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Peter Chien PhD

TitleAssistant Professor
InstitutionUniversity of Massachusetts Amherst
DepartmentCollege of Natural Sciences
AddressN325 Life Sciences Lab
Amherst, MA 01003
Phone413-545-2310
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    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Lariviere PJ, Mahone CR, Santiago-Collazo G, Howell M, Daitch AK, Zeinert R, Chien P, Brown PJB, Goley ED. An Essential Regulator of Bacterial Division Links FtsZ to Cell Wall Synthase Activation. Curr Biol. 2019 Apr 22. PMID: 31031115.
      View in: PubMed
    2. Liu J, Zeinert R, Francis L, Chien P. Lon recognition of the replication initiator DnaA requires a bipartite degron. Mol Microbiol. 2018 Oct 04. PMID: 30288816.
      View in: PubMed
    3. Joshi KK, Battle CM, Chien P. The polar localization hub protein PopZ restrains adaptor dependent ClpXP proteolysis in Caulobacter crescentus. J Bacteriol. 2018 Aug 06. PMID: 30082457.
      View in: PubMed
    4. Mahmoud SA, Chien P. Regulated Proteolysis in Bacteria. Annu Rev Biochem. 2018 Jun 20; 87:677-696. PMID: 29648875.
      View in: PubMed
    5. Joshi KK, Sutherland M, Chien P. Cargo engagement protects protease adaptors from degradation in a substrate-specific manner. J Biol Chem. 2017 May 15. PMID: 28507098.
      View in: PubMed
    6. Vass RH, Nascembeni J, Chien P. The Essential Role of ClpXP in Caulobacter crescentus Requires Species Constrained Substrate Specificity. Front Mol Biosci. 2017; 4:28. PMID: 28536693.
      View in: PubMed
    7. Kuhlmann NJ, Chien P. Selective adaptor dependent protein degradation in bacteria. Curr Opin Microbiol. 2017 Apr 27; 36:118-127. PMID: 28458096.
      View in: PubMed
    8. Liu J, Francis LI, Jonas K, Laub MT, Chien P. ClpAP is an auxiliary protease for DnaA degradation in Caulobacter crescentus. Mol Microbiol. 2016 Dec; 102(6):1075-1085. PMID: 27667502.
      View in: PubMed
    9. Joshi KK, Chien P. Regulated Proteolysis in Bacteria: Caulobacter. Annu Rev Genet. 2016 Nov 23; 50:423-445. PMID: 27893963.
      View in: PubMed
    10. Vass RH, Zeinert RD, Chien P. Protease regulation and capacity during Caulobacter growth. Curr Opin Microbiol. 2016 Dec; 34:75-81. PMID: 27543838.
      View in: PubMed
    11. Vass RH, Chien P. Two ways to skin a cat: acyldepsipeptides antibiotics can kill bacteria through activation or inhibition of ClpP activity. Mol Microbiol. 2016 Jul; 101(2):183-5. PMID: 27000447.
      View in: PubMed
    12. Joshi KK, Bergé M, Radhakrishnan SK, Viollier PH, Chien P. An Adaptor Hierarchy Regulates Proteolysis during a Bacterial Cell Cycle. Cell. 2015 Oct 08; 163(2):419-31. PMID: 26451486.
      View in: PubMed
    13. Chien P. Not Throwing Baby Out with the Bathwater. Plant Cell. 2015 Oct; 27(10):2669-70. PMID: 26419669.
      View in: PubMed
    14. Lau J, Hernandez-Alicea L, Vass RH, Chien P. A Phosphosignaling Adaptor Primes the AAA+ Protease ClpXP to Drive Cell Cycle-Regulated Proteolysis. Mol Cell. 2015 Jul 2; 59(1):104-16. PMID: 26073542.
      View in: PubMed
    15. Schallies KB, Sadowski C, Meng J, Chien P, Gibson KE. Sinorhizobium meliloti CtrA Stability Is Regulated in a CbrA-Dependent Manner That Is Influenced by CpdR1. J Bacteriol. 2015 Jul; 197(13):2139-49. PMID: 25897034.
      View in: PubMed
    16. Mukherjee S, Bree AC, Liu J, Patrick JE, Chien P, Kearns DB. Adaptor-mediated Lon proteolysis restricts Bacillus subtilis hyperflagellation. Proc Natl Acad Sci U S A. 2015 Jan 06; 112(1):250-5. PMID: 25538299; PMCID: PMC4291670.
    17. Chien P, Gierasch LM. Challenges and dreams: physics of weak interactions essential to life. Mol Biol Cell. 2014 Nov 5; 25(22):3474-7. PMID: 25368424.
      View in: PubMed
    18. Liu J, Chien P. Structure and activation of a heteromeric protease complex. Proc Natl Acad Sci U S A. 2014 Oct 28; 111(43):15289-90. PMID: 25331885.
      View in: PubMed
    19. Smith SC, Joshi KK, Zik JJ, Trinh K, Kamajaya A, Chien P, Ryan KR. Cell cycle-dependent adaptor complex for ClpXP-mediated proteolysis directly integrates phosphorylation and second messenger signals. Proc Natl Acad Sci U S A. 2014 Sep 30; 111(39):14229-34. PMID: 25197043.
      View in: PubMed
    20. Williams B, Bhat N, Chien P, Shapiro L. ClpXP and ClpAP proteolytic activity on divisome substrates is differentially regulated following the Caulobacter asymmetric cell division. Mol Microbiol. 2014 Sep; 93(5):853-66. PMID: 24989075.
      View in: PubMed
    21. Vass RH, Chien P. Critical clamp loader processing by an essential AAA+ protease in Caulobacter crescentus. Proc Natl Acad Sci U S A. 2013 Nov 5; 110(45):18138-43. PMID: 24145408.
      View in: PubMed
    22. Jonas K, Liu J, Chien P, Laub MT. Proteotoxic stress induces a cell-cycle arrest by stimulating Lon to degrade the replication initiator DnaA. Cell. 2013 Aug 1; 154(3):623-36. PMID: 23911325.
      View in: PubMed
    23. Bhat NH, Vass RH, Stoddard PR, Shin DK, Chien P. Identification of ClpP substrates in Caulobacter crescentus reveals a role for regulated proteolysis in bacterial development. Mol Microbiol. 2013 Jun; 88(6):1083-92. PMID: 23647068.
      View in: PubMed
    24. Gora KG, Cantin A, Wohlever M, Joshi KK, Perchuk BS, Chien P, Laub MT. Regulated proteolysis of a transcription factor complex is critical to cell cycle progression in Caulobacter crescentus. Mol Microbiol. 2013 Mar; 87(6):1277-89. PMID: 23368090.
      View in: PubMed
    25. Rood KL, Clark NE, Stoddard PR, Garman SC, Chien P. Adaptor-dependent degradation of a cell-cycle regulator uses a unique substrate architecture. Structure. 2012 Jul 3; 20(7):1223-32. PMID: 22682744.
      View in: PubMed
    26. Abel S, Chien P, Wassmann P, Schirmer T, Kaever V, Laub MT, Baker TA, Jenal U. Regulatory cohesion of cell cycle and cell differentiation through interlinked phosphorylation and second messenger networks. Mol Cell. 2011 Aug 19; 43(4):550-60. PMID: 21855795.
      View in: PubMed
    27. Chowdhury T, Chien P, Ebrahim S, Sauer RT, Baker TA. Versatile modes of peptide recognition by the ClpX N domain mediate alternative adaptor-binding specificities in different bacterial species. Protein Sci. 2010 Feb; 19(2):242-54. PMID: 20014030.
      View in: PubMed
    28. Kobayashi H, De Nisco NJ, Chien P, Simmons LA, Walker GC. Sinorhizobium meliloti CpdR1 is critical for co-ordinating cell cycle progression and the symbiotic chronic infection. Mol Microbiol. 2009 Aug; 73(4):586-600. PMID: 19602145.
      View in: PubMed
    29. Chien P, Grant RA, Sauer RT, Baker TA. Structure and substrate specificity of an SspB ortholog: design implications for AAA+ adaptors. Structure. 2007 Oct; 15(10):1296-305. PMID: 17937918.
      View in: PubMed
    30. Chien P, Perchuk BS, Laub MT, Sauer RT, Baker TA. Direct and adaptor-mediated substrate recognition by an essential AAA+ protease. Proc Natl Acad Sci U S A. 2007 Apr 17; 104(16):6590-5. PMID: 17420450.
      View in: PubMed
    31. Tanaka M, Chien P, Yonekura K, Weissman JS. Mechanism of cross-species prion transmission: an infectious conformation compatible with two highly divergent yeast prion proteins. Cell. 2005 Apr 8; 121(1):49-62. PMID: 15820678.
      View in: PubMed
    32. Chien P, Weissman JS, DePace AH. Emerging principles of conformation-based prion inheritance. Annu Rev Biochem. 2004; 73:617-56. PMID: 15189155.
      View in: PubMed
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