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John P Haran MD

TitleAssociate Professor
InstitutionUniversity of Massachusetts Medical School
DepartmentEmergency Medicine
AddressUniversity of Massachusetts Medical School
55 Lake Avenue North
Worcester MA 01655
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    Other Positions
    InstitutionUMMS - School of Medicine
    DepartmentEmergency Medicine

    InstitutionUMMS - School of Medicine
    DepartmentMicrobiology and Physiological Systems


    Collapse Biography 
    Collapse education and training
    Rensselaer Polytechnic Institute, Troy, NY, United StatesBSBiochemistry & Biophysics
    University of Massachusetts Medical School, Worcester, MA, United StatesMD
    University of Massachusetts Medical School, Worcester, MA, United StatesPhDBiomedical Sciences

    Collapse Overview 
    Collapse overview
    Education:

    BS: Rensselaer Polytechnic Institute                                                                    
    MD: University of Massachusetts Medical School                                                
    Residency Training: Alpert Medical School of Brown University                                
    PhD: University of Massachusetts Medical School Millennium PhD Program

    Appointments:

    Associate Professor of Emergency Medicine                                                   
    Associate Professor in the Department of Microbiology & Physiological Systems 
    Associate Clinical Director of the Center for Microbiome Research

    Research Overview:

     Dr. Haran is an NIH funded investigator who’s research interests include: 1) stemming the spread of Clostridium difficile infection and colonization among nursing home residents and hospitalized elders; 2) preventing the transmission of multi-drug resistant organisms within the hospital setting; and 3) implementing novel treatment guidelines to reduce unnecessary antibiotic usage.

     Dr. Haran’s current research is supported by internal grant funding through UMMS and an R03 GEMSSTAR award through NIA which focuses on the complex interplay between medication use and Clostridium difficile (C. difficile) colonization/infection in both community-dwelling elders and those residing in nursing homes. We have built a large research network of nursing home facilities within central Massachusetts where we collect longitudinal samples and monitor for colonization with C. difficile and other drug resistant organisms. This investigates both: 1) the nursing home microbiome and its association with these organisms; and 2) clinical and nutritional factors that influence the microbiome. The ultimate goal of this work is to identify microbiome changes that occur as an elder transitions to nursing home care which leads to a bacterial carrier state. This will lay the foundation for targeted interventions to prevent the spread of C. difficile and other drug resistant organisms in the elderly nursing home community.

     We are not only working to understand and prevent the spread of these organisms within the nursing home but also within the hospital setting. We are working to combine machine-learning approaches and novel numerical integrators for the prediction of changing dynamics of complex systems that will allow for a personalized evaluation of C. difficile risk in real-time among hospitalized patients undergoing antibiotic treatment. We are working towards establishing a model that will lay the foundation for the future use of rapid point-of-care testing to stratify at-risk patients.

     Finally as a member of the hospital Antimicrobial Stewardship Taskforce, Dr. Haran has worked with other committee members to implement novel antimicrobial treatment algorithms to reduce the unnecessary use of antibiotics within the Emergency Department and the hospital wards. Our current project had dramatically reduced Vancomycin use as a treatment for non-purulent skin infections and helped the hospital to align with the IDSA treatment guidelines for skin and soft tissue infections.


    Collapse Rotation Projects

    Rotation projects are available related to antibiotic usage and the sequelae of antibiotic use in hospitalized patients which include Clostridium difficile and multi-drug resistant organism infection and colonization.




    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Bradley ES, Howe E, Wu X, Haran JP. Proton pump inhibitors and 180-day mortality in the elderly after Clostridium difficile treatment. Gut Pathog. 2019; 11:29. PMID: 31210787.
      View in: PubMed
    2. Haran JP, Bhattarai SK, Foley SE, Dutta P, Ward DV, Bucci V, McCormick BA. Alzheimer's Disease Microbiome Is Associated with Dysregulation of the Anti-Inflammatory P-Glycoprotein Pathway. MBio. 2019 May 07; 10(3). PMID: 31064831.
      View in: PubMed
    3. Haran JP, Volturo GA. Macrolide Resistance in Cases of Community-Acquired Bacterial Pneumonia in the Emergency Department. J Emerg Med. 2018 May 19. PMID: 29789175.
      View in: PubMed
    4. Haran JP, Bucci V, Dutta P, Ward D, McCormick B. The nursing home elder microbiome stability and associations with age, frailty, nutrition and physical location. J Med Microbiol. 2017 Nov 14. PMID: 29134939.
      View in: PubMed
    5. Haran JP, Bradley E, Howe E, Wu X, Tjia J. Medication Exposure and Risk of Recurrent Clostridium difficile Infection in Community-Dwelling Older People and Nursing Home Residents. J Am Geriatr Soc. 2017 Nov 09. PMID: 29120481.
      View in: PubMed
    6. Haran JP, Wilsterman E, Zeoli T, Beaudoin FL, Tjia J, Hibberd PL. Elderly patients are at increased risk for treatment failure in outpatient management of purulent skin infections. Am J Emerg Med. 2016 Oct 29. PMID: 27836315.
      View in: PubMed
    7. Haran JP, Wu G, Bucci V, Fischer A, Keang L, Boyer EW, Hibberd PL. Antibiotic-associated diarrhoea in emergency department observation unit patients. Epidemiol Infect. 2016 Jul; 144(10):2176-83. PMID: 27324463.
      View in: PubMed
    8. Haran JP, Wu G, Bucci V, Fischer A, Boyer EW, Hibberd PL. Treatment of bacterial skin infections in ED observation units: factors influencing prescribing practice. Am J Emerg Med. 2015 Dec; 33(12):1780-5. PMID: 26381681.
      View in: PubMed
    9. Haran JP, Hayward G, Skinner S, Merritt C, Hoaglin DC, Hibberd PL, Lu S, Boyer EW. Factors influencing the development of antibiotic associated diarrhea in ED patients discharged home: risk of administering IV antibiotics. Am J Emerg Med. 2014 Oct; 32(10):1195-9. PMID: 25149599.
      View in: PubMed
    10. Haran JP, Hoaglin DC, Chen H, Boyer EW, Lu S. Antigen-specific H1N1 influenza antibody responses in acute respiratory tract infections and their relation to influenza infection and disease course. J Clin Virol. 2014 Aug; 60(4):367-73. PMID: 24930707.
      View in: PubMed
    11. Haran JP, Pezzella L. A case of neck pain: The presentation of Chairi 1 malformations in children. J Emerg Trauma Shock. 2014 Jan; 7(1):32-4. PMID: 24550627.
      View in: PubMed
    12. Merritt C, Haran JP, Mintzer J, Stricker J, Merchant RC. All purulence is local - epidemiology and management of skin and soft tissue infections in three urban emergency departments. BMC Emerg Med. 2013; 13:26. PMID: 24359038.
      View in: PubMed
    13. Moise L, Tassone R, Latimer H, Terry F, Levitz L, Haran JP, Ross TM, Boyle CM, Martin WD, De Groot AS. Immunization with cross-conserved H1N1 influenza CD4+ T-cell epitopes lowers viral burden in HLA DR3 transgenic mice. Hum Vaccin Immunother. 2013 Oct; 9(10):2060-8. PMID: 24045788.
      View in: PubMed
    14. Beaudoin FL, Haran JP, Liebmann O. A comparison of ultrasound-guided three-in-one femoral nerve block versus parenteral opioids alone for analgesia in emergency department patients with hip fractures: a randomized controlled trial. Acad Emerg Med. 2013 Jun; 20(6):584-91. PMID: 23758305.
      View in: PubMed
    15. Haran JP, Buglione-Corbett R, Lu S. Cytokine markers as predictors of type of respiratory infection in patients during the influenza season. Am J Emerg Med. 2013 May; 31(5):816-21. PMID: 23481156.
      View in: PubMed
    16. Haran JP, Beaudoin FL, Suner S, Lu S. C-reactive protein as predictor of bacterial infection among patients with an influenza-like illness. Am J Emerg Med. 2013 Jan; 31(1):137-44. PMID: 22944552.
      View in: PubMed
    17. Haran JP, Suner S, Gardiner F. Correlation of C-reactive protein to severity of symptoms in acute influenza A infection. J Emerg Trauma Shock. 2012 Apr; 5(2):149-52. PMID: 22787345.
      View in: PubMed
    18. Wessolossky M, Haran JP, Bagchi K. Paecilomyces lilacinus olecranon bursitis in an immunocompromised host: case report and review. Diagn Microbiol Infect Dis. 2008 Jul; 61(3):354-7. PMID: 18358663.
      View in: PubMed
    19. Haran JP, Greenough TC, Luzuriaga K, Sullivan JL, Flanigan T, Somasundaran M. Enhanced culture method for detection of replication-competent virus in peripheral blood mononuclear cells of HIV type 1-infected individuals. AIDS Res Hum Retroviruses. 2002 May 20; 18(8):577-83. PMID: 12036487.
      View in: PubMed
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