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Roger J Davis PhD, FRS

TitleChair and Professor
Endowed TitleH. Arthur Smith Chair in Cancer Research
InstitutionUMass Chan Medical School
DepartmentProgram in Molecular Medicine
AddressUMass Chan Medical School
373 Plantation Street Two Biotech Suite 309
Worcester MA 01605
Phone508-856-6054
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    Other Positions
    InstitutionT.H. Chan School of Medicine
    DepartmentBiochemistry and Molecular Biotechnology

    InstitutionT.H. Chan School of Medicine
    DepartmentNeuroNexus Institute

    InstitutionT.H. Chan School of Medicine
    DepartmentProgram in Molecular Medicine

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentBiochemistry and Molecular Biotechnology

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentCancer Biology

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentInterdisciplinary Graduate Program

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentMD/PhD Program

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentNeuroscience

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentTranslational Science


    Collapse Biography 
    Collapse education and training
    Queens' College Cambridge, Cambridge, , United KingdomBABiochemistry
    Queens' College Cambridge, Cambridge, , United KingdomMAArts
    Queens' College Cambridge, Cambridge, , United KingdomPHMBiochemistry
    Queens' College Cambridge, Cambridge, , United KingdomPHDBiochemistry
    Collapse awards and honors
    2002Fellow, The Royal Society
    2010Member, European Molecular Biology Organization (EMBO)
    2012Fellow, American Academy of Microbiology (AAM)
    2012Fellow, American Association for the Advancement of Science (AAAS)
    2012Member, National Academy of Inventors (NAI)
    2018Member, National Academy of Sciences (NAS)

    Collapse Overview 
    Collapse overview

    Academic Background

    Dr. Roger J. Davis is an Investigator of the Howard Hughes Medical Institute and is the H. Arthur Smith Professor and Chair, Program in Molecular Medicine at the University of Massachusetts Medical School. He received his initial training as a student at Cambridge University.  He also trained as a Damon Runyon Cancer Research Foundation fellow with Michael P. Czech at the University of Massachusetts Medical School.  He subsequently joined the faculty of the University of Massachusetts Medical School and was a founding member of the Program in Molecular Medicine.

     

    Dr. Davis’ studies of signal transduction mechanisms led to the molecular cloning of the first human stress-activated MAP kinase, the cJun NH2-terminal kinase (JNK).  Subsequent studies defined the molecular structure of the JNK pathway, including the identification of upstream and down-stream pathway components and scaffold proteins.  This signaling pathway is activated in response to many pathological / physiological stimuli and is implicated in inflammatory diseases (e.g. arthritis), cancer, stroke, heart disease, and diabetes.  The overall goal of Dr. Davis’ research is to understand the molecular basis for these diseases and to design novel therapeutic strategies.  

     

    Dr. Davis has served as a Howard Hughes Medical Institute Investigator for 30 years.  He was identified as the most highly cited scientist world-wide in 1995-1996 by the Citation Index (Thompson Reuters) and is the author of more than 400 scientific papers.  He was elected to the National Academy of SciencesThe Royal SocietyAmerican Academy of MicrobiologyAmerican Association for the Advancement of SciencesNational Academy of Inventors, and the European Molecular Biology Organization.  He was also the recipient of the Steven C. Beering Award from Indiana University.  Dr. Davis was the Editor-in-Chief of the journal Molecular and Cellular Biology, and he currently serves on the Editorial Boards of eLifeGenes & Development, and Molecular Cell.  He also served as the Chair of the Cellular Aspects of Diabetes & Obesity Study Section (National Institutes of Health). 

     

    Mechanisms by which growth factors regulate cellular proliferation

    Photo: Roger DavisThe goal of this laboratory is to understand the molecular mechanism by which growth factors and cytokines regulate cellular proliferation and survival. A specific focus of our studies is to understand how MAP kinase signaling pathways, which are initiated at the cell surface, regulate the expression of genes in the nucleus.

    These MAP kinase pathways include the extracellular signal-regulated kinases (ERKs), the c-Jun amino-terminal kinases (JNKs), and the p38 MAP kinases. The methods that we are using include recombinant DNA technology, protein chemistry, somatic cell genetics, and general biochemical techniques.

    The significance of this research is that there are many disease states, such as cancer, that are characterized by abnormal cellular proliferation. A detailed understanding of the molecular processes involved in the control of cell growth is required for the design of rational treatments for these diseases.

    Figure

    Schematic diagram

    Figure Legend

    Schematic representation of the human MAP kinase signal transduction pathway network.


    Collapse Rotation Projects

    Rotation Projects

    Laboratory rotations are available to study signal mammalian transduction mechanisms. Several projects are available, including studies of protein kinase cascades, gene expression, the cell cycle, and apoptosis. Targeted gene disruption approaches in mice combined with biochemical and molecular biology studies will be examined.


    Collapse webpage

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Mohamed MR, Zhao G, Volkert I, Molinaro A, Schneider CV, Strnad P, Hengstler JG, Xu C, Davis RJ, Schneider KM, Cubero FJ, Trautwein C. Differential Protective Roles of c-Jun N-terminal Kinase-2 in Nonparenchymal Liver Cells and Hepatocytes During Cholestasis. Cell Mol Gastroenterol Hepatol. 2025 Jul 16; 19(11):101588. PMID: 40681041.
      Citations:    
    2. Tamir TY, Chaudhary S, Li AX, Trojan SE, Flower CT, Vo P, Cui Y, Davis JC, Mukkamala R, Venditti FN, Hillis AL, Toker A, Vander Heiden MG, Spinelli JB, Kennedy NJ, Davis RJ, White FM. Structural and systems characterization of phosphorylation on metabolic enzymes identifies sex-specific metabolic reprogramming in obesity. Mol Cell. 2025 Jun 05; 85(11):2211-2229.e8. PMID: 40441152.
      Citations:    
    3. Fern?ndez-Gonz?lez I, Freire-Agulleiro O, Ferreira V, Silveira-Loureiro M, Rial-Pensado E, Garrido-Gil P, Mart?nez G, Rada P, Labandeira-Garc?a JL, Mittag J, Gonz?lez-Garc?a I, Di?guez C, Nogueiras R, Valverde ?M, Davis RJ, Sabio G, Barca-Mayo O, L?pez M. JNK1 in SF1 neurons regulates the central action of thyroid hormones on hepatic lipid metabolism. Mol Metab. 2025 Aug; 98:102170. PMID: 40419019.
      Citations:    
    4. Kant S, Caliz AD, Yoo HJ, Kaur G, Learnard H, Khalil HA, Davis RJ, Keaney JFJ. Mixed lineage kinase (MLK) controls tumor development and angiogenesis. Angiogenesis. 2025 May 02; 28(3):29. PMID: 40314847.
      Citations:    
    5. Pittala S, Haspula D, Cui Y, Yang WM, Kim YB, Davis RJ, Wing A, Rotman Y, McGuinness OP, Inoue A, Wess J. G12/13-mediated signaling stimulates hepatic glucose production and has a major impact on whole body glucose homeostasis. Nat Commun. 2024 11 19; 15(1):9996. PMID: 39557854.
      Citations:    
    6. Tamir TY, Chaudhary S, Li AX, Trojan SE, Flower CT, Vo P, Cui Y, Davis JC, Mukkamala RS, Venditti FN, Hillis AL, Toker A, Vander Heiden MG, Spinelli JB, Kennedy NJ, Davis RJ, White FM. Structural and systems characterization of phosphorylation on metabolic enzymes identifies sex-specific metabolic reprogramming in obesity. bioRxiv. 2024 Aug 29. PMID: 39257804.
      Citations:    
    7. Mari?o P?rez L, Ielasi FS, Lee A, Delaforge E, Juyoux P, Tengo M, Davis RJ, Palencia A, Jensen MR. Structural basis of homodimerization of the JNK scaffold protein JIP2 and its heterodimerization with JIP1. Structure. 2024 09 05; 32(9):1394-1403.e5. PMID: 39013462.
      Citations:    
    8. Zhang X, Shan P, Otterbein LE, Alam J, Flavell RA, Davis RJ, Choi AMK, Lee PJ. Correction: Carbon monoxide inhibition of apoptosis during ischemia-reperfusion lung injury is dependent on the p38 mitogen-activated protein kinase pathway and involves caspase 3. J Biol Chem. 2023 Oct; 299(10):105304. PMID: 37826982.
      Citations:    
    9. Mohamed MR, Haybaeck J, Wu H, Su H, Bartneck M, Lin C, Boekschoten MV, Boor P, Goeppert B, Rupp C, Strnad P, Davis RJ, Cubero FJ, Trautwein C. JNKs protect from cholestatic liver disease progression by modulating Apelin signalling. JHEP Rep. 2023 Nov; 5(11):100854. PMID: 37791376.
      Citations:    
    10. Ferreira V, Folgueira C, Garc?a-Altares M, Guill?n M, Ru?z-Rosario M, DiNunzio G, Garcia-Martinez I, Alen R, Bookmeyer C, Jones JG, Cigudosa JC, L?pez-Larrubia P, Correig-Blanchar X, Davis RJ, Sabio G, Rada P, Valverde ?M. Hypothalamic JNK1-hepatic fatty acid synthase axis mediates a metabolic rewiring that prevents hepatic steatosis in male mice treated with olanzapine via intraperitoneal: Additional effects of PTP1B inhibition. Redox Biol. 2023 07; 63:102741. PMID: 37230004.
      Citations:    
    11. Itah Z, Chaudhry S, Raju Ponny S, Aydemir O, Lee A, Cavanagh-Kyros J, Tournier C, Muller WJ, Davis RJ. HER2-driven breast cancer suppression by the JNK signaling pathway. Proc Natl Acad Sci U S A. 2023 01 24; 120(4):e2218373120. PMID: 36656864.
      Citations: 2     Fields:    Translation:HumansCells
    12. Vernia S, Lee A, Kennedy NJ, Han MS, Isasa M, Cavanagh-Kyros J, Roy A, Syed A, Chaudhry S, Edwards YJK, Gygi SP, Gao G, Davis RJ. Phosphorylation of RXRa mediates the effect of JNK to suppress hepatic FGF21 expression and promote metabolic syndrome. Proc Natl Acad Sci U S A. 2022 11; 119(44):e2210434119. PMID: 36282921.
      Citations: 2     Fields:    Translation:AnimalsCells
    13. Liu PW, Martin GL, Lin W, Huang W, Pande S, Aronovitz MJ, Davis RJ, Blanton RM. Mixed lineage kinase 3 requires a functional CRIB domain for regulation of blood pressure, cardiac hypertrophy, and left ventricular function. Am J Physiol Heart Circ Physiol. 2022 09 01; 323(3):H513-H522. PMID: 35867711.
      Citations:    
    14. Im DS, Joselin A, Svoboda D, Takano T, Rousseaux MWC, Callaghan S, Slack RS, Hisanaga SI, Davis RJ, Park DS, Qu D. Cdk5-mediated JIP1 phosphorylation regulates axonal outgrowth through Notch1 inhibition. BMC Biol. 2022 05 17; 20(1):115. PMID: 35581583.
      Citations:    
    15. Smith AO, Jonassen JA, Preval KM, Davis RJ, Pazour GJ. c-JUN n-Terminal Kinase (JNK) Signaling in Autosomal Dominant Polycystic Kidney Disease. J Cell Signal. 2022; 3(1):62-78. PMID: 35253003.
      Citations:    
    16. Smith AO, Jonassen JA, Preval KM, Davis RJ, Pazour GJ. c-Jun N-terminal kinase (JNK) signaling contributes to cystic burden in polycystic kidney disease. PLoS Genet. 2021 12; 17(12):e1009711. PMID: 34962918.
      Citations: 4     Fields:    Translation:HumansCells
    17. Chen C, Wu H, Ye H, Tortajada A, Rodr?guez-Perales S, Torres-Ruiz R, Vidal A, Peligros MI, Reissing J, Bruns T, Mohamed MR, Zheng K, Lujambio A, Iraburu MJ, Colyn L, Latasa MU, Arechederra M, Fern?ndez-Barrena MG, Berasain C, Vaquero J, Ba?ares R, Nelson LJ, Trautwein C, Davis RJ, Martinez-Naves E, Nevzorova YA, Villanueva A, Avila MA, Cubero FJ. Activation of the Unfolded Protein Response (UPR) Is Associated with Cholangiocellular Injury, Fibrosis and Carcinogenesis in an Experimental Model of Fibropolycystic Liver Disease. Cancers (Basel). 2021 Dec 24; 14(1). PMID: 35008241.
      Citations:    
    18. Guney E, Arruda AP, Parlakgul G, Cagampan E, Min N, Lee GY, Greene L, Tsaousidou E, Inouye K, Han MS, Davis RJ, Hotamisligil GS. Aberrant Ca2+ signaling by IP3Rs in adipocytes links inflammation to metabolic dysregulation in obesity. Sci Signal. 2021 Dec 14; 14(713):eabf2059. PMID: 34905386.
      Citations:    
    19. Calamaras TD, Pande S, Baumgartner RA, Kim SK, McCarthy JC, Martin GL, Tam K, McLaughlin AL, Wang GR, Aronovitz MJ, Lin W, Aguirre JI, Baca P, Liu P, Richards DA, Davis RJ, Karas RH, Jaffe IZ, Blanton RM. MLK3 mediates impact of PKG1a on cardiac function and controls blood pressure through separate mechanisms. JCI Insight. 2021 09 22; 6(18). PMID: 34324442.
      Citations:    
    20. Caliz AD, Yoo HJ, Vertii A, Dolan AC, Tournier C, Davis RJ, Keaney JF, Kant S. Mitogen Kinase Kinase (MKK7) Controls Cytokine Production In Vitro and In Vivo in Mice. Int J Mol Sci. 2021 Aug 29; 22(17). PMID: 34502275.
      Citations: 4     Fields:    Translation:AnimalsCells
    21. M?ller K, Honcharova-Biletska H, Koppe C, Egger M, Chan LK, Schneider AT, K?sgens L, B?hm F, Boege Y, Healy ME, Schmitt J, Comtesse S, Castoldi M, Preisinger C, Szydlowska M, Focaccia E, Gaisa NT, Loosen SH, J?rs S, Tacke F, Roderburg C, Keitel V, Bode JG, Boor P, Davis RJ, Longerich T, Geisler F, Heikenwalder M, Weber A, Vucur M, Luedde T. JNK signaling prevents biliary cyst formation through a CASPASE-8-dependent function of RIPK1 during aging. Proc Natl Acad Sci U S A. 2021 03 23; 118(12). PMID: 33798093.
      Citations: 4     Fields:    Translation:AnimalsCells
    22. Grynberg K, Ozols E, Mulley WR, Davis RJ, Flavell RA, Nikolic-Paterson DJ, Ma FY. JUN Amino-Terminal Kinase 1 Signaling in the Proximal Tubule Causes Cell Death and Acute Renal Failure in Rat and Mouse Models of Renal Ischemia/Reperfusion Injury. Am J Pathol. 2021 05; 191(5):817-828. PMID: 33607044.
      Citations: 4     Fields:    Translation:AnimalsCells
    23. Han MS, Perry RJ, Camporez JP, Scherer PE, Shulman GI, Gao G, Davis RJ. A feed-forward regulatory loop in adipose tissue promotes signaling by the hepatokine FGF21. Genes Dev. 2021 01 01; 35(1-2):133-146. PMID: 33334822.
      Citations: 15     Fields:    Translation:AnimalsCells
    24. Crespo M, Gonzalez-Teran B, Nikolic I, Mora A, Folgueira C, Rodr?guez E, Leiva-Vega L, Pintor-Chocano A, Fern?ndez-Chac?n M, Ruiz-Garrido I, Cicu?ndez B, Tom?s-Loba A, A-Gonzalez N, Caballero-Molano A, Beiroa D, Hern?ndez-Cosido L, Torres JL, Kennedy NJ, Davis RJ, Benedito R, Marcos M, Nogueiras R, Hidalgo A, Matesanz N, Leiva M, Sabio G. Neutrophil infiltration regulates clock-gene expression to organize daily hepatic metabolism. Elife. 2020 12 08; 9. PMID: 33287957.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    25. Manieri E, Folgueira C, Rodr?guez ME, Leiva-Vega L, Esteban-Lafuente L, Chen C, Cubero FJ, Barrett T, Cavanagh-Kyros J, Seruggia D, Rosell A, Sanchez-Cabo F, G?mez MJ, Monte MJ, G Marin JJ, Davis RJ, Mora A, Sabio G. JNK-mediated disruption of bile acid homeostasis promotes intrahepatic cholangiocarcinoma. Proc Natl Acad Sci U S A. 2020 07 14; 117(28):16492-16499. PMID: 32601222.
      Citations:    
    26. Cubero FJ, Mohamed MR, Woitok MM, Zhao G, Hatting M, Nevzorova YA, Chen C, Haybaeck J, de Bruin A, Avila MA, Boekschoten MV, Davis RJ, Trautwein C. Loss of c-Jun N-terminal Kinase 1 and 2 Function in Liver Epithelial Cells Triggers Biliary Hyperproliferation Resembling Cholangiocarcinoma. Hepatol Commun. 2020 Jun; 4(6):834-851. PMID: 32490320.
      Citations: 9     Fields:    
    27. Han MS, White A, Perry RJ, Camporez JP, Hidalgo J, Shulman GI, Davis RJ. Regulation of adipose tissue inflammation by interleukin 6. Proc Natl Acad Sci U S A. 2020 02 11; 117(6):2751-2760. PMID: 31980524.
      Citations: 117     Fields:    Translation:HumansAnimalsCells
    28. van der Velden JL, Alcorn JF, Chapman DG, Lundblad LKA, Irvin CG, Davis RJ, Butnor K, Janssen-Heininger YMW. Airway epithelial specific deletion of Jun-N-terminal kinase 1 attenuates pulmonary fibrosis in two independent mouse models. PLoS One. 2020; 15(1):e0226904. PMID: 31935227.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    29. Win S, Min RW, Chen CQ, Zhang J, Chen Y, Li M, Suzuki A, Abdelmalek MF, Wang Y, Aghajan M, Aung FW, Diehl AM, Davis RJ, Than TA, Kaplowitz N. Expression of mitochondrial membrane-linked SAB determines severity of sex-dependent acute liver injury. J Clin Invest. 2019 12 02; 129(12):5278-5293. PMID: 31487267.
      Citations:    
    30. Kant S, Craige SM, Chen K, Reif MM, Learnard H, Kelly M, Caliz AD, Tran KV, Ramo K, Peters OM, Freeman M, Davis RJ, Keaney JF. Neural JNK3 regulates blood flow recovery after hindlimb ischemia in mice via an Egr1/Creb1 axis. Nat Commun. 2019 09 17; 10(1):4223. PMID: 31530804.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    31. Dittmann A, Kennedy NJ, Soltero NL, Morshed N, Mana MD, Yilmaz ?H, Davis RJ, White FM. High-fat diet in a mouse insulin-resistant model induces widespread rewiring of the phosphotyrosine signaling network. Mol Syst Biol. 2019 08; 15(8):e8849. PMID: 31464373.
      Citations: 8     Fields:    Translation:AnimalsCells
    32. Liu J, Wang T, Creighton CJ, Wu SP, Ray M, Janardhan KS, Willson CJ, Cho SN, Castro PD, Ittmann MM, Li JL, Davis RJ, DeMayo FJ. JNK1/2 represses Lkb1-deficiency-induced lung squamous cell carcinoma progression. Nat Commun. 2019 05 14; 10(1):2148. PMID: 31089135.
      Citations:    
    33. Jangalwe S, Kapoor VN, Xu J, Girnius N, Kennedy NJ, Edwards YJK, Welsh RM, Davis RJ, Brehm MA. Cutting Edge: Early Attrition of Memory T Cells during Inflammation and Costimulation Blockade Is Regulated Concurrently by Proapoptotic Proteins Fas and Bim. J Immunol. 2019 02 01; 202(3):647-651. PMID: 30610162.
      Citations: 4     Fields:    Translation:AnimalsCells
    34. Saleiro D, Blyth GT, Kosciuczuk EM, Ozark PA, Majchrzak-Kita B, Arslan AD, Fischietti M, Reddy NK, Horvath CM, Davis RJ, Fish EN, Platanias LC. IFN-?-inducible antiviral responses require ULK1-mediated activation of MLK3 and ERK5. Sci Signal. 2018 11 20; 11(557). PMID: 30459284.
      Citations:    
    35. Calamaras TD, Baumgartner RA, Aronovitz MJ, McLaughlin AL, Tam K, Richards DA, Cooper CW, Li N, Baur WE, Qiao X, Wang GR, Davis RJ, Kapur NK, Karas RH, Blanton RM. Mixed lineage kinase-3 prevents cardiac dysfunction and structural remodeling with pressure overload. Am J Physiol Heart Circ Physiol. 2019 01 01; 316(1):H145-H159. PMID: 30362822.
      Citations:    
    36. Bik EM, Fang FC, Kullas AL, Davis RJ, Casadevall A. Analysis and Correction of Inappropriate Image Duplication: the Molecular and Cellular Biology Experience. Mol Cell Biol. 2018 10 15; 38(20). PMID: 30037982.
      Citations: 9     Fields:    
    37. Haun F, Neumann S, Peintner L, Wieland K, Habicht J, Schwan C, ?stevold K, Koczorowska MM, Biniossek M, Kist M, Busch H, Boerries M, Davis RJ, Maurer U, Schilling O, Aktories K, Borner C. Identification of a novel anoikis signalling pathway using the fungal virulence factor gliotoxin. Nat Commun. 2018 08 30; 9(1):3524. PMID: 30166526.
      Citations:    
    38. Barutcu SA, Girnius N, Vernia S, Davis RJ. Role of the MAPK/cJun NH2-terminal kinase signaling pathway in starvation-induced autophagy. Autophagy. 2018; 14(9):1586-1595. PMID: 29950132.
      Citations: 12     Fields:    Translation:AnimalsCells
    39. Lessard SJ, MacDonald TL, Pathak P, Han MS, Coffey VG, Edge J, Rivas DA, Hirshman MF, Davis RJ, Goodyear LJ. JNK regulates muscle remodeling via myostatin/SMAD inhibition. Nat Commun. 2018 08 02; 9(1):3030. PMID: 30072727.
      Citations:    
    40. Girnius N, Edwards YJ, Garlick DS, Davis RJ. The cJUN NH2-terminal kinase (JNK) signaling pathway promotes genome stability and prevents tumor initiation. Elife. 2018 06 01; 7. PMID: 29856313.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    41. Morel C, Sherrin T, Kennedy NJ, Forest KH, Avcioglu Barutcu S, Robles M, Carpenter-Hyland E, Alfulaij N, Standen CL, Nichols RA, Benveniste M, Davis RJ, Todorovic C. JIP1-Mediated JNK Activation Negatively Regulates Synaptic Plasticity and Spatial Memory. J Neurosci. 2018 04 11; 38(15):3708-3728. PMID: 29540552.
      Citations: 15     Fields:    Translation:AnimalsCells
    42. Girnius N, Edwards YJK, Davis RJ. The cJUN NH2-terminal kinase (JNK) pathway contributes to mouse mammary gland remodeling during involution. Cell Death Differ. 2018 09; 25(9):1702-1715. PMID: 29511338.
      Citations: 7     Fields:    Translation:AnimalsCells
    43. Kim JH, Lee E, Friedline RH, Suk S, Jung DY, Dagdeviren S, Hu X, Inashima K, Noh HL, Kwon JY, Nambu A, Huh JR, Han MS, Davis RJ, Lee AS, Lee KW, Kim JK. Endoplasmic reticulum chaperone GRP78 regulates macrophage function and insulin resistance in diet-induced obesity. FASEB J. 2018 04; 32(4):2292-2304. PMID: 29242277.
      Citations: 16     Fields:    Translation:AnimalsCells
    44. Harper KL, Sosa MS, Entenberg D, Hosseini H, Cheung JF, Nobre R, Avivar-Valderas A, Nagi C, Girnius N, Davis RJ, Farias EF, Condeelis J, Klein CA, Aguirre-Ghiso JA. Corrigendum: Mechanism of early dissemination and metastasis in Her2+ mammary cancer. Nature. 2018 01 18; 553(7688):366. PMID: 29236689.
      Citations:    
    45. Soltis AR, Kennedy NJ, Xin X, Zhou F, Ficarro SB, Yap YS, Matthews BJ, Lauffenburger DA, White FM, Marto JA, Davis RJ, Fraenkel E. Hepatic Dysfunction Caused by Consumption of a High-Fat Diet. Cell Rep. 2017 Dec 12; 21(11):3317-3328. PMID: 29241556.
      Citations: 35     Fields:    Translation:AnimalsCells
    46. Girnius N, Davis RJ. JNK Promotes Epithelial Cell Anoikis by Transcriptional and Post-translational Regulation of BH3-Only Proteins. Cell Rep. 2017 Nov 14; 21(7):1910-1921. PMID: 29141222.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    47. Kant S, Standen CL, Morel C, Jung DY, Kim JK, Swat W, Flavell RA, Davis RJ. A Protein Scaffold Coordinates SRC-Mediated JNK Activation in Response to Metabolic Stress. Cell Rep. 2017 Sep 19; 20(12):2775-2783. PMID: 28930674.
      Citations: 20     Fields:    Translation:AnimalsCells
    48. Boege Y, Malehmir M, Healy ME, Bettermann K, Lorentzen A, Vucur M, Ahuja AK, B?hm F, Mertens JC, Shimizu Y, Frick L, Remouchamps C, Mutreja K, K?hne T, Sundaravinayagam D, Wolf MJ, Rehrauer H, Koppe C, Speicher T, Padrissa-Alt?s S, Maire R, Schattenberg JM, Jeong JS, Liu L, Zwirner S, Boger R, H?ser N, Davis RJ, M?llhaupt B, Moch H, Schulze-Bergkamen H, Clavien PA, Werner S, Borsig L, Luther SA, Jost PJ, Weinlich R, Unger K, Behrens A, Hillert L, Dillon C, Di Virgilio M, Wallach D, Dejardin E, Zender L, Naumann M, Walczak H, Green DR, Lopes M, Lavrik I, Luedde T, Heikenwalder M, Weber A. A Dual Role of Caspase-8 in Triggering and Sensing Proliferation-Associated DNA Damage, a Key Determinant of Liver Cancer Development. Cancer Cell. 2017 09 11; 32(3):342-359.e10. PMID: 28898696.
      Citations: 65     Fields:    Translation:HumansAnimalsCells
    49. Xu R, Zhang C, Shin DY, Kim JM, Lalani S, Li N, Yang YS, Liu Y, Eiseman M, Davis RJ, Shim JH, Greenblatt MB. c-Jun N-Terminal Kinases (JNKs) Are Critical Mediators of Osteoblast Activity In Vivo. J Bone Miner Res. 2017 Sep; 32(9):1811-1815. PMID: 28561373.
      Citations: 24     Fields:    Translation:AnimalsCells
    50. Xu P, Davis RJ. Correction for Xu and Davis, "c-Jun NH2-Terminal Kinase Is Required for Lineage-Specific Differentiation but Not Stem Cell Self-Renewal". Mol Cell Biol. 2017 09 01; 37(17). PMID: 28801454.
      Citations:    Fields:    
    51. Mart?nez-S?nchez N, Seoane-Collazo P, Contreras C, Varela L, Villarroya J, Rial-Pensado E, Buqu? X, Aurrekoetxea I, Delgado TC, V?zquez-Mart?nez R, Gonz?lez-Garc?a I, Roa J, Whittle AJ, Gomez-Santos B, Velagapudi V, Tung YCL, Morgan DA, Voshol PJ, Mart?nez de Morentin PB, L?pez-Gonz?lez T, Li?ares-Pose L, Gonzalez F, Chatterjee K, Sobrino T, Medina-G?mez G, Davis RJ, Casals N, Ore?ic M, Coll AP, Vidal-Puig A, Mittag J, Tena-Sempere M, Malag?n MM, Di?guez C, Mart?nez-Chantar ML, Aspichueta P, Rahmouni K, Nogueiras R, Sabio G, Villarroya F, L?pez M. Hypothalamic AMPK-ER Stress-JNK1 Axis Mediates the Central Actions of Thyroid Hormones on Energy Balance. Cell Metab. 2017 Jul 05; 26(1):212-229.e12. PMID: 28683288.
      Citations:    
    52. Yuan D, Huang S, Berger E, Liu L, Gross N, Heinzmann F, Ringelhan M, Connor TO, Stadler M, Meister M, Weber J, ?llinger R, Simonavicius N, Reisinger F, Hartmann D, Meyer R, Reich M, Seehawer M, Leone V, H?chst B, Wohlleber D, J?rs S, Prinz M, Spalding D, Protzer U, Luedde T, Terracciano L, Matter M, Longerich T, Knolle P, Ried T, Keitel V, Geisler F, Unger K, Cinnamon E, Pikarsky E, H?ser N, Davis RJ, Tschaharganeh DF, Rad R, Weber A, Zender L, Haller D, Heikenwalder M. Kupffer Cell-Derived Tnf Triggers Cholangiocellular Tumorigenesis through JNK due to Chronic Mitochondrial Dysfunction and ROS. Cancer Cell. 2017 06 12; 31(6):771-789.e6. PMID: 28609656.
      Citations:    
    53. Kullas AL, Davis RJ. Setting the (Scientific) Record Straight: Molecular and Cellular Biology Responds to Postpublication Review. Mol Cell Biol. 2017 06 01; 37(11). PMID: 28512216.
      Citations: 2     Fields:    Translation:Humans
    54. Soltis AR, Motola S, Vernia S, Ng CW, Kennedy NJ, Dalin S, Matthews BJ, Davis RJ, Fraenkel E. Hyper- and hypo- nutrition studies of the hepatic transcriptome and epigenome suggest that PPARa regulates anaerobic glycolysis. Sci Rep. 2017 03 14; 7(1):174. PMID: 28282965.
      Citations: 10     Fields:    Translation:AnimalsCells
    55. Davis RJ. Melanoma mystery. Elife. 2017 01 19; 6. PMID: 28100393.
      Citations: 2     Fields:    Translation:HumansAnimals
    56. Harper KL, Sosa MS, Entenberg D, Hosseini H, Cheung JF, Nobre R, Avivar-Valderas A, Nagi C, Girnius N, Davis RJ, Farias EF, Condeelis J, Klein CA, Aguirre-Ghiso JA. Mechanism of early dissemination and metastasis in Her2+ mammary cancer. Nature. 2016 Dec 22; 540(7634):588-592. PMID: 27974798.
      Citations:    
    57. Whitmarsh AJ, Davis RJ. Multisite phosphorylation by MAPK. Science. 2016 10 14; 354(6309):179-180. PMID: 27738159.
      Citations: 4     Fields:    Translation:HumansCells
    58. Hotamisligil GS, Davis RJ. Cell Signaling and Stress Responses. Cold Spring Harb Perspect Biol. 2016 Oct 03; 8(10). PMID: 27698029.
      Citations:    
    59. Casadevall A, Bertuzzi S, Buchmeier MJ, Davis RJ, Drake H, Fang FC, Gilbert J, Goldman BM, Imperiale MJ, Matsumura P, McAdam AJ, Pasetti MF, Sandri-Goldin RM, Silhavy T, Rice L, Young JA, Shenk T. ASM Journals Eliminate Impact Factor Information from Journal Websites. Clin Microbiol Rev. 2016 10; 29(4):i-ii. PMID: 27402659.
      Citations:    
    60. Vernia S, Edwards YJ, Han MS, Cavanagh-Kyros J, Barrett T, Kim JK, Davis RJ. An alternative splicing program promotes adipose tissue thermogenesis. Elife. 2016 09 16; 5. PMID: 27635635.
      Citations: 32     Fields:    Translation:AnimalsCells
    61. Casadevall A, Bertuzzi S, Buchmeier MJ, Davis RJ, Drake H, Fang FC, Gilbert J, Goldman BM, Imperiale MJ, Matsumura P, McAdam AJ, Pasetti MF, Sandri-Goldin RM, Silhavy T, Rice L, Young JA, Shenk T. ASM Journals Eliminate Impact Factor Information from Journal Websites. Appl Environ Microbiol. 2016 09 15; 82(18):5479-80. PMID: 27401972.
      Citations:    
    62. Casadevall A, Bertuzzi S, Buchmeier MJ, Davis RJ, Drake H, Fang FC, Gilbert J, Goldman BM, Imperiale MJ, Matsumura P, McAdam AJ, Pasetti MF, Sandri-Goldin RM, Silhavy T, Rice L, Young JA, Shenk T. ASM Journals Eliminate Impact Factor Information from Journal Websites. Antimicrob Agents Chemother. 2016 09; 60(9):5109-10. PMID: 27401573.
      Citations:    
    63. Casadevall A, Bertuzzi S, Buchmeier MJ, Davis RJ, Drake H, Fang FC, Gilbert J, Goldman BM, Imperiale MJ, Matsumura P, McAdam AJ, Pasetti MF, Sandri-Goldin RM, Silhavy T, Rice L, Young JA, Shenk T. ASM Journals Eliminate Impact Factor Information from Journal Websites. Infect Immun. 2016 09; 84(9):2407-8. PMID: 27400723.
      Citations:    
    64. Sayeed A, Lu H, Liu Q, Deming D, Duffy A, McCue P, Dicker AP, Davis RJ, Gabrilovich D, Rodeck U, Altieri DC, Languino LR. ?1 integrin- and JNK-dependent tumor growth upon hypofractionated radiation. Oncotarget. 2016 Aug 16; 7(33):52618-52630. PMID: 27438371.
      Citations:    
    65. Ramo K, Sugamura K, Craige S, Keaney JF, Davis RJ. Suppression of ischemia in arterial occlusive disease by JNK-promoted native collateral artery development. Elife. 2016 08 09; 5. PMID: 27504807.
      Citations: 8     Fields:    Translation:AnimalsCells
    66. Lu H, Wang T, Li J, Fedele C, Liu Q, Zhang J, Jiang Z, Jain D, Iozzo RV, Violette SM, Weinreb PH, Davis RJ, Gioeli D, FitzGerald TJ, Altieri DC, Languino LR. av?6 Integrin Promotes Castrate-Resistant Prostate Cancer through JNK1-Mediated Activation of Androgen Receptor. Cancer Res. 2016 09 01; 76(17):5163-74. PMID: 27450452.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    67. Casadevall A, Bertuzzi S, Buchmeier MJ, Davis RJ, Drake H, Fang FC, Gilbert J, Goldman BM, Imperiale MJ, Matsumura P, McAdam AJ, Pasetti MF, Sandri-Goldin RM, Silhavy T, Rice L, Young JA, Shenk T. ASM Journals Eliminate Impact Factor Information from Journal Websites. Microbiol Mol Biol Rev. 2016 09; 80(3):i-ii. PMID: 27412882.
      Citations:    
    68. Casadevall A, Bertuzzi S, Buchmeier MJ, Davis RJ, Drake H, Fang FC, Gilbert J, Goldman BM, Imperiale MJ, Matsumura P, McAdam AJ, Pasetti MF, Sandri-Goldin RM, Silhavy T, Rice L, Young JH, Shenk T. ASM Journals Eliminate Impact Factor Information from Journal Websites. mSystems. 2016 Jul-Aug; 1(4). PMID: 27822548.
      Citations:    
    69. Casadevall A, Bertuzzi S, Buchmeier MJ, Davis RJ, Drake H, Fang FC, Gilbert J, Goldman BM, Imperiale MJ, Matsumura P, McAdam AJ, Pasetti MF, Sandri-Goldin RM, Silhavy T, Rice L, Young JA, Shenk T. ASM Journals Eliminate Impact Factor Information from Journal Websites. J Clin Microbiol. 2016 09; 54(9):2216-7. PMID: 27402961.
      Citations:    
    70. Casadevall A, Bertuzzi S, Buchmeier MJ, Davis RJ, Drake H, Fang FC, Gilbert J, Goldman BM, Imperiale MJ, Matsumura P, McAdam AJ, Pasetti MF, Sandri-Goldin RM, Silhavy T, Rice L, Young JA, Shenk T. ASM Journals Eliminate Impact Factor Information from Journal Websites. mBio. 2016 07 11; 7(4). PMID: 27402825.
      Citations:    
    71. Casadevall A, Bertuzzi S, Buchmeier MJ, Davis RJ, Drake H, Fang FC, Gilbert J, Goldman BM, Imperiale MJ, Matsumura P, McAdam AJ, Pasetti MF, Sandri-Goldin RM, Silhavy T, Rice L, Young JA, Shenk T. ASM Journals Eliminate Impact Factor Information from Journal Websites. mSphere. 2016 Jul-Aug; 1(4). PMID: 27408939.
      Citations:    
    72. Han MS, Barrett T, Brehm MA, Davis RJ. Inflammation Mediated by JNK in Myeloid Cells Promotes the Development of Hepatitis and Hepatocellular Carcinoma. Cell Rep. 2016 Apr 05; 15(1):19-26. PMID: 27052181.
      Citations: 37     Fields:    Translation:AnimalsCells
    73. Vernia S, Cavanagh-Kyros J, Barrett T, Tournier C, Davis RJ. Fibroblast Growth Factor 21 Mediates Glycemic Regulation by Hepatic JNK. Cell Rep. 2016 Mar 15; 14(10):2273-80. PMID: 26947074.
      Citations: 22     Fields:    Translation:AnimalsCells
    74. Vernia S, Morel C, Madara JC, Cavanagh-Kyros J, Barrett T, Chase K, Kennedy NJ, Jung DY, Kim JK, Aronin N, Flavell RA, Lowell BB, Davis RJ. Excitatory transmission onto AgRP neurons is regulated by cJun NH2-terminal kinase 3 in response to metabolic stress. Elife. 2016 Feb 24; 5:e10031. PMID: 26910012.
      Citations: 17     Fields:    Translation:AnimalsCells
    75. Girnius N, Davis RJ. TNFa-Mediated Cytotoxic Responses to IAP Inhibition Are Limited by the p38a MAPK Pathway. Cancer Cell. 2016 Feb 08; 29(2):131-3. PMID: 26859448.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    76. Thornton TM, Delgado P, Chen L, Salas B, Krementsov D, Fernandez M, Vernia S, Davis RJ, Heimann R, Teuscher C, Krangel MS, Ramiro AR, Rinc?n M. Inactivation of nuclear GSK3? by Ser(389) phosphorylation promotes lymphocyte fitness during DNA double-strand break response. Nat Commun. 2016 Jan 29; 7:10553. PMID: 26822034.
      Citations:    
    77. Liu X, Li H, Rajurkar M, Li Q, Cotton JL, Ou J, Zhu LJ, Goel HL, Mercurio AM, Park JS, Davis RJ, Mao J. Tead and AP1 Coordinate Transcription and Motility. Cell Rep. 2016 Feb 09; 14(5):1169-1180. PMID: 26832411.
      Citations: 118     Fields:    Translation:HumansCells
    78. Cubero FJ, Zoubek ME, Hu W, Peng J, Zhao G, Nevzorova YA, Al Masaoudi M, Bechmann LP, Boekschoten MV, Muller M, Preisinger C, Gassler N, Canbay AE, Luedde T, Davis RJ, Liedtke C, Trautwein C. Combined Activities of JNK1 and JNK2 in Hepatocytes Protect Against Toxic Liver Injury. Gastroenterology. 2016 Apr; 150(4):968-81. PMID: 26708719.
      Citations:    
    79. Blodgett DM, Nowosielska A, Afik S, Pechhold S, Cura AJ, Kennedy NJ, Kim S, Kucukural A, Davis RJ, Kent SC, Greiner DL, Garber MG, Harlan DM, diIorio P. Novel Observations From Next-Generation RNA Sequencing of Highly Purified Human Adult and Fetal Islet Cell Subsets. Diabetes. 2015 Sep; 64(9):3172-81. PMID: 25931473.
      Citations: 162     Fields:    Translation:HumansCells
    80. Margevicius DR, Bastian C, Fan Q, Davis RJ, Pimplikar SW. JNK-interacting protein 1 mediates Alzheimer's-like pathological features in AICD-transgenic mice. Neurobiol Aging. 2015 Aug; 36(8):2370-9. PMID: 26022769.
      Citations:    
    81. Zhang Y, Nguyen T, Tang P, Kennedy NJ, Jiao H, Zhang M, Reynolds JM, Jaeschke A, Martin-Orozco N, Chung Y, He WM, Wang C, Jia W, Ge B, Davis RJ, Flavell RA, Dong C. Regulation of Adipose Tissue Inflammation and Insulin Resistance by MAPK Phosphatase 5. J Biol Chem. 2015 Jun 12; 290(24):14875-83. PMID: 25922079.
      Citations: 11     Fields:    Translation:AnimalsCells
    82. Mak P, Li J, Samanta S, Chang C, Jerry DJ, Davis RJ, Leav I, Mercurio AM. Prostate tumorigenesis induced by PTEN deletion involves estrogen receptor ? repression. Cell Rep. 2015 Mar 31; 10(12):1982-91. PMID: 25818291.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    83. Nistic? R, Florenzano F, Mango D, Ferraina C, Grilli M, Di Prisco S, Nobili A, Saccucci S, D'Amelio M, Morbin M, Marchi M, Mercuri NB, Davis RJ, Pittaluga A, Feligioni M. Presynaptic c-Jun N-terminal Kinase 2 regulates NMDA receptor-dependent glutamate release. Sci Rep. 2015 Mar 12; 5:9035. PMID: 25762148.
      Citations: 27     Fields:    Translation:AnimalsCells
    84. Perry RJ, Camporez JG, Kursawe R, Titchenell PM, Zhang D, Perry CJ, Jurczak MJ, Abudukadier A, Han MS, Zhang XM, Ruan HB, Yang X, Caprio S, Kaech SM, Sul HS, Birnbaum MJ, Davis RJ, Cline GW, Petersen KF, Shulman GI. Hepatic acetyl CoA links adipose tissue inflammation to hepatic insulin resistance and type 2 diabetes. Cell. 2015 Feb 12; 160(4):745-758. PMID: 25662011.
      Citations: 326     Fields:    Translation:HumansAnimalsCells
    85. Yang J, Wu Z, Renier N, Simon DJ, Uryu K, Park DS, Greer PA, Tournier C, Davis RJ, Tessier-Lavigne M. Pathological axonal death through a MAPK cascade that triggers a local energy deficit. Cell. 2015 Jan 15; 160(1-2):161-76. PMID: 25594179.
      Citations: 149     Fields:    Translation:AnimalsCells
    86. Greenblatt MB, Kim JM, Oh H, Park KH, Choo MK, Sano Y, Tye CE, Skobe Z, Davis RJ, Park JM, Bei M, Glimcher LH, Shim JH. p38a MAPK is required for tooth morphogenesis and enamel secretion. J Biol Chem. 2015 Jan 02; 290(1):284-95. PMID: 25406311.
      Citations: 14     Fields:    Translation:AnimalsCells
    87. Schaefer FM, Peng J, Hu W, Drvarov O, Nevzorova YA, Zhao G, Masaoudi MA, Davis RJ, Trautwein C, Cubero FJ. Bone marrow-derived c-jun N-terminal kinase-1 (JNK1) mediates liver regeneration. Biochim Biophys Acta. 2015 Jan; 1852(1):137-45. PMID: 25445542.
      Citations: 5     Fields:    Translation:Animals
    88. Cubero FJ, Zhao G, Nevzorova YA, Hatting M, Al Masaoudi M, Verdier J, Peng J, Schaefer FM, Hermanns N, Boekschoten MV, Grouls C, Gassler N, Kiessling F, Muller M, Davis RJ, Liedtke C, Trautwein C. Haematopoietic cell-derived Jnk1 is crucial for chronic inflammation and carcinogenesis in an experimental model of liver injury. J Hepatol. 2015 Jan; 62(1):140-9. PMID: 25173965.
      Citations:    
    89. Chiba K, Araseki M, Nozawa K, Furukori K, Araki Y, Matsushima T, Nakaya T, Hata S, Saito Y, Uchida S, Okada Y, Nairn AC, Davis RJ, Yamamoto T, Kinjo M, Taru H, Suzuki T. Quantitative analysis of APP axonal transport in neurons: role of JIP1 in enhanced APP anterograde transport. Mol Biol Cell. 2014 Nov 05; 25(22):3569-80. PMID: 25165140.
      Citations:    
    90. Vernia S, Cavanagh-Kyros J, Garcia-Haro L, Sabio G, Barrett T, Jung DY, Kim JK, Xu J, Shulha HP, Garber M, Gao G, Davis RJ. The PPARa-FGF21 hormone axis contributes to metabolic regulation by the hepatic JNK signaling pathway. Cell Metab. 2014 Sep 02; 20(3):512-25. PMID: 25043817.
      Citations: 89     Fields:    Translation:AnimalsCells
    91. Zaidi SK, Shen WJ, Bittner S, Bittner A, McLean MP, Han J, Davis RJ, Kraemer FB, Azhar S. p38 MAPK regulates steroidogenesis through transcriptional repression of STAR gene. J Mol Endocrinol. 2014 Aug; 53(1):1-16. PMID: 24780837.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    92. Maimon A, Mogilevsky M, Shilo A, Golan-Gerstl R, Obiedat A, Ben-Hur V, Lebenthal-Loinger I, Stein I, Reich R, Beenstock J, Zehorai E, Andersen CL, Thorsen K, ?rntoft TF, Davis RJ, Davidson B, Mu D, Karni R. Mnk2 alternative splicing modulates the p38-MAPK pathway and impacts Ras-induced transformation. Cell Rep. 2014 Apr 24; 7(2):501-513. PMID: 24726367.
      Citations:    
    93. Davies CC, Harvey E, McMahon RF, Finegan KG, Connor F, Davis RJ, Tuveson DA, Tournier C. Impaired JNK signaling cooperates with KrasG12D expression to accelerate pancreatic ductal adenocarcinoma. Cancer Res. 2014 Jun 15; 74(12):3344-56. PMID: 24713432.
      Citations: 15     Fields:    Translation:AnimalsCells
    94. Sabio G, Davis RJ. TNF and MAP kinase signalling pathways. Semin Immunol. 2014 Jun; 26(3):237-45. PMID: 24647229.
      Citations:    
    95. Vernia S, Cavanagh-Kyros J, Barrett T, Jung DY, Kim JK, Davis RJ. Diet-induced obesity mediated by the JNK/DIO2 signal transduction pathway. Genes Dev. 2013 Nov 01; 27(21):2345-55. PMID: 24186979.
      Citations: 26     Fields:    Translation:AnimalsCells
    96. Lo KA, Labadorf A, Kennedy NJ, Han MS, Yap YS, Matthews B, Xin X, Sun L, Davis RJ, Lodish HF, Fraenkel E. Analysis of in vitro insulin-resistance models and their physiological relevance to in vivo diet-induced adipose insulin resistance. Cell Rep. 2013 Oct 17; 5(1):259-70. PMID: 24095730.
      Citations: 53     Fields:    Translation:HumansAnimals
    97. Zhao G, Hatting M, Nevzorova YA, Peng J, Hu W, Boekschoten MV, Roskams T, Muller M, Gassler N, Liedtke C, Davis RJ, Cubero FJ, Trautwein C. Jnk1 in murine hepatic stellate cells is a crucial mediator of liver fibrogenesis. Gut. 2014 Jul; 63(7):1159-72. PMID: 24037431.
      Citations:    
    98. Kant S, Barrett T, Vertii A, Noh YH, Jung DY, Kim JK, Davis RJ. Role of the mixed-lineage protein kinase pathway in the metabolic stress response to obesity. Cell Rep. 2013 Aug 29; 4(4):681-8. PMID: 23954791.
      Citations: 17     Fields:    Translation:Animals
    99. Goel HL, Sayeed A, Breen M, Zarif MJ, Garlick DS, Leav I, Davis RJ, Fitzgerald TJ, Morrione A, Hsieh CC, Liu Q, Dicker AP, Altieri DC, Languino LR. ?1 integrins mediate resistance to ionizing radiation in vivo by inhibiting c-Jun amino terminal kinase 1. J Cell Physiol. 2013 Jul; 228(7):1601-9. PMID: 23359252.
      Citations: 33     Fields:    Translation:HumansAnimalsCells
    100. You H, Padmashali RM, Ranganathan A, Lei P, Girnius N, Davis RJ, Andreadis ST. JNK regulates compliance-induced adherens junctions formation in epithelial cells and tissues. J Cell Sci. 2013 Jun 15; 126(Pt 12):2718-29. PMID: 23591817.
      Citations:    
    101. Rubinow KB, Wall VZ, Nelson J, Mar D, Bomsztyk K, Askari B, Lai MA, Smith KD, Han MS, Vivekanandan-Giri A, Pennathur S, Albert CJ, Ford DA, Davis RJ, Bornfeldt KE. Acyl-CoA synthetase 1 is induced by Gram-negative bacteria and lipopolysaccharide and is required for phospholipid turnover in stimulated macrophages. J Biol Chem. 2013 Apr 05; 288(14):9957-9970. PMID: 23426369.
      Citations:    
    102. Han MS, Jung DY, Morel C, Lakhani SA, Kim JK, Flavell RA, Davis RJ. JNK expression by macrophages promotes obesity-induced insulin resistance and inflammation. Science. 2013 Jan 11; 339(6116):218-22. PMID: 23223452.
      Citations: 312     Fields:    Translation:AnimalsCells
    103. Gonz?lez-Ter?n B, Cort?s JR, Manieri E, Matesanz N, Verdugo ?, Rodr?guez ME, Gonz?lez-Rodr?guez ?, Valverde ?M, Valverde ?, Mart?n P, Davis RJ, Sabio G. Eukaryotic elongation factor 2 controls TNF-a translation in LPS-induced hepatitis. J Clin Invest. 2013 Jan; 123(1):164-78. PMID: 23202732.
      Citations:    
    104. Imbernon M, Beiroa D, V?zquez MJ, Morgan DA, Veyrat-Durebex C, Porteiro B, D?az-Arteaga A, Senra A, Busquets S, Vel?squez DA, Al-Massadi O, Varela L, G?ndara M, L?pez-Soriano FJ, Gallego R, Seoane LM, Argiles JM, L?pez M, Davis RJ, Sabio G, Rohner-Jeanrenaud F, Rahmouni K, Dieguez C, Nogueiras R. Central melanin-concentrating hormone influences liver and adipose metabolism via specific hypothalamic nuclei and efferent autonomic/JNK1 pathways. Gastroenterology. 2013 Mar; 144(3):636-649.e6. PMID: 23142626.
      Citations:    
    105. Davis RJ. Cell biology. A scaffold switch to insulate. Science. 2012 Sep 07; 337(6099):1178-9. PMID: 22955821.
      Citations:    Fields:    Translation:Animals
    106. Goel HL, Chang C, Pursell B, Leav I, Lyle S, Xi HS, Hsieh CC, Adisetiyo H, Roy-Burman P, Coleman IM, Nelson PS, Vessella RL, Davis RJ, Plymate SR, Mercurio AM. VEGF/neuropilin-2 regulation of Bmi-1 and consequent repression of IGF-IR define a novel mechanism of aggressive prostate cancer. Cancer Discov. 2012 Oct; 2(10):906-21. PMID: 22777769.
      Citations: 48     Fields:    Translation:HumansAnimalsCells
    107. H?bner A, Mulholland DJ, Standen CL, Karasarides M, Cavanagh-Kyros J, Barrett T, Chi H, Greiner DL, Tournier C, Sawyers CL, Flavell RA, Wu H, Davis RJ. JNK and PTEN cooperatively control the development of invasive adenocarcinoma of the prostate. Proc Natl Acad Sci U S A. 2012 Jul 24; 109(30):12046-51. PMID: 22753496.
      Citations: 52     Fields:    Translation:AnimalsCells
    108. Norseen J, Hosooka T, Hammarstedt A, Yore MM, Kant S, Aryal P, Kiernan UA, Phillips DA, Maruyama H, Kraus BJ, Usheva A, Davis RJ, Smith U, Kahn BB. Retinol-binding protein 4 inhibits insulin signaling in adipocytes by inducing proinflammatory cytokines in macrophages through a c-Jun N-terminal kinase- and toll-like receptor 4-dependent and retinol-independent mechanism. Mol Cell Biol. 2012 May; 32(10):2010-9. PMID: 22431523.
      Citations: 130     Fields:    Translation:HumansAnimalsCells
    109. Cellurale C, Girnius N, Jiang F, Cavanagh-Kyros J, Lu S, Garlick DS, Mercurio AM, Davis RJ. Role of JNK in mammary gland development and breast cancer. Cancer Res. 2012 Jan 15; 72(2):472-81. PMID: 22127926.
      Citations: 48     Fields:    Translation:AnimalsCells
    110. Mazzitelli S, Xu P, Ferrer I, Davis RJ, Tournier C. The loss of c-Jun N-terminal protein kinase activity prevents the amyloidogenic cleavage of amyloid precursor protein and the formation of amyloid plaques in vivo. J Neurosci. 2011 Nov 23; 31(47):16969-76. PMID: 22114267.
      Citations: 26     Fields:    Translation:HumansAnimalsCells
    111. Zou W, Greenblatt MB, Shim JH, Kant S, Zhai B, Lotinun S, Brady N, Hu DZ, Gygi SP, Baron R, Davis RJ, Jones D, Glimcher LH. MLK3 regulates bone development downstream of the faciogenital dysplasia protein FGD1 in mice. J Clin Invest. 2011 Nov; 121(11):4383-92. PMID: 21965325.
      Citations: 30     Fields:    Translation:HumansAnimalsCells
    112. Kant S, Swat W, Zhang S, Zhang ZY, Neel BG, Flavell RA, Davis RJ. TNF-stimulated MAP kinase activation mediated by a Rho family GTPase signaling pathway. Genes Dev. 2011 Oct 01; 25(19):2069-78. PMID: 21979919.
      Citations: 60     Fields:    Translation:AnimalsCells
    113. Lee J, Sun C, Zhou Y, Lee J, Gokalp D, Herrema H, Park SW, Davis RJ, Ozcan U. p38 MAPK-mediated regulation of Xbp1s is crucial for glucose homeostasis. Nat Med. 2011 Sep 04; 17(10):1251-60. PMID: 21892182.
      Citations:    
    114. Noubade R, Krementsov DN, Del Rio R, Thornton T, Nagaleekar V, Saligrama N, Spitzack A, Spach K, Sabio G, Davis RJ, Rincon M, Teuscher C. Activation of p38 MAPK in CD4 T cells controls IL-17 production and autoimmune encephalomyelitis. Blood. 2011 Sep 22; 118(12):3290-300. PMID: 21791428.
      Citations:    
    115. Wen HC, Avivar-Valderas A, Sosa MS, Girnius N, Farias EF, Davis RJ, Aguirre-Ghiso JA. p38a Signaling Induces Anoikis and Lumen Formation During Mammary Morphogenesis. Sci Signal. 2011 May 24; 4(174):ra34. PMID: 21610252.
      Citations:    
    116. Gao Z, Zhang J, Kheterpal I, Kennedy N, Davis RJ, Ye J. Sirtuin 1 (SIRT1) protein degradation in response to persistent c-Jun N-terminal kinase 1 (JNK1) activation contributes to hepatic steatosis in obesity. J Biol Chem. 2011 Jun 24; 286(25):22227-34. PMID: 21540183.
      Citations: 89     Fields:    Translation:HumansAnimalsCells
    117. Das M, Garlick DS, Greiner DL, Davis RJ. The role of JNK in the development of hepatocellular carcinoma. Genes Dev. 2011 Mar 15; 25(6):634-45. PMID: 21406557.
      Citations: 103     Fields:    Translation:AnimalsCells
    118. Nagaleekar VK, Sabio G, Aktan I, Chant A, Howe IW, Thornton TM, Benoit PJ, Davis RJ, Rincon M, Boyson JE. Translational control of NKT cell cytokine production by p38 MAPK. J Immunol. 2011 Apr 01; 186(7):4140-6. PMID: 21368234.
      Citations:    
    119. Xu P, Das M, Reilly J, Davis RJ. JNK regulates FoxO-dependent autophagy in neurons. Genes Dev. 2011 Feb 15; 25(4):310-22. PMID: 21325132.
      Citations: 130     Fields:    Translation:AnimalsCells
    120. Cellurale C, Sabio G, Kennedy NJ, Das M, Barlow M, Sandy P, Jacks T, Davis RJ. Requirement of c-Jun NH(2)-terminal kinase for Ras-initiated tumor formation. Mol Cell Biol. 2011 Apr; 31(7):1565-76. PMID: 21282468.
      Citations: 53     Fields:    Translation:AnimalsCells
    121. Liu W, Zi M, Chi H, Jin J, Prehar S, Neyses L, Cartwright EJ, Flavell RA, Davis RJ, Wang X. Deprivation of MKK7 in cardiomyocytes provokes heart failure in mice when exposed to pressure overload. J Mol Cell Cardiol. 2011 Apr; 50(4):702-11. PMID: 21284947.
      Citations:    
    122. Smith FD, Langeberg LK, Cellurale C, Pawson T, Morrison DK, Davis RJ, Scott JD. AKAP-Lbc enhances cyclic AMP control of the ERK1/2 cascade. Nat Cell Biol. 2010 Dec; 12(12):1242-9. PMID: 21102438.
      Citations: 81     Fields:    Translation:HumansAnimalsCells
    123. Sherrin T, Blank T, Hippel C, Rayner M, Davis RJ, Todorovic C. Hippocampal c-Jun-N-terminal kinases serve as negative regulators of associative learning. J Neurosci. 2010 Oct 06; 30(40):13348-61. PMID: 20926661.
      Citations: 34     Fields:    Translation:AnimalsCells
    124. Cellurale C, Weston CR, Reilly J, Garlick DS, Jerry DJ, Sluss HK, Davis RJ. Role of JNK in a Trp53-dependent mouse model of breast cancer. PLoS One. 2010 Aug 30; 5(8):e12469. PMID: 20814571.
      Citations: 28     Fields:    Translation:Animals
    125. Morel C, Standen CL, Jung DY, Gray S, Ong H, Flavell RA, Kim JK, Davis RJ. Requirement of JIP1-mediated c-Jun N-terminal kinase activation for obesity-induced insulin resistance. Mol Cell Biol. 2010 Oct; 30(19):4616-25. PMID: 20679483.
      Citations: 14     Fields:    Translation:AnimalsCells
    126. Barnat M, Enslen H, Propst F, Davis RJ, Soares S, Nothias F. Distinct roles of c-Jun N-terminal kinase isoforms in neurite initiation and elongation during axonal regeneration. J Neurosci. 2010 Jun 09; 30(23):7804-16. PMID: 20534829.
      Citations: 69     Fields:    Translation:AnimalsCells
    127. Sabio G, Davis RJ. cJun NH2-terminal kinase 1 (JNK1): roles in metabolic regulation of insulin resistance. Trends Biochem Sci. 2010 Sep; 35(9):490-6. PMID: 20452774.
      Citations:    
    128. Adam F, Kauskot A, Nurden P, Sulpice E, Hoylaerts MF, Davis RJ, Rosa JP, Bryckaert M. Platelet JNK1 is involved in secretion and thrombus formation. Blood. 2010 May 20; 115(20):4083-92. PMID: 20231429.
      Citations:    
    129. Gutierrez GJ, Tsuji T, Cross JV, Davis RJ, Templeton DJ, Jiang W, Ronai ZA. JNK-mediated phosphorylation of Cdc25C regulates cell cycle entry and G(2)/M DNA damage checkpoint. J Biol Chem. 2010 May 07; 285(19):14217-28. PMID: 20220133.
      Citations:    
    130. Bahl K, H?ebner A, Davis RJ, Welsh RM. Analysis of apoptosis of memory T cells and dendritic cells during the early stages of viral infection or exposure to toll-like receptor agonists. J Virol. 2010 May; 84(10):4866-77. PMID: 20200235.
      Citations: 27     Fields:    Translation:AnimalsCells
    131. Podkowa M, Zhao X, Chow CW, Coffey ET, Davis RJ, Attisano L. Microtubule stabilization by bone morphogenetic protein receptor-mediated scaffolding of c-Jun N-terminal kinase promotes dendrite formation. Mol Cell Biol. 2010 May; 30(9):2241-50. PMID: 20176805.
      Citations: 38     Fields:    Translation:AnimalsCells
    132. Sabio G, Cavanagh-Kyros J, Barrett T, Jung DY, Ko HJ, Ong H, Morel C, Mora A, Reilly J, Kim JK, Davis RJ. Role of the hypothalamic-pituitary-thyroid axis in metabolic regulation by JNK1. Genes Dev. 2010 Feb 01; 24(3):256-64. PMID: 20080940.
      Citations: 60     Fields:    Translation:AnimalsCells
    133. Xu P, Davis RJ. c-Jun NH2-terminal kinase is required for lineage-specific differentiation but not stem cell self-renewal. Mol Cell Biol. 2010 Mar; 30(6):1329-40. PMID: 20065035.
      Citations: 24     Fields:    Translation:AnimalsCells
    134. Sabio G, Kennedy NJ, Cavanagh-Kyros J, Jung DY, Ko HJ, Ong H, Barrett T, Kim JK, Davis RJ. Role of muscle c-Jun NH2-terminal kinase 1 in obesity-induced insulin resistance. Mol Cell Biol. 2010 Jan; 30(1):106-15. PMID: 19841069.
      Citations: 74     Fields:    Translation:AnimalsCells
    135. H?bner A, Cavanagh-Kyros J, Rincon M, Flavell RA, Davis RJ. Functional cooperation of the proapoptotic Bcl2 family proteins Bmf and Bim in vivo. Mol Cell Biol. 2010 Jan; 30(1):98-105. PMID: 19841067.
      Citations: 41     Fields:    Translation:AnimalsCells
    136. Remy G, Risco AM, I?esta-Vaquera FA, Gonz?lez-Ter?n B, Sabio G, Davis RJ, Cuenda A. Differential activation of p38MAPK isoforms by MKK6 and MKK3. Cell Signal. 2010 Apr; 22(4):660-7. PMID: 20004242.
      Citations:    
    137. Sabio G, Cavanagh-Kyros J, Ko HJ, Jung DY, Gray S, Jun JY, Barrett T, Mora A, Kim JK, Davis RJ. Prevention of steatosis by hepatic JNK1. Cell Metab. 2009 Dec; 10(6):491-8. PMID: 19945406.
      Citations: 88     Fields:    Translation:AnimalsCells
    138. Standen CL, Kennedy NJ, Flavell RA, Davis RJ. Signal transduction cross talk mediated by Jun N-terminal kinase-interacting protein and insulin receptor substrate scaffold protein complexes. Mol Cell Biol. 2009 Sep; 29(17):4831-40. PMID: 19564410.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    139. Morel C, Carlson SM, White FM, Davis RJ. Mcl-1 integrates the opposing actions of signaling pathways that mediate survival and apoptosis. Mol Cell Biol. 2009 Jul; 29(14):3845-52. PMID: 19433446.
      Citations: 82     Fields:    Translation:HumansAnimalsCells
    140. Das M, Sabio G, Jiang F, Rinc?n M, Flavell RA, Davis RJ. Induction of hepatitis by JNK-mediated expression of TNF-alpha. Cell. 2009 Jan 23; 136(2):249-60. PMID: 19167327.
      Citations: 84     Fields:    Translation:AnimalsCells
    141. Sabio G, Das M, Mora A, Zhang Z, Jun JY, Ko HJ, Barrett T, Kim JK, Davis RJ. A stress signaling pathway in adipose tissue regulates hepatic insulin resistance. Science. 2008 Dec 05; 322(5907):1539-43. PMID: 19056984.
      Citations: 278     Fields:    Translation:AnimalsCells
    142. Ongusaha PP, Qi HH, Raj L, Kim YB, Aaronson SA, Davis RJ, Shi Y, Liao JK, Lee SW. Identification of ROCK1 as an upstream activator of the JIP-3 to JNK signaling axis in response to UVB damage. Sci Signal. 2008 Nov 25; 1(47):ra14. PMID: 19036714.
      Citations: 28     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    143. Hu D, Fang W, Han A, Gallagher L, Davis RJ, Xiong B, Yang W. c-Jun N-terminal kinase 1 interacts with and negatively regulates Wnt/beta-catenin signaling through GSK3beta pathway. Carcinogenesis. 2008 Dec; 29(12):2317-24. PMID: 18952597.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    144. Fitzgerald TJ, Wang T, Goel HL, Huang J, Stein G, Lian J, Davis RJ, Doxsey S, Balaji KC, Aronowitz J, Languino LR. Prostate carcinoma and radiation therapy: therapeutic treatment resistance and strategies for targeted therapeutic intervention. Expert Rev Anticancer Ther. 2008 Jun; 8(6):967-74. PMID: 18533806.
      Citations: 15     Fields:    Translation:Humans
    145. H?bner A, Barrett T, Flavell RA, Davis RJ. Multisite phosphorylation regulates Bim stability and apoptotic activity. Mol Cell. 2008 May 23; 30(4):415-25. PMID: 18498746.
      Citations: 132     Fields:    Translation:HumansAnimalsCells
    146. Thornton TM, Pedraza-Alva G, Deng B, Wood CD, Aronshtam A, Clements JL, Sabio G, Davis RJ, Matthews DE, Doble B, Rincon M. Phosphorylation by p38 MAPK as an alternative pathway for GSK3beta inactivation. Science. 2008 May 02; 320(5876):667-70. PMID: 18451303.
      Citations:    
    147. Alcorn JF, Guala AS, van der Velden J, McElhinney B, Irvin CG, Davis RJ, Janssen-Heininger YM. Jun N-terminal kinase 1 regulates epithelial-to-mesenchymal transition induced by TGF-beta1. J Cell Sci. 2008 Apr 01; 121(Pt 7):1036-45. PMID: 18334556.
      Citations: 80     Fields:    Translation:AnimalsCells
    148. Fukuda K, Tesch GH, Yap FY, Forbes JM, Flavell RA, Davis RJ, Nikolic-Paterson DJ. MKK3 signalling plays an essential role in leukocyte-mediated pancreatic injury in the multiple low-dose streptozotocin model. Lab Invest. 2008 Apr; 88(4):398-407. PMID: 18283273.
      Citations:    
    149. Mendoza H, Campbell DG, Burness K, Hastie J, Ronkina N, Shim JH, Arthur JS, Davis RJ, Gaestel M, Johnson GL, Ghosh S, Cohen P. Roles for TAB1 in regulating the IL-1-dependent phosphorylation of the TAB3 regulatory subunit and activity of the TAK1 complex. Biochem J. 2008 Feb 01; 409(3):711-22. PMID: 18021073.
      Citations: 32     Fields:    Translation:AnimalsCells
    150. Pedra JH, Mattner J, Tao J, Kerfoot SM, Davis RJ, Flavell RA, Askenase PW, Yin Z, Fikrig E. c-Jun NH2-terminal kinase 2 inhibits gamma interferon production during Anaplasma phagocytophilum infection. Infect Immun. 2008 Jan; 76(1):308-16. PMID: 17998313.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    151. Keramaris E, Ruzhynsky VA, Callaghan SM, Wong E, Davis RJ, Flavell R, Slack RS, Park DS. Required roles of Bax and JNKs in central and peripheral nervous system death of retinoblastoma-deficient mice. J Biol Chem. 2008 Jan 04; 283(1):405-415. PMID: 17984095.
      Citations:    
    152. Das M, Jiang F, Sluss HK, Zhang C, Shokat KM, Flavell RA, Davis RJ. Suppression of p53-dependent senescence by the JNK signal transduction pathway. Proc Natl Acad Sci U S A. 2007 Oct 02; 104(40):15759-64. PMID: 17893331.
      Citations: 82     Fields:    Translation:AnimalsCells
    153. Kennedy NJ, Martin G, Ehrhardt AG, Cavanagh-Kyros J, Kuan CY, Rakic P, Flavell RA, Treistman SN, Davis RJ. Requirement of JIP scaffold proteins for NMDA-mediated signal transduction. Genes Dev. 2007 Sep 15; 21(18):2336-46. PMID: 17875667.
      Citations: 25     Fields:    Translation:AnimalsCells
    154. Mishra AK, Gangwani L, Davis RJ, Lambright DG. Structural insights into the interaction of the evolutionarily conserved ZPR1 domain tandem with eukaryotic EF1A, receptors, and SMN complexes. Proc Natl Acad Sci U S A. 2007 Aug 28; 104(35):13930-5. PMID: 17704259.
      Citations: 25     Fields:    Translation:AnimalsCells
    155. Ma FY, Tesch GH, Flavell RA, Davis RJ, Nikolic-Paterson DJ. MKK3-p38 signaling promotes apoptosis and the early inflammatory response in the obstructed mouse kidney. Am J Physiol Renal Physiol. 2007 Nov; 293(5):F1556-63. PMID: 17686961.
      Citations:    
    156. Jaeschke A, Davis RJ. Metabolic stress signaling mediated by mixed-lineage kinases. Mol Cell. 2007 Aug 03; 27(3):498-508. PMID: 17679097.
      Citations: 71     Fields:    Translation:AnimalsCells
    157. Lim JH, Stirling B, Derry J, Koga T, Jono H, Woo CH, Xu H, Bourne P, Ha UH, Ishinaga H, Xu H, Andalibi A, Feng XH, Zhu H, Huang Y, Zhang W, Weng X, Yan C, Yin Z, Briles DE, Davis RJ, Flavell RA, Li JD. Tumor suppressor CYLD regulates acute lung injury in lethal Streptococcus pneumoniae infections. Immunity. 2007 Aug; 27(2):349-60. PMID: 17723219.
      Citations:    
    158. Izadi H, Motameni AT, Bates TC, Olivera ER, Villar-Suarez V, Joshi I, Garg R, Osborne BA, Davis RJ, Rinc?n M, Anguita J. c-Jun N-terminal kinase 1 is required for Toll-like receptor 1 gene expression in macrophages. Infect Immun. 2007 Oct; 75(10):5027-34. PMID: 17664270.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    159. Tong C, Yin Z, Song Z, Dockendorff A, Huang C, Mariadason J, Flavell RA, Davis RJ, Augenlicht LH, Yang W. c-Jun NH2-terminal kinase 1 plays a critical role in intestinal homeostasis and tumor suppression. Am J Pathol. 2007 Jul; 171(1):297-303. PMID: 17591974.
      Citations: 50     Fields:    Translation:AnimalsCells
    160. Vivanco I, Palaskas N, Tran C, Finn SP, Getz G, Kennedy NJ, Jiao J, Rose J, Xie W, Loda M, Golub T, Mellinghoff IK, Davis RJ, Wu H, Sawyers CL. Identification of the JNK signaling pathway as a functional target of the tumor suppressor PTEN. Cancer Cell. 2007 Jun; 11(6):555-69. PMID: 17560336.
      Citations: 130     Fields:    Translation:HumansAnimalsCells
    161. Tao J, Gao Y, Li MO, He W, Chen L, Harvev B, Davis RJ, Flavell RA, Yin Z. JNK2 negatively regulates CD8+ T cell effector function and anti-tumor immune response. Eur J Immunol. 2007 Mar; 37(3):818-29. PMID: 17301952.
      Citations:    
    162. Clark JE, Flavell RA, Faircloth ME, Davis RJ, Heads RJ, Marber MS. Post-infarction remodeling is independent of mitogen-activated protein kinase kinase 3 (MKK3). Cardiovasc Res. 2007 Jun 01; 74(3):466-70. PMID: 17399693.
      Citations:    
    163. Weston CR, Davis RJ. The JNK signal transduction pathway. Curr Opin Cell Biol. 2007 Apr; 19(2):142-9. PMID: 17303404.
      Citations: 461     Fields:    Translation:HumansAnimalsCells
    164. Kennedy NJ, Cellurale C, Davis RJ. A radical role for p38 MAPK in tumor initiation. Cancer Cell. 2007 Feb; 11(2):101-3. PMID: 17292820.
      Citations: 27     Fields:    Translation:HumansAnimalsCells
    165. Henderson NC, Pollock KJ, Frew J, Mackinnon AC, Flavell RA, Davis RJ, Sethi T, Simpson KJ. Critical role of c-jun (NH2) terminal kinase in paracetamol- induced acute liver failure. Gut. 2007 Jul; 56(7):982-90. PMID: 17185352.
      Citations: 97     Fields:    Translation:HumansAnimalsCells
    166. Chow CW, Davis RJ. Proteins kinases: chromatin-associated enzymes? Cell. 2006 Dec 01; 127(5):887-90. PMID: 17129776.
      Citations: 32     Fields:    Translation:Cells
    167. H?bner A, Jaeschke A, Davis RJ. Oncogene addiction: role of signal attenuation. Dev Cell. 2006 Dec; 11(6):752-4. PMID: 17141149.
      Citations: 4     Fields:    Translation:HumansCells
    168. Liao G, Tao Q, Kofron M, Chen JS, Schloemer A, Davis RJ, Hsieh JC, Wylie C, Heasman J, Kuan CY. Jun NH2-terminal kinase (JNK) prevents nuclear beta-catenin accumulation and regulates axis formation in Xenopus embryos. Proc Natl Acad Sci U S A. 2006 Oct 31; 103(44):16313-8. PMID: 17060633.
      Citations: 40     Fields:    Translation:HumansAnimalsCells
    169. Groisman I, Ivshina M, Marin V, Kennedy NJ, Davis RJ, Richter JD. Control of cellular senescence by CPEB. Genes Dev. 2006 Oct 01; 20(19):2701-12. PMID: 17015432.
      Citations: 52     Fields:    Translation:AnimalsCells
    170. Jaeschke A, Karasarides M, Ventura JJ, Ehrhardt A, Zhang C, Flavell RA, Shokat KM, Davis RJ. JNK2 is a positive regulator of the cJun transcription factor. Mol Cell. 2006 Sep 15; 23(6):899-911. PMID: 16973441.
      Citations: 87     Fields:    Translation:AnimalsCells
    171. Tran EH, Azuma YT, Chen M, Weston C, Davis RJ, Flavell RA. Inactivation of JNK1 enhances innate IL-10 production and dampens autoimmune inflammation in the brain. Proc Natl Acad Sci U S A. 2006 Sep 05; 103(36):13451-6. PMID: 16938889.
      Citations: 15     Fields:    Translation:AnimalsCells
    172. Sluss HK, Davis RJ. H2AX is a target of the JNK signaling pathway that is required for apoptotic DNA fragmentation. Mol Cell. 2006 Jul 21; 23(2):152-3. PMID: 16857581.
      Citations: 24     Fields:    Translation:Cells
    173. Bellahcene M, Jacquet S, Cao XB, Tanno M, Haworth RS, Layland J, Kabir AM, Gaestel M, Davis RJ, Flavell RA, Shah AM, Avkiran M, Marber MS. Activation of p38 mitogen-activated protein kinase contributes to the early cardiodepressant action of tumor necrosis factor. J Am Coll Cardiol. 2006 Aug 01; 48(3):545-55. PMID: 16875982.
      Citations:    
    174. Doran B, Gherbesi N, Hendricks G, Flavell RA, Davis RJ, Gangwani L. Deficiency of the zinc finger protein ZPR1 causes neurodegeneration. Proc Natl Acad Sci U S A. 2006 May 09; 103(19):7471-5. PMID: 16648254.
      Citations: 28     Fields:    Translation:AnimalsCells
    175. Inoue T, Boyle DL, Corr M, Hammaker D, Davis RJ, Flavell RA, Firestein GS. Mitogen-activated protein kinase kinase 3 is a pivotal pathway regulating p38 activation in inflammatory arthritis. Proc Natl Acad Sci U S A. 2006 Apr 04; 103(14):5484-9. PMID: 16567640.
      Citations:    
    176. Tachibana H, Perrino C, Takaoka H, Davis RJ, Naga Prasad SV, Rockman HA. JNK1 is required to preserve cardiac function in the early response to pressure overload. Biochem Biophys Res Commun. 2006 May 19; 343(4):1060-6. PMID: 16579967.
      Citations: 30     Fields:    Translation:Animals
    177. Ventura JJ, H?bner A, Zhang C, Flavell RA, Shokat KM, Davis RJ. Chemical genetic analysis of the time course of signal transduction by JNK. Mol Cell. 2006 Mar 03; 21(5):701-10. PMID: 16507367.
      Citations: 146     Fields:    Translation:AnimalsCells
    178. Gao Y, Tao J, Li MO, Zhang D, Chi H, Henegariu O, Kaech SM, Davis RJ, Flavell RA, Yin Z. JNK1 is essential for CD8+ T cell-mediated tumor immune surveillance. J Immunol. 2005 Nov 01; 175(9):5783-9. PMID: 16237070.
      Citations:    
    179. Devries-Seimon T, Li Y, Yao PM, Stone E, Wang Y, Davis RJ, Flavell R, Tabas I. Cholesterol-induced macrophage apoptosis requires ER stress pathways and engagement of the type A scavenger receptor. J Cell Biol. 2005 Oct 10; 171(1):61-73. PMID: 16203857.
      Citations:    
    180. Kabir AM, Cao X, Gorog DA, Tanno M, Bassi R, Bellahcene M, Quinlan RA, Davis RJ, Flavell RA, Shattock MJ, Marber MS. Antimycin A induced cardioprotection is dependent on pre-ischemic p38-MAPK activation but independent of MKK3. J Mol Cell Cardiol. 2005 Oct; 39(4):709-17. PMID: 16140323.
      Citations:    
    181. Emerling BM, Platanias LC, Black E, Nebreda AR, Davis RJ, Chandel NS. Mitochondrial reactive oxygen species activation of p38 mitogen-activated protein kinase is required for hypoxia signaling. Mol Cell Biol. 2005 Jun; 25(12):4853-62. PMID: 15923604.
      Citations: 115     Fields:    Translation:AnimalsCells
    182. Jaeschke A, Rinc?n M, Doran B, Reilly J, Neuberg D, Greiner DL, Shultz LD, Rossini AA, Flavell RA, Davis RJ. Disruption of the Jnk2 (Mapk9) gene reduces destructive insulitis and diabetes in a mouse model of type I diabetes. Proc Natl Acad Sci U S A. 2005 May 10; 102(19):6931-5. PMID: 15867147.
      Citations: 27     Fields:    Translation:AnimalsCells
    183. Brancho D, Ventura JJ, Jaeschke A, Doran B, Flavell RA, Davis RJ. Role of MLK3 in the regulation of mitogen-activated protein kinase signaling cascades. Mol Cell Biol. 2005 May; 25(9):3670-81. PMID: 15831472.
      Citations: 72     Fields:    Translation:AnimalsCells
    184. Li Y, Schwabe RF, DeVries-Seimon T, Yao PM, Gerbod-Giannone MC, Tall AR, Davis RJ, Flavell R, Brenner DA, Tabas I. Free cholesterol-loaded macrophages are an abundant source of tumor necrosis factor-alpha and interleukin-6: model of NF-kappaB- and map kinase-dependent inflammation in advanced atherosclerosis. J Biol Chem. 2005 Jun 10; 280(23):21763-72. PMID: 15826936.
      Citations:    
    185. Gangwani L, Flavell RA, Davis RJ. ZPR1 is essential for survival and is required for localization of the survival motor neurons (SMN) protein to Cajal bodies. Mol Cell Biol. 2005 Apr; 25(7):2744-56. PMID: 15767679.
      Citations: 37     Fields:    Translation:AnimalsCells
    186. Kelkar N, Standen CL, Davis RJ. Role of the JIP4 scaffold protein in the regulation of mitogen-activated protein kinase signaling pathways. Mol Cell Biol. 2005 Apr; 25(7):2733-43. PMID: 15767678.
      Citations: 78     Fields:    Translation:AnimalsCells
    187. Oh SW, Mukhopadhyay A, Svrzikapa N, Jiang F, Davis RJ, Tissenbaum HA. JNK regulates lifespan in Caenorhabditis elegans by modulating nuclear translocation of forkhead transcription factor/DAF-16. Proc Natl Acad Sci U S A. 2005 Mar 22; 102(12):4494-9. PMID: 15767565.
      Citations: 238     Fields:    Translation:AnimalsCells
    188. Brecht S, Kirchhof R, Chromik A, Willesen M, Nicolaus T, Raivich G, Wessig J, Waetzig V, Goetz M, Claussen M, Pearse D, Kuan CY, Vaudano E, Behrens A, Wagner E, Flavell RA, Davis RJ, Herdegen T. Specific pathophysiological functions of JNK isoforms in the brain. Eur J Neurosci. 2005 Jan; 21(2):363-77. PMID: 15673436.
      Citations:    
    189. Kuan CY, Schloemer AJ, Lu A, Burns KA, Weng WL, Williams MT, Strauss KI, Vorhees CV, Flavell RA, Davis RJ, Sharp FR, Rakic P. Hypoxia-ischemia induces DNA synthesis without cell proliferation in dying neurons in adult rodent brain. J Neurosci. 2004 Nov 24; 24(47):10763-72. PMID: 15564594.
      Citations:    
    190. Ventura JJ, Cogswell P, Flavell RA, Baldwin AS, Davis RJ. JNK potentiates TNF-stimulated necrosis by increasing the production of cytotoxic reactive oxygen species. Genes Dev. 2004 Dec 01; 18(23):2905-15. PMID: 15545623.
      Citations: 126     Fields:    Translation:Animals
    191. Keramaris E, Vanderluit JL, Bahadori M, Mousavi K, Davis RJ, Flavell R, Slack RS, Park DS. c-Jun N-terminal kinase 3 deficiency protects neurons from axotomy-induced death in vivo through mechanisms independent of c-Jun phosphorylation. J Biol Chem. 2005 Jan 14; 280(2):1132-41. PMID: 15528206.
      Citations: 17     Fields:    Translation:AnimalsCells
    192. Weston CR, Wong A, Hall JP, Goad ME, Flavell RA, Davis RJ. The c-Jun NH2-terminal kinase is essential for epidermal growth factor expression during epidermal morphogenesis. Proc Natl Acad Sci U S A. 2004 Sep 28; 101(39):14114-9. PMID: 15375216.
      Citations: 33     Fields:    Translation:AnimalsCells
    193. Jaeschke A, Czech MP, Davis RJ. An essential role of the JIP1 scaffold protein for JNK activation in adipose tissue. Genes Dev. 2004 Aug 15; 18(16):1976-80. PMID: 15314024.
      Citations: 49     Fields:    Translation:AnimalsCells
    194. Morton S, Davis RJ, Cohen P. Signalling pathways involved in multisite phosphorylation of the transcription factor ATF-2. FEBS Lett. 2004 Aug 13; 572(1-3):177-83. PMID: 15304344.
      Citations: 38     Fields:    Translation:AnimalsCells
    195. Zhang Y, Blattman JN, Kennedy NJ, Duong J, Nguyen T, Wang Y, Davis RJ, Greenberg PD, Flavell RA, Dong C. Regulation of innate and adaptive immune responses by MAP kinase phosphatase 5. Nature. 2004 Aug 12; 430(7001):793-7. PMID: 15306813.
      Citations: 105     Fields:    Translation:HumansAnimalsCells
    196. Ventura JJ, Kennedy NJ, Flavell RA, Davis RJ. JNK regulates autocrine expression of TGF-beta1. Mol Cell. 2004 Jul 23; 15(2):269-78. PMID: 15260977.
      Citations: 31     Fields:    Translation:AnimalsCells
    197. Chi H, Lu B, Takekawa M, Davis RJ, Flavell RA. GADD45beta/GADD45gamma and MEKK4 comprise a genetic pathway mediating STAT4-independent IFNgamma production in T cells. EMBO J. 2004 Apr 07; 23(7):1576-86. PMID: 15044949.
      Citations:    
    198. Whitmarsh AJ, Davis RJ. Analyzing mitogen-activated protein kinase (MAPK) activities in T cells. Curr Protoc Immunol. 2004 Feb; Chapter 11:Unit 11.8. PMID: 18432922.
      Citations: 2     Fields:    Translation:AnimalsCells
    199. Hunot S, Vila M, Teismann P, Davis RJ, Hirsch EC, Przedborski S, Rakic P, Flavell RA. JNK-mediated induction of cyclooxygenase 2 is required for neurodegeneration in a mouse model of Parkinson's disease. Proc Natl Acad Sci U S A. 2004 Jan 13; 101(2):665-70. PMID: 14704277.
      Citations:    
    200. Xiu M, Kim J, Sampson E, Huang CY, Davis RJ, Paulson KE, Yee AS. The transcriptional repressor HBP1 is a target of the p38 mitogen-activated protein kinase pathway in cell cycle regulation. Mol Cell Biol. 2003 Dec; 23(23):8890-901. PMID: 14612426.
      Citations: 22     Fields:    Translation:AnimalsCells
    201. Kuan CY, Whitmarsh AJ, Yang DD, Liao G, Schloemer AJ, Dong C, Bao J, Banasiak KJ, Haddad GG, Flavell RA, Davis RJ, Rakic P. A critical role of neural-specific JNK3 for ischemic apoptosis. Proc Natl Acad Sci U S A. 2003 Dec 09; 100(25):15184-9. PMID: 14657393.
      Citations: 150     Fields:    Translation:AnimalsCells
    202. Lee TH, Huang Q, Oikemus S, Shank J, Ventura JJ, Cusson N, Vaillancourt RR, Su B, Davis RJ, Kelliher MA. The death domain kinase RIP1 is essential for tumor necrosis factor alpha signaling to p38 mitogen-activated protein kinase. Mol Cell Biol. 2003 Nov; 23(22):8377-85. PMID: 14585994.
      Citations: 29     Fields:    Translation:AnimalsCells
    203. Kelkar N, Delmotte MH, Weston CR, Barrett T, Sheppard BJ, Flavell RA, Davis RJ. Morphogenesis of the telencephalic commissure requires scaffold protein JNK-interacting protein 3 (JIP3). Proc Natl Acad Sci U S A. 2003 Aug 19; 100(17):9843-8. PMID: 12897243.
      Citations: 28     Fields:    Translation:AnimalsCells
    204. Brancho D, Tanaka N, Jaeschke A, Ventura JJ, Kelkar N, Tanaka Y, Kyuuma M, Takeshita T, Flavell RA, Davis RJ. Mechanism of p38 MAP kinase activation in vivo. Genes Dev. 2003 Aug 15; 17(16):1969-78. PMID: 12893778.
      Citations: 216     Fields:    Translation:AnimalsCells
    205. Morse D, Pischke SE, Zhou Z, Davis RJ, Flavell RA, Loop T, Otterbein SL, Otterbein LE, Choi AM. Suppression of inflammatory cytokine production by carbon monoxide involves the JNK pathway and AP-1. J Biol Chem. 2003 Sep 26; 278(39):36993-8. PMID: 12857751.
      Citations: 123     Fields:    Translation:AnimalsCells
    206. Tanno M, Bassi R, Gorog DA, Saurin AT, Jiang J, Heads RJ, Martin JL, Davis RJ, Flavell RA, Marber MS. Diverse mechanisms of myocardial p38 mitogen-activated protein kinase activation: evidence for MKK-independent activation by a TAB1-associated mechanism contributing to injury during myocardial ischemia. Circ Res. 2003 Aug 08; 93(3):254-61. PMID: 12829618.
      Citations: 51     Fields:    Translation:AnimalsCells
    207. Lamb JA, Ventura JJ, Hess P, Flavell RA, Davis RJ. JunD mediates survival signaling by the JNK signal transduction pathway. Mol Cell. 2003 Jun; 11(6):1479-89. PMID: 12820962.
      Citations: 101     Fields:    Translation:AnimalsCells
    208. Weston CR, Wong A, Hall JP, Goad ME, Flavell RA, Davis RJ. JNK initiates a cytokine cascade that causes Pax2 expression and closure of the optic fissure. Genes Dev. 2003 May 15; 17(10):1271-80. PMID: 12756228.
      Citations: 44     Fields:    Translation:AnimalsCells
    209. Kennedy NJ, Davis RJ. Role of JNK in tumor development. Cell Cycle. 2003 May-Jun; 2(3):199-201. PMID: 12734425.
      Citations: 77     Fields:    Translation:HumansAnimalsCells
    210. Zhang X, Shan P, Alam J, Davis RJ, Flavell RA, Lee PJ. Carbon monoxide modulates Fas/Fas ligand, caspases, and Bcl-2 family proteins via the p38alpha mitogen-activated protein kinase pathway during ischemia-reperfusion lung injury. J Biol Chem. 2003 Jun 13; 278(24):22061-70. PMID: 12690100.
      Citations:    
    211. Ventura JJ, Kennedy NJ, Lamb JA, Flavell RA, Davis RJ. c-Jun NH(2)-terminal kinase is essential for the regulation of AP-1 by tumor necrosis factor. Mol Cell Biol. 2003 Apr; 23(8):2871-82. PMID: 12665585.
      Citations: 63     Fields:    Translation:AnimalsCells
    212. Morse D, Otterbein LE, Watkins S, Alber S, Zhou Z, Flavell RA, Davis RJ, Choi AM. Deficiency in the c-Jun NH2-terminal kinase signaling pathway confers susceptibility to hyperoxic lung injury in mice. Am J Physiol Lung Cell Mol Physiol. 2003 Jul; 285(1):L250-7. PMID: 12651633.
      Citations: 14     Fields:    Translation:AnimalsCells
    213. Kennedy NJ, Sluss HK, Jones SN, Bar-Sagi D, Flavell RA, Davis RJ. Suppression of Ras-stimulated transformation by the JNK signal transduction pathway. Genes Dev. 2003 Mar 01; 17(5):629-37. PMID: 12629045.
      Citations: 57     Fields:    Translation:AnimalsCells
    214. Lei K, Davis RJ. JNK phosphorylation of Bim-related members of the Bcl2 family induces Bax-dependent apoptosis. Proc Natl Acad Sci U S A. 2003 Mar 04; 100(5):2432-7. PMID: 12591950.
      Citations: 386     Fields:    Translation:HumansCells
    215. Reuther-Madrid JY, Kashatus D, Chen S, Li X, Westwick J, Davis RJ, Earp HS, Wang CY, Baldwin AS. The p65/RelA subunit of NF-kappaB suppresses the sustained, antiapoptotic activity of Jun kinase induced by tumor necrosis factor. Mol Cell Biol. 2002 12; 22(23):8175-83. PMID: 12417721.
      Citations: 39     Fields:    Translation:HumansAnimalsCells
    216. Lee YH, Giraud J, Davis RJ, White MF. c-Jun N-terminal kinase (JNK) mediates feedback inhibition of the insulin signaling cascade. J Biol Chem. 2003 Jan 31; 278(5):2896-902. PMID: 12417588.
      Citations: 147     Fields:    Translation:HumansAnimalsCells
    217. Zhang X, Shan P, Otterbein LE, Alam J, Flavell RA, Davis RJ, Choi AM, Lee PJ. Carbon monoxide inhibition of apoptosis during ischemia-reperfusion lung injury is dependent on the p38 mitogen-activated protein kinase pathway and involves caspase 3. J Biol Chem. 2003 Jan 10; 278(2):1248-58. PMID: 12399465.
      Citations: 80     Fields:    Translation:AnimalsCells
    218. Hess P, Pihan G, Sawyers CL, Flavell RA, Davis RJ. Survival signaling mediated by c-Jun NH(2)-terminal kinase in transformed B lymphoblasts. Nat Genet. 2002 Sep; 32(1):201-5. PMID: 12161751.
      Citations: 56     Fields:    Translation:AnimalsCells
    219. Tanaka N, Kamanaka M, Enslen H, Dong C, Wysk M, Davis RJ, Flavell RA. Differential involvement of p38 mitogen-activated protein kinase kinases MKK3 and MKK6 in T-cell apoptosis. EMBO Rep. 2002 Aug; 3(8):785-91. PMID: 12151339.
      Citations:    
    220. Lei K, Nimnual A, Zong WX, Kennedy NJ, Flavell RA, Thompson CB, Bar-Sagi D, Davis RJ. The Bax subfamily of Bcl2-related proteins is essential for apoptotic signal transduction by c-Jun NH(2)-terminal kinase. Mol Cell Biol. 2002 Jul; 22(13):4929-42. PMID: 12052897.
      Citations: 173     Fields:    Translation:AnimalsCells
    221. Weston CR, Lambright DG, Davis RJ. Signal transduction. MAP kinase signaling specificity. Science. 2002 Jun 28; 296(5577):2345-7. PMID: 12089430.
      Citations: 42     Fields:    Translation:Cells
    222. Ghahremani MH, Keramaris E, Shree T, Xia Z, Davis RJ, Flavell R, Slack RS, Park DS. Interaction of the c-Jun/JNK pathway and cyclin-dependent kinases in death of embryonic cortical neurons evoked by DNA damage. J Biol Chem. 2002 Sep 20; 277(38):35586-96. PMID: 12091388.
      Citations: 13     Fields:    Translation:AnimalsCells
    223. Anguita J, Barthold SW, Persinski R, Hedrick MN, Huy CA, Davis RJ, Flavell RA, Fikrig E. Murine Lyme arthritis development mediated by p38 mitogen-activated protein kinase activity. J Immunol. 2002 Jun 15; 168(12):6352-7. PMID: 12055252.
      Citations:    
    224. Yang TT, Xiong Q, Enslen H, Davis RJ, Chow CW. Phosphorylation of NFATc4 by p38 mitogen-activated protein kinases. Mol Cell Biol. 2002 Jun; 22(11):3892-904. PMID: 11997522.
      Citations: 76     Fields:    Translation:AnimalsCells
    225. Arbour N, Naniche D, Homann D, Davis RJ, Flavell RA, Oldstone MB. c-Jun NH(2)-terminal kinase (JNK)1 and JNK2 signaling pathways have divergent roles in CD8(+) T cell-mediated antiviral immunity. J Exp Med. 2002 Apr 01; 195(7):801-10. PMID: 11927625.
      Citations: 37     Fields:    Translation:AnimalsCells
    226. Conze D, Krahl T, Kennedy N, Weiss L, Lumsden J, Hess P, Flavell RA, Le Gros G, Davis RJ, Rinc?n M. c-Jun NH(2)-terminal kinase (JNK)1 and JNK2 have distinct roles in CD8(+) T cell activation. J Exp Med. 2002 Apr 01; 195(7):811-23. PMID: 11927626.
      Citations: 54     Fields:    Translation:AnimalsCells
    227. Weston CR, Davis RJ. The JNK signal transduction pathway. Curr Opin Genet Dev. 2002 Feb; 12(1):14-21. PMID: 11790549.
      Citations: 223     Fields:    Translation:AnimalsCells
    228. Hall JP, Davis RJ. Inhibition of the p38 pathway upregulates macrophage JNK and ERK activities, and the ERK, JNK, and p38 MAP kinase pathways are reprogrammed during differentiation of the murine myeloid M1 cell line. J Cell Biochem. 2002; 86(1):1-11. PMID: 12112010.
      Citations: 11     Fields:    Translation:AnimalsCells
    229. Hall JP, Davis RJ. Analysis of c-Jun N-terminal kinase regulation and function. Methods Enzymol. 2002; 345:413-25. PMID: 11665625.
      Citations: 3     Fields:    Translation:AnimalsCells
    230. Dong C, Davis RJ, Flavell RA. MAP kinases in the immune response. Annu Rev Immunol. 2002; 20:55-72. PMID: 11861597.
      Citations:    
    231. Davis RJ. Signal transduction by the JNK group of MAP kinases. Cell. 2000 Oct 13; 103(2):239-52. PMID: 11057897.
      Citations: 1438     Fields:    Translation:Cells
    232. Whitmarsh AJ, Davis RJ. Signal transduction by MAP kinases: regulation by phosphorylation-dependent switches. Sci STKE. 1999 Sep 28; 1999(1):PE1. PMID: 11865181.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
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