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Peter Chien PhD

TitleAssistant Professor
InstitutionUniversity of Massachusetts Amherst
DepartmentCollege of Natural Sciences
AddressN325 Life Sciences Lab
Amherst, MA 01003
Phone413-545-2310
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Sarsani V, Aldikacti B, Zhao T, He S, Chien P, Flaherty P. Discovering genetic modulators of the protein homeostasis system through multilevel analysis. PNAS Nexus. 2025 Jan; 4(1):pgae574. PMID: 39807344.
      Citations:    
    2. Ogdahl JL, Chien P. Allosteric modulation of the Lon protease via ssDNA binding and local charge changes. J Biol Chem. 2025 Jan; 301(1):107993. PMID: 39542252.
      Citations:    
    3. Ogdahl JL, Chien P. Allosteric modulation of the Lon protease by effector binding and local charges. bioRxiv. 2024 Sep 06. PMID: 39282454.
      Citations:    
    4. Yigit K, Chien P. Proteolytic control of FixT by the Lon protease impacts FixLJ signaling in Caulobacter crescentus. J Bacteriol. 2024 07 25; 206(7):e0023724. PMID: 38940598.
      Citations:    
    5. Campbell M, Barton IS, Roop RM, Chien P. Comparison of CcrM-dependent methylation in Caulobacter crescentus and Brucella abortus by nanopore sequencing. J Bacteriol. 2024 06 20; 206(6):e0008324. PMID: 38722176.
      Citations:    
    6. Smith EL, Panis G, Woldemeskel SA, Viollier PH, Chien P, Goley ED. Regulation of the transcription factor CdnL promotes adaptation to nutrient stress in Caulobacter. PNAS Nexus. 2024 Apr; 3(4):pgae154. PMID: 38650860.
      Citations:    
    7. Campbell M, Barton IS, Roop RM, Chien P. Comparison of CcrM-dependent methylation in Caulobacter crescentus and Brucella abortus by nanopore sequencing. bioRxiv. 2024 Mar 02. PMID: 38464217.
      Citations:    
    8. Sarsani V, Aldikacti B, Zhao T, He S, Chien P, Flaherty P. Discovering Genetic Modulators of the Protein Homeostasis System through Multilevel Analysis. bioRxiv. 2024 Feb 29. PMID: 38464212.
      Citations:    
    9. Yigit K, Chien P. Proteolytic control of FixT by the Lon protease impacts FixLJ signaling in Caulobacter crescentus. bioRxiv. 2024 Feb 06. PMID: 38370668.
      Citations:    
    10. Smith EL, Panis G, Woldemeskel SA, Viollier PH, Chien P, Goley ED. Regulation of the transcription factor CdnL promotes adaptation to nutrient stress in Caulobacter. bioRxiv. 2023 Dec 21. PMID: 38187569.
      Citations:    
    11. Tashjian TF, Zeinert RD, Eyles SJ, Chien P. Proteomic survey of the DNA damage response in Caulobacter crescentus. J Bacteriol. 2023 10 26; 205(10):e0020623. PMID: 37730540.
      Citations:    Fields:    Translation:HumansCells
    12. LaBianca K, Butura J, McKnight A, Pan K, Whelan S, Punska E, Pause R, Igbinosa B, Ribbe A, Chien P, Russell D, Garlena R, Hatfull G, Jacobs-Sera D, Rocheleau J. Complete genome sequence of phi29-like Microbacterium foliorum podovirus phage PineapplePizza. Microbiol Resour Announc. 2023 Oct 19; 12(10):e0047823. PMID: 37671874.
      Citations:    
    13. Chien P, Goley ED. Editorial overview: Turtles all the way down: Bacterial cell regulation across scales. Curr Opin Microbiol. 2023 10; 75:102378. PMID: 37639941.
      Citations:    Fields:    Translation:Animals
    14. Tashjian TF, Zeinert RD, Eyles SJ, Chien P. Proteomic survey of the DNA damage response in Caulobacter crescentus. bioRxiv. 2023 Jun 30. PMID: 36993274.
      Citations:    
    15. Tashjian TF, Chien P. Clamp Loader Processing Is Important during DNA Replication Stress. J Bacteriol. 2023 02 22; 205(2):e0043722. PMID: 36728506.
      Citations: 1     Fields:    Translation:Cells
    16. Daitch AK, Orsburn BC, Chen Z, Alvarez L, Eberhard CD, Sundararajan K, Zeinert R, Kreitler DF, Jakoncic J, Chien P, Cava F, Gabelli SB, Goley ED. EstG is a novel esterase required for cell envelope integrity in Caulobacter. Curr Biol. 2023 01 23; 33(2):228-240.e7. PMID: 36516849.
      Citations: 1     Fields:    Translation:Cells
    17. Bamgbowu D, Bsoumai J, Butura J, Cady E, Cholod G, Collibee I, Dompreh L, Eisner S, Elmaleh M, Fitzgerald K, Gillis E, Horgan A, Judd D, Keefe J, Kovalski E, LaBianca K, Lee P, Lin F, Maiuri H, McDonald C, McKnight A, Meseerole M, Mizra F, Monger E, Moore E, Nguyen N, Noel B, O'Connor D, Pagani R, Palmgren M, Pan K, Pech B, Qian J, Rastegar S, Simas B, Southard A, Tracy M, Vuong H, Whelan S, Zou A, Punska E, Pause R, Zhang F, Ribbe A, Chien P, Rocheleau J. Genome Sequences of Microbacterium foliorum Phages Anseraureola, Pondwater, and Yasuo. Microbiol Resour Announc. 2022 Nov 17; 11(11):e0084922. PMID: 36227095.
      Citations:    
    18. Mahmoud SA, Aldikacti B, Chien P. ATP hydrolysis tunes specificity of a AAA+ protease. Cell Rep. 2022 09 20; 40(12):111405. PMID: 36130509.
      Citations: 3     Fields:    Translation:Cells
    19. Olney SG, Chien P, Kearns DB. SmiA is a hybrid priming/scaffolding adaptor for the LonA protease in Bacillus subtilis. J Biol Chem. 2022 07; 298(7):102045. PMID: 35595098.
      Citations: 2     Fields:    Translation:Cells
    20. Sarsani V, Aldikacti B, He S, Zeinert R, Chien P, Flaherty P. Model-based identification of conditionally-essential genes from transposon-insertion sequencing data. PLoS Comput Biol. 2022 03; 18(3):e1009273. PMID: 35255084.
      Citations: 1     Fields:    Translation:Cells
    21. Yang Q, Liu P, Anderson NS, Shpilka T, Du Y, Naresh NU, Li R, Zhu LJ, Luk K, Lavelle J, Zeinert RD, Chien P, Wolfe SA, Haynes CM. LONP-1 and ATFS-1 sustain deleterious heteroplasmy by promoting mtDNA replication in dysfunctional mitochondria. Nat Cell Biol. 2022 02; 24(2):181-193. PMID: 35165413.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    22. Sun Z, Wu R, Zhao B, Zeinert R, Chien P, You M. Live-Cell Imaging of Guanosine Tetra- and Pentaphosphate (p)ppGpp with RNA-based Fluorescent Sensors*. Angew Chem Int Ed Engl. 2021 11 02; 60(45):24070-24074. PMID: 34487413.
      Citations: 7     Fields:    Translation:Cells
    23. Kuhlmann NJ, Doxsey D, Chien P. Cargo competition for a dimerization interface restricts and stabilizes a bacterial protease adaptor. Proc Natl Acad Sci U S A. 2021 04 27; 118(17). PMID: 33875581.
      Citations: 3     Fields:    Translation:Cells
    24. Barros BB, Mahmoud SA, Chien P, Zeinert RD. Degradation of Lon in Caulobacter crescentus. J Bacteriol. 2020 12 07; 203(1). PMID: 33020222.
      Citations: 6     Fields:    Translation:Cells
    25. Tremblay CY, Vass RH, Vachet RW, Chien P. The Cleavage Profile of Protein Substrates by ClpXP Reveals Deliberate Starts and Pauses. Biochemistry. 2020 11 10; 59(44):4294-4301. PMID: 33135889.
      Citations: 3     Fields:    Translation:Cells
    26. Zeinert RD, Baniasadi H, Tu BP, Chien P. The Lon Protease Links Nucleotide Metabolism with Proteotoxic Stress. Mol Cell. 2020 09 03; 79(5):758-767.e6. PMID: 32755596.
      Citations: 10     Fields:    Translation:Cells
    27. Joshi A, Mahmoud SA, Kim SK, Ogdahl JL, Lee VT, Chien P, Yildiz FH. c-di-GMP inhibits LonA-dependent proteolysis of TfoY in Vibrio cholerae. PLoS Genet. 2020 06; 16(6):e1008897. PMID: 32589664.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    28. Woldemeskel SA, Daitch AK, Alvarez L, Panis G, Zeinert R, Gonzalez D, Smith E, Collier J, Chien P, Cava F, Viollier PH, Goley ED. The conserved transcriptional regulator CdnL is required for metabolic homeostasis and morphogenesis in Caulobacter. PLoS Genet. 2020 01; 16(1):e1008591. PMID: 31961855.
      Citations: 11     Fields:    Translation:Cells
    29. Lariviere PJ, Mahone CR, Santiago-Collazo G, Howell M, Daitch AK, Zeinert R, Chien P, Brown PJB, Goley ED. An Essential Regulator of Bacterial Division Links FtsZ to Cell Wall Synthase Activation. Curr Biol. 2019 05 06; 29(9):1460-1470.e4. PMID: 31031115.
      Citations: 9     Fields:    Translation:Cells
    30. Liu J, Zeinert R, Francis L, Chien P. Lon recognition of the replication initiator DnaA requires a bipartite degron. Mol Microbiol. 2019 01; 111(1):176-186. PMID: 30288816.
      Citations: 12     Fields:    Translation:Cells
    31. Joshi KK, Battle CM, Chien P. Polar Localization Hub Protein PopZ Restrains Adaptor-Dependent ClpXP Proteolysis in Caulobacter crescentus. J Bacteriol. 2018 10 15; 200(20). PMID: 30082457.
      Citations: 7     Fields:    Translation:Cells
    32. Mahmoud SA, Chien P. Regulated Proteolysis in Bacteria. Annu Rev Biochem. 2018 06 20; 87:677-696. PMID: 29648875.
      Citations: 61     Fields:    Translation:Cells
    33. Joshi KK, Sutherland M, Chien P. Cargo engagement protects protease adaptors from degradation in a substrate-specific manner. J Biol Chem. 2017 06 30; 292(26):10973-10982. PMID: 28507098.
      Citations: 3     Fields:    Translation:Cells
    34. Vass RH, Nascembeni J, Chien P. The Essential Role of ClpXP in Caulobacter crescentus Requires Species Constrained Substrate Specificity. Front Mol Biosci. 2017; 4:28. PMID: 28536693.
      Citations:    
    35. Kuhlmann NJ, Chien P. Selective adaptor dependent protein degradation in bacteria. Curr Opin Microbiol. 2017 Apr; 36:118-127. PMID: 28458096.
      Citations: 22     Fields:    Translation:Cells
    36. Liu J, Francis LI, Jonas K, Laub MT, Chien P. ClpAP is an auxiliary protease for DnaA degradation in Caulobacter crescentus. Mol Microbiol. 2016 12; 102(6):1075-1085. PMID: 27667502.
      Citations: 17     Fields:    Translation:Cells
    37. Joshi KK, Chien P. Regulated Proteolysis in Bacteria: Caulobacter. Annu Rev Genet. 2016 Nov 23; 50:423-445. PMID: 27893963.
      Citations: 25     Fields:    Translation:Cells
    38. Vass RH, Zeinert RD, Chien P. Protease regulation and capacity during Caulobacter growth. Curr Opin Microbiol. 2016 12; 34:75-81. PMID: 27543838.
      Citations: 9     Fields:    Translation:Cells
    39. Vass RH, Chien P. Two ways to skin a cat: acyldepsipeptides antibiotics can kill bacteria through activation or inhibition of ClpP activity. Mol Microbiol. 2016 07; 101(2):183-5. PMID: 27000447.
      Citations:    Fields:    Translation:Cells
    40. Joshi KK, Berg? M, Radhakrishnan SK, Viollier PH, Chien P. An Adaptor Hierarchy Regulates Proteolysis during a Bacterial Cell Cycle. Cell. 2015 Oct 08; 163(2):419-31. PMID: 26451486.
      Citations: 50     Fields:    Translation:Cells
    41. Chien P. Not Throwing Baby Out with the Bathwater. Plant Cell. 2015 Oct; 27(10):2669-70. PMID: 26419669.
      Citations:    Fields:    
    42. Lau J, Hernandez-Alicea L, Vass RH, Chien P. A Phosphosignaling Adaptor Primes the AAA+ Protease ClpXP to Drive Cell Cycle-Regulated Proteolysis. Mol Cell. 2015 Jul 02; 59(1):104-16. PMID: 26073542.
      Citations: 28     Fields:    Translation:Cells
    43. Schallies KB, Sadowski C, Meng J, Chien P, Gibson KE. Sinorhizobium meliloti CtrA Stability Is Regulated in a CbrA-Dependent Manner That Is Influenced by CpdR1. J Bacteriol. 2015 Jul; 197(13):2139-2149. PMID: 25897034.
      Citations: 6     Fields:    Translation:Cells
    44. Mukherjee S, Bree AC, Liu J, Patrick JE, Chien P, Kearns DB. Adaptor-mediated Lon proteolysis restricts Bacillus subtilis hyperflagellation. Proc Natl Acad Sci U S A. 2015 Jan 06; 112(1):250-5. PMID: 25538299.
      Citations: 55     Fields:    Translation:Cells
    45. Chien P, Gierasch LM. Challenges and dreams: physics of weak interactions essential to life. Mol Biol Cell. 2014 Nov 05; 25(22):3474-7. PMID: 25368424.
      Citations: 21     Fields:    Translation:Cells
    46. Liu J, Chien P. Structure and activation of a heteromeric protease complex. Proc Natl Acad Sci U S A. 2014 Oct 28; 111(43):15289-90. PMID: 25331885.
      Citations:    Fields:    Translation:Cells
    47. Smith SC, Joshi KK, Zik JJ, Trinh K, Kamajaya A, Chien P, Ryan KR. Cell cycle-dependent adaptor complex for ClpXP-mediated proteolysis directly integrates phosphorylation and second messenger signals. Proc Natl Acad Sci U S A. 2014 Sep 30; 111(39):14229-34. PMID: 25197043.
      Citations: 37     Fields:    Translation:Cells
    48. Williams B, Bhat N, Chien P, Shapiro L. ClpXP and ClpAP proteolytic activity on divisome substrates is differentially regulated following the Caulobacter asymmetric cell division. Mol Microbiol. 2014 Sep; 93(5):853-66. PMID: 24989075.
      Citations: 34     Fields:    Translation:Cells
    49. Vass RH, Chien P. Critical clamp loader processing by an essential AAA+ protease in Caulobacter crescentus. Proc Natl Acad Sci U S A. 2013 Nov 05; 110(45):18138-43. PMID: 24145408.
      Citations: 27     Fields:    Translation:Cells
    50. Jonas K, Liu J, Chien P, Laub MT. Proteotoxic stress induces a cell-cycle arrest by stimulating Lon to degrade the replication initiator DnaA. Cell. 2013 Aug 01; 154(3):623-36. PMID: 23911325.
      Citations: 84     Fields:    Translation:Cells
    51. Bhat NH, Vass RH, Stoddard PR, Shin DK, Chien P. Identification of ClpP substrates in Caulobacter crescentus reveals a role for regulated proteolysis in bacterial development. Mol Microbiol. 2013 Jun; 88(6):1083-92. PMID: 23647068.
      Citations: 44     Fields:    Translation:Cells
    52. Gora KG, Cantin A, Wohlever M, Joshi KK, Perchuk BS, Chien P, Laub MT. Regulated proteolysis of a transcription factor complex is critical to cell cycle progression in Caulobacter crescentus. Mol Microbiol. 2013 Mar; 87(6):1277-89. PMID: 23368090.
      Citations: 37     Fields:    Translation:Cells
    53. Rood KL, Clark NE, Stoddard PR, Garman SC, Chien P. Adaptor-dependent degradation of a cell-cycle regulator uses a unique substrate architecture. Structure. 2012 Jul 03; 20(7):1223-32. PMID: 22682744.
      Citations: 20     Fields:    Translation:Cells
    54. Abel S, Chien P, Wassmann P, Schirmer T, Kaever V, Laub MT, Baker TA, Jenal U. Regulatory cohesion of cell cycle and cell differentiation through interlinked phosphorylation and second messenger networks. Mol Cell. 2011 Aug 19; 43(4):550-60. PMID: 21855795.
      Citations: 98     Fields:    Translation:Cells
    55. Chowdhury T, Chien P, Ebrahim S, Sauer RT, Baker TA. Versatile modes of peptide recognition by the ClpX N domain mediate alternative adaptor-binding specificities in different bacterial species. Protein Sci. 2010 Feb; 19(2):242-54. PMID: 20014030.
      Citations: 10     Fields:    Translation:Cells
    56. Kobayashi H, De Nisco NJ, Chien P, Simmons LA, Walker GC. Sinorhizobium meliloti CpdR1 is critical for co-ordinating cell cycle progression and the symbiotic chronic infection. Mol Microbiol. 2009 Aug; 73(4):586-600. PMID: 19602145.
      Citations: 31     Fields:    Translation:Cells
    57. Chien P, Grant RA, Sauer RT, Baker TA. Structure and substrate specificity of an SspB ortholog: design implications for AAA+ adaptors. Structure. 2007 Oct; 15(10):1296-305. PMID: 17937918.
      Citations: 14     Fields:    Translation:Cells
    58. Chien P, Perchuk BS, Laub MT, Sauer RT, Baker TA. Direct and adaptor-mediated substrate recognition by an essential AAA+ protease. Proc Natl Acad Sci U S A. 2007 Apr 17; 104(16):6590-5. PMID: 17420450.
      Citations: 56     Fields:    Translation:Cells
    59. Tanaka M, Chien P, Yonekura K, Weissman JS. Mechanism of cross-species prion transmission: an infectious conformation compatible with two highly divergent yeast prion proteins. Cell. 2005 Apr 08; 121(1):49-62. PMID: 15820678.
      Citations: 79     Fields:    Translation:AnimalsCells
    60. Chien P, Weissman JS, DePace AH. Emerging principles of conformation-based prion inheritance. Annu Rev Biochem. 2004; 73:617-56. PMID: 15189155.
      Citations: 131     Fields:    Translation:HumansAnimalsCells
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