at Cambridge University.  He also trained as a Damon Runyon Cancer Research Foundation fellow with Michael P. Czech at the University of Massachusetts Medical School.  He subsequently joined the faculty of the University of Massachusetts Medical School and was a founding member of the Program in Molecular Medicine.


    Dr. Davis’ studies of signal transduction mechanisms led to the molecular cloning of the first human stress-activated MAP kinase, the cJun NH2-terminal kinase (JNK).  Subsequent studies defined the molecular structure of the JNK pathway, including the identification of upstream and down-stream pathway components and scaffold proteins.  This signaling pathway is activated in response to many pathological / physiological stimuli and is implicated in inflammatory diseases (e.g. arthritis), cancer, stroke, heart disease, and diabetes.  The overall goal of Dr. Davis’ research is to understand the molecular basis for these diseases and to design novel therapeutic strategies.  


    Dr. Davis has served as a Howard Hughes Medical Institute Investigator for 30 years.  He was identified as the most highly cited scientist world-wide in 1995-1996 by the Citation Index (Thompson Reuters) and is the author of more than 400 scientific papers.  He was elected to the National Academy of SciencesThe Royal SocietyAmerican Academy of MicrobiologyAmerican Association for the Advancement of SciencesNational Academy of Inventors, and the European Molecular Biology Organization.  He was also the recipient of the Steven C. Beering Award from Indiana University.  Dr. Davis was the Editor-in-Chief of the journal Molecular and Cellular Biology, and he currently serves on the Editorial Boards of eLifeGenes & Development, and Molecular Cell.  He also served as the Chair of the Cellular Aspects of Diabetes & Obesity Study Section (National Institutes of Health). 


    Mechanisms by which growth factors regulate cellular proliferation

    Photo: Roger DavisThe goal of this laboratory is to understand the molecular mechanism by which growth factors and cytokines regulate cellular proliferation and survival. A specific focus of our studies is to understand how MAP kinase signaling pathways, which are initiated at the cell surface, regulate the expression of genes in the nucleus.

    These MAP kinase pathways include the extracellular signal-regulated kinases (ERKs), the c-Jun amino-terminal kinases (JNKs), and the p38 MAP kinases. The methods that we are using include recombinant DNA technology, protein chemistry, somatic cell genetics, and general biochemical techniques.

    The significance of this research is that there are many disease states, such as cancer, that are characterized by abnormal cellular proliferation. A detailed understanding of the molecular processes involved in the control of cell growth is required for the design of rational treatments for these diseases.


    Schematic diagram

    Figure Legend

    Schematic representation of the human MAP kinase signal transduction pathway network.

    Collapse Rotation Projects

    Rotation Projects

    Laboratory rotations are available to study signal mammalian transduction mechanisms. Several projects are available, including studies of protein kinase cascades, gene expression, the cell cycle, and apoptosis. Targeted gene disruption approaches in mice combined with biochemical and molecular biology studies will be examined.

    Collapse webpage

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Itah Z, Chaudhry S, Raju Ponny S, Aydemir O, Lee A, Cavanagh-Kyros J, Tournier C, Muller WJ, Davis RJ. HER2-driven breast cancer suppression by the JNK signaling pathway. Proc Natl Acad Sci U S A. 2023 01 24; 120(4):e2218373120. PMID: 36656864.
      Citations: 2     Fields:    Translation:HumansCells
    2. Smith AO, Jonassen JA, Preval KM, Davis RJ, Pazour GJ. c-JUN n-Terminal Kinase (JNK) Signaling in Autosomal Dominant Polycystic Kidney Disease. J Cell Signal. 2022; 3(1):62-78. PMID: 35253003.
    3. Smith AO, Jonassen JA, Preval KM, Davis RJ, Pazour GJ. c-Jun N-terminal kinase (JNK) signaling contributes to cystic burden in polycystic kidney disease. PLoS Genet. 2021 12; 17(12):e1009711. PMID: 34962918.
      Citations: 4     Fields:    Translation:HumansCells
    4. M?ller K, Honcharova-Biletska H, Koppe C, Egger M, Chan LK, Schneider AT, K?sgens L, B?hm F, Boege Y, Healy ME, Schmitt J, Comtesse S, Castoldi M, Preisinger C, Szydlowska M, Focaccia E, Gaisa NT, Loosen SH, J?rs S, Tacke F, Roderburg C, Keitel V, Bode JG, Boor P, Davis RJ, Longerich T, Geisler F, Heikenwalder M, Weber A, Vucur M, Luedde T. JNK signaling prevents biliary cyst formation through a CASPASE-8-dependent function of RIPK1 during aging. Proc Natl Acad Sci U S A. 2021 03 23; 118(12). PMID: 33798093.
      Citations: 4     Fields:    Translation:AnimalsCells
    5. Grynberg K, Ozols E, Mulley WR, Davis RJ, Flavell RA, Nikolic-Paterson DJ, Ma FY. JUN Amino-Terminal Kinase 1 Signaling in the Proximal Tubule Causes Cell Death and Acute Renal Failure in Rat and Mouse Models of Renal Ischemia/Reperfusion Injury. Am J Pathol. 2021 05; 191(5):817-828. PMID: 33607044.
      Citations: 4     Fields:    Translation:AnimalsCells
    6. Han MS, Perry RJ, Camporez JP, Scherer PE, Shulman GI, Gao G, Davis RJ. A feed-forward regulatory loop in adipose tissue promotes signaling by the hepatokine FGF21. Genes Dev. 2021 01 01; 35(1-2):133-146. PMID: 33334822.
      Citations: 15     Fields:    Translation:AnimalsCells
    7. Cubero FJ, Mohamed MR, Woitok MM, Zhao G, Hatting M, Nevzorova YA, Chen C, Haybaeck J, de Bruin A, Avila MA, Boekschoten MV, Davis RJ, Trautwein C. Loss of c-Jun N-terminal Kinase 1 and 2 Function in Liver Epithelial Cells Triggers Biliary Hyperproliferation Resembling Cholangiocarcinoma. Hepatol Commun. 2020 Jun; 4(6):834-851. PMID: 32490320.
      Citations: 9     Fields:    
    8. Han MS, White A, Perry RJ, Camporez JP, Hidalgo J, Shulman GI, Davis RJ. Regulation of adipose tissue inflammation by interleukin 6. Proc Natl Acad Sci U S A. 2020 02 11; 117(6):2751-2760. PMID: 31980524.
      Citations: 117     Fields:    Translation:HumansAnimalsCells
    9. van der Velden JL, Alcorn JF, Chapman DG, Lundblad LKA, Irvin CG, Davis RJ, Butnor K, Janssen-Heininger YMW. Airway epithelial specific deletion of Jun-N-terminal kinase 1 attenuates pulmonary fibrosis in two independent mouse models. PLoS One. 2020; 15(1):e0226904. PMID: 31935227.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    10. Kant S, Craige SM, Chen K, Reif MM, Learnard H, Kelly M, Caliz AD, Tran KV, Ramo K, Peters OM, Freeman M, Davis RJ, Keaney JF. Neural JNK3 regulates blood flow recovery after hindlimb ischemia in mice via an Egr1/Creb1 axis. Nat Commun. 2019 09 17; 10(1):4223. PMID: 31530804.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    11. Jangalwe S, Kapoor VN, Xu J, Girnius N, Kennedy NJ, Edwards YJK, Welsh RM, Davis RJ, Brehm MA. Cutting Edge: Early Attrition of Memory T Cells during Inflammation and Costimulation Blockade Is Regulated Concurrently by Proapoptotic Proteins Fas and Bim. J Immunol. 2019 02 01; 202(3):647-651. PMID: 30610162.
      Citations: 4     Fields:    Translation:AnimalsCells
    12. Bik EM, Fang FC, Kullas AL, Davis RJ, Casadevall A. Analysis and Correction of Inappropriate Image Duplication: the Molecular and Cellular Biology Experience. Mol Cell Biol. 2018 10 15; 38(20). PMID: 30037982.
      Citations: 9     Fields:    
    13. Barutcu SA, Girnius N, Vernia S, Davis RJ. Role of the MAPK/cJun NH2-terminal kinase signaling pathway in starvation-induced autophagy. Autophagy. 2018; 14(9):1586-1595. PMID: 29950132.
      Citations: 12     Fields:    Translation:AnimalsCells
    14. Girnius N, Edwards YJ, Garlick DS, Davis RJ. The cJUN NH2-terminal kinase (JNK) signaling pathway promotes genome stability and prevents tumor initiation. Elife. 2018 06 01; 7. PMID: 29856313.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    15. Girnius N, Edwards YJK, Davis RJ. The cJUN NH2-terminal kinase (JNK) pathway contributes to mouse mammary gland remodeling during involution. Cell Death Differ. 2018 09; 25(9):1702-1715. PMID: 29511338.
      Citations: 7     Fields:    Translation:AnimalsCells
    16. Kim JH, Lee E, Friedline RH, Suk S, Jung DY, Dagdeviren S, Hu X, Inashima K, Noh HL, Kwon JY, Nambu A, Huh JR, Han MS, Davis RJ, Lee AS, Lee KW, Kim JK. Endoplasmic reticulum chaperone GRP78 regulates macrophage function and insulin resistance in diet-induced obesity. FASEB J. 2018 04; 32(4):2292-2304. PMID: 29242277.
      Citations: 16     Fields:    Translation:AnimalsCells
    17. Girnius N, Davis RJ. JNK Promotes Epithelial Cell Anoikis by Transcriptional and Post-translational Regulation of BH3-Only Proteins. Cell Rep. 2017 Nov 14; 21(7):1910-1921. PMID: 29141222.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    18. Kant S, Standen CL, Morel C, Jung DY, Kim JK, Swat W, Flavell RA, Davis RJ. A Protein Scaffold Coordinates SRC-Mediated JNK Activation in Response to Metabolic Stress. Cell Rep. 2017 Sep 19; 20(12):2775-2783. PMID: 28930674.
      Citations: 20     Fields:    Translation:AnimalsCells
    19. Boege Y, Malehmir M, Healy ME, Bettermann K, Lorentzen A, Vucur M, Ahuja AK, B?hm F, Mertens JC, Shimizu Y, Frick L, Remouchamps C, Mutreja K, K?hne T, Sundaravinayagam D, Wolf MJ, Rehrauer H, Koppe C, Speicher T, Padrissa-Alt?s S, Maire R, Schattenberg JM, Jeong JS, Liu L, Zwirner S, Boger R, H?ser N, Davis RJ, M?llhaupt B, Moch H, Schulze-Bergkamen H, Clavien PA, Werner S, Borsig L, Luther SA, Jost PJ, Weinlich R, Unger K, Behrens A, Hillert L, Dillon C, Di Virgilio M, Wallach D, Dejardin E, Zender L, Naumann M, Walczak H, Green DR, Lopes M, Lavrik I, Luedde T, Heikenwalder M, Weber A. A Dual Role of Caspase-8 in Triggering and Sensing Proliferation-Associated DNA Damage, a Key Determinant of Liver Cancer Development. Cancer Cell. 2017 09 11; 32(3):342-359.e10. PMID: 28898696.
      Citations: 65     Fields:    Translation:HumansAnimalsCells
    20. Xu P, Davis RJ. Correction for Xu and Davis, "c-Jun NH2-Terminal Kinase Is Required for Lineage-Specific Differentiation but Not Stem Cell Self-Renewal". Mol Cell Biol. 2017 09 01; 37(17). PMID: 28801454.
      Citations:    Fields:    
    21. Kullas AL, Davis RJ. Setting the (Scientific) Record Straight: Molecular and Cellular Biology Responds to Postpublication Review. Mol Cell Biol. 2017 06 01; 37(11). PMID: 28512216.
      Citations: 2     Fields:    Translation:Humans
    22. Davis RJ. Melanoma mystery. Elife. 2017 01 19; 6. PMID: 28100393.
      Citations: 2     Fields:    Translation:HumansAnimals
    23. Whitmarsh AJ, Davis RJ. Multisite phosphorylation by MAPK. Science. 2016 10 14; 354(6309):179-180. PMID: 27738159.
      Citations: 4     Fields:    Translation:HumansCells
    24. Vernia S, Edwards YJ, Han MS, Cavanagh-Kyros J, Barrett T, Kim JK, Davis RJ. An alternative splicing program promotes adipose tissue thermogenesis. Elife. 2016 09 16; 5. PMID: 27635635.
      Citations: 32     Fields:    Translation:AnimalsCells
    25. Ramo K, Sugamura K, Craige S, Keaney JF, Davis RJ. Suppression of ischemia in arterial occlusive disease by JNK-promoted native collateral artery development. Elife. 2016 08 09; 5. PMID: 27504807.
      Citations: 8     Fields:    Translation:AnimalsCells
    26. Han MS, Barrett T, Brehm MA, Davis RJ. Inflammation Mediated by JNK in Myeloid Cells Promotes the Development of Hepatitis and Hepatocellular Carcinoma. Cell Rep. 2016 Apr 05; 15(1):19-26. PMID: 27052181.
      Citations: 37     Fields:    Translation:AnimalsCells
    27. Vernia S, Cavanagh-Kyros J, Barrett T, Tournier C, Davis RJ. Fibroblast Growth Factor 21 Mediates Glycemic Regulation by Hepatic JNK. Cell Rep. 2016 Mar 15; 14(10):2273-80. PMID: 26947074.
      Citations: 22     Fields:    Translation:AnimalsCells
    28. Vernia S, Morel C, Madara JC, Cavanagh-Kyros J, Barrett T, Chase K, Kennedy NJ, Jung DY, Kim JK, Aronin N, Flavell RA, Lowell BB, Davis RJ. Excitatory transmission onto AgRP neurons is regulated by cJun NH2-terminal kinase 3 in response to metabolic stress. Elife. 2016 Feb 24; 5:e10031. PMID: 26910012.
      Citations: 17     Fields:    Translation:AnimalsCells
    29. Girnius N, Davis RJ. TNFa-Mediated Cytotoxic Responses to IAP Inhibition Are Limited by the p38a MAPK Pathway. Cancer Cell. 2016 Feb 08; 29(2):131-3. PMID: 26859448.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    30. Liu X, Li H, Rajurkar M, Li Q, Cotton JL, Ou J, Zhu LJ, Goel HL, Mercurio AM, Park JS, Davis RJ, Mao J. Tead and AP1 Coordinate Transcription and Motility. Cell Rep. 2016 Feb 09; 14(5):1169-1180. PMID: 26832411.
      Citations: 118     Fields:    Translation:HumansCells
    31. Blodgett DM, Nowosielska A, Afik S, Pechhold S, Cura AJ, Kennedy NJ, Kim S, Kucukural A, Davis RJ, Kent SC, Greiner DL, Garber MG, Harlan DM, diIorio P. Novel Observations From Next-Generation RNA Sequencing of Highly Purified Human Adult and Fetal Islet Cell Subsets. Diabetes. 2015 Sep; 64(9):3172-81. PMID: 25931473.
      Citations: 162     Fields:    Translation:HumansCells
    32. Mak P, Li J, Samanta S, Chang C, Jerry DJ, Davis RJ, Leav I, Mercurio AM. Prostate tumorigenesis induced by PTEN deletion involves estrogen receptor ? repression. Cell Rep. 2015 Mar 31; 10(12):1982-91. PMID: 25818291.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    33. Nistic? R, Florenzano F, Mango D, Ferraina C, Grilli M, Di Prisco S, Nobili A, Saccucci S, D'Amelio M, Morbin M, Marchi M, Mercuri NB, Davis RJ, Pittaluga A, Feligioni M. Presynaptic c-Jun N-terminal Kinase 2 regulates NMDA receptor-dependent glutamate release. Sci Rep. 2015 Mar 12; 5:9035. PMID: 25762148.
      Citations: 27     Fields:    Translation:AnimalsCells
    34. Perry RJ, Camporez JG, Kursawe R, Titchenell PM, Zhang D, Perry CJ, Jurczak MJ, Abudukadier A, Han MS, Zhang XM, Ruan HB, Yang X, Caprio S, Kaech SM, Sul HS, Birnbaum MJ, Davis RJ, Cline GW, Petersen KF, Shulman GI. Hepatic acetyl CoA links adipose tissue inflammation to hepatic insulin resistance and type 2 diabetes. Cell. 2015 Feb 12; 160(4):745-758. PMID: 25662011.
      Citations: 326     Fields:    Translation:HumansAnimalsCells
    35. Yang J, Wu Z, Renier N, Simon DJ, Uryu K, Park DS, Greer PA, Tournier C, Davis RJ, Tessier-Lavigne M. Pathological axonal death through a MAPK cascade that triggers a local energy deficit. Cell. 2015 Jan 15; 160(1-2):161-76. PMID: 25594179.
      Citations: 149     Fields:    Translation:AnimalsCells
    36. Schaefer FM, Peng J, Hu W, Drvarov O, Nevzorova YA, Zhao G, Masaoudi MA, Davis RJ, Trautwein C, Cubero FJ. Bone marrow-derived c-jun N-terminal kinase-1 (JNK1) mediates liver regeneration. Biochim Biophys Acta. 2015 Jan; 1852(1):137-45. PMID: 25445542.
      Citations: 5     Fields:    Translation:Animals
    37. Vernia S, Cavanagh-Kyros J, Garcia-Haro L, Sabio G, Barrett T, Jung DY, Kim JK, Xu J, Shulha HP, Garber M, Gao G, Davis RJ. The PPARa-FGF21 hormone axis contributes to metabolic regulation by the hepatic JNK signaling pathway. Cell Metab. 2014 Sep 02; 20(3):512-25. PMID: 25043817.
      Citations: 89     Fields:    Translation:AnimalsCells
    38. Zaidi SK, Shen WJ, Bittner S, Bittner A, McLean MP, Han J, Davis RJ, Kraemer FB, Azhar S. p38 MAPK regulates steroidogenesis through transcriptional repression of STAR gene. J Mol Endocrinol. 2014 Aug; 53(1):1-16. PMID: 24780837.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    39. Davies CC, Harvey E, McMahon RF, Finegan KG, Connor F, Davis RJ, Tuveson DA, Tournier C. Impaired JNK signaling cooperates with KrasG12D expression to accelerate pancreatic ductal adenocarcinoma. Cancer Res. 2014 Jun 15; 74(12):3344-56. PMID: 24713432.
      Citations: 15     Fields:    Translation:AnimalsCells
    40. Vernia S, Cavanagh-Kyros J, Barrett T, Jung DY, Kim JK, Davis RJ. Diet-induced obesity mediated by the JNK/DIO2 signal transduction pathway. Genes Dev. 2013 Nov 01; 27(21):2345-55. PMID: 24186979.
      Citations: 26     Fields:    Translation:AnimalsCells
    41. Kant S, Barrett T, Vertii A, Noh YH, Jung DY, Kim JK, Davis RJ. Role of the mixed-lineage protein kinase pathway in the metabolic stress response to obesity. Cell Rep. 2013 Aug 29; 4(4):681-8. PMID: 23954791.
      Citations: 17     Fields:    Translation:Animals
    42. Goel HL, Sayeed A, Breen M, Zarif MJ, Garlick DS, Leav I, Davis RJ, Fitzgerald TJ, Morrione A, Hsieh CC, Liu Q, Dicker AP, Altieri DC, Languino LR. ?1 integrins mediate resistance to ionizing radiation in vivo by inhibiting c-Jun amino terminal kinase 1. J Cell Physiol. 2013 Jul; 228(7):1601-9. PMID: 23359252.
      Citations: 33     Fields:    Translation:HumansAnimalsCells
    43. Han MS, Jung DY, Morel C, Lakhani SA, Kim JK, Flavell RA, Davis RJ. JNK expression by macrophages promotes obesity-induced insulin resistance and inflammation. Science. 2013 Jan 11; 339(6116):218-22. PMID: 23223452.
      Citations: 312     Fields:    Translation:AnimalsCells
    44. Davis RJ. Cell biology. A scaffold switch to insulate. Science. 2012 Sep 07; 337(6099):1178-9. PMID: 22955821.
      Citations:    Fields:    Translation:Animals
    45. Goel HL, Chang C, Pursell B, Leav I, Lyle S, Xi HS, Hsieh CC, Adisetiyo H, Roy-Burman P, Coleman IM, Nelson PS, Vessella RL, Davis RJ, Plymate SR, Mercurio AM. VEGF/neuropilin-2 regulation of Bmi-1 and consequent repression of IGF-IR define a novel mechanism of aggressive prostate cancer. Cancer Discov. 2012 Oct; 2(10):906-21. PMID: 22777769.
      Citations: 48     Fields:    Translation:HumansAnimalsCells
    46. H?bner A, Mulholland DJ, Standen CL, Karasarides M, Cavanagh-Kyros J, Barrett T, Chi H, Greiner DL, Tournier C, Sawyers CL, Flavell RA, Wu H, Davis RJ. JNK and PTEN cooperatively control the development of invasive adenocarcinoma of the prostate. Proc Natl Acad Sci U S A. 2012 Jul 24; 109(30):12046-51. PMID: 22753496.
      Citations: 52     Fields:    Translation:AnimalsCells
    47. Norseen J, Hosooka T, Hammarstedt A, Yore MM, Kant S, Aryal P, Kiernan UA, Phillips DA, Maruyama H, Kraus BJ, Usheva A, Davis RJ, Smith U, Kahn BB. Retinol-binding protein 4 inhibits insulin signaling in adipocytes by inducing proinflammatory cytokines in macrophages through a c-Jun N-terminal kinase- and toll-like receptor 4-dependent and retinol-independent mechanism. Mol Cell Biol. 2012 May; 32(10):2010-9. PMID: 22431523.
      Citations: 130     Fields:    Translation:HumansAnimalsCells
    48. Cellurale C, Girnius N, Jiang F, Cavanagh-Kyros J, Lu S, Garlick DS, Mercurio AM, Davis RJ. Role of JNK in mammary gland development and breast cancer. Cancer Res. 2012 Jan 15; 72(2):472-81. PMID: 22127926.
      Citations: 48     Fields:    Translation:AnimalsCells
    49. Mazzitelli S, Xu P, Ferrer I, Davis RJ, Tournier C. The loss of c-Jun N-terminal protein kinase activity prevents the amyloidogenic cleavage of amyloid precursor protein and the formation of amyloid plaques in vivo. J Neurosci. 2011 Nov 23; 31(47):16969-76. PMID: 22114267.
      Citations: 26     Fields:    Translation:HumansAnimalsCells
    50. Kant S, Swat W, Zhang S, Zhang ZY, Neel BG, Flavell RA, Davis RJ. TNF-stimulated MAP kinase activation mediated by a Rho family GTPase signaling pathway. Genes Dev. 2011 Oct 01; 25(19):2069-78. PMID: 21979919.
      Citations: 60     Fields:    Translation:AnimalsCells
    51. Gao Z, Zhang J, Kheterpal I, Kennedy N, Davis RJ, Ye J. Sirtuin 1 (SIRT1) protein degradation in response to persistent c-Jun N-terminal kinase 1 (JNK1) activation contributes to hepatic steatosis in obesity. J Biol Chem. 2011 Jun 24; 286(25):22227-34. PMID: 21540183.
      Citations: 89     Fields:    Translation:HumansAnimalsCells
    52. Das M, Garlick DS, Greiner DL, Davis RJ. The role of JNK in the development of hepatocellular carcinoma. Genes Dev. 2011 Mar 15; 25(6):634-45. PMID: 21406557.
      Citations: 103     Fields:    Translation:AnimalsCells
    53. Xu P, Das M, Reilly J, Davis RJ. JNK regulates FoxO-dependent autophagy in neurons. Genes Dev. 2011 Feb 15; 25(4):310-22. PMID: 21325132.
      Citations: 130     Fields:    Translation:AnimalsCells
    54. Cellurale C, Sabio G, Kennedy NJ, Das M, Barlow M, Sandy P, Jacks T, Davis RJ. Requirement of c-Jun NH(2)-terminal kinase for Ras-initiated tumor formation. Mol Cell Biol. 2011 Apr; 31(7):1565-76. PMID: 21282468.
      Citations: 53     Fields:    Translation:AnimalsCells
    55. Smith FD, Langeberg LK, Cellurale C, Pawson T, Morrison DK, Davis RJ, Scott JD. AKAP-Lbc enhances cyclic AMP control of the ERK1/2 cascade. Nat Cell Biol. 2010 Dec; 12(12):1242-9. PMID: 21102438.
      Citations: 81     Fields:    Translation:HumansAnimalsCells
    56. Sherrin T, Blank T, Hippel C, Rayner M, Davis RJ, Todorovic C. Hippocampal c-Jun-N-terminal kinases serve as negative regulators of associative learning. J Neurosci. 2010 Oct 06; 30(40):13348-61. PMID: 20926661.
      Citations: 34     Fields:    Translation:AnimalsCells
    57. Cellurale C, Weston CR, Reilly J, Garlick DS, Jerry DJ, Sluss HK, Davis RJ. Role of JNK in a Trp53-dependent mouse model of breast cancer. PLoS One. 2010 Aug 30; 5(8):e12469. PMID: 20814571.
      Citations: 28     Fields:    Translation:Animals
    58. Morel C, Standen CL, Jung DY, Gray S, Ong H, Flavell RA, Kim JK, Davis RJ. Requirement of JIP1-mediated c-Jun N-terminal kinase activation for obesity-induced insulin resistance. Mol Cell Biol. 2010 Oct; 30(19):4616-25. PMID: 20679483.
      Citations: 14     Fields:    Translation:AnimalsCells
    59. Barnat M, Enslen H, Propst F, Davis RJ, Soares S, Nothias F. Distinct roles of c-Jun N-terminal kinase isoforms in neurite initiation and elongation during axonal regeneration. J Neurosci. 2010 Jun 09; 30(23):7804-16. PMID: 20534829.
      Citations: 69     Fields:    Translation:AnimalsCells
    60. Bahl K, H?ebner A, Davis RJ, Welsh RM. Analysis of apoptosis of memory T cells and dendritic cells during the early stages of viral infection or exposure to toll-like receptor agonists. J Virol. 2010 May; 84(10):4866-77. PMID: 20200235.
      Citations: 27     Fields:    Translation:AnimalsCells
    61. Podkowa M, Zhao X, Chow CW, Coffey ET, Davis RJ, Attisano L. Microtubule stabilization by bone morphogenetic protein receptor-mediated scaffolding of c-Jun N-terminal kinase promotes dendrite formation. Mol Cell Biol. 2010 May; 30(9):2241-50. PMID: 20176805.
      Citations: 38     Fields:    Translation:AnimalsCells
    62. Sabio G, Cavanagh-Kyros J, Barrett T, Jung DY, Ko HJ, Ong H, Morel C, Mora A, Reilly J, Kim JK, Davis RJ. Role of the hypothalamic-pituitary-thyroid axis in metabolic regulation by JNK1. Genes Dev. 2010 Feb 01; 24(3):256-64. PMID: 20080940.
      Citations: 60     Fields:    Translation:AnimalsCells
    63. Xu P, Davis RJ. c-Jun NH2-terminal kinase is required for lineage-specific differentiation but not stem cell self-renewal. Mol Cell Biol. 2010 Mar; 30(6):1329-40. PMID: 20065035.
      Citations: 24     Fields:    Translation:AnimalsCells
    64. Sabio G, Kennedy NJ, Cavanagh-Kyros J, Jung DY, Ko HJ, Ong H, Barrett T, Kim JK, Davis RJ. Role of muscle c-Jun NH2-terminal kinase 1 in obesity-induced insulin resistance. Mol Cell Biol. 2010 Jan; 30(1):106-15. PMID: 19841069.
      Citations: 74     Fields:    Translation:AnimalsCells
    65. H?bner A, Cavanagh-Kyros J, Rincon M, Flavell RA, Davis RJ. Functional cooperation of the proapoptotic Bcl2 family proteins Bmf and Bim in vivo. Mol Cell Biol. 2010 Jan; 30(1):98-105. PMID: 19841067.
      Citations: 41     Fields:    Translation:AnimalsCells
    66. Sabio G, Cavanagh-Kyros J, Ko HJ, Jung DY, Gray S, Jun JY, Barrett T, Mora A, Kim JK, Davis RJ. Prevention of steatosis by hepatic JNK1. Cell Metab. 2009 Dec; 10(6):491-8. PMID: 19945406.
      Citations: 88     Fields:    Translation:AnimalsCells
    67. Standen CL, Kennedy NJ, Flavell RA, Davis RJ. Signal transduction cross talk mediated by Jun N-terminal kinase-interacting protein and insulin receptor substrate scaffold protein complexes. Mol Cell Biol. 2009 Sep; 29(17):4831-40. PMID: 19564410.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    68. Morel C, Carlson SM, White FM, Davis RJ. Mcl-1 integrates the opposing actions of signaling pathways that mediate survival and apoptosis. Mol Cell Biol. 2009 Jul; 29(14):3845-52. PMID: 19433446.
      Citations: 82     Fields:    Translation:HumansAnimalsCells
    69. Das M, Sabio G, Jiang F, Rinc?n M, Flavell RA, Davis RJ. Induction of hepatitis by JNK-mediated expression of TNF-alpha. Cell. 2009 Jan 23; 136(2):249-60. PMID: 19167327.
      Citations: 84     Fields:    Translation:AnimalsCells
    70. Sabio G, Das M, Mora A, Zhang Z, Jun JY, Ko HJ, Barrett T, Kim JK, Davis RJ. A stress signaling pathway in adipose tissue regulates hepatic insulin resistance. Science. 2008 Dec 05; 322(5907):1539-43. PMID: 19056984.
      Citations: 278     Fields:    Translation:AnimalsCells
    71. Ongusaha PP, Qi HH, Raj L, Kim YB, Aaronson SA, Davis RJ, Shi Y, Liao JK, Lee SW. Identification of ROCK1 as an upstream activator of the JIP-3 to JNK signaling axis in response to UVB damage. Sci Signal. 2008 Nov 25; 1(47):ra14. PMID: 19036714.
      Citations: 28     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    72. Hu D, Fang W, Han A, Gallagher L, Davis RJ, Xiong B, Yang W. c-Jun N-terminal kinase 1 interacts with and negatively regulates Wnt/beta-catenin signaling through GSK3beta pathway. Carcinogenesis. 2008 Dec; 29(12):2317-24. PMID: 18952597.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    73. Fitzgerald TJ, Wang T, Goel HL, Huang J, Stein G, Lian J, Davis RJ, Doxsey S, Balaji KC, Aronowitz J, Languino LR. Prostate carcinoma and radiation therapy: therapeutic treatment resistance and strategies for targeted therapeutic intervention. Expert Rev Anticancer Ther. 2008 Jun; 8(6):967-74. PMID: 18533806.
      Citations: 15     Fields:    Translation:Humans
    74. H?bner A, Barrett T, Flavell RA, Davis RJ. Multisite phosphorylation regulates Bim stability and apoptotic activity. Mol Cell. 2008 May 23; 30(4):415-25. PMID: 18498746.
      Citations: 132     Fields:    Translation:HumansAnimalsCells
    75. Alcorn JF, Guala AS, van der Velden J, McElhinney B, Irvin CG, Davis RJ, Janssen-Heininger YM. Jun N-terminal kinase 1 regulates epithelial-to-mesenchymal transition induced by TGF-beta1. J Cell Sci. 2008 Apr 01; 121(Pt 7):1036-45. PMID: 18334556.
      Citations: 80     Fields:    Translation:AnimalsCells
    76. Pedra JH, Mattner J, Tao J, Kerfoot SM, Davis RJ, Flavell RA, Askenase PW, Yin Z, Fikrig E. c-Jun NH2-terminal kinase 2 inhibits gamma interferon production during Anaplasma phagocytophilum infection. Infect Immun. 2008 Jan; 76(1):308-16. PMID: 17998313.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    77. Das M, Jiang F, Sluss HK, Zhang C, Shokat KM, Flavell RA, Davis RJ. Suppression of p53-dependent senescence by the JNK signal transduction pathway. Proc Natl Acad Sci U S A. 2007 Oct 02; 104(40):15759-64. PMID: 17893331.
      Citations: 82     Fields:    Translation:AnimalsCells
    78. Kennedy NJ, Martin G, Ehrhardt AG, Cavanagh-Kyros J, Kuan CY, Rakic P, Flavell RA, Treistman SN, Davis RJ. Requirement of JIP scaffold proteins for NMDA-mediated signal transduction. Genes Dev. 2007 Sep 15; 21(18):2336-46. PMID: 17875667.
      Citations: 25     Fields:    Translation:AnimalsCells
    79. Mishra AK, Gangwani L, Davis RJ, Lambright DG. Structural insights into the interaction of the evolutionarily conserved ZPR1 domain tandem with eukaryotic EF1A, receptors, and SMN complexes. Proc Natl Acad Sci U S A. 2007 Aug 28; 104(35):13930-5. PMID: 17704259.
      Citations: 25     Fields:    Translation:AnimalsCells
    80. Jaeschke A, Davis RJ. Metabolic stress signaling mediated by mixed-lineage kinases. Mol Cell. 2007 Aug 03; 27(3):498-508. PMID: 17679097.
      Citations: 71     Fields:    Translation:AnimalsCells
    81. Izadi H, Motameni AT, Bates TC, Olivera ER, Villar-Suarez V, Joshi I, Garg R, Osborne BA, Davis RJ, Rinc?n M, Anguita J. c-Jun N-terminal kinase 1 is required for Toll-like receptor 1 gene expression in macrophages. Infect Immun. 2007 Oct; 75(10):5027-34. PMID: 17664270.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    82. Tong C, Yin Z, Song Z, Dockendorff A, Huang C, Mariadason J, Flavell RA, Davis RJ, Augenlicht LH, Yang W. c-Jun NH2-terminal kinase 1 plays a critical role in intestinal homeostasis and tumor suppression. Am J Pathol. 2007 Jul; 171(1):297-303. PMID: 17591974.
      Citations: 50     Fields:    Translation:AnimalsCells
    83. Weston CR, Davis RJ. The JNK signal transduction pathway. Curr Opin Cell Biol. 2007 Apr; 19(2):142-9. PMID: 17303404.
      Citations: 461     Fields:    Translation:HumansAnimalsCells
    84. Kennedy NJ, Cellurale C, Davis RJ. A radical role for p38 MAPK in tumor initiation. Cancer Cell. 2007 Feb; 11(2):101-3. PMID: 17292820.
      Citations: 27     Fields:    Translation:HumansAnimalsCells
    85. Henderson NC, Pollock KJ, Frew J, Mackinnon AC, Flavell RA, Davis RJ, Sethi T, Simpson KJ. Critical role of c-jun (NH2) terminal kinase in paracetamol- induced acute liver failure. Gut. 2007 Jul; 56(7):982-90. PMID: 17185352.
      Citations: 97     Fields:    Translation:HumansAnimalsCells
    86. Chow CW, Davis RJ. Proteins kinases: chromatin-associated enzymes? Cell. 2006 Dec 01; 127(5):887-90. PMID: 17129776.
      Citations: 32     Fields:    Translation:Cells
    87. H?bner A, Jaeschke A, Davis RJ. Oncogene addiction: role of signal attenuation. Dev Cell. 2006 Dec; 11(6):752-4. PMID: 17141149.
      Citations: 4     Fields:    Translation:HumansCells
    88. Liao G, Tao Q, Kofron M, Chen JS, Schloemer A, Davis RJ, Hsieh JC, Wylie C, Heasman J, Kuan CY. Jun NH2-terminal kinase (JNK) prevents nuclear beta-catenin accumulation and regulates axis formation in Xenopus embryos. Proc Natl Acad Sci U S A. 2006 Oct 31; 103(44):16313-8. PMID: 17060633.
      Citations: 40     Fields:    Translation:HumansAnimalsCells
    89. Groisman I, Ivshina M, Marin V, Kennedy NJ, Davis RJ, Richter JD. Control of cellular senescence by CPEB. Genes Dev. 2006 Oct 01; 20(19):2701-12. PMID: 17015432.
      Citations: 52     Fields:    Translation:AnimalsCells
    90. Jaeschke A, Karasarides M, Ventura JJ, Ehrhardt A, Zhang C, Flavell RA, Shokat KM, Davis RJ. JNK2 is a positive regulator of the cJun transcription factor. Mol Cell. 2006 Sep 15; 23(6):899-911. PMID: 16973441.
      Citations: 87     Fields:    Translation:AnimalsCells
    91. Tran EH, Azuma YT, Chen M, Weston C, Davis RJ, Flavell RA. Inactivation of JNK1 enhances innate IL-10 production and dampens autoimmune inflammation in the brain. Proc Natl Acad Sci U S A. 2006 Sep 05; 103(36):13451-6. PMID: 16938889.
      Citations: 15     Fields:    Translation:AnimalsCells
    92. Sluss HK, Davis RJ. H2AX is a target of the JNK signaling pathway that is required for apoptotic DNA fragmentation. Mol Cell. 2006 Jul 21; 23(2):152-3. PMID: 16857581.
      Citations: 24     Fields:    Translation:Cells
    93. Doran B, Gherbesi N, Hendricks G, Flavell RA, Davis RJ, Gangwani L. Deficiency of the zinc finger protein ZPR1 causes neurodegeneration. Proc Natl Acad Sci U S A. 2006 May 09; 103(19):7471-5. PMID: 16648254.
      Citations: 28     Fields:    Translation:AnimalsCells
    94. Tachibana H, Perrino C, Takaoka H, Davis RJ, Naga Prasad SV, Rockman HA. JNK1 is required to preserve cardiac function in the early response to pressure overload. Biochem Biophys Res Commun. 2006 May 19; 343(4):1060-6. PMID: 16579967.
      Citations: 30     Fields:    Translation:Animals
    95. Ventura JJ, H?bner A, Zhang C, Flavell RA, Shokat KM, Davis RJ. Chemical genetic analysis of the time course of signal transduction by JNK. Mol Cell. 2006 Mar 03; 21(5):701-10. PMID: 16507367.
      Citations: 146     Fields:    Translation:AnimalsCells
    96. Emerling BM, Platanias LC, Black E, Nebreda AR, Davis RJ, Chandel NS. Mitochondrial reactive oxygen species activation of p38 mitogen-activated protein kinase is required for hypoxia signaling. Mol Cell Biol. 2005 Jun; 25(12):4853-62. PMID: 15923604.
      Citations: 115     Fields:    Translation:AnimalsCells
    97. Jaeschke A, Rinc?n M, Doran B, Reilly J, Neuberg D, Greiner DL, Shultz LD, Rossini AA, Flavell RA, Davis RJ. Disruption of the Jnk2 (Mapk9) gene reduces destructive insulitis and diabetes in a mouse model of type I diabetes. Proc Natl Acad Sci U S A. 2005 May 10; 102(19):6931-5. PMID: 15867147.
      Citations: 27     Fields:    Translation:AnimalsCells
    98. Brancho D, Ventura JJ, Jaeschke A, Doran B, Flavell RA, Davis RJ. Role of MLK3 in the regulation of mitogen-activated protein kinase signaling cascades. Mol Cell Biol. 2005 May; 25(9):3670-81. PMID: 15831472.
      Citations: 72     Fields:    Translation:AnimalsCells
    99. Gangwani L, Flavell RA, Davis RJ. ZPR1 is essential for survival and is required for localization of the survival motor neurons (SMN) protein to Cajal bodies. Mol Cell Biol. 2005 Apr; 25(7):2744-56. PMID: 15767679.
      Citations: 37     Fields:    Translation:AnimalsCells
    100. Kelkar N, Standen CL, Davis RJ. Role of the JIP4 scaffold protein in the regulation of mitogen-activated protein kinase signaling pathways. Mol Cell Biol. 2005 Apr; 25(7):2733-43. PMID: 15767678.
      Citations: 78     Fields:    Translation:AnimalsCells
    101. Oh SW, Mukhopadhyay A, Svrzikapa N, Jiang F, Davis RJ, Tissenbaum HA. JNK regulates lifespan in Caenorhabditis elegans by modulating nuclear translocation of forkhead transcription factor/DAF-16. Proc Natl Acad Sci U S A. 2005 Mar 22; 102(12):4494-9. PMID: 15767565.
      Citations: 238     Fields:    Translation:AnimalsCells
    102. Ventura JJ, Cogswell P, Flavell RA, Baldwin AS, Davis RJ. JNK potentiates TNF-stimulated necrosis by increasing the production of cytotoxic reactive oxygen species. Genes Dev. 2004 Dec 01; 18(23):2905-15. PMID: 15545623.
      Citations: 126     Fields:    Translation:Animals
    103. Keramaris E, Vanderluit JL, Bahadori M, Mousavi K, Davis RJ, Flavell R, Slack RS, Park DS. c-Jun N-terminal kinase 3 deficiency protects neurons from axotomy-induced death in vivo through mechanisms independent of c-Jun phosphorylation. J Biol Chem. 2005 Jan 14; 280(2):1132-41. PMID: 15528206.
      Citations: 17     Fields:    Translation:AnimalsCells
    104. Weston CR, Wong A, Hall JP, Goad ME, Flavell RA, Davis RJ. The c-Jun NH2-terminal kinase is essential for epidermal growth factor expression during epidermal morphogenesis. Proc Natl Acad Sci U S A. 2004 Sep 28; 101(39):14114-9. PMID: 15375216.
      Citations: 33     Fields:    Translation:AnimalsCells
    105. Jaeschke A, Czech MP, Davis RJ. An essential role of the JIP1 scaffold protein for JNK activation in adipose tissue. Genes Dev. 2004 Aug 15; 18(16):1976-80. PMID: 15314024.
      Citations: 49     Fields:    Translation:AnimalsCells
    106. Morton S, Davis RJ, Cohen P. Signalling pathways involved in multisite phosphorylation of the transcription factor ATF-2. FEBS Lett. 2004 Aug 13; 572(1-3):177-83. PMID: 15304344.
      Citations: 38     Fields:    Translation:AnimalsCells
    107. Ventura JJ, Kennedy NJ, Flavell RA, Davis RJ. JNK regulates autocrine expression of TGF-beta1. Mol Cell. 2004 Jul 23; 15(2):269-78. PMID: 15260977.
      Citations: 31     Fields:    Translation:AnimalsCells
    108. Whitmarsh AJ, Davis RJ. Analyzing mitogen-activated protein kinase (MAPK) activities in T cells. Curr Protoc Immunol. 2004 Feb; Chapter 11:Unit 11.8. PMID: 18432922.
      Citations: 2     Fields:    Translation:AnimalsCells
    109. Xiu M, Kim J, Sampson E, Huang CY, Davis RJ, Paulson KE, Yee AS. The transcriptional repressor HBP1 is a target of the p38 mitogen-activated protein kinase pathway in cell cycle regulation. Mol Cell Biol. 2003 Dec; 23(23):8890-901. PMID: 14612426.
      Citations: 22     Fields:    Translation:AnimalsCells
    110. Kuan CY, Whitmarsh AJ, Yang DD, Liao G, Schloemer AJ, Dong C, Bao J, Banasiak KJ, Haddad GG, Flavell RA, Davis RJ, Rakic P. A critical role of neural-specific JNK3 for ischemic apoptosis. Proc Natl Acad Sci U S A. 2003 Dec 09; 100(25):15184-9. PMID: 14657393.
      Citations: 150     Fields:    Translation:AnimalsCells
    111. Lee TH, Huang Q, Oikemus S, Shank J, Ventura JJ, Cusson N, Vaillancourt RR, Su B, Davis RJ, Kelliher MA. The death domain kinase RIP1 is essential for tumor necrosis factor alpha signaling to p38 mitogen-activated protein kinase. Mol Cell Biol. 2003 Nov; 23(22):8377-85. PMID: 14585994.
      Citations: 29     Fields:    Translation:AnimalsCells
    112. Kelkar N, Delmotte MH, Weston CR, Barrett T, Sheppard BJ, Flavell RA, Davis RJ. Morphogenesis of the telencephalic commissure requires scaffold protein JNK-interacting protein 3 (JIP3). Proc Natl Acad Sci U S A. 2003 Aug 19; 100(17):9843-8. PMID: 12897243.
      Citations: 28     Fields:    Translation:AnimalsCells
    113. Brancho D, Tanaka N, Jaeschke A, Ventura JJ, Kelkar N, Tanaka Y, Kyuuma M, Takeshita T, Flavell RA, Davis RJ. Mechanism of p38 MAP kinase activation in vivo. Genes Dev. 2003 Aug 15; 17(16):1969-78. PMID: 12893778.
      Citations: 216     Fields:    Translation:AnimalsCells
    114. Morse D, Pischke SE, Zhou Z, Davis RJ, Flavell RA, Loop T, Otterbein SL, Otterbein LE, Choi AM. Suppression of inflammatory cytokine production by carbon monoxide involves the JNK pathway and AP-1. J Biol Chem. 2003 Sep 26; 278(39):36993-8. PMID: 12857751.
      Citations: 123     Fields:    Translation:AnimalsCells
    115. Tanno M, Bassi R, Gorog DA, Saurin AT, Jiang J, Heads RJ, Martin JL, Davis RJ, Flavell RA, Marber MS. Diverse mechanisms of myocardial p38 mitogen-activated protein kinase activation: evidence for MKK-independent activation by a TAB1-associated mechanism contributing to injury during myocardial ischemia. Circ Res. 2003 Aug 08; 93(3):254-61. PMID: 12829618.
      Citations: 51     Fields:    Translation:AnimalsCells
    116. Lamb JA, Ventura JJ, Hess P, Flavell RA, Davis RJ. JunD mediates survival signaling by the JNK signal transduction pathway. Mol Cell. 2003 Jun; 11(6):1479-89. PMID: 12820962.
      Citations: 101     Fields:    Translation:AnimalsCells
    117. Weston CR, Wong A, Hall JP, Goad ME, Flavell RA, Davis RJ. JNK initiates a cytokine cascade that causes Pax2 expression and closure of the optic fissure. Genes Dev. 2003 May 15; 17(10):1271-80. PMID: 12756228.
      Citations: 44     Fields:    Translation:AnimalsCells
    118. Kennedy NJ, Davis RJ. Role of JNK in tumor development. Cell Cycle. 2003 May-Jun; 2(3):199-201. PMID: 12734425.
      Citations: 77     Fields:    Translation:HumansAnimalsCells
    119. Ventura JJ, Kennedy NJ, Lamb JA, Flavell RA, Davis RJ. c-Jun NH(2)-terminal kinase is essential for the regulation of AP-1 by tumor necrosis factor. Mol Cell Biol. 2003 Apr; 23(8):2871-82. PMID: 12665585.
      Citations: 63     Fields:    Translation:AnimalsCells
    120. Morse D, Otterbein LE, Watkins S, Alber S, Zhou Z, Flavell RA, Davis RJ, Choi AM. Deficiency in the c-Jun NH2-terminal kinase signaling pathway confers susceptibility to hyperoxic lung injury in mice. Am J Physiol Lung Cell Mol Physiol. 2003 Jul; 285(1):L250-7. PMID: 12651633.
      Citations: 14     Fields:    Translation:AnimalsCells
    121. Kennedy NJ, Sluss HK, Jones SN, Bar-Sagi D, Flavell RA, Davis RJ. Suppression of Ras-stimulated transformation by the JNK signal transduction pathway. Genes Dev. 2003 Mar 01; 17(5):629-37. PMID: 12629045.
      Citations: 57     Fields:    Translation:AnimalsCells
    122. Lei K, Davis RJ. JNK phosphorylation of Bim-related members of the Bcl2 family induces Bax-dependent apoptosis. Proc Natl Acad Sci U S A. 2003 Mar 04; 100(5):2432-7. PMID: 12591950.
      Citations: 386     Fields:    Translation:HumansCells
    123. Zhang X, Shan P, Otterbein LE, Alam J, Flavell RA, Davis RJ, Choi AM, Lee PJ. Carbon monoxide inhibition of apoptosis during ischemia-reperfusion lung injury is dependent on the p38 mitogen-activated protein kinase pathway and involves caspase 3. J Biol Chem. 2003 Jan 10; 278(2):1248-58. PMID: 12399465.
      Citations: 80     Fields:    Translation:AnimalsCells
    124. Hess P, Pihan G, Sawyers CL, Flavell RA, Davis RJ. Survival signaling mediated by c-Jun NH(2)-terminal kinase in transformed B lymphoblasts. Nat Genet. 2002 Sep; 32(1):201-5. PMID: 12161751.
      Citations: 56     Fields:    Translation:AnimalsCells
    125. Ghahremani MH, Keramaris E, Shree T, Xia Z, Davis RJ, Flavell R, Slack RS, Park DS. Interaction of the c-Jun/JNK pathway and cyclin-dependent kinases in death of embryonic cortical neurons evoked by DNA damage. J Biol Chem. 2002 Sep 20; 277(38):35586-96. PMID: 12091388.
      Citations: 13     Fields:    Translation:AnimalsCells
    126. Weston CR, Lambright DG, Davis RJ. Signal transduction. MAP kinase signaling specificity. Science. 2002 Jun 28; 296(5577):2345-7. PMID: 12089430.
      Citations: 42     Fields:    Translation:Cells
    127. Yang TT, Xiong Q, Enslen H, Davis RJ, Chow CW. Phosphorylation of NFATc4 by p38 mitogen-activated protein kinases. Mol Cell Biol. 2002 Jun; 22(11):3892-904. PMID: 11997522.
      Citations: 76     Fields:    Translation:AnimalsCells
    128. Arbour N, Naniche D, Homann D, Davis RJ, Flavell RA, Oldstone MB. c-Jun NH(2)-terminal kinase (JNK)1 and JNK2 signaling pathways have divergent roles in CD8(+) T cell-mediated antiviral immunity. J Exp Med. 2002 Apr 01; 195(7):801-10. PMID: 11927625.
      Citations: 37     Fields:    Translation:AnimalsCells
    129. Conze D, Krahl T, Kennedy N, Weiss L, Lumsden J, Hess P, Flavell RA, Le Gros G, Davis RJ, Rinc?n M. c-Jun NH(2)-terminal kinase (JNK)1 and JNK2 have distinct roles in CD8(+) T cell activation. J Exp Med. 2002 Apr 01; 195(7):811-23. PMID: 11927626.
      Citations: 54     Fields:    Translation:AnimalsCells
    130. Weston CR, Davis RJ. The JNK signal transduction pathway. Curr Opin Genet Dev. 2002 Feb; 12(1):14-21. PMID: 11790549.
      Citations: 223     Fields:    Translation:AnimalsCells
    131. Hall JP, Davis RJ. Inhibition of the p38 pathway upregulates macrophage JNK and ERK activities, and the ERK, JNK, and p38 MAP kinase pathways are reprogrammed during differentiation of the murine myeloid M1 cell line. J Cell Biochem. 2002; 86(1):1-11. PMID: 12112010.
      Citations: 11     Fields:    Translation:AnimalsCells
    132. Davis RJ. Signal transduction by the JNK group of MAP kinases. Cell. 2000 Oct 13; 103(2):239-52. PMID: 11057897.
      Citations: 1438     Fields:    Translation:Cells
    133. Whitmarsh AJ, Davis RJ. Signal transduction by MAP kinases: regulation by phosphorylation-dependent switches. Sci STKE. 1999 Sep 28; 1999(1):PE1. PMID: 11865181.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
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