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Norman J Kennedy PhD

TitleAssistant Professor
InstitutionUMass Chan Medical School
DepartmentProgram in Molecular Medicine
AddressUMass Chan Medical School
373 Plantation Street
Worcester MA 01605
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    Other Positions
    InstitutionT.H. Chan School of Medicine
    DepartmentProgram in Molecular Medicine

    Collapse Biography 
    Collapse education and training
    Dartmouth College, Hanover, NH, United StatesBAArts
    University of Vermont, Burlington, VT, United StatesPHDPhilosophy

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Vernia S, Lee A, Kennedy NJ, Han MS, Isasa M, Cavanagh-Kyros J, Roy A, Syed A, Chaudhry S, Edwards YJK, Gygi SP, Gao G, Davis RJ. Phosphorylation of RXRa mediates the effect of JNK to suppress hepatic FGF21 expression and promote metabolic syndrome. Proc Natl Acad Sci U S A. 2022 11; 119(44):e2210434119. PMID: 36282921.
      Citations: 2     Fields:    Translation:AnimalsCells
    2. Crespo M, Gonzalez-Teran B, Nikolic I, Mora A, Folgueira C, Rodr?guez E, Leiva-Vega L, Pintor-Chocano A, Fern?ndez-Chac?n M, Ruiz-Garrido I, Cicu?ndez B, Tom?s-Loba A, A-Gonzalez N, Caballero-Molano A, Beiroa D, Hern?ndez-Cosido L, Torres JL, Kennedy NJ, Davis RJ, Benedito R, Marcos M, Nogueiras R, Hidalgo A, Matesanz N, Leiva M, Sabio G. Neutrophil infiltration regulates clock-gene expression to organize daily hepatic metabolism. Elife. 2020 12 08; 9. PMID: 33287957.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    3. Dittmann A, Kennedy NJ, Soltero NL, Morshed N, Mana MD, Yilmaz ?H, Davis RJ, White FM. High-fat diet in a mouse insulin-resistant model induces widespread rewiring of the phosphotyrosine signaling network. Mol Syst Biol. 2019 08; 15(8):e8849. PMID: 31464373.
      Citations: 9     Fields:    Translation:AnimalsCells
    4. Jangalwe S, Kapoor VN, Xu J, Girnius N, Kennedy NJ, Edwards YJK, Welsh RM, Davis RJ, Brehm MA. Cutting Edge: Early Attrition of Memory T Cells during Inflammation and Costimulation Blockade Is Regulated Concurrently by Proapoptotic Proteins Fas and Bim. J Immunol. 2019 02 01; 202(3):647-651. PMID: 30610162.
      Citations: 4     Fields:    Translation:AnimalsCells
    5. Morel C, Sherrin T, Kennedy NJ, Forest KH, Avcioglu Barutcu S, Robles M, Carpenter-Hyland E, Alfulaij N, Standen CL, Nichols RA, Benveniste M, Davis RJ, Todorovic C. JIP1-Mediated JNK Activation Negatively Regulates Synaptic Plasticity and Spatial Memory. J Neurosci. 2018 04 11; 38(15):3708-3728. PMID: 29540552.
      Citations: 14     Fields:    Translation:AnimalsCells
    6. Soltis AR, Kennedy NJ, Xin X, Zhou F, Ficarro SB, Yap YS, Matthews BJ, Lauffenburger DA, White FM, Marto JA, Davis RJ, Fraenkel E. Hepatic Dysfunction Caused by Consumption of a High-Fat Diet. Cell Rep. 2017 Dec 12; 21(11):3317-3328. PMID: 29241556.
      Citations: 36     Fields:    Translation:AnimalsCells
    7. Soltis AR, Motola S, Vernia S, Ng CW, Kennedy NJ, Dalin S, Matthews BJ, Davis RJ, Fraenkel E. Hyper- and hypo- nutrition studies of the hepatic transcriptome and epigenome suggest that PPARa regulates anaerobic glycolysis. Sci Rep. 2017 03 14; 7(1):174. PMID: 28282965.
      Citations: 10     Fields:    Translation:AnimalsCells
    8. Vernia S, Morel C, Madara JC, Cavanagh-Kyros J, Barrett T, Chase K, Kennedy NJ, Jung DY, Kim JK, Aronin N, Flavell RA, Lowell BB, Davis RJ. Excitatory transmission onto AgRP neurons is regulated by cJun NH2-terminal kinase 3 in response to metabolic stress. Elife. 2016 Feb 24; 5:e10031. PMID: 26910012.
      Citations: 17     Fields:    Translation:AnimalsCells
    9. Blodgett DM, Nowosielska A, Afik S, Pechhold S, Cura AJ, Kennedy NJ, Kim S, Kucukural A, Davis RJ, Kent SC, Greiner DL, Garber MG, Harlan DM, diIorio P. Novel Observations From Next-Generation RNA Sequencing of Highly Purified Human Adult and Fetal Islet Cell Subsets. Diabetes. 2015 Sep; 64(9):3172-81. PMID: 25931473.
      Citations: 159     Fields:    Translation:HumansCells
    10. Zhang Y, Nguyen T, Tang P, Kennedy NJ, Jiao H, Zhang M, Reynolds JM, Jaeschke A, Martin-Orozco N, Chung Y, He WM, Wang C, Jia W, Ge B, Davis RJ, Flavell RA, Dong C. Regulation of Adipose Tissue Inflammation and Insulin Resistance by MAPK Phosphatase 5. J Biol Chem. 2015 Jun 12; 290(24):14875-83. PMID: 25922079.
      Citations: 11     Fields:    Translation:AnimalsCells
    11. Lo KA, Labadorf A, Kennedy NJ, Han MS, Yap YS, Matthews B, Xin X, Sun L, Davis RJ, Lodish HF, Fraenkel E. Analysis of in vitro insulin-resistance models and their physiological relevance to in vivo diet-induced adipose insulin resistance. Cell Rep. 2013 Oct 17; 5(1):259-70. PMID: 24095730.
      Citations: 52     Fields:    Translation:HumansAnimals
    12. Gao Z, Zhang J, Kheterpal I, Kennedy N, Davis RJ, Ye J. Sirtuin 1 (SIRT1) protein degradation in response to persistent c-Jun N-terminal kinase 1 (JNK1) activation contributes to hepatic steatosis in obesity. J Biol Chem. 2011 Jun 24; 286(25):22227-34. PMID: 21540183.
      Citations: 89     Fields:    Translation:HumansAnimalsCells
    13. Cellurale C, Sabio G, Kennedy NJ, Das M, Barlow M, Sandy P, Jacks T, Davis RJ. Requirement of c-Jun NH(2)-terminal kinase for Ras-initiated tumor formation. Mol Cell Biol. 2011 Apr; 31(7):1565-76. PMID: 21282468.
      Citations: 52     Fields:    Translation:AnimalsCells
    14. Sabio G, Kennedy NJ, Cavanagh-Kyros J, Jung DY, Ko HJ, Ong H, Barrett T, Kim JK, Davis RJ. Role of muscle c-Jun NH2-terminal kinase 1 in obesity-induced insulin resistance. Mol Cell Biol. 2010 Jan; 30(1):106-15. PMID: 19841069.
      Citations: 74     Fields:    Translation:AnimalsCells
    15. Standen CL, Kennedy NJ, Flavell RA, Davis RJ. Signal transduction cross talk mediated by Jun N-terminal kinase-interacting protein and insulin receptor substrate scaffold protein complexes. Mol Cell Biol. 2009 Sep; 29(17):4831-40. PMID: 19564410.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    16. Kennedy NJ, Martin G, Ehrhardt AG, Cavanagh-Kyros J, Kuan CY, Rakic P, Flavell RA, Treistman SN, Davis RJ. Requirement of JIP scaffold proteins for NMDA-mediated signal transduction. Genes Dev. 2007 Sep 15; 21(18):2336-46. PMID: 17875667.
      Citations: 25     Fields:    Translation:AnimalsCells
    17. Vivanco I, Palaskas N, Tran C, Finn SP, Getz G, Kennedy NJ, Jiao J, Rose J, Xie W, Loda M, Golub T, Mellinghoff IK, Davis RJ, Wu H, Sawyers CL. Identification of the JNK signaling pathway as a functional target of the tumor suppressor PTEN. Cancer Cell. 2007 Jun; 11(6):555-69. PMID: 17560336.
      Citations: 127     Fields:    Translation:HumansAnimalsCells
    18. Kennedy NJ, Cellurale C, Davis RJ. A radical role for p38 MAPK in tumor initiation. Cancer Cell. 2007 Feb; 11(2):101-3. PMID: 17292820.
      Citations: 27     Fields:    Translation:HumansAnimalsCells
    19. Groisman I, Ivshina M, Marin V, Kennedy NJ, Davis RJ, Richter JD. Control of cellular senescence by CPEB. Genes Dev. 2006 Oct 01; 20(19):2701-12. PMID: 17015432.
      Citations: 52     Fields:    Translation:AnimalsCells
    20. Zhang Y, Blattman JN, Kennedy NJ, Duong J, Nguyen T, Wang Y, Davis RJ, Greenberg PD, Flavell RA, Dong C. Regulation of innate and adaptive immune responses by MAP kinase phosphatase 5. Nature. 2004 Aug 12; 430(7001):793-7. PMID: 15306813.
      Citations: 104     Fields:    Translation:HumansAnimalsCells
    21. Ventura JJ, Kennedy NJ, Flavell RA, Davis RJ. JNK regulates autocrine expression of TGF-beta1. Mol Cell. 2004 Jul 23; 15(2):269-78. PMID: 15260977.
      Citations: 30     Fields:    Translation:AnimalsCells
    22. Kennedy NJ, Davis RJ. Role of JNK in tumor development. Cell Cycle. 2003 May-Jun; 2(3):199-201. PMID: 12734425.
      Citations: 77     Fields:    Translation:HumansAnimalsCells
    23. Ventura JJ, Kennedy NJ, Lamb JA, Flavell RA, Davis RJ. c-Jun NH(2)-terminal kinase is essential for the regulation of AP-1 by tumor necrosis factor. Mol Cell Biol. 2003 Apr; 23(8):2871-82. PMID: 12665585.
      Citations: 62     Fields:    Translation:AnimalsCells
    24. Kennedy NJ, Sluss HK, Jones SN, Bar-Sagi D, Flavell RA, Davis RJ. Suppression of Ras-stimulated transformation by the JNK signal transduction pathway. Genes Dev. 2003 Mar 01; 17(5):629-37. PMID: 12629045.
      Citations: 57     Fields:    Translation:AnimalsCells
    25. Conze D, Krahl T, Kennedy N, Weiss L, Lumsden J, Hess P, Flavell RA, Le Gros G, Davis RJ, Rinc?n M. c-Jun NH(2)-terminal kinase (JNK)1 and JNK2 have distinct roles in CD8(+) T cell activation. J Exp Med. 2002 Apr 01; 195(7):811-23. PMID: 11927626.
      Citations: 53     Fields:    Translation:AnimalsCells
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