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Michael Thomas Heneka MD

TitleAdjunct Professor
InstitutionUMass Chan Medical School
DepartmentMedicine
AddressKlinische Neurowissenschaften, Universitat Bonn
Sigmund Freud Str. 33
Bon 53127
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    Other Positions
    InstitutionT.H. Chan School of Medicine
    DepartmentMedicine
    DivisionInfectious Diseases


    Collapse Biography 
    Collapse education and training
    Universitat Tubingen, Tubingen, , GermanyMD

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Schuster J, Dreyhaupt J, M?nkem?ller K, Dupuis L, Dieterl? S, Weishaupt JH, Kassubek J, Petri S, Meyer T, Grosskreutz J, Schrank B, Boentert M, Emmer A, Hermann A, Zeller D, Prudlo J, Winkler AS, Grehl T, Heneka MT, Johannesen S, G?ricke B, Witzel S, Dorst J, Ludolph AC. In-depth analysis of data from the RAS-ALS study reveals new insights in rasagiline treatment for amyotrophic lateral sclerosis. Eur J Neurol. 2024 Jan 19; e16204. PMID: 38240416.
      Citations:    Fields:    
    2. Hayek D, Ziegler G, Kleineidam L, Brosseron F, Nemali A, Vockert N, Ravichandran KA, Betts MJ, Peters O, Schneider LS, Wang X, Priller J, Altenstein S, Schneider A, Fliessbach K, Wiltfang J, Bartels C, Rostamzadeh A, Glanz W, Buerger K, Janowitz D, Perneczky R, Rauchmann BS, Teipel S, Kilimann I, Laske C, Mengel D, Synofzik M, Munk MH, Spottke A, Roy N, Roeske S, Kuhn E, Ramirez A, Dobisch L, Schmid M, Berger M, Wolfsgruber S, Yakupov R, Hetzer S, Dechent P, Ewers M, Scheffler K, Schott BH, Schreiber S, Orellana A, de Rojas I, Marqui? M, Boada M, Sotolongo O, Gonz?lez PG, Puerta R, D?zel E, Jessen F, Wagner M, Ruiz A, Heneka MT, Maass A. Different inflammatory signatures based on CSF biomarkers relate to preserved or diminished brain structure and cognition. Mol Psychiatry. 2024 Jan 12. PMID: 38216727.
      Citations:    Fields:    
    3. Teipel SJ, Dyrba M, Kleineidam L, Brosseron F, Levin F, Bruno D, Buerger K, Cosma N, Schneider LS, D?zel E, Glanz W, Fliessbach K, Janowitz D, Kilimann I, Laske C, Munk MH, Maier F, Peters O, Pomara N, Perneczky R, Rauchmann BS, Priller J, Ramirez A, Roy N, Schneider A, Spottke A, Spruth EJ, Roeske S, Wagner M, Wiltfang J, Wolfsgruber S, Bartels C, Jessen F, Heneka MT. Association of latent factors of neuroinflammation with Alzheimer's disease pathology and longitudinal cognitive decline. Alzheimers Dement (Amst). 2024 Jan-Mar; 16(1):e12510. PMID: 38213951.
      Citations:    
    4. Ravichandran KA, Heneka MT. Inflammasomes in neurological disorders - mechanisms and therapeutic potential. Nat Rev Neurol. 2024 Feb; 20(2):67-83. PMID: 38195712.
      Citations:    Fields:    Translation:Humans
    5. Dadwal S, Heneka MT. Microglia heterogeneity in health and disease. FEBS Open Bio. 2024 02; 14(2):217-229. PMID: 37945346.
      Citations: 2     Fields:    Translation:HumansCells
    6. Stark M, Wolfsgruber S, Kleineidam L, Frommann I, Altenstein S, Bartels C, Brosseron F, Buerger K, Burow L, Butryn M, Ewers M, Fliessbach K, Gabelin T, Glanz W, Goerss D, Gref D, Hansen N, Heneka MT, Hinderer P, Incesoy EI, Janowitz D, Kilimann I, Kimmich O, Laske C, Munk MH, Perneczky R, Peters O, Preis L, Priller J, Rauchmann BS, Rostamzadeh A, Roy-Kluth N, Sanzenbacher C, Schneider A, Schott BH, Spottke A, Spruth EJ, Teipel S, Vogt IR, Wiltfang J, Duzel E, Jessen F, Wagner M. Relevance of Minor Neuropsychological Deficits in Patients With Subjective Cognitive Decline. Neurology. 2023 Nov 21; 101(21):e2185-e2196. PMID: 37821235.
      Citations: 1     Fields:    Translation:Humans
    7. Waschkies KF, Soch J, Darna M, Richter A, Altenstein S, Beyle A, Brosseron F, Buchholz F, Butryn M, Dobisch L, Ewers M, Fliessbach K, Gabelin T, Glanz W, Goerss D, Gref D, Janowitz D, Kilimann I, Lohse A, Munk MH, Rauchmann BS, Rostamzadeh A, Roy N, Spruth EJ, Dechent P, Heneka MT, Hetzer S, Ramirez A, Scheffler K, Buerger K, Laske C, Perneczky R, Peters O, Priller J, Schneider A, Spottke A, Teipel S, D?zel E, Jessen F, Wiltfang J, Schott BH, Kizilirmak JM. Machine learning-based classification of Alzheimer's disease and its at-risk states using personality traits, anxiety, and depression. Int J Geriatr Psychiatry. 2023 10; 38(10):e6007. PMID: 37800601.
      Citations: 1     Fields:    Translation:Humans
    8. Teipel SJ, Dyrba M, Levin F, Altenstein S, Berger M, Beyle A, Brosseron F, Buerger K, Burow L, Dobisch L, Ewers M, Fliessbach K, Frommann I, Glanz W, Goerss D, Gref D, Hansen N, Heneka MT, Incesoy EI, Janowitz D, Keles D, Kilimann I, Laske C, Lohse A, Munk MH, Perneczky R, Peters O, Preis L, Priller J, Rostamzadeh A, Roy N, Schmid M, Schneider A, Spottke A, Spruth EJ, Wiltfang J, D?zel E, Jessen F, Kleineidam L, Wagner M. Cognitive Trajectories in Preclinical and Prodromal Alzheimer's Disease Related to Amyloid Status and Brain Atrophy: A Bayesian Approach. J Alzheimers Dis Rep. 2023; 7(1):1055-1076. PMID: 37849637.
      Citations:    
    9. Bartsch T, Berg D, Heneka M, Leypoldt F. [Parkinson's and Alzheimer's disease as system-wide neurodegenerative disorders]. Nervenarzt. 2023 Oct; 94(10):875-884. PMID: 37672086.
      Citations:    Fields:    
    10. Kapadia A, Theil S, Opitz S, Villacampa N, Beckert H, Schoch S, Heneka MT, Kumar S, Walter J. Phosphorylation-state dependent intraneuronal sorting of A? differentially impairs autophagy and the endo-lysosomal system. Autophagy. 2024 Jan; 20(1):166-187. PMID: 37642583.
      Citations:    Fields:    Translation:Cells
    11. Karabag D, Scheiblich H, Griep A, Santarelli F, Schwartz S, Heneka MT, Ising C. Characterizing microglial senescence: Tau as a key player. J Neurochem. 2023 08; 166(3):517-533. PMID: 37278117.
      Citations: 2     Fields:    Translation:AnimalsCells
    12. Walker KA, Le Page LM, Terrando N, Duggan MR, Heneka MT, Bettcher BM. The role of peripheral inflammatory insults in Alzheimer's disease: a review and research roadmap. Mol Neurodegener. 2023 06 05; 18(1):37. PMID: 37277738.
      Citations: 4     Fields:    Translation:Humans
    13. Bendella Z, Widmann CN, Layer JP, Layer YL, Haase R, Sauer M, Bieler L, Lehnen NC, Paech D, Heneka MT, Radbruch A, Schmeel FC. Brain Volume Changes after COVID-19 Compared to Healthy Controls by Artificial Intelligence-Based MRI Volumetry. Diagnostics (Basel). 2023 May 12; 13(10). PMID: 37238200.
      Citations:    
    14. Stratoulias V, Ruiz R, Kanatani S, Osman AM, Keane L, Armengol JA, Rodr?guez-Moreno A, Murgoci AN, Garc?a-Dom?nguez I, Alonso-Bellido I, Gonz?lez Ib??ez F, Picard K, V?zquez-Cabrera G, Posada-P?rez M, Vernoux N, Tejera D, Grabert K, Cheray M, Gonz?lez-Rodr?guez P, P?rez-Villegas EM, Mart?nez-Gallego I, Lastra-Romero A, Brodin D, Avila-Cari?o J, Cao Y, Airavaara M, Uhl?n P, Heneka MT, Tremblay M?, Blomgren K, Venero JL, Joseph B. ARG1-expressing microglia show a distinct molecular signature and modulate postnatal development and function of the mouse brain. Nat Neurosci. 2023 06; 26(6):1008-1020. PMID: 37169859.
      Citations: 5     Fields:    Translation:AnimalsCells
    15. Nemy M, Dyrba M, Brosseron F, Buerger K, Dechent P, Dobisch L, Ewers M, Fliessbach K, Glanz W, Goerss D, Heneka MT, Hetzer S, Incesoy EI, Janowitz D, Kilimann I, Laske C, Maier F, Munk MH, Perneczky R, Peters O, Preis L, Priller J, Rauchmann BS, R?ske S, Roy N, Scheffler K, Schneider A, Schott BH, Spottke A, Spruth EJ, Wagner M, Wiltfang J, Yakupov R, Eriksdotter M, Westman E, Stepankova O, Vyslouzilova L, D?zel E, Jessen F, Teipel SJ, Ferreira D. Cholinergic white matter pathways along the Alzheimer's disease continuum. Brain. 2023 05 02; 146(5):2075-2088. PMID: 36288546.
      Citations: 3     Fields:    Translation:Humans
    16. Ising C, Heneka MT. Chronic inflammation: a potential target in tauopathies. Lancet Neurol. 2023 05; 22(5):371-373. PMID: 37059499.
      Citations:    Fields:    Translation:Humans
    17. Kloske CM, Barnum CJ, Batista AF, Bradshaw EM, Brickman AM, Bu G, Dennison J, Gearon MD, Goate AM, Haass C, Heneka MT, Hu WT, Huggins LKL, Jones NS, Koldamova R, Lemere CA, Liddelow SA, Marcora E, Marsh SE, Nielsen HM, Petersen KK, Petersen M, Pi?a-Escudero SD, Qiu WQ, Quiroz YT, Reiman E, Sexton C, Tansey MG, Tcw J, Teunissen CE, Tijms BM, van der Kant R, Wallings R, Weninger SC, Wharton W, Wilcock DM, Wishard TJ, Worley SL, Zetterberg H, Carrillo MC. APOE and immunity: Research highlights. Alzheimers Dement. 2023 06; 19(6):2677-2696. PMID: 36975090.
      Citations: 4     Fields:    Translation:HumansCells
    18. Heinzinger N, Maass A, Berron D, Yakupov R, Peters O, Fiebach J, Villringer K, Preis L, Priller J, Spruth EJ, Altenstein S, Schneider A, Fliessbach K, Wiltfang J, Bartels C, Jessen F, Maier F, Glanz W, Buerger K, Janowitz D, Perneczky R, Rauchmann BS, Teipel S, Killimann I, G?er? D, Laske C, Munk MH, Spottke A, Roy N, Heneka MT, Brosseron F, Dobisch L, Ewers M, Dechent P, Haynes JD, Scheffler K, Wolfsgruber S, Kleineidam L, Schmid M, Berger M, D?zel E, Ziegler G. Exploring the ATN classification system using brain morphology. Alzheimers Res Ther. 2023 03 13; 15(1):50. PMID: 36915139.
      Citations: 1     Fields:    Translation:Humans
    19. Yildirim Z, Delen F, Berron D, Baumeister H, Ziegler G, Sch?tze H, Glanz W, Dobisch L, Peters O, Freiesleben SD, Schneider LS, Priller J, Spruth EJ, Schneider A, Fliessbach K, Wiltfang J, Schott BH, Meiberth D, Buerger K, Janowitz D, Perneczky R, Rauchmann BS, Teipel S, Kilimann I, Laske C, Munk MH, Spottke A, Roy N, Heneka M, Brosseron F, Wagner M, Roeske S, Ramirez A, Ewers M, Dechent P, Hetzer S, Scheffler K, Kleineidam L, Wolfsgruber S, Yakupov R, Schmid M, Berger M, Gurvit H, Jessen F, Duzel E. Brain reserve contributes to distinguishing preclinical Alzheimer's stages 1 and 2. Alzheimers Res Ther. 2023 02 28; 15(1):43. PMID: 36855049.
      Citations:    Fields:    Translation:Humans
    20. Braatz C, Komes MP, Ravichandran KA, de Fragas MG, Griep A, Schwartz S, McManus RM, Heneka MT. NLRP3-directed antisense oligonucleotides reduce microglial immunoactivities in vitro. J Neurochem. 2023 Feb 17. PMID: 36799439.
      Citations: 1     Fields:    
    21. de Rojas I, Moreno-Grau S, Tesi N, Grenier-Boley B, Andrade V, Jansen IE, Pedersen NL, Stringa N, Zettergren A, Hern?ndez I, Montrreal L, Ant?nez C, Antonell A, Tankard RM, Bis JC, Sims R, Bellenguez C, Quintela I, Gonz?lez-Perez A, Calero M, Franco-Mac?as E, Mac?as J, Blesa R, Cervera-Carles L, Men?ndez-Gonz?lez M, Frank-Garc?a A, Royo JL, Moreno F, Huerto Vilas R, Baquero M, Diez-Fairen M, Lage C, Garc?a-Madrona S, Garc?a-Gonz?lez P, Alarc?n-Mart?n E, Valero S, Sotolongo-Grau O, Ullgren A, Naj AC, Lemstra AW, Benaque A, P?rez-Cord?n A, Benussi A, R?bano A, Padovani A, Squassina A, de Mendon?a A, Arias Pastor A, Kok AAL, Meggy A, Pastor AB, Espinosa A, Corma-G?mez A, Mart?n Montes A, Sanabria ?, DeStefano AL, Schneider A, Haapasalo A, Kinhult St?hlbom A, Tybj?rg-Hansen A, Hartmann AM, Spottke A, Corbat?n-Anchuelo A, Rongve A, Borroni B, Arosio B, Nacmias B, Nordestgaard BG, Kunkle BW, Charbonnier C, Abdelnour C, Masullo C, Mart?nez Rodr?guez C, Mu?oz-Fernandez C, Dufouil C, Graff C, Ferreira CB, Chillotti C, Reynolds CA, Fenoglio C, Van Broeckhoven C, Clark C, Pisanu C, Satizabal CL, Holmes C, Buiza-Rueda D, Aarsland D, Rujescu D, Alcolea D, Galimberti D, Wallon D, Seripa D, Gr?nblatt E, Dardiotis E, D?zel E, Scarpini E, Conti E, Rubino E, Gelpi E, Rodriguez-Rodriguez E, Duron E, Boerwinkle E, Ferri E, Tagliavini F, K???kali F, Pasquier F, Sanchez-Garcia F, Mangialasche F, Jessen F, Nicolas G, Selb?k G, Ortega G, Ch?ne G, Hadjigeorgiou G, Rossi G, Spalletta G, Giaccone G, Grande G, Binetti G, Papenberg G, Hampel H, Bailly H, Zetterberg H, Soininen H, Karlsson IK, Alvarez I, Appollonio I, Giegling I, Skoog I, Saltvedt I, Rainero I, Rosas Allende I, Hort J, Diehl-Schmid J, Van Dongen J, Vidal JS, Lehtisalo J, Wiltfang J, Thomassen JQ, Kornhuber J, Haines JL, Vogelgsang J, Pineda JA, Fortea J, Popp J, Deckert J, Buerger K, Morgan K, Flie?bach K, Sleegers K, Molina-Porcel L, Kilander L, Weinhold L, Farrer LA, Wang LS, Kleineidam L, Farotti L, Parnetti L, Tremolizzo L, Hausner L, Benussi L, Froelich L, Ikram MA, Deniz-Naranjo MC, Tsolaki M, Rosende-Roca M, L?wenmark M, Hulsman M, Spallazzi M, Pericak-Vance MA, Esiri M, Bernal S?nchez-Arjona M, Dalmasso MC, Mart?nez-Larrad MT, Arcaro M, N?then MM, Fern?ndez-Fuertes M, Dichgans M, Ingelsson M, Herrmann MJ, Scherer M, Vyhnalek M, Kosmidis MH, Yannakoulia M, Schmid M, Ewers M, Heneka MT, Wagner M, Scamosci M, Kivipelto M, Hiltunen M, Zulaica M, Alegret M, Fornage M, Roberto N, van Schoor NM, Seidu NM, Banaj N, Armstrong NJ, Scarmeas N, Scherbaum N, Goldhardt O, Hanon O, Peters O, Skrobot OA, Quenez O, Lerch O, Boss? P, Caffarra P, Dionigi Rossi P, Sakka P, Mecocci P, Hoffmann P, Holmans PA, Fischer P, Riederer P, Yang Q, Marshall R, Kalaria RN, Mayeux R, Vandenberghe R, Cecchetti R, Ghidoni R, Frikke-Schmidt R, Sorbi S, H?gg S, Engelborghs S, Helisalmi S, Botne Sando S, Kern S, Archetti S, Boschi S, Fostinelli S, Gil S, Mendoza S, Mead S, Ciccone S, Djurovic S, Heilmann-Heimbach S, Riedel-Heller S, Kuulasmaa T, Del Ser T, Lebouvier T, Polak T, Ngandu T, Grimmer T, Bessi V, Escott-Price V, Giedraitis V, Deramecourt V, Maier W, Jian X, Pijnenburg YAL, Kehoe PG, Garcia-Ribas G, S?nchez-Juan P, Pastor P, P?rez-Tur J, Pi?ol-Ripoll G, Lopez de Munain A, Garc?a-Alberca JM, Bullido MJ, ?lvarez V, Lle? A, Real LM, Mir P, Medina M, Scheltens P, Holstege H, Marqui? M, S?ez ME, Carracedo ?, Amouyel P, Schellenberg GD, Williams J, Seshadri S, van Duijn CM, Mather KA, S?nchez-Valle R, Serrano-R?os M, Orellana A, T?rraga L, Blennow K, Huisman M, Andreassen OA, Posthuma D, Clarim?n J, Boada M, van der Flier WM, Ramirez A, Lambert JC, van der Lee SJ, Ruiz A. Author Correction: Common variants in Alzheimer's disease and risk stratification by polygenic risk scores. Nat Commun. 2023 Feb 09; 14(1):716. PMID: 36759603.
      Citations:    Fields:    
    22. Heneka MT. ApoE4 makes microglia trem2bling. Neuron. 2023 01 18; 111(2):142-144. PMID: 36657395.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    23. Brosseron F, Maass A, Kleineidam L, Ravichandran KA, Kolbe CC, Wolfsgruber S, Santarelli F, H?sler LM, McManus R, Ising C, R?ske S, Peters O, Cosma NC, Schneider LS, Wang X, Priller J, Spruth EJ, Altenstein S, Schneider A, Fliessbach K, Wiltfang J, Schott BH, Buerger K, Janowitz D, Dichgans M, Perneczky R, Rauchmann BS, Teipel S, Kilimann I, G?r? D, Laske C, Munk MH, D?zel E, Yakupow R, Dobisch L, Metzger CD, Glanz W, Ewers M, Dechent P, Haynes JD, Scheffler K, Roy N, Rostamzadeh A, Spottke A, Ramirez A, Mengel D, Synofzik M, Jucker M, Latz E, Jessen F, Wagner M, Heneka MT. Serum IL-6, sAXL, and YKL-40 as systemic correlates of reduced brain structure and function in Alzheimer's disease: results from the DELCODE study. Alzheimers Res Ther. 2023 01 12; 15(1):13. PMID: 36631909.
      Citations: 5     Fields:    Translation:Humans
    24. Ersoezlue E, Perneczky R, Tato M, Utecht J, Kurz C, H?ckert J, Guersel S, Burow L, Koller G, Stoecklein S, Keeser D, Papazov B, Totzke M, Ballarini T, Brosseron F, Buerger K, Dechent P, Dobisch L, Ewers M, Fliessbach K, Glanz W, Haynes JD, Heneka MT, Janowitz D, Kilimann I, Kleineidam L, Laske C, Maier F, Munk MH, Peters O, Priller J, Ramirez A, Roeske S, Roy N, Scheffler K, Schneider A, Schott BH, Spottke A, Spruth EJ, Teipel S, Unterfeld C, Wagner M, Wang X, Wiltfang J, Wolfsgruber S, Yakupov R, Duezel E, Jessen F, Rauchmann BS. A Residual Marker of Cognitive Reserve Is Associated with Resting-State Intrinsic Functional Connectivity Along the Alzheimer's Disease Continuum. J Alzheimers Dis. 2023; 92(3):925-940. PMID: 36806502.
      Citations:    Fields:    Translation:Humans
    25. Raku?a E, Fink A, Tamg?ney G, Heneka MT, Doblhammer G. Sporadic Use of Antibiotics in Older Adults and the Risk of Dementia: A Nested Case-Control Study Based on German Health Claims Data. J Alzheimers Dis. 2023; 93(4):1329-1339. PMID: 37182873.
      Citations: 1     Fields:    Translation:Humans
    26. Mercan D, Heneka MT. The Contribution of the Locus Coeruleus-Noradrenaline System Degeneration during the Progression of Alzheimer's Disease. Biology (Basel). 2022 Dec 14; 11(12). PMID: 36552331.
      Citations:    
    27. Kleineidam L, Wolfsgruber S, Weyrauch AS, Zulka LE, Forstmeier S, Roeske S, van den Bussche H, Kaduszkiewicz H, Wiese B, Weyerer S, Werle J, Fuchs A, Pentzek M, Brettschneider C, K?nig HH, Weeg D, Bickel H, Luppa M, Rodriguez FS, Freiesleben SD, Erdogan S, Unterfeld C, Peters O, Spruth EJ, Altenstein S, Lohse A, Priller J, Fliessbach K, Kobeleva X, Schneider A, Bartels C, Schott BH, Wiltfang J, Maier F, Glanz W, Incesoy EI, Butryn M, D?zel E, Buerger K, Janowitz D, Ewers M, Rauchmann BS, Perneczky R, Kilimann I, G?r? D, Teipel S, Laske C, Munk MHJ, Spottke A, Roy N, Brosseron F, Heneka MT, Ramirez A, Yakupov R, Scherer M, Maier W, Jessen F, Riedel-Heller SG, Wagner M. Midlife occupational cognitive requirements protect cognitive function in old age by increasing cognitive reserve. Front Psychol. 2022; 13:957308. PMID: 36571008.
      Citations:    
    28. Castro-Gomez S, Binder J, Schievelkamp AH, Heneka MT. CNS Superficial Siderosis Mimicking a Motor Neuron Disease. Brain Sci. 2022 Nov 16; 12(11). PMID: 36421882.
      Citations:    
    29. Paolicelli RC, Sierra A, Stevens B, Tremblay ME, Aguzzi A, Ajami B, Amit I, Audinat E, Bechmann I, Bennett M, Bennett F, Bessis A, Biber K, Bilbo S, Blurton-Jones M, Boddeke E, Brites D, Br?ne B, Brown GC, Butovsky O, Carson MJ, Castellano B, Colonna M, Cowley SA, Cunningham C, Davalos D, De Jager PL, de Strooper B, Denes A, Eggen BJL, Eyo U, Galea E, Garel S, Ginhoux F, Glass CK, Gokce O, Gomez-Nicola D, Gonz?lez B, Gordon S, Graeber MB, Greenhalgh AD, Gressens P, Greter M, Gutmann DH, Haass C, Heneka MT, Heppner FL, Hong S, Hume DA, Jung S, Kettenmann H, Kipnis J, Koyama R, Lemke G, Lynch M, Majewska A, Malcangio M, Malm T, Mancuso R, Masuda T, Matteoli M, McColl BW, Miron VE, Molofsky AV, Monje M, Mracsko E, Nadjar A, Neher JJ, Neniskyte U, Neumann H, Noda M, Peng B, Peri F, Perry VH, Popovich PG, Pridans C, Priller J, Prinz M, Ragozzino D, Ransohoff RM, Salter MW, Schaefer A, Schafer DP, Schwartz M, Simons M, Smith CJ, Streit WJ, Tay TL, Tsai LH, Verkhratsky A, von Bernhardi R, Wake H, Wittamer V, Wolf SA, Wu LJ, Wyss-Coray T. Microglia states and nomenclature: A field at its crossroads. Neuron. 2022 11 02; 110(21):3458-3483. PMID: 36327895.
      Citations: 225     Fields:    Translation:Cells
    30. Ersoezlue E, Rauchmann BS, Schneider-Axmann T, Wagner M, Ballarini T, Tato M, Utecht J, Kurz C, Papazov B, Guersel S, Burow L, Koller G, St?cklein S, Keeser D, Bartels C, Brosseron F, Buerger K, Cetindag AC, Dechent P, Dobisch L, Ewers M, Fliessbach K, Frommann I, Haynes JD, Heneka MT, Janowitz D, Kilimann I, Kleinedam L, Laske C, Maier F, Metzger CD, Munk MH, Peters O, Preis L, Priller J, Ramirez A, Roeske S, Roy N, Scheffler K, Schneider A, Spottke A, Spruth EJ, Teipel S, Wiltfang J, Wolfsgruber S, Yakupov R, Duezel E, Jessen F, Perneczky R. Lifelong experiences as a proxy of cognitive reserve moderate the association between connectivity and cognition in Alzheimer's disease. Neurobiol Aging. 2023 02; 122:33-44. PMID: 36476760.
      Citations: 2     Fields:    Translation:Humans
    31. Henning L, Antony H, Breuer A, M?ller J, Seifert G, Audinat E, Singh P, Brosseron F, Heneka MT, Steinh?user C, Bedner P. Reactive microglia are the major source of tumor necrosis factor alpha and contribute to astrocyte dysfunction and acute seizures in experimental temporal lobe epilepsy. Glia. 2023 02; 71(2):168-186. PMID: 36373840.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    32. Jansen IE, van der Lee SJ, Gomez-Fonseca D, de Rojas I, Dalmasso MC, Grenier-Boley B, Zettergren A, Mishra A, Ali M, Andrade V, Bellenguez C, Kleineidam L, K???kali F, Sung YJ, Tes? N, Vromen EM, Wightman DP, Alcolea D, Alegret M, Alvarez I, Amouyel P, Athanasiu L, Bahrami S, Bailly H, Belbin O, Bergh S, Bertram L, Biessels GJ, Blennow K, Blesa R, Boada M, Boland A, Buerger K, Carracedo ?, Cervera-Carles L, Chene G, Claassen JAHR, Debette S, Deleuze JF, de Deyn PP, Diehl-Schmid J, Djurovic S, Dols-Icardo O, Dufouil C, Duron E, D?zel E, Fladby T, Fortea J, Fr?lich L, Garc?a-Gonz?lez P, Garcia-Martinez M, Giegling I, Goldhardt O, Gobom J, Grimmer T, Haapasalo A, Hampel H, Hanon O, Hausner L, Heilmann-Heimbach S, Helisalmi S, Heneka MT, Hern?ndez I, Herukka SK, Holstege H, Jarholm J, Kern S, Knapskog AB, Koivisto AM, Kornhuber J, Kuulasmaa T, Lage C, Laske C, Leinonen V, Lewczuk P, Lle? A, de Munain AL, Lopez-Garcia S, Maier W, Marqui? M, Mol MO, Montrreal L, Moreno F, Moreno-Grau S, Nicolas G, N?then MM, Orellana A, P?lhaugen L, Papma JM, Pasquier F, Perneczky R, Peters O, Pijnenburg YAL, Popp J, Posthuma D, Pozueta A, Priller J, Puerta R, Quintela I, Ramakers I, Rodriguez-Rodriguez E, Rujescu D, Saltvedt I, Sanchez-Juan P, Scheltens P, Scherbaum N, Schmid M, Schneider A, Selb?k G, Selnes P, Shadrin A, Skoog I, Soininen H, T?rraga L, Teipel S, Tijms B, Tsolaki M, Van Broeckhoven C, Van Dongen J, van Swieten JC, Vandenberghe R, Vidal JS, Visser PJ, Vogelgsang J, Waern M, Wagner M, Wiltfang J, Wittens MMJ, Zetterberg H, Zulaica M, van Duijn CM, Bjerke M, Engelborghs S, Jessen F, Teunissen CE, Pastor P, Hiltunen M, Ingelsson M, Andreassen OA, Clarim?n J, Sleegers K, Ruiz A, Ramirez A, Cruchaga C, Lambert JC, van der Flier W. Genome-wide meta-analysis for Alzheimer's disease cerebrospinal fluid biomarkers. Acta Neuropathol. 2022 Nov; 144(5):821-842. PMID: 36066633.
      Citations: 18     Fields:    Translation:Humans
    33. Krieger J, Frackowiak M, Berger M, Heneka MT, Jacobs AH. Falls at advanced age - The importance to search for benign paroxysmal positional vertigo (BPPV). Exp Gerontol. 2022 08; 165:111868. PMID: 35700849.
      Citations:    Fields:    Translation:Humans
    34. Billette OV, Ziegler G, Aruci M, Sch?tze H, Kizilirmak JM, Richter A, Altenstein S, Bartels C, Brosseron F, Cardenas-Blanco A, Dahmen P, Dechent P, Dobisch L, Fliessbach K, Freiesleben SD, Glanz W, G?er? D, Haynes JD, Heneka MT, Kilimann I, Kimmich O, Kleineidam L, Laske C, Lohse A, Rostamzadeh A, Metzger C, Munk MH, Peters O, Preis L, Priller J, Scheffler K, Schneider A, Spottke A, Spruth EJ, Ramirez A, R?ske S, Roy N, Teipel S, Wagner M, Wiltfang J, Wolfsgruber S, Yakupov R, Zeidman P, Jessen F, Schott BH, D?zel E, Maass A. Novelty-Related fMRI Responses of Precuneus and Medial Temporal Regions in Individuals at Risk for Alzheimer Disease. Neurology. 2022 08 23; 99(8):e775-e788. PMID: 35995589.
      Citations: 10     Fields:    Translation:Humans
    35. Berron D, Ziegler G, Vieweg P, Billette O, G?sten J, Grande X, Heneka MT, Schneider A, Teipel S, Jessen F, Wagner M, D?zel E. Feasibility of Digital Memory Assessments in an Unsupervised and Remote Study Setting. Front Digit Health. 2022; 4:892997. PMID: 35721797.
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    36. D?zel E, Ziegler G, Berron D, Maass A, Sch?tze H, Cardenas-Blanco A, Glanz W, Metzger C, Dobisch L, Reuter M, Spottke A, Brosseron F, Fliessbach K, Heneka MT, Laske C, Peters O, Priller J, Spruth EJ, Ramirez A, Speck O, Schneider A, Teipel S, Kilimann I, Jens W, Schott BH, Preis L, Gref D, Maier F, Munk MH, Roy N, Ballarini T, Yakupov R, Haynes JD, Dechent P, Scheffler K, Wagner M, Jessen F. Amyloid pathology but not APOE e4 status is permissive for tau-related hippocampal dysfunction. Brain. 2022 05 24; 145(4):1473-1485. PMID: 35352105.
      Citations: 7     Fields:    Translation:Humans
    37. Jessen F, Wolfsgruber S, Kleineindam L, Spottke A, Altenstein S, Bartels C, Berger M, Brosseron F, Daamen M, Dichgans M, Dobisch L, Ewers M, Fenski F, Fliessbach K, Freiesleben SD, Glanz W, G?r? D, G?rsel S, Janowitz D, Kilimann I, Kobeleva X, Lohse A, Maier F, Metzger C, Munk M, Preis L, Sanzenbacher C, Spruth E, Rauchmann B, Vukovich R, Yakupov R, Weyrauch AS, Ziegler G, Schmid M, Laske C, Perneczky R, Schneider A, Wiltfang J, Teipel S, B?rger K, Priller J, Peters O, Ramirez A, Boecker H, Heneka MT, Wagner M, D?zel E. Subjective cognitive decline and stage 2 of Alzheimer disease in patients from memory centers. Alzheimers Dement. 2023 02; 19(2):487-497. PMID: 35451563.
      Citations: 10     Fields:    Translation:Humans
    38. Whitson HE, Colton C, El Khoury J, Gate D, Goate A, Heneka MT, Kaddurah-Daouk R, Klein RS, Shinohara ML, Sisodia S, Spudich SS, Stevens B, Tanzi R, Ting JP, Garden G. Infection and inflammation: New perspectives on Alzheimer's disease. Brain Behav Immun Health. 2022 Jul; 22:100462. PMID: 36118272.
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    39. Bellenguez C, K???kali F, Jansen IE, Kleineidam L, Moreno-Grau S, Amin N, Naj AC, Campos-Martin R, Grenier-Boley B, Andrade V, Holmans PA, Boland A, Damotte V, van der Lee SJ, Costa MR, Kuulasmaa T, Yang Q, de Rojas I, Bis JC, Yaqub A, Prokic I, Chapuis J, Ahmad S, Giedraitis V, Aarsland D, Garcia-Gonzalez P, Abdelnour C, Alarc?n-Mart?n E, Alcolea D, Alegret M, Alvarez I, ?lvarez V, Armstrong NJ, Tsolaki A, Ant?nez C, Appollonio I, Arcaro M, Archetti S, Pastor AA, Arosio B, Athanasiu L, Bailly H, Banaj N, Baquero M, Barral S, Beiser A, Pastor AB, Below JE, Benchek P, Benussi L, Berr C, Besse C, Bessi V, Binetti G, Bizarro A, Blesa R, Boada M, Boerwinkle E, Borroni B, Boschi S, Boss? P, Br?then G, Bressler J, Bresner C, Brodaty H, Brookes KJ, Brusco LI, Buiza-Rueda D, B?rger K, Burholt V, Bush WS, Calero M, Cantwell LB, Chene G, Chung J, Cuccaro ML, Carracedo ?, Cecchetti R, Cervera-Carles L, Charbonnier C, Chen HH, Chillotti C, Ciccone S, Claassen JAHR, Clark C, Conti E, Corma-G?mez A, Costantini E, Custodero C, Daian D, Dalmasso MC, Daniele A, Dardiotis E, Dartigues JF, de Deyn PP, de Paiva Lopes K, de Witte LD, Debette S, Deckert J, Del Ser T, Denning N, DeStefano A, Dichgans M, Diehl-Schmid J, Diez-Fairen M, Rossi PD, Djurovic S, Duron E, D?zel E, Dufouil C, Eiriksdottir G, Engelborghs S, Escott-Price V, Espinosa A, Ewers M, Faber KM, Fabrizio T, Nielsen SF, Fardo DW, Farotti L, Fenoglio C, Fern?ndez-Fuertes M, Ferrari R, Ferreira CB, Ferri E, Fin B, Fischer P, Fladby T, Flie?bach K, Fongang B, Fornage M, Fortea J, Foroud TM, Fostinelli S, Fox NC, Franco-Mac?as E, Bullido MJ, Frank-Garc?a A, Froelich L, Fulton-Howard B, Galimberti D, Garc?a-Alberca JM, Garc?a-Gonz?lez P, Garcia-Madrona S, Garcia-Ribas G, Ghidoni R, Giegling I, Giorgio G, Goate AM, Goldhardt O, Gomez-Fonseca D, Gonz?lez-P?rez A, Graff C, Grande G, Green E, Grimmer T, Gr?nblatt E, Grunin M, Gudnason V, Guetta-Baranes T, Haapasalo A, Hadjigeorgiou G, Haines JL, Hamilton-Nelson KL, Hampel H, Hanon O, Hardy J, Hartmann AM, Hausner L, Harwood J, Heilmann-Heimbach S, Helisalmi S, Heneka MT, Hern?ndez I, Herrmann MJ, Hoffmann P, Holmes C, Holstege H, Vilas RH, Hulsman M, Humphrey J, Biessels GJ, Jian X, Johansson C, Jun GR, Kastumata Y, Kauwe J, Kehoe PG, Kilander L, St?hlbom AK, Kivipelto M, Koivisto A, Kornhuber J, Kosmidis MH, Kukull WA, Kuksa PP, Kunkle BW, Kuzma AB, Lage C, Laukka EJ, Launer L, Lauria A, Lee CY, Lehtisalo J, Lerch O, Lle? A, Longstreth W, Lopez O, de Munain AL, Love S, L?wemark M, Luckcuck L, Lunetta KL, Ma Y, Mac?as J, MacLeod CA, Maier W, Mangialasche F, Spallazzi M, Marqui? M, Marshall R, Martin ER, Montes AM, Rodr?guez CM, Masullo C, Mayeux R, Mead S, Mecocci P, Medina M, Meggy A, Mehrabian S, Mendoza S, Men?ndez-Gonz?lez M, Mir P, Moebus S, Mol M, Molina-Porcel L, Montrreal L, Morelli L, Moreno F, Morgan K, Mosley T, N?then MM, Muchnik C, Mukherjee S, Nacmias B, Ngandu T, Nicolas G, Nordestgaard BG, Olaso R, Orellana A, Orsini M, Ortega G, Padovani A, Paolo C, Papenberg G, Parnetti L, Pasquier F, Pastor P, Peloso G, P?rez-Cord?n A, P?rez-Tur J, Pericard P, Peters O, Pijnenburg YAL, Pineda JA, Pi?ol-Ripoll G, Pisanu C, Polak T, Popp J, Posthuma D, Priller J, Puerta R, Quenez O, Quintela I, Thomassen JQ, R?bano A, Rainero I, Rajabli F, Ramakers I, Real LM, Reinders MJT, Reitz C, Reyes-Dumeyer D, Ridge P, Riedel-Heller S, Riederer P, Roberto N, Rodriguez-Rodriguez E, Rongve A, Allende IR, Rosende-Roca M, Royo JL, Rubino E, Rujescu D, S?ez ME, Sakka P, Saltvedt I, Sanabria ?, S?nchez-Arjona MB, Sanchez-Garcia F, Juan PS, S?nchez-Valle R, Sando SB, Sarnowski C, Satizabal CL, Scamosci M, Scarmeas N, Scarpini E, Scheltens P, Scherbaum N, Scherer M, Schmid M, Schneider A, Schott JM, Selb?k G, Seripa D, Serrano M, Sha J, Shadrin AA, Skrobot O, Slifer S, Snijders GJL, Soininen H, Solfrizzi V, Solomon A, Song Y, Sorbi S, Sotolongo-Grau O, Spalletta G, Spottke A, Squassina A, Stordal E, Tartan JP, T?rraga L, Tes? N, Thalamuthu A, Thomas T, et al. New insights into the genetic etiology of Alzheimer's disease and related dementias. Nat Genet. 2022 04; 54(4):412-436. PMID: 35379992.
      Citations: 331     Fields:    Translation:Humans
    40. Jansen WJ, Janssen O, Tijms BM, Vos SJB, Ossenkoppele R, Visser PJ, Aarsland D, Alcolea D, Altomare D, von Arnim C, Baiardi S, Baldeiras I, Barthel H, Bateman RJ, Van Berckel B, Binette AP, Blennow K, Boada M, Boecker H, Bottlaender M, den Braber A, Brooks DJ, Van Buchem MA, Camus V, Carill JM, Cerman J, Chen K, Ch?telat G, Chipi E, Cohen AD, Daniels A, Delarue M, Didic M, Drzezga A, Dubois B, Eckerstr?m M, Ekblad LL, Engelborghs S, Epelbaum S, Fagan AM, Fan Y, Fladby T, Fleisher AS, Van der Flier WM, F?rster S, Fortea J, Frederiksen KS, Freund-Levi Y, Frings L, Frisoni GB, Fr?hlich L, Gabryelewicz T, Gertz HJ, Gill KD, Gkatzima O, G?mez-Tortosa E, Grimmer T, Guedj E, Habeck CG, Hampel H, Handels R, Hansson O, Hausner L, Hellwig S, Heneka MT, Herukka SK, Hildebrandt H, Hodges J, Hort J, Huang CC, Iriondo AJ, Itoh Y, Ivanoiu A, Jagust WJ, Jessen F, Johannsen P, Johnson KA, Kandimalla R, Kapaki EN, Kern S, Kilander L, Klimkowicz-Mrowiec A, Klunk WE, Koglin N, Kornhuber J, Kramberger MG, Kuo HC, Van Laere K, Landau SM, Landeau B, Lee DY, de Leon M, Leyton CE, Lin KJ, Lle? A, L?wenmark M, Madsen K, Maier W, Marcusson J, Marqui? M, Martinez-Lage P, Maserejian N, Mattsson N, de Mendon?a A, Meyer PT, Miller BL, Minatani S, Mintun MA, Mok VCT, Molinuevo JL, Morbelli SD, Morris JC, Mroczko B, Na DL, Newberg A, Nobili F, Nordberg A, Olde Rikkert MGM, de Oliveira CR, Olivieri P, Orellana A, Paraskevas G, Parchi P, Pardini M, Parnetti L, Peters O, Poirier J, Popp J, Prabhakar S, Rabinovici GD, Ramakers IH, Rami L, Reiman EM, Rinne JO, Rodrigue KM, Rodr?guez-Rodriguez E, Roe CM, Rosa-Neto P, Rosen HJ, Rot U, Rowe CC, R?ther E, Ruiz A, Sabri O, Sakhardande J, S?nchez-Juan P, Sando SB, Santana I, Sarazin M, Scheltens P, Schr?der J, Selnes P, Seo SW, Silva D, Skoog I, Snyder PJ, Soininen H, Sollberger M, Sperling RA, Spiru L, Stern Y, Stomrud E, Takeda A, Teichmann M, Teunissen CE, Thompson LI, Tomassen J, Tsolaki M, Vandenberghe R, Verbeek MM, Verhey FRJ, Villemagne V, Villeneuve S, Vogelgsang J, Waldemar G, Wallin A, Wallin ?K, Wiltfang J, Wolk DA, Yen TC, Zboch M, Zetterberg H. Prevalence Estimates of Amyloid Abnormality Across the Alzheimer Disease Clinical Spectrum. JAMA Neurol. 2022 03 01; 79(3):228-243. PMID: 35099509.
      Citations: 54     Fields:    Translation:Humans
    41. Perea JR, Bol?s M, Cuadros R, Garc?a E, Garc?a-Escudero V, Hern?ndez F, McManus RM, Heneka MT, Avila J. p38 Inhibition Decreases Tau Toxicity in Microglia and Improves Their Phagocytic Function. Mol Neurobiol. 2022 Mar; 59(3):1632-1648. PMID: 35006531.
      Citations: 1     Fields:    Translation:HumansCells
    42. Brosseron F, Maass A, Kleineidam L, Ravichandran KA, Gonz?lez PG, McManus RM, Ising C, Santarelli F, Kolbe CC, H?sler LM, Wolfsgruber S, Marqui? M, Boada M, Orellana A, de Rojas I, R?ske S, Peters O, Cosma NC, Cetindag A, Wang X, Priller J, Spruth EJ, Altenstein S, Schneider A, Fliessbach K, Wiltfang J, Schott BH, B?rger K, Janowitz D, Dichgans M, Perneczky R, Rauchmann BS, Teipel S, Kilimann I, Goerss D, Laske C, Munk MH, D?zel E, Yakupov R, Dobisch L, Metzger CD, Glanz W, Ewers M, Dechent P, Haynes JD, Scheffler K, Roy N, Rostamzadeh A, Teunissen CE, Marchant NL, Spottke A, Jucker M, Latz E, Wagner M, Mengel D, Synofzik M, Jessen F, Ramirez A, Ruiz A, Heneka MT. Soluble TAM receptors sAXL and sTyro3 predict structural and functional protection in Alzheimer's disease. Neuron. 2022 03 16; 110(6):1009-1022.e4. PMID: 34995486.
      Citations: 13     Fields:    Translation:Humans
    43. Wolfsgruber S, Kleineidam L, Weyrauch AS, Barkhoff M, R?ske S, Peters O, Preis L, Gref D, Spruth EJ, Altenstein S, Priller J, Flie?bach K, Schneider A, Wiltfang J, Bartels C, Jessen F, Maier F, D?zel E, Metzger C, Glanz W, Buerger K, Janowitz D, Perneczky R, Rauchmann BS, Kilimann I, Teipel S, Laske C, Munk MH, Roy N, Spottke A, Ramirez A, Heneka MT, Brosseron F, Wagner M. Relevance of Subjective Cognitive Decline in Older Adults with a First-Degree Family History of Alzheimer's Disease. J Alzheimers Dis. 2022; 87(2):545-555. PMID: 35275535.
      Citations: 4     Fields:    Translation:Humans
    44. Teipel SJ, Dyrba M, Ballarini T, Brosseron F, Bruno D, Buerger K, Cosma NC, Dechent P, Dobisch L, D?zel E, Ewers M, Fliessbach K, Haynes JD, Janowitz D, Kilimann I, Laske C, Maier F, Metzger CD, Munk MH, Peters O, Pomara N, Preis L, Priller J, Ram?rez A, Roy N, Scheffler K, Schneider A, Schott BH, Spottke A, Spruth EJ, Wagner M, Wiltfang J, Jessen F, Heneka MT. Association of Cholinergic Basal Forebrain Volume and Functional Connectivity with Markers of Inflammatory Response in the Alzheimer's Disease Spectrum. J Alzheimers Dis. 2022; 85(3):1267-1282. PMID: 34924387.
      Citations: 6     Fields:    Translation:Humans
    45. Ravichandran KA, Heneka MT. Inflammasome activation in neurodegenerative diseases. Essays Biochem. 2021 12 22; 65(7):885-904. PMID: 34846519.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    46. Janssen O, Jansen WJ, Vos SJB, Boada M, Parnetti L, Gabryelewicz T, Fladby T, Molinuevo JL, Villeneuve S, Hort J, Epelbaum S, Lle? A, Engelborghs S, van der Flier WM, Landau S, Popp J, Wallin A, Scheltens P, Rikkert MO, Snyder PJ, Rowe C, Ch?telat G, Ru?z A, Marqui? M, Chipi E, Wolfsgruber S, Heneka M, Boecker H, Peters O, Jarholm J, Rami L, Tort-Merino A, Binette AP, Poirier J, Rosa-Neto P, Cerman J, Dubois B, Teichmann M, Alcolea D, Fortea J, S?nchez-Saudin?s MB, Ebenau J, Pocnet C, Eckerstr?m M, Thompson L, Villemagne V, Buckley R, Burnham S, Delarue M, Freund-Levi Y, Wallin ?K, Ramakers I, Tsolaki M, Soininen H, Hampel H, Spiru L, Tijms B, Ossenkoppele R, Verhey FRJ, Jessen F, Visser PJ. Characteristics of subjective cognitive decline associated with amyloid positivity. Alzheimers Dement. 2022 Oct; 18(10):1832-1845. PMID: 34877782.
      Citations: 9     Fields:    Translation:Humans
    47. Gordon MN, Heneka MT, Le Page LM, Limberger C, Morgan D, Tenner AJ, Terrando N, Willette AA, Willette SA. Impact of COVID-19 on the Onset and Progression of Alzheimer's Disease and Related Dementias: A Roadmap for Future Research. Alzheimers Dement. 2022 05; 18(5):1038-1046. PMID: 34874605.
      Citations: 18     Fields:    Translation:HumansPHPublic Health
    48. Kummer MP, Ising C, Kummer C, Sarlus H, Griep A, Vieira-Saecker A, Schwartz S, Halle A, Br?ckner M, H?ndler K, Schultze JL, Beyer M, Latz E, Heneka MT. Microglial PD-1 stimulation by astrocytic PD-L1 suppresses neuroinflammation and Alzheimer's disease pathology. EMBO J. 2021 12 15; 40(24):e108662. PMID: 34825707.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    49. Dyrba M, Hanzig M, Altenstein S, Bader S, Ballarini T, Brosseron F, Buerger K, Cantr? D, Dechent P, Dobisch L, D?zel E, Ewers M, Fliessbach K, Glanz W, Haynes JD, Heneka MT, Janowitz D, Keles DB, Kilimann I, Laske C, Maier F, Metzger CD, Munk MH, Perneczky R, Peters O, Preis L, Priller J, Rauchmann B, Roy N, Scheffler K, Schneider A, Schott BH, Spottke A, Spruth EJ, Weber MA, Ertl-Wagner B, Wagner M, Wiltfang J, Jessen F, Teipel SJ. Improving 3D convolutional neural network comprehensibility via interactive visualization of relevance maps: evaluation in Alzheimer's disease. Alzheimers Res Ther. 2021 11 23; 13(1):191. PMID: 34814936.
      Citations: 9     Fields:    Translation:Humans
    50. Castro-Gomez S, Radermacher B, Tacik P, Mirandola SR, Heneka MT, Weydt P. Teaching an old dog new tricks: serum troponin T as a biomarker in amyotrophic lateral sclerosis. Brain Commun. 2021; 3(4):fcab274. PMID: 34993474.
      Citations:    
    51. Manabe T, Heneka MT. Cerebral dysfunctions caused by sepsis during ageing. Nat Rev Immunol. 2022 07; 22(7):444-458. PMID: 34764472.
      Citations: 29     Fields:    Translation:Humans
    52. Widmann CN, Wieberneit M, Bieler L, Bernsen S, Gr?fenk?mper R, Brosseron F, Schmeel C, Tacik P, Skowasch D, Radbruch A, Heneka MT. Longitudinal Neurocognitive and Pulmonological Profile of Long COVID-19: Protocol for the COVIMMUNE-Clin Study. JMIR Res Protoc. 2021 Nov 11; 10(11):e30259. PMID: 34559059.
      Citations:    
    53. Bettcher BM, Tansey MG, Doroth?e G, Heneka MT. Publisher Correction: Peripheral and central immune system crosstalk in Alzheimer disease - a research prospectus. Nat Rev Neurol. 2021 Nov; 17(11):724. PMID: 34625724.
      Citations: 2     Fields:    
    54. Joshi P, Riffel F, Kumar S, Villacampa N, Theil S, Parhizkar S, Haass C, Colonna M, Heneka MT, Arzberger T, Herms J, Walter J. TREM2 modulates differential deposition of modified and non-modified A? species in extracellular plaques and intraneuronal deposits. Acta Neuropathol Commun. 2021 10 18; 9(1):168. PMID: 34663480.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    55. Keane L, Antignano I, Riechers SP, Zollinger R, Dumas AA, Offermann N, Bernis ME, Russ J, Graelmann F, McCormick PN, Esser J, Tejera D, Nagano A, Wang J, Chelala C, Biederbick Y, Halle A, Salomoni P, Heneka MT, Capasso M. mTOR-dependent translation amplifies microglia priming in aging mice. J Clin Invest. 2021 10 15; 131(20). PMID: 34651589.
      Citations: 2     Fields:    
    56. Islam MR, Kaurani L, Berulava T, Heilbronner U, Budde M, Centeno TP, Elerdashvili V, Zafieriou MP, Benito E, Sertel SM, Goldberg M, Senner F, Kalman JL, Burkhardt S, Oepen AS, Sakib MS, Kerimoglu C, Wirths O, Bickeb?ller H, Bartels C, Brosseron F, Buerger K, Cosma NC, Fliessbach K, Heneka MT, Janowitz D, Kilimann I, Kleinedam L, Laske C, Metzger CD, Munk MH, Perneczky R, Peters O, Priller J, Rauchmann BS, Roy N, Schneider A, Spottke A, Spruth EJ, Teipel S, Tscheuschler M, Wagner M, Wiltfang J, D?zel E, Jessen F, Rizzoli SO, Zimmermann WH, Schulze TG, Falkai P, Sananbenesi F, Fischer A. A microRNA signature that correlates with cognition and is a target against cognitive decline. EMBO Mol Med. 2021 11 08; 13(11):e13659. PMID: 34633146.
      Citations: 18     Fields:    Translation:Humans
    57. Rauchmann BS, Ersoezlue E, Stoecklein S, Keeser D, Brosseron F, Buerger K, Dechent P, Dobisch L, Ertl-Wagner B, Fliessbach K, Haynes JD, Heneka MT, Incesoy EI, Janowitz D, Kilimann I, Laske C, Metzger CD, Munk MH, Peters O, Priller J, Ramirez A, Roeske S, Roy N, Scheffler K, Schneider A, Spottke A, Spruth EJ, Teipel S, Tscheuschler M, Vukovich R, Wagner M, Wiltfang J, Yakupov R, Duezel E, Jessen F, Perneczky R. Resting-State Network Alterations Differ between Alzheimer's Disease Atrophy Subtypes. Cereb Cortex. 2021 10 01; 31(11):4901-4915. PMID: 34080613.
      Citations: 6     Fields:    Translation:Humans
    58. Rueda-Carrasco J, Martin-Bermejo MJ, Pereyra G, Mateo MI, Borroto A, Brosseron F, Kummer MP, Schwartz S, L?pez-Atalaya JP, Alarcon B, Esteve P, Heneka MT, Bovolenta P. SFRP1 modulates astrocyte-to-microglia crosstalk in acute and chronic neuroinflammation. EMBO Rep. 2021 11 04; 22(11):e51696. PMID: 34569685.
      Citations: 14     Fields:    Translation:AnimalsCells
    59. Scheiblich H, Dansokho C, Mercan D, Schmidt SV, Bousset L, Wischhof L, Eikens F, Odainic A, Spitzer J, Griep A, Schwartz S, Bano D, Latz E, Melki R, Heneka MT. Microglia jointly degrade fibrillar alpha-synuclein cargo by distribution through tunneling nanotubes. Cell. 2021 09 30; 184(20):5089-5106.e21. PMID: 34555357.
      Citations: 87     Fields:    Translation:HumansAnimalsCells
    60. Jiang S, Maphis NM, Binder J, Chisholm D, Weston L, Duran W, Peterson C, Zimmerman A, Mandell MA, Jett SD, Bigio E, Geula C, Mellios N, Weick JP, Rosenberg GA, Latz E, Heneka MT, Bhaskar K. Proteopathic tau primes and activates interleukin-1? via myeloid-cell-specific MyD88- and NLRP3-ASC-inflammasome pathway. Cell Rep. 2021 09 21; 36(12):109720. PMID: 34551296.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    61. Bettcher BM, Tansey MG, Doroth?e G, Heneka MT. Peripheral and central immune system crosstalk in Alzheimer disease - a research prospectus. Nat Rev Neurol. 2021 11; 17(11):689-701. PMID: 34522039.
      Citations: 96     Fields:    Translation:HumansAnimals
    62. Scheiblich H, Bousset L, Schwartz S, Griep A, Latz E, Melki R, Heneka MT. Microglial NLRP3 Inflammasome Activation upon TLR2 and TLR5 Ligation by Distinct a-Synuclein Assemblies. J Immunol. 2021 10 15; 207(8):2143-2154. PMID: 34507948.
      Citations: 30     Fields:    Translation:AnimalsCells
    63. Joshi P, Riffel F, Satoh K, Enomoto M, Qamar S, Scheiblich H, Villacampa N, Kumar S, Theil S, Parhizkar S, Haass C, Heneka MT, Fraser PE, St George-Hyslop P, Walter J. Differential interaction with TREM2 modulates microglial uptake of modified A? species. Glia. 2021 12; 69(12):2917-2932. PMID: 34427354.
      Citations: 8     Fields:    Translation:AnimalsCells
    64. Manabe T, R?cz I, Schwartz S, Oberle L, Santarelli F, Emmrich JV, Neher JJ, Heneka MT. Systemic inflammation induced the delayed reduction of excitatory synapses in the CA3 during ageing. J Neurochem. 2021 11; 159(3):525-542. PMID: 34379806.
      Citations: 13     Fields:    Translation:AnimalsCells
    65. Aretz B, Janssen F, Vonk JM, Heneka MT, Boezen HM, Doblhammer G. Long-term exposure to fine particulate matter, lung function and cognitive performance: A prospective Dutch cohort study on the underlying routes. Environ Res. 2021 10; 201:111533. PMID: 34153335.
      Citations: 6     Fields:    Translation:HumansPHPublic Health
    66. Bergstr?m S, Remnest?l J, Yousef J, Olofsson J, Markaki I, Carvalho S, Corvol JC, Kultima K, Kilander L, L?wenmark M, Ingelsson M, Blennow K, Zetterberg H, Nellg?rd B, Brosseron F, Heneka MT, Bosch B, Sanchez-Valle R, M?nberg A, Svenningsson P, Nilsson P. Multi-cohort profiling reveals elevated CSF levels of brain-enriched proteins in Alzheimer's disease. Ann Clin Transl Neurol. 2021 07; 8(7):1456-1470. PMID: 34129723.
      Citations: 9     Fields:    Translation:Humans
    67. Ballarini T, Melo van Lent D, Brunner J, Schr?der A, Wolfsgruber S, Altenstein S, Brosseron F, Buerger K, Dechent P, Dobisch L, Duzel E, Ertl-Wagner B, Fliessbach K, Freiesleben SD, Frommann I, Glanz W, Hauser D, Haynes JD, Heneka MT, Janowitz D, Kilimann I, Laske C, Maier F, Metzger CD, Munk M, Perneczky R, Peters O, Priller J, Ramirez A, Rauchmann B, Roy N, Scheffler K, Schneider A, Spottke A, Spruth EJ, Teipel SJ, Vukovich R, Wiltfang J, Jessen F, Wagner M. Mediterranean Diet, Alzheimer Disease Biomarkers and Brain Atrophy in Old Age. Neurology. 2021 06 15; 96(24):e2920-e2932. PMID: 33952652.
      Citations: 39     Fields:    
    68. de Rojas I, Moreno-Grau S, Tesi N, Grenier-Boley B, Andrade V, Jansen IE, Pedersen NL, Stringa N, Zettergren A, Hern?ndez I, Montrreal L, Ant?nez C, Antonell A, Tankard RM, Bis JC, Sims R, Bellenguez C, Quintela I, Gonz?lez-Perez A, Calero M, Franco-Mac?as E, Mac?as J, Blesa R, Cervera-Carles L, Men?ndez-Gonz?lez M, Frank-Garc?a A, Royo JL, Moreno F, Huerto Vilas R, Baquero M, Diez-Fairen M, Lage C, Garc?a-Madrona S, Garc?a-Gonz?lez P, Alarc?n-Mart?n E, Valero S, Sotolongo-Grau O, Ullgren A, Naj AC, Lemstra AW, Benaque A, P?rez-Cord?n A, Benussi A, R?bano A, Padovani A, Squassina A, de Mendon?a A, Arias Pastor A, Kok AAL, Meggy A, Pastor AB, Espinosa A, Corma-G?mez A, Mart?n Montes A, Sanabria ?, DeStefano AL, Schneider A, Haapasalo A, Kinhult St?hlbom A, Tybj?rg-Hansen A, Hartmann AM, Spottke A, Corbat?n-Anchuelo A, Rongve A, Borroni B, Arosio B, Nacmias B, Nordestgaard BG, Kunkle BW, Charbonnier C, Abdelnour C, Masullo C, Mart?nez Rodr?guez C, Mu?oz-Fernandez C, Dufouil C, Graff C, Ferreira CB, Chillotti C, Reynolds CA, Fenoglio C, Van Broeckhoven C, Clark C, Pisanu C, Satizabal CL, Holmes C, Buiza-Rueda D, Aarsland D, Rujescu D, Alcolea D, Galimberti D, Wallon D, Seripa D, Gr?nblatt E, Dardiotis E, D?zel E, Scarpini E, Conti E, Rubino E, Gelpi E, Rodriguez-Rodriguez E, Duron E, Boerwinkle E, Ferri E, Tagliavini F, K???kali F, Pasquier F, Sanchez-Garcia F, Mangialasche F, Jessen F, Nicolas G, Selb?k G, Ortega G, Ch?ne G, Hadjigeorgiou G, Rossi G, Spalletta G, Giaccone G, Grande G, Binetti G, Papenberg G, Hampel H, Bailly H, Zetterberg H, Soininen H, Karlsson IK, Alvarez I, Appollonio I, Giegling I, Skoog I, Saltvedt I, Rainero I, Rosas Allende I, Hort J, Diehl-Schmid J, Van Dongen J, Vidal JS, Lehtisalo J, Wiltfang J, Thomassen JQ, Kornhuber J, Haines JL, Vogelgsang J, Pineda JA, Fortea J, Popp J, Deckert J, Buerger K, Morgan K, Flie?bach K, Sleegers K, Molina-Porcel L, Kilander L, Weinhold L, Farrer LA, Wang LS, Kleineidam L, Farotti L, Parnetti L, Tremolizzo L, Hausner L, Benussi L, Froelich L, Ikram MA, Deniz-Naranjo MC, Tsolaki M, Rosende-Roca M, L?wenmark M, Hulsman M, Spallazzi M, Pericak-Vance MA, Esiri M, Bernal S?nchez-Arjona M, Dalmasso MC, Mart?nez-Larrad MT, Arcaro M, N?then MM, Fern?ndez-Fuertes M, Dichgans M, Ingelsson M, Herrmann MJ, Scherer M, Vyhnalek M, Kosmidis MH, Yannakoulia M, Schmid M, Ewers M, Heneka MT, Wagner M, Scamosci M, Kivipelto M, Hiltunen M, Zulaica M, Alegret M, Fornage M, Roberto N, van Schoor NM, Seidu NM, Banaj N, Armstrong NJ, Scarmeas N, Scherbaum N, Goldhardt O, Hanon O, Peters O, Skrobot OA, Quenez O, Lerch O, Boss? P, Caffarra P, Dionigi Rossi P, Sakka P, Mecocci P, Hoffmann P, Holmans PA, Fischer P, Riederer P, Yang Q, Marshall R, Kalaria RN, Mayeux R, Vandenberghe R, Cecchetti R, Ghidoni R, Frikke-Schmidt R, Sorbi S, H?gg S, Engelborghs S, Helisalmi S, Botne Sando S, Kern S, Archetti S, Boschi S, Fostinelli S, Gil S, Mendoza S, Mead S, Ciccone S, Djurovic S, Heilmann-Heimbach S, Riedel-Heller S, Kuulasmaa T, Del Ser T, Lebouvier T, Polak T, Ngandu T, Grimmer T, Bessi V, Escott-Price V, Giedraitis V, Deramecourt V, Maier W, Jian X, Pijnenburg YAL, Kehoe PG, Garcia-Ribas G, S?nchez-Juan P, Pastor P, P?rez-Tur J, Pi?ol-Ripoll G, Lopez de Munain A, Garc?a-Alberca JM, Bullido MJ, ?lvarez V, Lle? A, Real LM, Mir P, Medina M, Scheltens P, Holstege H, Marqui? M, S?ez ME, Carracedo ?, Amouyel P, Schellenberg GD, Williams J, Seshadri S, van Duijn CM, Mather KA, S?nchez-Valle R, Serrano-R?os M, Orellana A, T?rraga L, Blennow K, Huisman M, Andreassen OA, Posthuma D, Clarim?n J, Boada M, van der Flier WM, Ramirez A, Lambert JC, van der Lee SJ, Ruiz A. Common variants in Alzheimer's disease and risk stratification by polygenic risk scores. Nat Commun. 2021 06 07; 12(1):3417. PMID: 34099642.
      Citations: 72     Fields:    Translation:Humans
    69. Odoj K, Brawek B, Asavapanumas N, Mojtahedi N, Heneka MT, Garaschuk O. In vivo mechanisms of cortical network dysfunction induced by systemic inflammation. Brain Behav Immun. 2021 08; 96:113-126. PMID: 34052361.
      Citations: 6     Fields:    Translation:AnimalsCells
    70. Nitsch L, Petzinna S, Zimmermann J, Schneider L, Krauthausen M, Heneka MT, Getts DR, Becker A, M?ller M. Astrocyte-specific expression of interleukin 23 leads to an aggravated phenotype and enhanced inflammatory response with B cell accumulation in the EAE model. J Neuroinflammation. 2021 Apr 27; 18(1):101. PMID: 33906683.
      Citations: 7     Fields:    Translation:AnimalsCells
    71. Hansen N, Singh A, Bartels C, Brosseron F, Buerger K, Cetindag AC, Dobisch L, Dechent P, Ertl-Wagner BB, Fliessbach K, Haynes JD, Heneka MT, Janowitz D, Kilimann I, Laske C, Metzger CD, Munk MH, Peters O, Priller J, Roy N, Scheffler K, Schneider A, Spottke A, Spruth EJ, Teipel S, Tscheuschler M, Vukovich R, Wiltfang J, Duezel E, Jessen F, Goya-Maldonado R. Hippocampal and Hippocampal-Subfield Volumes From Early-Onset Major Depression and Bipolar Disorder to Cognitive Decline. Front Aging Neurosci. 2021; 13:626974. PMID: 33967736.
      Citations:    
    72. Netea MG, Balkwill F, Chonchol M, Cominelli F, Donath MY, Giamarellos-Bourboulis EJ, Golenbock D, Gresnigt MS, Heneka MT, Hoffman HM, Hotchkiss R, Joosten LAB, Kastner DL, Korte M, Latz E, Libby P, Mandrup-Poulsen T, Mantovani A, Mills KHG, Nowak KL, O'Neill LA, Pickkers P, van der Poll T, Ridker PM, Schalkwijk J, Schwartz DA, Siegmund B, Steer CJ, Tilg H, van der Meer JWM, van de Veerdonk FL, Dinarello CA. Author Correction: A guiding map for inflammation. Nat Immunol. 2021 Feb; 22(2):254. PMID: 33288963.
      Citations: 3     Fields:    
    73. Ribon M, Leone C, Chiot A, Berriat F, Rampanana M, Cottin J, Bohl D, Millecamps S, Lobsiger CS, Heneka MT, Boill?e S. Deletion of the inflammatory S100-A9/MRP14 protein does not influence survival in hSOD1G93A ALS mice. Neurobiol Aging. 2021 05; 101:181-186. PMID: 33626479.
      Citations: 1     Fields:    Translation:AnimalsCells
    74. Kumar S, Kapadia A, Theil S, Joshi P, Riffel F, Heneka MT, Walter J. Novel Phosphorylation-State Specific Antibodies Reveal Differential Deposition of Ser26 Phosphorylated A? Species in a Mouse Model of Alzheimer's Disease. Front Mol Neurosci. 2020; 13:619639. PMID: 33519377.
      Citations:    
    75. Keane L, Antignano I, Riechers SP, Zollinger R, Dumas AA, Offermann N, Bernis ME, Russ J, Graelmann F, McCormick PN, Esser J, Tejera D, Nagano A, Wang J, Chelala C, Biederbick Y, Halle A, Salomoni P, Heneka MT, Capasso M. mTOR-dependent translation amplifies microglia priming in aging mice. J Clin Invest. 2021 01 04; 131(1). PMID: 33108356.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    76. Lage C, Gonz?lez-Su?rez A, Alcalde-Hierro MP, Sampedro-Gonz?lez MI, Villanueva-Eguaras M?, S?nchez-Crespo MR, Widmann C, Brosseron F, Pozueta A, L?pez-Garc?a S, Garc?a-Mart?nez M, Kazimierczak M, Bravo-Gonz?lez M, Fern?ndez-Rodr?guez A, Drake-P?rez M, Irure-Ventura J, L?pez-Hoyos M, Rodr?guez-Rodr?guez E, Heneka MT, S?nchez-Juan P. Major Surgery Affects Memory in Individuals with Cerebral Amyloid-? Pathology. J Alzheimers Dis. 2021; 79(2):863-874. PMID: 33361588.
      Citations: 5     Fields:    Translation:Humans
    77. Fritze T, Doblhammer G, Widmann CN, Heneka MT. Time course of dementia following sepsis in German health claims data. Neurol Neuroimmunol Neuroinflamm. 2021 01; 8(1). PMID: 33293458.
      Citations: 4     Fields:    Translation:Humans
    78. Herdick M, Dyrba M, Fritz HJ, Altenstein S, Ballarini T, Brosseron F, Buerger K, Can Cetindag A, Dechent P, Dobisch L, Duezel E, Ertl-Wagner B, Fliessbach K, Dawn Freiesleben S, Frommann I, Glanz W, Dylan Haynes J, Heneka MT, Janowitz D, Kilimann I, Laske C, Metzger CD, Munk MH, Peters O, Priller J, Roy N, Scheffler K, Schneider A, Spottke A, Jakob Spruth E, Tscheuschler M, Vukovich R, Wiltfang J, Jessen F, Teipel S, Grothe MJ. Multimodal MRI analysis of basal forebrain structure and function across the Alzheimer's disease spectrum. Neuroimage Clin. 2020; 28:102495. PMID: 33395986.
      Citations: 10     Fields:    Translation:Humans
    79. Sannemann L, Schild AK, Altenstein S, Bartels C, Brosseron F, Buerger K, Cosma NC, Fliessbach K, Freiesleben SD, Glanz W, Heneka MT, Janowitz D, Kilimann I, Kobeleva X, Laske C, Metzger CD, Munk MHJ, Perneczky R, Peters O, Polcher A, Priller J, Rauchmann B, R?sch C, Rudolph J, Schneider A, Spottke A, Spruth EJ, Teipel S, Vukovich R, Wagner M, Wiltfang J, Wolfsgruber S, Duezel E, Jessen F. Neuropsychiatric symptoms in at-risk groups for AD dementia and their association with worry and AD biomarkers-results from the DELCODE study. Alzheimers Res Ther. 2020 10 16; 12(1):131. PMID: 33066827.
      Citations: 5     Fields:    Translation:Humans
    80. Brosseron F, Kleemann K, Kolbe CC, Santarelli F, Castro-Gomez S, Tacik P, Latz E, Jessen F, Heneka MT. Interrelations of Alzheimer?s disease candidate biomarkers neurogranin, fatty acid-binding protein 3 and ferritin to neurodegeneration and neuroinflammation. J Neurochem. 2021 06; 157(6):2210-2224. PMID: 32894885.
      Citations: 8     Fields:    Translation:Humans
    81. Finsterwalder S, Vlegels N, Gesierich B, Araque Caballero M?, Weaver NA, Franzmeier N, Georgakis MK, Konieczny MJ, Koek HL, Karch CM, Graff-Radford NR, Salloway S, Oh H, Allegri RF, Chhatwal JP, Jessen F, D?zel E, Dobisch L, Metzger C, Peters O, Incesoy EI, Priller J, Spruth EJ, Schneider A, Flie?bach K, Buerger K, Janowitz D, Teipel SJ, Kilimann I, Laske C, Buchmann M, Heneka MT, Brosseron F, Spottke A, Roy N, Ertl-Wagner B, Scheffler K, Seo SW, Kim Y, Na DL, Kim HJ, Jang H, Ewers M, Levin J, Schmidt R, Pasternak O, Dichgans M, Biessels GJ, Duering M. Small vessel disease more than Alzheimer's disease determines diffusion MRI alterations in memory clinic patients. Alzheimers Dement. 2020 11; 16(11):1504-1514. PMID: 32808747.
      Citations: 23     Fields:    Translation:Humans
    82. Wolfsgruber S, Kleineidam L, Guski J, Polcher A, Frommann I, Roeske S, Spruth EJ, Franke C, Priller J, Kilimann I, Teipel S, Buerger K, Janowitz D, Laske C, Buchmann M, Peters O, Menne F, Fuentes Casan M, Wiltfang J, Bartels C, D?zel E, Metzger C, Glanz W, Thelen M, Spottke A, Ramirez A, Kofler B, Flie?bach K, Schneider A, Heneka MT, Brosseron F, Meiberth D, Jessen F, Wagner M. Minor neuropsychological deficits in patients with subjective cognitive decline. Neurology. 2020 09 01; 95(9):e1134-e1143. PMID: 32636322.
      Citations: 23     Fields:    Translation:HumansCells
    83. Beyer MMS, Lonnemann N, Remus A, Latz E, Heneka MT, Korte M. Enduring Changes in Neuronal Function upon Systemic Inflammation Are NLRP3 Inflammasome Dependent. J Neurosci. 2020 07 08; 40(28):5480-5494. PMID: 32499379.
      Citations: 24     Fields:    Translation:Animals
    84. Heneka MT, Golenbock D, Latz E, Morgan D, Brown R. Immediate and long-term consequences of COVID-19 infections for the development of neurological disease. Alzheimers Res Ther. 2020 06 04; 12(1):69. PMID: 32498691.
      Citations: 207     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    85. Schr?der N, Schaffrath A, Welter JA, Putzka T, Griep A, Ziegler P, Brandt E, Samer S, Heneka MT, Kaddatz H, Zhan J, Kipp E, Pufe T, Tauber SC, Kipp M, Brandenburg LO. Inhibition of formyl peptide receptors improves the outcome in a mouse model of Alzheimer disease. J Neuroinflammation. 2020 Apr 24; 17(1):131. PMID: 32331524.
      Citations: 13     Fields:    Translation:Animals
    86. Villacampa N, Heneka MT. Microglia in Alzheimer's disease: Local heroes! J Exp Med. 2020 04 06; 217(4). PMID: 32126139.
      Citations: 6     Fields:    Translation:HumansCells
    87. McManus RM, Heneka MT. T cells in Alzheimer's disease: space invaders. Lancet Neurol. 2020 04; 19(4):285-287. PMID: 32199089.
      Citations: 7     Fields:    Translation:HumansCells
    88. Friker LL, Scheiblich H, Hochheiser IV, Brinkschulte R, Riedel D, Latz E, Geyer M, Heneka MT. ?-Amyloid Clustering around ASC Fibrils Boosts Its Toxicity in Microglia. Cell Rep. 2020 03 17; 30(11):3743-3754.e6. PMID: 32187546.
      Citations: 68     Fields:    Translation:HumansAnimalsCells
    89. Kleineidam L, Chouraki V, Pr?chnicki T, van der Lee SJ, Madrid-M?rquez L, Wagner-Thelen H, Karaca I, Weinhold L, Wolfsgruber S, Boland A, Martino Adami PV, Lewczuk P, Popp J, Brosseron F, Jansen IE, Hulsman M, Kornhuber J, Peters O, Berr C, Heun R, Fr?lich L, Tzourio C, Dartigues JF, H?ll M, Espinosa A, Hern?ndez I, de Rojas I, Orellana A, Valero S, Stringa N, van Schoor NM, Huisman M, Scheltens P, R?ther E, Deleuze JF, Wiltfang J, Tarraga L, Schmid M, Scherer M, Riedel-Heller S, Heneka MT, Amouyel P, Jessen F, Boada M, Maier W, Schneider A, Gonz?lez-P?rez A, van der Flier WM, Wagner M, Lambert JC, Holstege H, S?ez ME, Latz E, Ruiz A, Ramirez A. PLCG2 protective variant p.P522R modulates tau pathology and disease progression in patients with mild cognitive impairment. Acta Neuropathol. 2020 06; 139(6):1025-1044. PMID: 32166339.
      Citations: 23     Fields:    Translation:Humans
    90. Itzhaki RF, Golde TE, Heneka MT, Readhead B. Do infections have a role in the pathogenesis of Alzheimer disease? Nat Rev Neurol. 2020 04; 16(4):193-197. PMID: 32152461.
      Citations: 54     Fields:    Translation:HumansCells
    91. Scheiblich H, Trombly M, Ramirez A, Heneka MT. Neuroimmune Connections in Aging and Neurodegenerative Diseases. Trends Immunol. 2020 04; 41(4):300-312. PMID: 32147113.
      Citations: 63     Fields:    Translation:Humans
    92. Luciunaite A, McManus RM, Jankunec M, R?cz I, Dansokho C, Dalgediene I, Schwartz S, Brosseron F, Heneka MT. Soluble A? oligomers and protofibrils induce NLRP3 inflammasome activation in microglia. J Neurochem. 2020 12; 155(6):650-661. PMID: 31872431.
      Citations: 55     Fields:    Translation:AnimalsCells
    93. Brosseron F, Kolbe CC, Santarelli F, Carvalho S, Antonell A, Castro-Gomez S, Tacik P, Namasivayam AA, Mangone G, Schneider R, Latz E, W?llner U, Svenningsson P, S?nchez-Valle R, Molinuevo JL, Corvol JC, Heneka MT. Multicenter Alzheimer's and Parkinson's disease immune biomarker verification study. Alzheimers Dement. 2020 02; 16(2):292-304. PMID: 31630996.
      Citations: 18     Fields:    Translation:Humans
    94. Heneka MT. An immune-cell signature marks the brain in Alzheimer's disease. Nature. 2020 01; 577(7790):322-323. PMID: 31937952.
      Citations: 7     Fields:    Translation:HumansCells
    95. Trasch?tz A, Enkirch SJ, Polomac N, Widmann CN, Schild HH, Heneka MT, Hattingen E. The Entorhinal Cortex Atrophy Score Is Diagnostic and Prognostic in Mild Cognitive Impairment. J Alzheimers Dis. 2020; 75(1):99-108. PMID: 32250289.
      Citations: 8     Fields:    Translation:Humans
    96. Riester K, Brawek B, Savitska D, Fr?hlich N, Zirdum E, Mojtahedi N, Heneka MT, Garaschuk O. In vivo characterization of functional states of cortical microglia during peripheral inflammation. Brain Behav Immun. 2020 07; 87:243-255. PMID: 31837418.
      Citations: 11     Fields:    Translation:HumansCells
    97. Mantile F, Capasso A, Villacampa N, Donnini M, Liguori GL, Constantin G, De Berardinis P, Heneka MT, Prisco A. Vaccination with (1-11)E2 in alum efficiently induces an antibody response to ?-amyloid without affecting brain ?-amyloid load and microglia activation in 3xTg mice. Aging Clin Exp Res. 2021 May; 33(5):1383-1387. PMID: 31758499.
      Citations: 3     Fields:    Translation:AnimalsCellsPHPublic Health
    98. Ising C, Venegas C, Zhang S, Scheiblich H, Schmidt SV, Vieira-Saecker A, Schwartz S, Albasset S, McManus RM, Tejera D, Griep A, Santarelli F, Brosseron F, Opitz S, Stunden J, Merten M, Kayed R, Golenbock DT, Blum D, Latz E, Bu?e L, Heneka MT. NLRP3 inflammasome activation drives tau pathology. Nature. 2019 11; 575(7784):669-673. PMID: 31748742.
      Citations: 459     Fields:    Translation:HumansAnimalsCells
    99. Webers A, Heneka MT, Gleeson PA. The role of innate immune responses and neuroinflammation in amyloid accumulation and progression of Alzheimer's disease. Immunol Cell Biol. 2020 01; 98(1):28-41. PMID: 31654430.
      Citations: 141     Fields:    Translation:HumansAnimalsCells
    100. Venegas C, Heneka MT. Inflammasome-mediated innate immunity in Alzheimer's disease. FASEB J. 2019 12; 33(12):13075-13084. PMID: 31702392.
      Citations: 30     Fields:    Translation:HumansAnimalsCells
    101. Mercan D, Heneka MT. Norepinephrine as a modulator of microglial dynamics. Nat Neurosci. 2019 11; 22(11):1745-1746. PMID: 31636450.
      Citations: 2     Fields:    Translation:AnimalsCells
    102. Wijasa TS, Sylvester M, Brocke-Ahmadinejad N, Schwartz S, Santarelli F, Gieselmann V, Klockgether T, Brosseron F, Heneka MT. Quantitative proteomics of synaptosome S-nitrosylation in Alzheimer's disease. J Neurochem. 2020 03; 152(6):710-726. PMID: 31520481.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    103. Berron D, Cardenas-Blanco A, Bittner D, Metzger CD, Spottke A, Heneka MT, Fliessbach K, Schneider A, Teipel SJ, Wagner M, Speck O, Jessen F, D?zel E. Higher CSF Tau Levels Are Related to Hippocampal Hyperactivity and Object Mnemonic Discrimination in Older Adults. J Neurosci. 2019 10 30; 39(44):8788-8797. PMID: 31541019.
      Citations: 34     Fields:    Translation:Humans
    104. Karsak M, Glebov K, Scheffold M, Bajaj T, Kawalia A, Karaca I, Rading S, Kornhuber J, Peters O, Diez-Fairen M, Fr?lich L, H?ll M, Wiltfang J, Scherer M, Riedel-Heller S, Schneider A, Heneka MT, Fliessbach K, Sharaf A, Thiele H, Lennarz M, Jessen F, Maier W, Kubisch C, Ignatova Z, N?rnberg P, Pastor P, Walter J, Ramirez A. A rare heterozygous TREM2 coding variant identified in familial clustering of dementia affects an intrinsically disordered protein region and function of TREM2. Hum Mutat. 2020 01; 41(1):169-181. PMID: 31464095.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    105. Bainbridge WA, Berron D, Sch?tze H, Cardenas-Blanco A, Metzger C, Dobisch L, Bittner D, Glanz W, Spottke A, Rudolph J, Brosseron F, Buerger K, Janowitz D, Fliessbach K, Heneka M, Laske C, Buchmann M, Peters O, Diesing D, Li S, Priller J, Spruth EJ, Altenstein S, Schneider A, Kofler B, Teipel S, Kilimann I, Wiltfang J, Bartels C, Wolfsgruber S, Wagner M, Jessen F, Baker CI, D?zel E. Memorability of photographs in subjective cognitive decline and mild cognitive impairment: Implications for cognitive assessment. Alzheimers Dement (Amst). 2019 Dec; 11:610-618. PMID: 31517023.
      Citations:    
    106. Castro-Gomez S, Binder J, Heneka MT. [Neuroinflammation as motor of Alzheimer's disease]. Nervenarzt. 2019 Sep; 90(9):898-906. PMID: 31428829.
      Citations: 5     Fields:    Translation:HumansCells
    107. Bertens D, Vos S, Kehoe P, Wolf H, Nobili F, Mendon?a A, van Rossum I, Hort J, Molinuevo JL, Heneka M, Petersen R, Scheltens P, Visser PJ. Use of mild cognitive impairment and prodromal AD/MCI due to AD in clinical care: a European survey. Alzheimers Res Ther. 2019 08 22; 11(1):74. PMID: 31439020.
      Citations: 13     Fields:    Translation:Humans
    108. Miebach L, Wolfsgruber S, Polcher A, Peters O, Menne F, Luther K, Incesoy E, Priller J, Spruth E, Altenstein S, Buerger K, Catak C, Janowitz D, Perneczky R, Utecht J, Laske C, Buchmann M, Schneider A, Fliessbach K, Kalbhen P, Heneka MT, Brosseron F, Spottke A, Roy N, Teipel SJ, Kilimann I, Wiltfang J, Bartels C, D?zel E, Dobisch L, Metzger C, Meiberth D, Ramirez A, Jessen F, Wagner M. Which features of subjective cognitive decline are related to amyloid pathology? Findings from the DELCODE study. Alzheimers Res Ther. 2019 07 31; 11(1):66. PMID: 31366409.
      Citations: 38     Fields:    Translation:Humans
    109. Tejera D, Mercan D, Sanchez-Caro JM, Hanan M, Greenberg D, Soreq H, Latz E, Golenbock D, Heneka MT. Systemic inflammation impairs microglial A? clearance through NLRP3 inflammasome. EMBO J. 2019 09 02; 38(17):e101064. PMID: 31359456.
      Citations: 123     Fields:    Translation:HumansAnimalsCells
    110. Esteve P, Rueda-Carrasco J, In?s Mateo M, Martin-Bermejo MJ, Draffin J, Pereyra G, Sandon?s ?, Crespo I, Moreno I, Aso E, Garcia-Esparcia P, Gomez-Tortosa E, R?bano A, Fortea J, Alcolea D, Lleo A, Heneka MT, Valpuesta JM, Esteban JA, Ferrer I, Dom?nguez M, Bovolenta P. Elevated levels of Secreted-Frizzled-Related-Protein 1 contribute to Alzheimer's disease pathogenesis. Nat Neurosci. 2019 08; 22(8):1258-1268. PMID: 31308530.
      Citations: 27     Fields:    Translation:HumansAnimalsCells
    111. Nitsch L, Zimmermann J, Krauthausen M, Hofer MJ, Saggu R, Petzold GC, Heneka MT, Getts DR, Becker A, Campbell IL, M?ller M. CNS-Specific Synthesis of Interleukin 23 Induces a Progressive Cerebellar Ataxia and the Accumulation of Both T and B Cells in the Brain: Characterization of a Novel Transgenic Mouse Model. Mol Neurobiol. 2019 Dec; 56(12):7977-7993. PMID: 31154574.
      Citations: 8     Fields:    Translation:AnimalsCells
    112. Franzmeier N, Ren J, Damm A, Mont?-Rubio G, Boada M, Ruiz A, Ramirez A, Jessen F, D?zel E, Rodr?guez G?mez O, Benzinger T, Goate A, Karch CM, Fagan AM, McDade E, Buerger K, Levin J, Duering M, Dichgans M, Su?rez-Calvet M, Haass C, Gordon BA, Lim YY, Masters CL, Janowitz D, Catak C, Wolfsgruber S, Wagner M, Milz E, Moreno-Grau S, Teipel S, Grothe MJ, Kilimann I, Rossor M, Fox N, Laske C, Chhatwal J, Falkai P, Perneczky R, Lee JH, Spottke A, Boecker H, Brosseron F, Fliessbach K, Heneka MT, Nestor P, Peters O, Fuentes M, Menne F, Priller J, Spruth EJ, Franke C, Schneider A, Westerteicher C, Speck O, Wiltfang J, Bartels C, Araque Caballero M?, Metzger C, Bittner D, Salloway S, Danek A, Hassenstab J, Yakushev I, Schofield PR, Morris JC, Bateman RJ, Ewers M. The BDNFVal66Met SNP modulates the association between beta-amyloid and hippocampal disconnection in Alzheimer's disease. Mol Psychiatry. 2021 02; 26(2):614-628. PMID: 30899092.
      Citations: 29     Fields:    Translation:Humans
    113. Herrera-Rivero M, Santarelli F, Brosseron F, Kummer MP, Heneka MT. Dysregulation of TLR5 and TAM Ligands in the Alzheimer's Brain as Contributors to Disease Progression. Mol Neurobiol. 2019 Sep; 56(9):6539-6550. PMID: 30852796.
      Citations: 16     Fields:    Translation:HumansCells
    114. Heneka MT, McManus RM, Latz E. Author Correction: Inflammasome signalling in brain function and neurodegenerative disease. Nat Rev Neurosci. 2019 Mar; 20(3):187. PMID: 30742056.
      Citations: 4     Fields:    
    115. Heneka MT. Microglia take centre stage in neurodegenerative disease. Nat Rev Immunol. 2019 02; 19(2):79-80. PMID: 30610221.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    116. Wolfsgruber S, Molinuevo JL, Wagner M, Teunissen CE, Rami L, Coll-Padr?s N, Bouwman FH, Slot RER, Wesselman LMP, Peters O, Luther K, Buerger K, Priller J, Laske C, Teipel S, Spottke A, Heneka MT, D?zel E, Drzezga A, Wiltfang J, Sikkes SAM, van der Flier WM, Jessen F. Prevalence of abnormal Alzheimer's disease biomarkers in patients with subjective cognitive decline: cross-sectional comparison of three European memory clinic samples. Alzheimers Res Ther. 2019 01 17; 11(1):8. PMID: 30654834.
      Citations: 12     Fields:    Translation:Humans
    117. Tejera D, Heneka MT. Microglia in Neurodegenerative Disorders. Methods Mol Biol. 2019; 2034:57-67. PMID: 31392677.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    118. Tejera D, Heneka MT. In Vivo Phagocytosis Analysis of Amyloid Beta. Methods Mol Biol. 2019; 2034:287-292. PMID: 31392693.
      Citations: 7     Fields:    Translation:AnimalsCells
    119. Teipel SJ, Kuper-Smith JO, Bartels C, Brosseron F, Buchmann M, Buerger K, Catak C, Janowitz D, Dechent P, Dobisch L, Ertl-Wagner B, Flie?bach K, Haynes JD, Heneka MT, Kilimann I, Laske C, Li S, Menne F, Metzger CD, Priller J, Pross V, Ramirez A, Scheffler K, Schneider A, Spottke A, Spruth EJ, Wagner M, Wiltfang J, Wolfsgruber S, D?zel E, Jessen F, Dyrba M. Multicenter Tract-Based Analysis of Microstructural Lesions within the Alzheimer's Disease Spectrum: Association with Amyloid Pathology and Diagnostic Usefulness. J Alzheimers Dis. 2019; 72(2):455-465. PMID: 31594223.
      Citations: 6     Fields:    Translation:Humans
    120. D?zel E, Berron D, Sch?tze H, Cardenas-Blanco A, Metzger C, Betts M, Ziegler G, Chen Y, Dobisch L, Bittner D, Glanz W, Reuter M, Spottke A, Rudolph J, Brosseron F, Buerger K, Janowitz D, Fliessbach K, Heneka M, Laske C, Buchmann M, Nestor P, Peters O, Diesing D, Li S, Priller J, Spruth EJ, Altenstein S, Ramirez A, Schneider A, Kofler B, Speck O, Teipel S, Kilimann I, Dyrba M, Wiltfang J, Bartels C, Wolfsgruber S, Wagner M, Jessen F. CSF total tau levels are associated with hippocampal novelty irrespective of hippocampal volume. Alzheimers Dement (Amst). 2018; 10:782-790. PMID: 30555890.
      Citations:    
    121. Hu X, Teunissen CE, Spottke A, Heneka MT, D?zel E, Peters O, Li S, Priller J, Buerger K, Teipel S, Laske C, Verfaillie SCJ, Barkhof F, Coll-Padr?s N, Rami L, Molinuevo JL, van der Flier WM, Jessen F. Smaller medial temporal lobe volumes in individuals with subjective cognitive decline and biomarker evidence of Alzheimer's disease-Data from three memory clinic studies. Alzheimers Dement. 2019 02; 15(2):185-193. PMID: 30321506.
      Citations: 17     Fields:    Translation:Humans
    122. Heneka MT, McManus RM, Latz E. Inflammasome signalling in brain function and neurodegenerative disease. Nat Rev Neurosci. 2018 10; 19(10):610-621. PMID: 30206330.
      Citations: 278     Fields:    Translation:HumansAnimalsCells
    123. Trasch?tz A, Heneka MT. Screening for Niemann-Pick Type C Disease in a Memory Clinic Cohort. JIMD Rep. 2019; 44:109-114. PMID: 30187371.
      Citations:    
    124. Ativie F, Komorowska JA, Beins E, Albayram ?, Zimmer T, Zimmer A, Tejera D, Heneka M, Bilkei-Gorzo A. Cannabinoid 1 Receptor Signaling on Hippocampal GABAergic Neurons Influences Microglial Activity. Front Mol Neurosci. 2018; 11:295. PMID: 30210289.
      Citations:    
    125. Tzeng TC, Hasegawa Y, Iguchi R, Cheung A, Caffrey DR, Thatcher EJ, Mao W, Germain G, Tamburro ND, Okabe S, Heneka MT, Latz E, Futai K, Golenbock DT. Inflammasome-derived cytokine IL18 suppresses amyloid-induced seizures in Alzheimer-prone mice. Proc Natl Acad Sci U S A. 2018 09 04; 115(36):9002-9007. PMID: 30127003.
      Citations: 26     Fields:    Translation:AnimalsCells
    126. Rammes G, Seeser F, Mattusch K, Zhu K, Haas L, Kummer M, Heneka M, Herms J, Parsons CG. The NMDA receptor antagonist Radiprodil reverses the synaptotoxic effects of different amyloid-beta (A?) species on long-term potentiation (LTP). Neuropharmacology. 2018 09 15; 140:184-192. PMID: 30016667.
      Citations: 11     Fields:    Translation:AnimalsCells
    127. Faivre E, Coelho JE, Zornbach K, Malik E, Baqi Y, Schneider M, Cellai L, Carvalho K, Sebda S, Figeac M, Eddarkaoui S, Caillierez R, Chern Y, Heneka M, Sergeant N, M?ller CE, Halle A, Bu?e L, Lopes LV, Blum D. Beneficial Effect of a Selective Adenosine A2A Receptor Antagonist in the APPswe/PS1dE9 Mouse Model of Alzheimer's Disease. Front Mol Neurosci. 2018; 11:235. PMID: 30050407.
      Citations:    
    128. Ludolph AC, Schuster J, Dorst J, Dupuis L, Dreyhaupt J, Weishaupt JH, Kassubek J, Weiland U, Petri S, Meyer T, Grosskreutz J, Schrank B, Boentert M, Emmer A, Hermann A, Zeller D, Prudlo J, Winkler AS, Grehl T, Heneka MT, Wolleb?k Johannesen S, G?ricke B. Safety and efficacy of rasagiline as an add-on therapy to riluzole in patients with amyotrophic lateral sclerosis: a randomised, double-blind, parallel-group, placebo-controlled, phase 2 trial. Lancet Neurol. 2018 08; 17(8):681-688. PMID: 29934198.
      Citations: 19     Fields:    Translation:HumansCTClinical Trials
    129. Lehmer C, Schludi MH, Ransom L, Greiling J, Jungh?nel M, Exner N, Riemenschneider H, van der Zee J, Van Broeckhoven C, Weydt P, Heneka MT, Edbauer D. A novel CHCHD10 mutation implicates a Mia40-dependent mitochondrial import deficit in ALS. EMBO Mol Med. 2018 06; 10(6). PMID: 29789341.
      Citations: 24     Fields:    Translation:HumansCells
    130. Kalinin S, Gonz?lez-Prieto M, Scheiblich H, Lisi L, Kusumo H, Heneka MT, Madrigal JLM, Pandey SC, Feinstein DL. Transcriptome analysis of alcohol-treated microglia reveals downregulation of beta amyloid phagocytosis. J Neuroinflammation. 2018 May 14; 15(1):141. PMID: 29759078.
      Citations: 20     Fields:    Translation:AnimalsCells
    131. Unger MS, Marschallinger J, Kaindl J, Klein B, Johnson M, Khundakar AA, Ro?ner S, Heneka MT, Couillard-Despres S, Rockenstein E, Masliah E, Attems J, Aigner L. Doublecortin expression in CD8+ T-cells and microglia at sites of amyloid-? plaques: A potential role in shaping plaque pathology? Alzheimers Dement. 2018 08; 14(8):1022-1037. PMID: 29630865.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    132. Franzmeier N, D?zel E, Jessen F, Buerger K, Levin J, Duering M, Dichgans M, Haass C, Su?rez-Calvet M, Fagan AM, Paumier K, Benzinger T, Masters CL, Morris JC, Perneczky R, Janowitz D, Catak C, Wolfsgruber S, Wagner M, Teipel S, Kilimann I, Ramirez A, Rossor M, Jucker M, Chhatwal J, Spottke A, Boecker H, Brosseron F, Falkai P, Fliessbach K, Heneka MT, Laske C, Nestor P, Peters O, Fuentes M, Menne F, Priller J, Spruth EJ, Franke C, Schneider A, Kofler B, Westerteicher C, Speck O, Wiltfang J, Bartels C, Araque Caballero M?, Metzger C, Bittner D, Weiner M, Lee JH, Salloway S, Danek A, Goate A, Schofield PR, Bateman RJ, Ewers M. Left frontal hub connectivity delays cognitive impairment in autosomal-dominant and sporadic Alzheimer's disease. Brain. 2018 04 01; 141(4):1186-1200. PMID: 29462334.
      Citations: 50     Fields:    Translation:Humans
    133. Enkirch SJ, Trasch?tz A, M?ller A, Widmann CN, Gielen GH, Heneka MT, Jurcoane A, Schild HH, Hattingen E. The ERICA Score: An MR Imaging-based Visual Scoring System for the Assessment of Entorhinal Cortex Atrophy in Alzheimer Disease. Radiology. 2018 Jul; 288(1):226-333. PMID: 29514015.
      Citations: 16     Fields:    Translation:Humans
    134. Brosseron F, Trasch?tz A, Widmann CN, Kummer MP, Tacik P, Santarelli F, Jessen F, Heneka MT. Characterization and clinical use of inflammatory cerebrospinal fluid protein markers in Alzheimer's disease. Alzheimers Res Ther. 2018 02 26; 10(1):25. PMID: 29482610.
      Citations: 42     Fields:    Translation:Humans
    135. Villacampa N, Heneka MT. Microglia: You'll Never Walk Alone! Immunity. 2018 02 20; 48(2):195-197. PMID: 29466750.
      Citations: 6     Fields:    Translation:HumansCells
    136. Jessen F, Spottke A, Boecker H, Brosseron F, Buerger K, Catak C, Fliessbach K, Franke C, Fuentes M, Heneka MT, Janowitz D, Kilimann I, Laske C, Menne F, Nestor P, Peters O, Priller J, Pross V, Ramirez A, Schneider A, Speck O, Spruth EJ, Teipel S, Vukovich R, Westerteicher C, Wiltfang J, Wolfsgruber S, Wagner M, D?zel E. Design and first baseline data of the DZNE multicenter observational study on predementia Alzheimer's disease (DELCODE). Alzheimers Res Ther. 2018 02 07; 10(1):15. PMID: 29415768.
      Citations: 68     Fields:    Translation:Humans
    137. Ising C, Heneka MT. Functional and structural damage of neurons by innate immune mechanisms during neurodegeneration. Cell Death Dis. 2018 01 25; 9(2):120. PMID: 29371603.
      Citations: 46     Fields:    Translation:HumansAnimalsCells
    138. Teipel SJ, Metzger CD, Brosseron F, Buerger K, Brueggen K, Catak C, Diesing D, Dobisch L, Fliebach K, Franke C, Heneka MT, Kilimann I, Kofler B, Menne F, Peters O, Polcher A, Priller J, Schneider A, Spottke A, Spruth EJ, Thelen M, Thyrian RJ, Wagner M, D?zel E, Jessen F, Dyrba M. Multicenter Resting State Functional Connectivity in Prodromal and Dementia Stages of Alzheimer's Disease. J Alzheimers Dis. 2018; 64(3):801-813. PMID: 29914027.
      Citations: 8     Fields:    Translation:Humans
    139. Dansokho C, Heneka MT. Neuroinflammatory responses in Alzheimer's disease. J Neural Transm (Vienna). 2018 05; 125(5):771-779. PMID: 29273951.
      Citations: 59     Fields:    Translation:HumansAnimalsCells
    140. Kaczmarczyk R, Tejera D, Simon BJ, Heneka MT. Microglia modulation through external vagus nerve stimulation in a murine model of Alzheimer's disease. J Neurochem. 2017 Dec 21. PMID: 29266221.
      Citations: 45     Fields:    
    141. Venegas C, Kumar S, Franklin BS, Dierkes T, Brinkschulte R, Tejera D, Vieira-Saecker A, Schwartz S, Santarelli F, Kummer MP, Griep A, Gelpi E, Beilharz M, Riedel D, Golenbock DT, Geyer M, Walter J, Latz E, Heneka MT. Microglia-derived ASC specks cross-seed amyloid-? in Alzheimer's disease. Nature. 2017 12 20; 552(7685):355-361. PMID: 29293211.
      Citations: 379     Fields:    Translation:HumansAnimalsCells
    142. Tejera D, Heneka MT. United Again: STING and the Police. Neuron. 2017 12 20; 96(6):1207-1208. PMID: 29268089.
      Citations:    Fields:    Translation:HumansAnimalsCells
    143. Ardura-Fabregat A, Boddeke EWGM, Boza-Serrano A, Brioschi S, Castro-Gomez S, Ceyz?riat K, Dansokho C, Dierkes T, Gelders G, Heneka MT, Hoeijmakers L, Hoffmann A, Iaccarino L, Jahnert S, Kuhbandner K, Landreth G, Lonnemann N, L?schmann PA, McManus RM, Paulus A, Reemst K, Sanchez-Caro JM, Tiberi A, Van der Perren A, Vautheny A, Venegas C, Webers A, Weydt P, Wijasa TS, Xiang X, Yang Y. Targeting Neuroinflammation to Treat Alzheimer's Disease. CNS Drugs. 2017 12; 31(12):1057-1082. PMID: 29260466.
      Citations: 95     Fields:    Translation:HumansAnimals
    144. Trasch?tz A, Kummer MP, Schwartz S, Heneka MT. Variability and temporal dynamics of novel object recognition in aging male C57BL/6 mice. Behav Processes. 2018 Dec; 157:711-716. PMID: 29155004.
      Citations: 7     Fields:    Translation:Animals
    145. Labzin LI, Heneka MT, Latz E. Innate Immunity and Neurodegeneration. Annu Rev Med. 2018 01 29; 69:437-449. PMID: 29106805.
      Citations: 142     Fields:    Translation:HumansCells
    146. Scheiblich H, Schl?tter A, Golenbock DT, Latz E, Martinez-Martinez P, Heneka MT. Activation of the NLRP3 inflammasome in microglia: the role of ceramide. J Neurochem. 2017 12; 143(5):534-550. PMID: 28940479.
      Citations: 64     Fields:    Translation:AnimalsCells
    147. Sarlus H, Heneka MT. Microglia in Alzheimer's disease. J Clin Invest. 2017 Sep 01; 127(9):3240-3249. PMID: 28862638.
      Citations: 370     Fields:    Translation:HumansAnimalsCells
    148. M?ller S, Preische O, G?pfert JC, Ya?ez VAC, Joos TO, Boecker H, D?zel E, Falkai P, Priller J, Buerger K, Catak C, Janowitz D, Heneka MT, Brosseron F, Nestor P, Peters O, Menne F, Schipke CG, Schneider A, Spottke A, Flie?bach K, Kilimann I, Teipel S, Wagner M, Wiltfang J, Jessen F, Laske C. Tau plasma levels in subjective cognitive decline: Results from the DELCODE study. Sci Rep. 2017 08 25; 7(1):9529. PMID: 28842559.
      Citations: 16     Fields:    Translation:Humans
    149. Wijasa TS, Sylvester M, Brocke-Ahmadinejad N, Kummer MP, Brosseron F, Gieselmann V, Heneka MT. Proteome profiling of s-nitrosylated synaptosomal proteins by isobaric mass tags. J Neurosci Methods. 2017 11 01; 291:95-100. PMID: 28789995.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    150. Netea MG, Balkwill F, Chonchol M, Cominelli F, Donath MY, Giamarellos-Bourboulis EJ, Golenbock D, Gresnigt MS, Heneka MT, Hoffman HM, Hotchkiss R, Joosten LAB, Kastner DL, Korte M, Latz E, Libby P, Mandrup-Poulsen T, Mantovani A, Mills KHG, Nowak KL, O'Neill LA, Pickkers P, van der Poll T, Ridker PM, Schalkwijk J, Schwartz DA, Siegmund B, Steer CJ, Tilg H, van der Meer JWM, van de Veerdonk FL, Dinarello CA. A guiding map for inflammation. Nat Immunol. 2017 Jul 19; 18(8):826-831. PMID: 28722720.
      Citations: 260     Fields:    Translation:Humans
    151. Kemmerling N, Wunderlich P, Theil S, Linnartz-Gerlach B, Hersch N, Hoffmann B, Heneka MT, de Strooper B, Neumann H, Walter J. Intramembranous processing by ?-secretase regulates reverse signaling of ephrin-B2 in migration of microglia. Glia. 2017 07; 65(7):1103-1118. PMID: 28370426.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    152. Simchovitz A, Heneka MT, Soreq H. Personalized genetics of the cholinergic blockade of neuroinflammation. J Neurochem. 2017 08; 142 Suppl 2:178-187. PMID: 28326544.
      Citations: 18     Fields:    Translation:HumansAnimals
    153. McManus RM, Heneka MT. Role of neuroinflammation in neurodegeneration: new insights. Alzheimers Res Ther. 2017 Mar 04; 9(1):14. PMID: 28259169.
      Citations: 105     Fields:    Translation:Humans
    154. Heneka MT. Inflammasome activation and innate immunity in Alzheimer's disease. Brain Pathol. 2017 03; 27(2):220-222. PMID: 28019679.
      Citations: 59     Fields:    Translation:HumansAnimalsCells
    155. van der Zee J, Gijselinck I, Van Mossevelde S, Perrone F, Dillen L, Heeman B, B?umer V, Engelborghs S, De Bleecker J, Baets J, Gelpi E, Rojas-Garc?a R, Clarim?n J, Lle? A, Diehl-Schmid J, Alexopoulos P, Perneczky R, Synofzik M, Just J, Sch?ls L, Graff C, Thonberg H, Borroni B, Padovani A, Jordanova A, Sarafov S, Tournev I, de Mendon?a A, Miltenberger-Milt?nyi G, Sim?es do Couto F, Ramirez A, Jessen F, Heneka MT, G?mez-Tortosa E, Danek A, Cras P, Vandenberghe R, De Jonghe P, De Deyn PP, Sleegers K, Cruts M, Van Broeckhoven C, Goeman J, Nuytten D, Smets K, Robberecht W, Damme PV, Bleecker J, Santens P, Dermaut B, Versijpt J, Michotte A, Ivanoiu A, Deryck O, Bergmans B, Delbeck J, Bruyland M, Willems C, Salmon E, Pastor P, Ortega-Cubero S, Benussi L, Ghidoni R, Binetti G, Hern?ndez I, Boada M, Ruiz A, Sorbi S, Nacmias B, Bagnoli S, Sorbi S, Sanchez-Valle R, Llado A, Santana I, Ros?rio Almeida M, Frisoni GB, Maetzler W, Matej R, Fraidakis MJ, Kovacs GG, Fabrizi GM, Testi S. TBK1 Mutation Spectrum in an Extended European Patient Cohort with Frontotemporal Dementia and Amyotrophic Lateral Sclerosis. Hum Mutat. 2017 03; 38(3):297-309. PMID: 28008748.
      Citations: 38     Fields:    Translation:HumansCells
    156. Zimmermann J, Emrich M, Krauthausen M, Saxe S, Nitsch L, Heneka MT, Campbell IL, M?ller M. IL-17A Promotes Granulocyte Infiltration, Myelin Loss, Microglia Activation, and Behavioral Deficits During Cuprizone-Induced Demyelination. Mol Neurobiol. 2018 02; 55(2):946-957. PMID: 28084589.
      Citations: 23     Fields:    Translation:AnimalsCells
    157. Venegas C, Heneka MT. Danger-associated molecular patterns in Alzheimer's disease. J Leukoc Biol. 2017 01; 101(1):87-98. PMID: 28049142.
      Citations: 85     Fields:    Translation:HumansAnimals
    158. Unger MS, Marschallinger J, Kaindl J, H?fling C, Rossner S, Heneka MT, Van der Linden A, Aigner L. Early Changes in Hippocampal Neurogenesis in Transgenic Mouse Models for Alzheimer's Disease. Mol Neurobiol. 2016 10; 53(8):5796-806. PMID: 27544234.
      Citations: 40     Fields:    Translation:AnimalsCells
    159. Heneka MT, Nicotera P. Thoughts on Obesity and Brain Glucose. Cell. 2016 May 05; 165(4):773-5. PMID: 27153489.
      Citations: 4     Fields:    Translation:Humans
    160. Su?rez-Calvet M, Kleinberger G, Araque Caballero M?, Brendel M, Rominger A, Alcolea D, Fortea J, Lle? A, Blesa R, Gispert JD, S?nchez-Valle R, Antonell A, Rami L, Molinuevo JL, Brosseron F, Trasch?tz A, Heneka MT, Struyfs H, Engelborghs S, Sleegers K, Van Broeckhoven C, Zetterberg H, Nellg?rd B, Blennow K, Crispin A, Ewers M, Haass C. sTREM2 cerebrospinal fluid levels are a potential biomarker for microglia activity in early-stage Alzheimer's disease and associate with neuronal injury markers. EMBO Mol Med. 2016 05; 8(5):466-76. PMID: 26941262.
      Citations: 221     Fields:    Translation:HumansCells
    161. Zimmer S, Grebe A, Bakke SS, Bode N, Halvorsen B, Ulas T, Skjelland M, De Nardo D, Labzin LI, Kerksiek A, Hempel C, Heneka MT, Hawxhurst V, Fitzgerald ML, Trebicka J, Bj?rkhem I, Gustafsson J?, Westerterp M, Tall AR, Wright SD, Espevik T, Schultze JL, Nickenig G, L?tjohann D, Latz E. Cyclodextrin promotes atherosclerosis regression via macrophage reprogramming. Sci Transl Med. 2016 Apr 06; 8(333):333ra50. PMID: 27053774.
      Citations: 111     Fields:    Translation:HumansAnimalsCells
    162. Tejera D, Heneka MT. Microglia in Alzheimer's disease: the good, the bad and the ugly. Curr Alzheimer Res. 2016; 13(4):370-80. PMID: 26567746.
      Citations: 35     Fields:    Translation:HumansAnimalsCells
    163. Trasch?tz A, Tzaridis T, Penner AH, Kuchelmeister K, Urbach H, Hattingen E, Heneka MT. Reduction of microbleeds by immunosuppression in a patient with A?-related vascular inflammation. Neurol Neuroimmunol Neuroinflamm. 2015 Dec; 2(6):e165. PMID: 26516630.
      Citations: 4     Fields:    
    164. Willem M, Tahirovic S, Busche MA, Ovsepian SV, Chafai M, Kootar S, Hornburg D, Evans LD, Moore S, Daria A, Hampel H, M?ller V, Giudici C, Nuscher B, Wenninger-Weinzierl A, Kremmer E, Heneka MT, Thal DR, Giedraitis V, Lannfelt L, M?ller U, Livesey FJ, Meissner F, Herms J, Konnerth A, Marie H, Haass C. ?-Secretase processing of APP inhibits neuronal activity in the hippocampus. Nature. 2015 Oct 15; 526(7573):443-7. PMID: 26322584.
      Citations: 170     Fields:    Translation:HumansAnimalsCells
    165. Bach JP, Gold M, Mengel D, Hattesohl A, Lubbe D, Schmid S, Tackenberg B, Rieke J, Maddula S, Baumbach JI, Nell C, Boeselt T, Michelis J, Alferink J, Heneka M, Oertel W, Jessen F, Janciauskiene S, Vogelmeier C, Dodel R, Koczulla AR. Measuring Compounds in Exhaled Air to Detect Alzheimer's Disease and Parkinson's Disease. PLoS One. 2015; 10(7):e0132227. PMID: 26168044.
      Citations: 16     Fields:    Translation:HumansAnimals
    166. Heneka MT, Fink A, Doblhammer G. Effect of pioglitazone medication on the incidence of dementia. Ann Neurol. 2015 Aug; 78(2):284-94. PMID: 25974006.
      Citations: 85     Fields:    Translation:Humans
    167. Heilmann S, Drichel D, Clarimon J, Fern?ndez V, Lacour A, Wagner H, Thelen M, Hern?ndez I, Fortea J, Alegret M, Blesa R, Maule?n A, Roca MR, Kornhuber J, Peters O, Heun R, Fr?lich L, H?ll M, Heneka MT, R?ther E, Riedel-Heller S, Scherer M, Wiltfang J, Jessen F, Becker T, T?rraga L, Boada M, Maier W, Lle? A, Ruiz A, N?then MM, Ramirez A. PLD3 in non-familial Alzheimer's disease. Nature. 2015 Apr 02; 520(7545):E3-5. PMID: 25832411.
      Citations: 28     Fields:    Translation:Humans
    168. Heneka MT, Carson MJ, El Khoury J, Landreth GE, Brosseron F, Feinstein DL, Jacobs AH, Wyss-Coray T, Vitorica J, Ransohoff RM, Herrup K, Frautschy SA, Finsen B, Brown GC, Verkhratsky A, Yamanaka K, Koistinaho J, Latz E, Halle A, Petzold GC, Town T, Morgan D, Shinohara ML, Perry VH, Holmes C, Bazan NG, Brooks DJ, Hunot S, Joseph B, Deigendesch N, Garaschuk O, Boddeke E, Dinarello CA, Breitner JC, Cole GM, Golenbock DT, Kummer MP. Neuroinflammation in Alzheimer's disease. Lancet Neurol. 2015 Apr; 14(4):388-405. PMID: 25792098.
      Citations: 2198     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    169. Heneka MT, Golenbock DT, Latz E. Innate immunity in Alzheimer's disease. Nat Immunol. 2015 Mar; 16(3):229-36. PMID: 25689443.
      Citations: 338     Fields:    Translation:HumansAnimals
    170. Kurzwelly D, Kr?ger S, Biskup S, Heneka MT. A distinct clinical phenotype in a German kindred with motor neuron disease carrying a CHCHD10 mutation. Brain. 2015 Sep; 138(Pt 9):e376. PMID: 25681414.
      Citations: 24     Fields:    Translation:HumansCells
    171. Meiberth D, Scheef L, Wolfsgruber S, Boecker H, Block W, Tr?ber F, Erk S, Heneka MT, Jacobi H, Spottke A, Walter H, Wagner M, Hu X, Jessen F. Cortical thinning in individuals with subjective memory impairment. J Alzheimers Dis. 2015; 45(1):139-46. PMID: 25471190.
      Citations: 34     Fields:    Translation:Humans
    172. Krauthausen M, Kummer MP, Zimmermann J, Reyes-Irisarri E, Terwel D, Bulic B, Heneka MT, M?ller M. CXCR3 promotes plaque formation and behavioral deficits in an Alzheimer's disease model. J Clin Invest. 2015 Jan; 125(1):365-78. PMID: 25500888.
      Citations: 64     Fields:    Translation:AnimalsCells
    173. Widmann CN, Schewe JC, Heneka MT. Sepsis-associated encephalopathy versus sepsis-induced encephalopathy--authors' reply. Lancet Neurol. 2014 Oct; 13(10):968-9. PMID: 25231518.
      Citations: 6     Fields:    Translation:Humans
    174. Heneka MT. Macrophages derived from infiltrating monocytes mediate autoimmune myelin destruction. J Exp Med. 2014 Jul 28; 211(8):1500. PMID: 25071159.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    175. Ramirez A, van der Flier WM, Herold C, Ramonet D, Heilmann S, Lewczuk P, Popp J, Lacour A, Drichel D, Louwersheimer E, Kummer MP, Cruchaga C, Hoffmann P, Teunissen C, Holstege H, Kornhuber J, Peters O, Naj AC, Chouraki V, Bellenguez C, Gerrish A, Heun R, Fr?lich L, H?ll M, Buscemi L, Herms S, K?lsch H, Scheltens P, Breteler MM, R?ther E, Wiltfang J, Goate A, Jessen F, Maier W, Heneka MT, Becker T, N?then MM. SUCLG2 identified as both a determinator of CSF A?1-42 levels and an attenuator of cognitive decline in Alzheimer's disease. Hum Mol Genet. 2014 Dec 15; 23(24):6644-58. PMID: 25027320.
      Citations: 27     Fields:    Translation:HumansCells
    176. Gockel I, Becker J, Wouters MM, Niebisch S, Gockel HR, Hess T, Ramonet D, Zimmermann J, Vigo AG, Trynka G, de Le?n AR, de la Serna JP, Urcelay E, Kumar V, Franke L, Westra HJ, Drescher D, Kneist W, Marquardt JU, Galle PR, Mattheisen M, Annese V, Latiano A, Fumagalli U, Laghi L, Cuomo R, Sarnelli G, M?ller M, Eckardt AJ, Tack J, Hoffmann P, Herms S, Mangold E, Heilmann S, Kiesslich R, von Rahden BH, Allescher HD, Schulz HG, Wijmenga C, Heneka MT, Lang H, Hopfner KP, N?then MM, Boeckxstaens GE, de Bakker PI, Knapp M, Schumacher J. Common variants in the HLA-DQ region confer susceptibility to idiopathic achalasia. Nat Genet. 2014 Aug; 46(8):901-4. PMID: 24997987.
      Citations: 41     Fields:    Translation:Humans
    177. Kleinberger G, Yamanishi Y, Su?rez-Calvet M, Czirr E, Lohmann E, Cuyvers E, Struyfs H, Pettkus N, Wenninger-Weinzierl A, Mazaheri F, Tahirovic S, Lle? A, Alcolea D, Fortea J, Willem M, Lammich S, Molinuevo JL, S?nchez-Valle R, Antonell A, Ramirez A, Heneka MT, Sleegers K, van der Zee J, Martin JJ, Engelborghs S, Demirtas-Tatlidede A, Zetterberg H, Van Broeckhoven C, Gurvit H, Wyss-Coray T, Hardy J, Colonna M, Haass C. TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis. Sci Transl Med. 2014 Jul 02; 6(243):243ra86. PMID: 24990881.
      Citations: 342     Fields:    Translation:HumansCells
    178. Heneka MT, Kummer MP, Latz E. Innate immune activation in neurodegenerative disease. Nat Rev Immunol. 2014 Jul; 14(7):463-77. PMID: 24962261.
      Citations: 561     Fields:    Translation:HumansCells
    179. Kummer MP, Hammerschmidt T, Martinez A, Terwel D, Eichele G, Witten A, Figura S, Stoll M, Schwartz S, Pape HC, Schultze JL, Weinshenker D, Heneka MT, Urban I. Ear2 deletion causes early memory and learning deficits in APP/PS1 mice. J Neurosci. 2014 Jun 25; 34(26):8845-54. PMID: 24966384.
      Citations: 36     Fields:    Translation:AnimalsCells
    180. Thelen M, Razquin C, Hern?ndez I, Gorostidi A, S?nchez-Valle R, Ortega-Cubero S, Wolfsgruber S, Drichel D, Fliessbach K, Duenkel T, Damian M, Heilmann S, Slotosch A, Lennarz M, Seijo-Mart?nez M, Rene R, Kornhuber J, Peters O, Luckhaus C, Jahn H, H?ll M, R?ther E, Wiltfang J, Lorenzo E, Gascon J, Lle? A, Llad? A, Campdelacreu J, Moreno F, Ahmadzadehfar H, Fortea J, Indakoetxea B, Heneka MT, Wetter A, Pastor MA, Riverol M, Becker T, Fr?lich L, T?rraga L, Boada M, Wagner M, Jessen F, Maier W, Clarim?n J, L?pez de Munain A, Ruiz A, Pastor P, Ramirez A. Investigation of the role of rare TREM2 variants in frontotemporal dementia subtypes. Neurobiol Aging. 2014 Nov; 35(11):2657.e13-2657.e19. PMID: 25042114.
      Citations: 14     Fields:    Translation:Humans
    181. Krauthausen M, Saxe S, Zimmermann J, Emrich M, Heneka MT, M?ller M. CXCR3 modulates glial accumulation and activation in cuprizone-induced demyelination of the central nervous system. J Neuroinflammation. 2014 Jun 16; 11:109. PMID: 24930935.
      Citations: 17     Fields:    Translation:AnimalsCells
    182. van der Zee J, Van Langenhove T, Kovacs GG, Dillen L, Deschamps W, Engelborghs S, Matej R, Vandenbulcke M, Sieben A, Dermaut B, Smets K, Van Damme P, Merlin C, Laureys A, Van Den Broeck M, Mattheijssens M, Peeters K, Benussi L, Binetti G, Ghidoni R, Borroni B, Padovani A, Archetti S, Pastor P, Razquin C, Ortega-Cubero S, Hern?ndez I, Boada M, Ruiz A, de Mendon?a A, Miltenberger-Milt?nyi G, do Couto FS, Sorbi S, Nacmias B, Bagnoli S, Graff C, Chiang HH, Thonberg H, Perneczky R, Diehl-Schmid J, Alexopoulos P, Frisoni GB, Bonvicini C, Synofzik M, Maetzler W, vom Hagen JM, Sch?ls L, Haack TB, Strom TM, Prokisch H, Dols-Icardo O, Clarim?n J, Lle? A, Santana I, Almeida MR, Santiago B, Heneka MT, Jessen F, Ramirez A, Sanchez-Valle R, Llado A, Gelpi E, Sarafov S, Tournev I, Jordanova A, Parobkova E, Fabrizi GM, Testi S, Salmon E, Str?bel T, Santens P, Robberecht W, De Jonghe P, Martin JJ, Cras P, Vandenberghe R, De Deyn PP, Cruts M, Sleegers K, Van Broeckhoven C. Rare mutations in SQSTM1 modify susceptibility to frontotemporal lobar degeneration. Acta Neuropathol. 2014 Sep; 128(3):397-410. PMID: 24899140.
      Citations: 44     Fields:    Translation:HumansAnimals
    183. Widmann CN, Heneka MT. Long-term cerebral consequences of sepsis. Lancet Neurol. 2014 Jun; 13(6):630-6. PMID: 24849863.
      Citations: 145     Fields:    Translation:Humans
    184. Kummer MP, Heneka MT. Truncated and modified amyloid-beta species. Alzheimers Res Ther. 2014; 6(3):28. PMID: 25031638.
      Citations: 115     Fields:    
    185. Kummer MP, Schwarzenberger R, Sayah-Jeanne S, Dubernet M, Walczak R, Hum DW, Schwartz S, Axt D, Heneka MT. Pan-PPAR modulation effectively protects APP/PS1 mice from amyloid deposition and cognitive deficits. Mol Neurobiol. 2015 Apr; 51(2):661-71. PMID: 24838579.
      Citations: 22     Fields:    Translation:AnimalsCells
    186. Brosseron F, Krauthausen M, Kummer M, Heneka MT. Body fluid cytokine levels in mild cognitive impairment and Alzheimer's disease: a comparative overview. Mol Neurobiol. 2014 Oct; 50(2):534-44. PMID: 24567119.
      Citations: 185     Fields:    Translation:HumansAnimals
    187. Peter J, Scheef L, Abdulkadir A, Boecker H, Heneka M, Wagner M, Koppara A, Kl?ppel S, Jessen F. Gray matter atrophy pattern in elderly with subjective memory impairment. Alzheimers Dement. 2014 Jan; 10(1):99-108. PMID: 23867795.
      Citations: 63     Fields:    Translation:Humans
    188. Malhotra A, Younesi E, G?ndel M, M?ller B, Heneka MT, Hofmann-Apitius M. ADO: a disease ontology representing the domain knowledge specific to Alzheimer's disease. Alzheimers Dement. 2014 Mar; 10(2):238-46. PMID: 23830913.
      Citations: 33     Fields:    Translation:Humans
    189. Chalermpalanupap T, Kinkead B, Hu WT, Kummer MP, Hammerschmidt T, Heneka MT, Weinshenker D, Levey AI. Targeting norepinephrine in mild cognitive impairment and Alzheimer's disease. Alzheimers Res Ther. 2013; 5(2):21. PMID: 23634965.
      Citations: 72     Fields:    
    190. Zimmermann J, Krauthausen M, Hofer MJ, Heneka MT, Campbell IL, M?ller M. CNS-targeted production of IL-17A induces glial activation, microvascular pathology and enhances the neuroinflammatory response to systemic endotoxemia. PLoS One. 2013; 8(2):e57307. PMID: 23468966.
      Citations: 35     Fields:    Translation:AnimalsCells
    191. Okroglic S, Widmann CN, Urbach H, Scheltens P, Heneka MT. Clinical symptoms and risk factors in cerebral microangiopathy patients. PLoS One. 2013; 8(2):e53455. PMID: 23393549.
      Citations: 22     Fields:    Translation:Humans
    192. van der Zee J, Gijselinck I, Dillen L, Van Langenhove T, Theuns J, Engelborghs S, Philtjens S, Vandenbulcke M, Sleegers K, Sieben A, B?umer V, Maes G, Corsmit E, Borroni B, Padovani A, Archetti S, Perneczky R, Diehl-Schmid J, de Mendon?a A, Miltenberger-Miltenyi G, Pereira S, Pimentel J, Nacmias B, Bagnoli S, Sorbi S, Graff C, Chiang HH, Westerlund M, Sanchez-Valle R, Llado A, Gelpi E, Santana I, Almeida MR, Santiago B, Frisoni G, Zanetti O, Bonvicini C, Synofzik M, Maetzler W, Vom Hagen JM, Sch?ls L, Heneka MT, Jessen F, Matej R, Parobkova E, Kovacs GG, Str?bel T, Sarafov S, Tournev I, Jordanova A, Danek A, Arzberger T, Fabrizi GM, Testi S, Salmon E, Santens P, Martin JJ, Cras P, Vandenberghe R, De Deyn PP, Cruts M, Van Broeckhoven C, van der Zee J, Gijselinck I, Dillen L, Van Langenhove T, Theuns J, Philtjens S, Sleegers K, B?umer V, Maes G, Corsmit E, Cruts M, Van Broeckhoven C, van der Zee J, Gijselinck I, Dillen L, Van Langenhove T, Philtjens S, Theuns J, Sleegers K, B?umer V, Maes G, Cruts M, Van Broeckhoven C, Engelborghs S, De Deyn PP, Cras P, Engelborghs S, De Deyn PP, Vandenbulcke M, Vandenbulcke M, Borroni B, Padovani A, Archetti S, Perneczky R, Diehl-Schmid J, Synofzik M, Maetzler W, M?ller Vom Hagen J, Sch?ls L, Synofzik M, Maetzler W, M?ller Vom Hagen J, Sch?ls L, Heneka MT, Jessen F, Ramirez A, Kurzwelly D, Sachtleben C, Mairer W, de Mendon?a A, Miltenberger-Miltenyi G, Pereira S, Firmo C, Pimentel J, Sanchez-Valle R, Llado A, Antonell A, Molinuevo J, Gelpi E, Graff C, Chiang HH, Westerlund M, Graff C, Kinhult St?hlbom A, Thonberg H, Nennesmo I, B?rjesson-Hanson A, Nacmias B, Bagnoli S, Sorbi S, Bessi V, Piaceri I, Santana I, Santiago B, Santana I, Helena Ribeiro M, Ros?rio Almeida M, Oliveira C, Massano J, Garret C, Pires P, Frisoni G, Zanetti O, Bonvicini C, Sarafov S, Tournev I, Jordanova A, Tournev I, Kovacs GG, Str?bel T, Heneka MT, Jessen F, Ramirez A, Kurzwelly D, Sachtleben C, Mairer W, Jessen F, Matej R, Parobkova E, Danel A, Arzberger T, Maria Fabrizi G, Testi S, Ferrari S, Cavallaro T, Salmon E, Santens P, Cras P. A pan-European study of the C9orf72 repeat associated with FTLD: geographic prevalence, genomic instability, and intermediate repeats. Hum Mutat. 2013 Feb; 34(2):363-73. PMID: 23111906.
      Citations: 112     Fields:    Translation:HumansCells
    193. Molinuevo JL, Gispert JD, Dubois B, Heneka MT, Lleo A, Engelborghs S, Pujol J, de Souza LC, Alcolea D, Jessen F, Sarazin M, Lamari F, Balasa M, Antonell A, Rami L. The AD-CSF-index discriminates Alzheimer's disease patients from healthy controls: a validation study. J Alzheimers Dis. 2013; 36(1):67-77. PMID: 23524657.
      Citations: 22     Fields:    Translation:Humans
    194. Gaikwad SM, Heneka MT. Studying M1 and M2 states in adult microglia. Methods Mol Biol. 2013; 1041:185-97. PMID: 23813380.
      Citations: 13     Fields:    Translation:AnimalsCells
    195. Heneka MT, Kummer MP, Stutz A, Delekate A, Schwartz S, Vieira-Saecker A, Griep A, Axt D, Remus A, Tzeng TC, Gelpi E, Halle A, Korte M, Latz E, Golenbock DT. NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 mice. Nature. 2013 Jan 31; 493(7434):674-8. PMID: 23254930.
      Citations: 1174     Fields:    Translation:HumansAnimals
    196. Kummer MP, Vogl T, Axt D, Griep A, Vieira-Saecker A, Jessen F, Gelpi E, Roth J, Heneka MT. Mrp14 deficiency ameliorates amyloid ? burden by increasing microglial phagocytosis and modulation of amyloid precursor protein processing. J Neurosci. 2012 Dec 05; 32(49):17824-9. PMID: 23223301.
      Citations: 32     Fields:    Translation:HumansAnimalsCells
    197. Yamanaka M, Ishikawa T, Griep A, Axt D, Kummer MP, Heneka MT. PPAR?/RXRa-induced and CD36-mediated microglial amyloid-? phagocytosis results in cognitive improvement in amyloid precursor protein/presenilin 1 mice. J Neurosci. 2012 Nov 28; 32(48):17321-31. PMID: 23197723.
      Citations: 171     Fields:    Translation:AnimalsCells
    198. Semmler A, Widmann CN, Okulla T, Urbach H, Kaiser M, Widman G, Mormann F, Weide J, Fliessbach K, Hoeft A, Jessen F, Putensen C, Heneka MT. Persistent cognitive impairment, hippocampal atrophy and EEG changes in sepsis survivors. J Neurol Neurosurg Psychiatry. 2013 Jan; 84(1):62-9. PMID: 23134661.
      Citations: 119     Fields:    Translation:Humans
    199. Scheef L, Spottke A, Daerr M, Joe A, Striepens N, K?lsch H, Popp J, Daamen M, Gorris D, Heneka MT, Boecker H, Biersack HJ, Maier W, Schild HH, Wagner M, Jessen F. Glucose metabolism, gray matter structure, and memory decline in subjective memory impairment. Neurology. 2012 Sep 25; 79(13):1332-9. PMID: 22914828.
      Citations: 123     Fields:    Translation:Humans
    200. Hammerschmidt T, Kummer MP, Terwel D, Martinez A, Gorji A, Pape HC, Rommelfanger KS, Schroeder JP, Stoll M, Schultze J, Weinshenker D, Heneka MT. Selective loss of noradrenaline exacerbates early cognitive dysfunction and synaptic deficits in APP/PS1 mice. Biol Psychiatry. 2013 Mar 01; 73(5):454-63. PMID: 22883210.
      Citations: 46     Fields:    Translation:AnimalsCells
    201. Semmler A, Okulla T, Kaiser M, Seifert B, Heneka MT. Long-term neuromuscular sequelae of critical illness. J Neurol. 2013 Jan; 260(1):151-7. PMID: 22820684.
      Citations: 18     Fields:    Translation:Humans
    202. Dupuis L, Dengler R, Heneka MT, Meyer T, Zierz S, Kassubek J, Fischer W, Steiner F, Lindauer E, Otto M, Dreyhaupt J, Grehl T, Hermann A, Winkler AS, Bogdahn U, Benecke R, Schrank B, Wessig C, Grosskreutz J, Ludolph AC. A randomized, double blind, placebo-controlled trial of pioglitazone in combination with riluzole in amyotrophic lateral sclerosis. PLoS One. 2012; 7(6):e37885. PMID: 22715372.
      Citations: 63     Fields:    Translation:HumansAnimalsCTClinical Trials
    203. Rapic S, Backes H, Viel T, Kummer MP, Monfared P, Neumaier B, Vollmar S, Hoehn M, Van der Linden A, Heneka MT, Jacobs AH. Imaging microglial activation and glucose consumption in a mouse model of Alzheimer's disease. Neurobiol Aging. 2013 Jan; 34(1):351-4. PMID: 22651996.
      Citations: 24     Fields:    Translation:HumansAnimalsCells
    204. Parpura V, Heneka MT, Montana V, Oliet SH, Schousboe A, Haydon PG, Stout RF, Spray DC, Reichenbach A, Pannicke T, Pekny M, Pekna M, Zorec R, Verkhratsky A. Glial cells in (patho)physiology. J Neurochem. 2012 Apr; 121(1):4-27. PMID: 22251135.
      Citations: 237     Fields:    Translation:HumansAnimalsCells
    205. Kummer MP, H?lsmann C, Hermes M, Axt D, Heneka MT. Nitric oxide decreases the enzymatic activity of insulin degrading enzyme in APP/PS1 mice. J Neuroimmune Pharmacol. 2012 Mar; 7(1):165-72. PMID: 22227962.
      Citations: 9     Fields:    Translation:Animals
    206. Liu S, Liu Y, Hao W, Wolf L, Kiliaan AJ, Penke B, R?be CE, Walter J, Heneka MT, Hartmann T, Menger MD, Fassbender K. TLR2 is a primary receptor for Alzheimer's amyloid ? peptide to trigger neuroinflammatory activation. J Immunol. 2012 Feb 01; 188(3):1098-107. PMID: 22198949.
      Citations: 202     Fields:    Translation:HumansAnimalsCells
    207. Heneka MT, Reyes-Irisarri E, H?ll M, Kummer MP. Impact and Therapeutic Potential of PPARs in Alzheimer's Disease. Curr Neuropharmacol. 2011 Dec; 9(4):643-50. PMID: 22654722.
      Citations: 46     Fields:    
    208. Krauthausen M, Ellis SL, Zimmermann J, Sarris M, Wakefield D, Heneka MT, Campbell IL, M?ller M. Opposing roles for CXCR3 signaling in central nervous system versus ocular inflammation mediated by the astrocyte-targeted production of IL-12. Am J Pathol. 2011 Nov; 179(5):2346-59. PMID: 21925471.
      Citations: 5     Fields:    Translation:AnimalsCells
    209. Kummer MP, Hermes M, Delekarte A, Hammerschmidt T, Kumar S, Terwel D, Walter J, Pape HC, K?nig S, Roeber S, Jessen F, Klockgether T, Korte M, Heneka MT. Nitration of tyrosine 10 critically enhances amyloid ? aggregation and plaque formation. Neuron. 2011 Sep 08; 71(5):833-44. PMID: 21903077.
      Citations: 147     Fields:    Translation:HumansAnimalsCells
    210. Mildner A, Schlevogt B, Kierdorf K, B?ttcher C, Erny D, Kummer MP, Quinn M, Br?ck W, Bechmann I, Heneka MT, Priller J, Prinz M. Distinct and non-redundant roles of microglia and myeloid subsets in mouse models of Alzheimer's disease. J Neurosci. 2011 Aug 03; 31(31):11159-71. PMID: 21813677.
      Citations: 178     Fields:    Translation:AnimalsCells
    211. Juckel G, Manitz MP, Br?ne M, Friebe A, Heneka MT, Wolf RJ. Microglial activation in a neuroinflammational animal model of schizophrenia--a pilot study. Schizophr Res. 2011 Sep; 131(1-3):96-100. PMID: 21752601.
      Citations: 67     Fields:    Translation:AnimalsCells
    212. Mattsson N, Andreasson U, Persson S, Arai H, Batish SD, Bernardini S, Bocchio-Chiavetto L, Blankenstein MA, Carrillo MC, Chalbot S, Coart E, Chiasserini D, Cutler N, Dahlfors G, Duller S, Fagan AM, Forlenza O, Frisoni GB, Galasko D, Galimberti D, Hampel H, Handberg A, Heneka MT, Herskovits AZ, Herukka SK, Holtzman DM, Humpel C, Hyman BT, Iqbal K, Jucker M, Kaeser SA, Kaiser E, Kapaki E, Kidd D, Klivenyi P, Knudsen CS, Kummer MP, Lui J, Llad? A, Lewczuk P, Li QX, Martins R, Masters C, McAuliffe J, Mercken M, Moghekar A, Molinuevo JL, Montine TJ, Nowatzke W, O'Brien R, Otto M, Paraskevas GP, Parnetti L, Petersen RC, Prvulovic D, de Reus HP, Rissman RA, Scarpini E, Stefani A, Soininen H, Schr?der J, Shaw LM, Skinningsrud A, Skrogstad B, Spreer A, Talib L, Teunissen C, Trojanowski JQ, Tumani H, Umek RM, Van Broeck B, Vanderstichele H, Vecsei L, Verbeek MM, Windisch M, Zhang J, Zetterberg H, Blennow K. The Alzheimer's Association external quality control program for cerebrospinal fluid biomarkers. Alzheimers Dement. 2011 Jul; 7(4):386-395.e6. PMID: 21784349.
      Citations: 149     Fields:    Translation:HumansCells
    213. Terwel D, L?schmann YN, Schmidt HH, Sch?ler HR, Cantz T, Heneka MT. Neuroinflammatory and behavioural changes in the Atp7B mutant mouse model of Wilson's disease. J Neurochem. 2011 Jul; 118(1):105-12. PMID: 21517843.
      Citations: 23     Fields:    Translation:Animals
    214. Terwel D, Steffensen KR, Verghese PB, Kummer MP, Gustafsson J?, Holtzman DM, Heneka MT. Critical role of astroglial apolipoprotein E and liver X receptor-a expression for microglial A? phagocytosis. J Neurosci. 2011 May 11; 31(19):7049-59. PMID: 21562267.
      Citations: 105     Fields:    Translation:AnimalsCells
    215. Kumar S, Rezaei-Ghaleh N, Terwel D, Thal DR, Richard M, Hoch M, Mc Donald JM, W?llner U, Glebov K, Heneka MT, Walsh DM, Zweckstetter M, Walter J. Extracellular phosphorylation of the amyloid ?-peptide promotes formation of toxic aggregates during the pathogenesis of Alzheimer's disease. EMBO J. 2011 Jun 01; 30(11):2255-65. PMID: 21527912.
      Citations: 90     Fields:    Translation:HumansAnimalsCells
    216. Perez Nievas BG, Hammerschmidt T, Kummer MP, Terwel D, Leza JC, Heneka MT. Restraint stress increases neuroinflammation independently of amyloid ? levels in amyloid precursor protein/PS1 transgenic mice. J Neurochem. 2011 Jan; 116(1):43-52. PMID: 21044080.
      Citations: 11     Fields:    Translation:Animals
    217. Rey NL, Jardanhazi-Kurutz D, Terwel D, Kummer MP, Jourdan F, Didier A, Heneka MT. Locus coeruleus degeneration exacerbates olfactory deficits in APP/PS1 transgenic mice. Neurobiol Aging. 2012 Feb; 33(2):426.e1-11. PMID: 21109328.
      Citations: 32     Fields:    Translation:Animals
    218. Fleisher-Berkovich S, Filipovich-Rimon T, Ben-Shmuel S, H?lsmann C, Kummer MP, Heneka MT. Distinct modulation of microglial amyloid ? phagocytosis and migration by neuropeptides (i). J Neuroinflammation. 2010 Oct 11; 7:61. PMID: 20937084.
      Citations: 34     Fields:    Translation:AnimalsCells
    219. Tamboli IY, Barth E, Christian L, Siepmann M, Kumar S, Singh S, Tolksdorf K, Heneka MT, L?tjohann D, Wunderlich P, Walter J. Statins promote the degradation of extracellular amyloid {beta}-peptide by microglia via stimulation of exosome-associated insulin-degrading enzyme (IDE) secretion. J Biol Chem. 2010 Nov 26; 285(48):37405-14. PMID: 20876579.
      Citations: 106     Fields:    Translation:HumansAnimalsCells
    220. Heneka MT, O'Banion MK, Terwel D, Kummer MP. Neuroinflammatory processes in Alzheimer's disease. J Neural Transm (Vienna). 2010 Aug; 117(8):919-47. PMID: 20632195.
      Citations: 164     Fields:    Translation:HumansAnimalsCells
    221. Heneka MT, Nadrigny F, Regen T, Martinez-Hernandez A, Dumitrescu-Ozimek L, Terwel D, Jardanhazi-Kurutz D, Walter J, Kirchhoff F, Hanisch UK, Kummer MP. Locus ceruleus controls Alzheimer's disease pathology by modulating microglial functions through norepinephrine. Proc Natl Acad Sci U S A. 2010 Mar 30; 107(13):6058-63. PMID: 20231476.
      Citations: 207     Fields:    Translation:HumansAnimalsCells
    222. Jardanhazi-Kurutz D, Kummer MP, Terwel D, Vogel K, Dyrks T, Thiele A, Heneka MT. Induced LC degeneration in APP/PS1 transgenic mice accelerates early cerebral amyloidosis and cognitive deficits. Neurochem Int. 2010 Nov; 57(4):375-82. PMID: 20144675.
      Citations: 59     Fields:    Translation:Animals
    223. Schlachetzki JC, Fiebich BL, Haake E, de Oliveira AC, Candelario-Jalil E, Heneka MT, H?ll M. Norepinephrine enhances the LPS-induced expression of COX-2 and secretion of PGE2 in primary rat microglia. J Neuroinflammation. 2010 Jan 11; 7:2. PMID: 20064241.
      Citations: 25     Fields:    Translation:AnimalsCells
    224. J?ger S, Leuchtenberger S, Martin A, Czirr E, Wesselowski J, Dieckmann M, Waldron E, Korth C, Koo EH, Heneka M, Weggen S, Pietrzik CU. alpha-secretase mediated conversion of the amyloid precursor protein derived membrane stub C99 to C83 limits Abeta generation. J Neurochem. 2009 Dec; 111(6):1369-82. PMID: 19804379.
      Citations: 39     Fields:    Translation:HumansAnimalsCells
    225. Heneka MT, Rodr?guez JJ, Verkhratsky A. Neuroglia in neurodegeneration. Brain Res Rev. 2010 May; 63(1-2):189-211. PMID: 19944719.
      Citations: 115     Fields:    Translation:HumansAnimalsCells
    226. Weberpals M, Hermes M, Hermann S, Kummer MP, Terwel D, Semmler A, Berger M, Sch?fers M, Heneka MT. NOS2 gene deficiency protects from sepsis-induced long-term cognitive deficits. J Neurosci. 2009 Nov 11; 29(45):14177-84. PMID: 19906966.
      Citations: 64     Fields:    Translation:AnimalsCells
    227. Papi A, Tatenhorst L, Terwel D, Hermes M, Kummer MP, Orlandi M, Heneka MT. PPARgamma and RXRgamma ligands act synergistically as potent antineoplastic agents in vitro and in vivo glioma models. J Neurochem. 2009 Jun; 109(6):1779-90. PMID: 19457135.
      Citations: 28     Fields:    Translation:HumansAnimalsCells
    228. Heneka MT. Noradrenergic denervation facilitates the release of acetylcholine and serotonin in the hippocampus: towards a mechanism underlying upregulations described in MCI patients. Exp Neurol. 2009 Jun; 217(2):237-9. PMID: 19328200.
      Citations:    Fields:    Translation:HumansAnimalsCells
    229. Tamboli IY, Prager K, Thal DR, Thelen KM, Dewachter I, Pietrzik CU, St George-Hyslop P, Sisodia SS, De Strooper B, Heneka MT, Filippov MA, M?ller U, van Leuven F, L?tjohann D, Walter J. Loss of gamma-secretase function impairs endocytosis of lipoprotein particles and membrane cholesterol homeostasis. J Neurosci. 2008 Nov 12; 28(46):12097-106. PMID: 19005074.
      Citations: 38     Fields:    Translation:HumansAnimalsCells
    230. Semmler A, Hermann S, Mormann F, Weberpals M, Paxian SA, Okulla T, Sch?fers M, Kummer MP, Klockgether T, Heneka MT. Sepsis causes neuroinflammation and concomitant decrease of cerebral metabolism. J Neuroinflammation. 2008 Sep 15; 5:38. PMID: 18793399.
      Citations: 133     Fields:    Translation:HumansAnimalsCells
    231. Landreth G, Jiang Q, Mandrekar S, Heneka M. PPARgamma agonists as therapeutics for the treatment of Alzheimer's disease. Neurotherapeutics. 2008 Jul; 5(3):481-9. PMID: 18625459.
      Citations: 109     Fields:    Translation:HumansAnimals
    232. Kummer MP, Heneka MT. PPARs in Alzheimer's Disease. PPAR Res. 2008; 2008:403896. PMID: 18645613.
      Citations:    
    233. Tatenhorst L, Hahnen E, Heneka MT. Peroxisome Proliferator-Activated Receptors (PPARs) as Potential Inducers of Antineoplastic Effects in CNS Tumors. PPAR Res. 2008; 2008:204514. PMID: 18725982.
      Citations:    
    234. Jiang Q, Heneka M, Landreth GE. The role of peroxisome proliferator-activated receptor-gamma (PPARgamma) in Alzheimer's disease: therapeutic implications. CNS Drugs. 2008; 22(1):1-14. PMID: 18072811.
      Citations: 74     Fields:    Translation:HumansAnimals
    235. Seufert S, Coras R, Tr?nkle C, Zlotos DP, Bl?mcke I, Tatenhorst L, Heneka MT, Hahnen E. PPAR Gamma Activators: Off-Target Against Glioma Cell Migration and Brain Invasion. PPAR Res. 2008; 2008:513943. PMID: 18815619.
      Citations:    
    236. Heneka MT, Landreth GE, H?ll M. Drug insight: effects mediated by peroxisome proliferator-activated receptor-gamma in CNS disorders. Nat Clin Pract Neurol. 2007 Sep; 3(9):496-504. PMID: 17805244.
      Citations: 38     Fields:    Translation:HumansAnimals
    237. Winkeler A, Sena-Esteves M, Paulis LE, Li H, Waerzeggers Y, R?ckriem B, Himmelreich U, Klein M, Monfared P, Rueger MA, Heneka M, Vollmar S, Hoehn M, Fraefel C, Graf R, Wienhard K, Heiss WD, Jacobs AH. Switching on the lights for gene therapy. PLoS One. 2007 Jun 13; 2(6):e528. PMID: 17565381.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    238. Heneka MT, Landreth GE. PPARs in the brain. Biochim Biophys Acta. 2007 Aug; 1771(8):1031-45. PMID: 17569578.
      Citations: 128     Fields:    Translation:HumansAnimals
    239. Kummer C, Winkeler A, Dittmar C, Bauer B, Rueger MA, Rueckriem B, Heneka MT, Vollmar S, Wienhard K, Fraefel C, Heiss WD, Jacobs AH. Multitracer positron emission tomographic imaging of exogenous gene expression mediated by a universal herpes simplex virus 1 amplicon vector. Mol Imaging. 2007 May-Jun; 6(3):181-92. PMID: 17532884.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    240. Jacobs AH, Rueger MA, Winkeler A, Li H, Vollmar S, Waerzeggers Y, Rueckriem B, Kummer C, Dittmar C, Klein M, Heneka MT, Herrlinger U, Fraefel C, Graf R, Wienhard K, Heiss WD. Imaging-guided gene therapy of experimental gliomas. Cancer Res. 2007 Feb 15; 67(4):1706-15. PMID: 17308112.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    241. Semmler A, Frisch C, Debeir T, Ramanathan M, Okulla T, Klockgether T, Heneka MT. Long-term cognitive impairment, neuronal loss and reduced cortical cholinergic innervation after recovery from sepsis in a rodent model. Exp Neurol. 2007 Apr; 204(2):733-40. PMID: 17306796.
      Citations: 111     Fields:    Translation:AnimalsCells
    242. Heneka MT, O'Banion MK. Inflammatory processes in Alzheimer's disease. J Neuroimmunol. 2007 Mar; 184(1-2):69-91. PMID: 17222916.
      Citations: 285     Fields:    Translation:HumansAnimalsCells
    243. Thees C, Kaiser M, Scholz M, Semmler A, Heneka MT, Baumgarten G, Hoeft A, Putensen C. Cerebral haemodynamics and carbon dioxide reactivity during sepsis syndrome. Crit Care. 2007; 11(6):R123. PMID: 18045492.
      Citations: 11     Fields:    Translation:Humans
    244. Wahle T, Thal DR, Sastre M, Rentmeister A, Bogdanovic N, Famulok M, Heneka MT, Walter J. GGA1 is expressed in the human brain and affects the generation of amyloid beta-peptide. J Neurosci. 2006 Dec 06; 26(49):12838-46. PMID: 17151287.
      Citations: 46     Fields:    Translation:HumansCells
    245. Grommes C, Landreth GE, Sastre M, Beck M, Feinstein DL, Jacobs AH, Schlegel U, Heneka MT. Inhibition of in vivo glioma growth and invasion by peroxisome proliferator-activated receptor gamma agonist treatment. Mol Pharmacol. 2006 Nov; 70(5):1524-33. PMID: 16887936.
      Citations: 37     Fields:    Translation:HumansAnimals
    246. Ambr?e O, Leimer U, Herring A, G?rtz N, Sachser N, Heneka MT, Paulus W, Keyvani K. Reduction of amyloid angiopathy and Abeta plaque burden after enriched housing in TgCRND8 mice: involvement of multiple pathways. Am J Pathol. 2006 Aug; 169(2):544-52. PMID: 16877355.
      Citations: 36     Fields:    Translation:HumansAnimalsCells
    247. Kalinin S, Gavrilyuk V, Polak PE, Vasser R, Zhao J, Heneka MT, Feinstein DL. Noradrenaline deficiency in brain increases beta-amyloid plaque burden in an animal model of Alzheimer's disease. Neurobiol Aging. 2007 Aug; 28(8):1206-14. PMID: 16837104.
      Citations: 84     Fields:    Translation:HumansAnimalsCells
    248. Sundararajan S, Jiang Q, Heneka M, Landreth G. PPARgamma as a therapeutic target in central nervous system diseases. Neurochem Int. 2006 Jul; 49(2):136-44. PMID: 16766086.
      Citations: 41     Fields:    Translation:HumansAnimals
    249. Sastre M, Klockgether T, Heneka MT. Contribution of inflammatory processes to Alzheimer's disease: molecular mechanisms. Int J Dev Neurosci. 2006 Apr-May; 24(2-3):167-76. PMID: 16472958.
      Citations: 173     Fields:    Translation:HumansAnimalsCells
    250. Heneka MT, Ramanathan M, Jacobs AH, Dumitrescu-Ozimek L, Bilkei-Gorzo A, Debeir T, Sastre M, Galldiks N, Zimmer A, Hoehn M, Heiss WD, Klockgether T, Staufenbiel M. Locus ceruleus degeneration promotes Alzheimer pathogenesis in amyloid precursor protein 23 transgenic mice. J Neurosci. 2006 Feb 01; 26(5):1343-54. PMID: 16452658.
      Citations: 138     Fields:    Translation:AnimalsCells
    251. Sastre M, Dewachter I, Rossner S, Bogdanovic N, Rosen E, Borghgraef P, Evert BO, Dumitrescu-Ozimek L, Thal DR, Landreth G, Walter J, Klockgether T, van Leuven F, Heneka MT. Nonsteroidal anti-inflammatory drugs repress beta-secretase gene promoter activity by the activation of PPARgamma. Proc Natl Acad Sci U S A. 2006 Jan 10; 103(2):443-8. PMID: 16407166.
      Citations: 156     Fields:    Translation:HumansAnimalsCells
    252. H?ll M, Berger M, Heneka M. Disease-modifying therapies in Alzheimer's disease: how far have we come? Drugs. 2006; 66(16):2075-93. PMID: 17112302.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    253. Klotz L, Schmidt M, Giese T, Sastre M, Knolle P, Klockgether T, Heneka MT. Proinflammatory stimulation and pioglitazone treatment regulate peroxisome proliferator-activated receptor gamma levels in peripheral blood mononuclear cells from healthy controls and multiple sclerosis patients. J Immunol. 2005 Oct 15; 175(8):4948-55. PMID: 16210596.
      Citations: 46     Fields:    Translation:HumansCells
    254. Heneka MT, Sastre M, Dumitrescu-Ozimek L, Dewachter I, Walter J, Klockgether T, Van Leuven F. Focal glial activation coincides with increased BACE1 activation and precedes amyloid plaque deposition in APP[V717I] transgenic mice. J Neuroinflammation. 2005 Oct 07; 2:22. PMID: 16212664.
      Citations: 142     Fields:    
    255. Semmler A, Okulla T, Sastre M, Dumitrescu-Ozimek L, Heneka MT. Systemic inflammation induces apoptosis with variable vulnerability of different brain regions. J Chem Neuroanat. 2005 Oct; 30(2-3):144-57. PMID: 16122904.
      Citations: 140     Fields:    Translation:AnimalsCells
    256. Sch?tz B, Reimann J, Dumitrescu-Ozimek L, Kappes-Horn K, Landreth GE, Sch?rmann B, Zimmer A, Heneka MT. The oral antidiabetic pioglitazone protects from neurodegeneration and amyotrophic lateral sclerosis-like symptoms in superoxide dismutase-G93A transgenic mice. J Neurosci. 2005 Aug 24; 25(34):7805-12. PMID: 16120782.
      Citations: 100     Fields:    Translation:HumansAnimals
    257. Tamboli IY, Prager K, Barth E, Heneka M, Sandhoff K, Walter J. Inhibition of glycosphingolipid biosynthesis reduces secretion of the beta-amyloid precursor protein and amyloid beta-peptide. J Biol Chem. 2005 Jul 29; 280(30):28110-7. PMID: 15923191.
      Citations: 65     Fields:    Translation:HumansAnimalsCells
    258. Heneka MT, Sastre M, Dumitrescu-Ozimek L, Hanke A, Dewachter I, Kuiperi C, O'Banion K, Klockgether T, Van Leuven F, Landreth GE. Acute treatment with the PPARgamma agonist pioglitazone and ibuprofen reduces glial inflammation and Abeta1-42 levels in APPV717I transgenic mice. Brain. 2005 Jun; 128(Pt 6):1442-53. PMID: 15817521.
      Citations: 237     Fields:    Translation:AnimalsCells
    259. Grommes C, Landreth GE, Schlegel U, Heneka MT. The nonthiazolidinedione tyrosine-based peroxisome proliferator-activated receptor gamma ligand GW7845 induces apoptosis and limits migration and invasion of rat and human glioma cells. J Pharmacol Exp Ther. 2005 May; 313(2):806-13. PMID: 15665144.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    260. Lacombe P, Mathews PM, Schmidt SD, Breidert T, Heneka MT, Landreth GE, Feinstein DL, Galea E. Effect of anti-inflammatory agents on transforming growth factor beta over-expressing mouse brains: a model revised. J Neuroinflammation. 2004 Jul 02; 1(1):11. PMID: 15285804.
      Citations: 18     Fields:    
    261. Grommes C, Landreth GE, Heneka MT. Antineoplastic effects of peroxisome proliferator-activated receptor gamma agonists. Lancet Oncol. 2004 Jul; 5(7):419-29. PMID: 15231248.
      Citations: 156     Fields:    Translation:HumansAnimalsCells
    262. Pershadsingh HA, Heneka MT, Saini R, Amin NM, Broeske DJ, Feinstein DL. Effect of pioglitazone treatment in a patient with secondary multiple sclerosis. J Neuroinflammation. 2004 Apr 20; 1(1):3. PMID: 15285799.
      Citations: 29     Fields:    
    263. Dehmer T, Heneka MT, Sastre M, Dichgans J, Schulz JB. Protection by pioglitazone in the MPTP model of Parkinson's disease correlates with I kappa B alpha induction and block of NF kappa B and iNOS activation. J Neurochem. 2004 Jan; 88(2):494-501. PMID: 14690537.
      Citations: 138     Fields:    Translation:AnimalsCells
    264. Schmidt S, Moric E, Schmidt M, Sastre M, Feinstein DL, Heneka MT. Anti-inflammatory and antiproliferative actions of PPAR-gamma agonists on T lymphocytes derived from MS patients. J Leukoc Biol. 2004 Mar; 75(3):478-85. PMID: 14657213.
      Citations: 31     Fields:    Translation:HumansCells
    265. Pedraza CE, Baltrons MA, Heneka MT, Garc?a A. Interleukin-1 beta and lipopolysaccharide decrease soluble guanylyl cyclase in brain cells: NO-independent destabilization of protein and NO-dependent decrease of mRNA. J Neuroimmunol. 2003 Nov; 144(1-2):80-90. PMID: 14597101.
      Citations: 9     Fields:    Translation:AnimalsCells
    266. Sastre M, Dewachter I, Landreth GE, Willson TM, Klockgether T, van Leuven F, Heneka MT. Nonsteroidal anti-inflammatory drugs and peroxisome proliferator-activated receptor-gamma agonists modulate immunostimulated processing of amyloid precursor protein through regulation of beta-secretase. J Neurosci. 2003 Oct 29; 23(30):9796-804. PMID: 14586007.
      Citations: 143     Fields:    Translation:HumansAnimalsCells
    267. Galea E, Heneka MT, Dello Russo C, Feinstein DL. Intrinsic regulation of brain inflammatory responses. Cell Mol Neurobiol. 2003 Oct; 23(4-5):625-35. PMID: 14514020.
      Citations: 18     Fields:    Translation:HumansAnimals
    268. Klotz L, Sastre M, Kreutz A, Gavrilyuk V, Klockgether T, Feinstein DL, Heneka MT. Noradrenaline induces expression of peroxisome proliferator activated receptor gamma (PPARgamma) in murine primary astrocytes and neurons. J Neurochem. 2003 Aug; 86(4):907-16. PMID: 12887689.
      Citations: 13     Fields:    Translation:AnimalsCells
    269. Heneka MT, Gavrilyuk V, Landreth GE, O'Banion MK, Weinberg G, Feinstein DL. Noradrenergic depletion increases inflammatory responses in brain: effects on IkappaB and HSP70 expression. J Neurochem. 2003 Apr; 85(2):387-98. PMID: 12675915.
      Citations: 36     Fields:    Translation:Animals
    270. Harzheim M, Altenschmidt M, Heneka MT, Schr?der R, Klockgether T, Schmidt S. IFN-beta1a (Rebif) modifies the expression of microfilament-associated cell-cell contacts in C6 glioma cells. J Interferon Cytokine Res. 2003 Feb; 23(2):83-9. PMID: 12744773.
      Citations: 1     Fields:    Translation:HumansCells
    271. Feinstein DL, Heneka MT, Gavrilyuk V, Dello Russo C, Weinberg G, Galea E. Noradrenergic regulation of inflammatory gene expression in brain. Neurochem Int. 2002 Nov; 41(5):357-65. PMID: 12176079.
      Citations: 89     Fields:    Translation:HumansAnimals
    272. Baltrons MA, Pedraza CE, Heneka MT, Garc?a A. Beta-amyloid peptides decrease soluble guanylyl cyclase expression in astroglial cells. Neurobiol Dis. 2002 Jul; 10(2):139-49. PMID: 12127152.
      Citations: 15     Fields:    Translation:AnimalsCells
    273. Feinstein DL, Galea E, Gavrilyuk V, Brosnan CF, Whitacre CC, Dumitrescu-Ozimek L, Landreth GE, Pershadsingh HA, Weinberg G, Heneka MT. Peroxisome proliferator-activated receptor-gamma agonists prevent experimental autoimmune encephalomyelitis. Ann Neurol. 2002 Jun; 51(6):694-702. PMID: 12112074.
      Citations: 110     Fields:    Translation:HumansAnimalsCells
    274. Heneka MT, Galea E, Gavriluyk V, Dumitrescu-Ozimek L, Daeschner J, O'Banion MK, Weinberg G, Klockgether T, Feinstein DL. Noradrenergic depletion potentiates beta -amyloid-induced cortical inflammation: implications for Alzheimer's disease. J Neurosci. 2002 Apr 01; 22(7):2434-42. PMID: 11923407.
      Citations: 107     Fields:    Translation:AnimalsCells
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