Self-renewal of CD133(hi) cells by IL6/Notch3 signalling regulates endocrine resistance in metastatic breast cancer.
Sansone P, Ceccarelli C, Berishaj M, Chang Q, Rajasekhar VK, Perna F, Bowman RL, Vidone M, Daly L, Nnoli J, Santini D, Taffurelli M, Shih NN, Feldman M, Mao JJ, Colameco C, Chen J, DeMichele A, Fabbri N, Healey JH, Cricca M, Gasparre G, Lyden D, Bonaf? M, Bromberg J. Self-renewal of CD133(hi) cells by IL6/Notch3 signalling regulates endocrine resistance in metastatic breast cancer. Nat Commun. 2016 Feb 09; 7:10442.
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AC133 Antigen
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Androstadienes
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Animals
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Antigens, CD
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Antineoplastic Agents, Hormonal
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Bone Neoplasms
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Breast Neoplasms
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Carcinoma, Ductal, Breast
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Carcinoma, Lobular
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Cell Line, Tumor
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Cell Self Renewal
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Drug Resistance, Neoplasm
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Estradiol
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Female
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Flow Cytometry
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Gene Expression Regulation, Neoplastic
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Glycoproteins
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Humans
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In Vitro Techniques
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Interleukin-6
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Leuprolide
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MCF-7 Cells
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Mice, Inbred NOD
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Mice, SCID
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Neoplasm Metastasis
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Neoplasm Transplantation
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Neoplastic Stem Cells
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Nitriles
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Oxidative Phosphorylation
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Peptides
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Real-Time Polymerase Chain Reaction
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Receptor, Notch3
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Receptors, Estrogen
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Receptors, Notch
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Signal Transduction
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Tamoxifen
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Triazoles