Loading...
Header Logo
Keywords
Last Name
Institution

Nikolaus Grigorieff PhD

TitleProfessor
InstitutionUniversity of Massachusetts Medical School
DepartmentRNA Therapeutics Institute
AddressUniversity of Massachusetts Medical School
368 Plantation Street, AS4-1009
Worcester MA 01605
Phone571-209-4169
vCardDownload vCard
    Other Positions
    InstitutionUMMS - School of Medicine
    DepartmentRNA Therapeutics Institute


    Collapse Biography 
    Collapse education and training
    University of Bristol, Bristol, , United KingdomPHD

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Jenni S, Salgado EN, Herrmann T, Li Z, Grant T, Grigorieff N, Trapani S, Estrozi LF, Harrison SC. In situ Structure of Rotavirus VP1 RNA-Dependent RNA Polymerase. J Mol Biol. 2019 Jun 21. PMID: 31233764.
      View in: PubMed
    2. Jung J, Grant T, Thomas DR, Diehnelt CW, Grigorieff N, Joshua-Tor L. High-resolution cryo-EM structures of outbreak strain human norovirus shells reveal size variations. Proc Natl Acad Sci U S A. 2019 Jun 10. PMID: 31182604.
      View in: PubMed
    3. Liberta F, Loerch S, Rennegarbe M, Schierhorn A, Westermark P, Westermark GT, Hazenberg BPC, Grigorieff N, Fändrich M, Schmidt M. Cryo-EM fibril structures from systemic AA amyloidosis reveal the species complementarity of pathological amyloids. Nat Commun. 2019 Mar 07; 10(1):1104. PMID: 30846696.
      View in: PubMed
    4. Zhang C, Cantara W, Jeon Y, Musier-Forsyth K, Grigorieff N, Lyumkis D. Analysis of discrete local variability and structural covariance in macromolecular assemblies using Cryo-EM and focused classification. Ultramicroscopy. 2018 Nov 29. PMID: 30528101.
      View in: PubMed
    5. Vemu A, Szczesna E, Zehr EA, Spector JO, Grigorieff N, Deaconescu AM, Roll-Mecak A. Severing enzymes amplify microtubule arrays through lattice GTP-tubulin incorporation. Science. 2018 08 24; 361(6404). PMID: 30139843.
      View in: PubMed
    6. Bartesaghi A, Aguerrebere C, Falconieri V, Banerjee S, Earl LA, Zhu X, Grigorieff N, Milne JLS, Sapiro G, Wu X, Subramaniam S. Atomic Resolution Cryo-EM Structure of ß-Galactosidase. Structure. 2018 Jun 05; 26(6):848-856.e3. PMID: 29754826.
      View in: PubMed
    7. Regan MC, Grant T, McDaniel MJ, Karakas E, Zhang J, Traynelis SF, Grigorieff N, Furukawa H. Structural Mechanism of Functional Modulation by Gene Splicing in NMDA Receptors. Neuron. 2018 May 02; 98(3):521-529.e3. PMID: 29656875.
      View in: PubMed
    8. Grant T, Rohou A, Grigorieff N. cisTEM, user-friendly software for single-particle image processing. Elife. 2018 Mar 07; 7. PMID: 29513216.
      View in: PubMed
    9. Close W, Neumann M, Schmidt A, Hora M, Annamalai K, Schmidt M, Reif B, Schmidt V, Grigorieff N, Fändrich M. Physical basis of amyloid fibril polymorphism. Nat Commun. 2018 02 16; 9(1):699. PMID: 29453354.
      View in: PubMed
    10. Demo G, Rasouly A, Vasilyev N, Svetlov V, Loveland AB, Diaz-Avalos R, Grigorieff N, Nudler E, Korostelev AA. Structure of RNA polymerase bound to ribosomal 30S subunit. Elife. 2017 10 13; 6. PMID: 29027901.
      View in: PubMed
    11. Abeyrathne PD, Grigorieff N. Expression, purification, and contaminant detection for structural studies of Ralstonia metallidurance ClC protein rm1. PLoS One. 2017; 12(7):e0180163. PMID: 28692650.
      View in: PubMed
    12. Loveland AB, Demo G, Grigorieff N, Korostelev AA. Ensemble cryo-EM elucidates the mechanism of translation fidelity. Nature. 2017 Jun 01; 546(7656):113-117. PMID: 28538735.
      View in: PubMed
    13. Liu Y, Pan J, Jenni S, Raymond DD, Caradonna T, Do KT, Schmidt AG, Harrison SC, Grigorieff N. CryoEM Structure of an Influenza Virus Receptor-Binding Site Antibody-Antigen Interface. J Mol Biol. 2017 Jun 16; 429(12):1829-1839. PMID: 28506635.
      View in: PubMed
    14. Rickgauer JP, Grigorieff N, Denk W. Single-protein detection in crowded molecular environments in cryo-EM images. Elife. 2017 05 03; 6. PMID: 28467302.
      View in: PubMed
    15. Liu Y, Pan J, Cai Y, Grigorieff N, Harrison SC, Chen B. Conformational States of a Soluble, Uncleaved HIV-1 Envelope Trimer. J Virol. 2017 05 15; 91(10). PMID: 28250125.
      View in: PubMed
    16. Demo G, Svidritskiy E, Madireddy R, Diaz-Avalos R, Grant T, Grigorieff N, Sousa D, Korostelev AA. Mechanism of ribosome rescue by ArfA and RF2. Elife. 2017 Mar 16; 6. PMID: 28300532.
      View in: PubMed
    17. Oldham ML, Grigorieff N, Chen J. Structure of the transporter associated with antigen processing trapped by herpes simplex virus. Elife. 2016 12 09; 5. PMID: 27935481.
      View in: PubMed
    18. Loveland AB, Bah E, Madireddy R, Zhang Y, Brilot AF, Grigorieff N, Korostelev AA. Ribosome•RelA structures reveal the mechanism of stringent response activation. Elife. 2016 Jul 19; 5. PMID: 27434674.
      View in: PubMed
    19. Grigorieff N. Frealign: An Exploratory Tool for Single-Particle Cryo-EM. Methods Enzymol. 2016; 579:191-226. PMID: 27572728.
      View in: PubMed
    20. Laxmikanthan G, Xu C, Brilot AF, Warren D, Steele L, Seah N, Tong W, Grigorieff N, Landy A, Van Duyne GD. Structure of a Holliday junction complex reveals mechanisms governing a highly regulated DNA transaction. Elife. 2016 05 25; 5. PMID: 27223329; PMCID: PMC4880445.
    21. Schmidt A, Annamalai K, Schmidt M, Grigorieff N, Fändrich M. Cryo-EM reveals the steric zipper structure of a light chain-derived amyloid fibril. Proc Natl Acad Sci U S A. 2016 May 31; 113(22):6200-5. PMID: 27185936; PMCID: PMC4896715 [Available on 11/30/16].
    22. Abeyrathne PD, Koh CS, Grant T, Grigorieff N, Korostelev AA. Ensemble cryo-EM uncovers inchworm-like translocation of a viral IRES through the ribosome. Elife. 2016 May 09; 5. PMID: 27159452.
      View in: PubMed
    23. Tajima N, Karakas E, Grant T, Simorowski N, Diaz-Avalos R, Grigorieff N, Furukawa H. Activation of NMDA receptors and the mechanism of inhibition by ifenprodil. Nature. 2016 06 02; 534(7605):63-8. PMID: 27135925.
      View in: PubMed
    24. Zhou A, Rohou A, Schep DG, Bason JV, Montgomery MG, Walker JE, Grigorieff N, Rubinstein JL. Structure and conformational states of the bovine mitochondrial ATP synthase by cryo-EM. Elife. 2015 Oct 06; 4:e10180. PMID: 26439008; PMCID: PMC4718723.
    25. Schmidt M, Rohou A, Lasker K, Yadav JK, Schiene-Fischer C, Fändrich M, Grigorieff N. Peptide dimer structure in an Aß(1-42) fibril visualized with cryo-EM. Proc Natl Acad Sci U S A. 2015 Sep 22; 112(38):11858-63. PMID: 26351699; PMCID: PMC4586870.
    26. Chiu PL, Li X, Li Z, Beckett B, Brilot AF, Grigorieff N, Agard DA, Cheng Y, Walz T. Evaluation of super-resolution performance of the K2 electron-counting camera using 2D crystals of aquaporin-0. J Struct Biol. 2015 Nov; 192(2):163-73. PMID: 26318383; PMCID: PMC4633381 [Available on 11/01/16].
    27. Rohou A, Grigorieff N. CTFFIND4: Fast and accurate defocus estimation from electron micrographs. J Struct Biol. 2015 Nov; 192(2):216-21. PMID: 26278980.
      View in: PubMed
    28. Grant T, Grigorieff N. Automatic estimation and correction of anisotropic magnification distortion in electron microscopes. J Struct Biol. 2015 Nov; 192(2):204-8. PMID: 26278979.
      View in: PubMed
    29. Liang B, Li Z, Jenni S, Rahmeh AA, Morin BM, Grant T, Grigorieff N, Harrison SC, Whelan SPJ. Structure of the L Protein of Vesicular Stomatitis Virus from Electron Cryomicroscopy. Cell. 2015 Jul 16; 162(2):314-327. PMID: 26144317; PMCID: PMC4557768.
    30. Grant T, Grigorieff N. Measuring the optimal exposure for single particle cryo-EM using a 2.6 Å reconstruction of rotavirus VP6. Elife. 2015 May 29; 4:e06980. PMID: 26023829; PMCID: PMC4471936.
    31. Cheng Y, Grigorieff N, Penczek PA, Walz T. A primer to single-particle cryo-electron microscopy. Cell. 2015 Apr 23; 161(3):438-449. PMID: 25910204; PMCID: PMC4409659.
    32. Svidritskiy E, Brilot AF, Koh CS, Grigorieff N, Korostelev AA. Structures of yeast 80S ribosome-tRNA complexes in the rotated and nonrotated conformations. Structure. 2014 Aug 5; 22(8):1210-8. PMID: 25043550.
      View in: PubMed
    33. Koh CS, Brilot AF, Grigorieff N, Korostelev AA. Taura syndrome virus IRES initiates translation by binding its tRNA-mRNA-like structural element in the ribosomal decoding center. Proc Natl Acad Sci U S A. 2014 Jun 24; 111(25):9139-44. PMID: 24927574.
      View in: PubMed
    34. Szyk A, Deaconescu AM, Spector J, Goodman B, Valenstein ML, Ziolkowska NE, Kormendi V, Grigorieff N, Roll-Mecak A. Molecular basis for age-dependent microtubule acetylation by tubulin acetyltransferase. Cell. 2014 Jun 05; 157(6):1405-15. PMID: 24906155.
      View in: PubMed
    35. Rohou A, Grigorieff N. Frealix: model-based refinement of helical filament structures from electron micrographs. J Struct Biol. 2014 May; 186(2):234-44. PMID: 24657230; PMCID: PMC4067737.
    36. Brilot AF, Korostelev AA, Ermolenko DN, Grigorieff N. Structure of the ribosome with elongation factor G trapped in the pretranslocation state. Proc Natl Acad Sci U S A. 2013 Dec 24; 110(52):20994-9. PMID: 24324137.
      View in: PubMed
    37. Ruskin RS, Yu Z, Grigorieff N. Quantitative characterization of electron detectors for transmission electron microscopy. J Struct Biol. 2013 Dec; 184(3):385-93. PMID: 24189638; PMCID: PMC3876735.
    38. Lyumkis D, Brilot AF, Theobald DL, Grigorieff N. Likelihood-based classification of cryo-EM images using FREALIGN. J Struct Biol. 2013 Sep; 183(3):377-388. PMID: 23872434; PMCID: PMC3824613.
    39. Grigorieff N. Direct detection pays off for electron cryo-microscopy. Elife. 2013 Feb 19; 2:e00573. PMID: 23426864; PMCID: PMC3576708.
    40. Estrozi LF, Settembre EC, Goret G, McClain B, Zhang X, Chen JZ, Grigorieff N, Harrison SC. Location of the dsRNA-dependent polymerase, VP1, in rotavirus particles. J Mol Biol. 2013 Jan 09; 425(1):124-32. PMID: 23089332; PMCID: PMC3540981.
    41. Deaconescu AM, Artsimovitch I, Grigorieff N. Interplay of DNA repair with transcription: from structures to mechanisms. Trends Biochem Sci. 2012 Dec; 37(12):543-52. PMID: 23084398; PMCID: PMC3588851.
    42. Campbell MG, Cheng A, Brilot AF, Moeller A, Lyumkis D, Veesler D, Pan J, Harrison SC, Potter CS, Carragher B, Grigorieff N. Movies of ice-embedded particles enhance resolution in electron cryo-microscopy. Structure. 2012 Nov 07; 20(11):1823-8. PMID: 23022349; PMCID: PMC3510009.
    43. Veesler D, Quispe J, Grigorieff N, Potter CS, Carragher B, Johnson JE. Maturation in action: CryoEM study of a viral capsid caught during expansion. Structure. 2012 Aug 08; 20(8):1384-90. PMID: 22748764; PMCID: PMC3418467.
    44. Sindelar CV, Grigorieff N. Optimal noise reduction in 3D reconstructions of single particles using a volume-normalized filter. J Struct Biol. 2012 Oct; 180(1):26-38. PMID: 22613568; PMCID: PMC3498508.
    45. Brilot AF, Chen JZ, Cheng A, Pan J, Harrison SC, Potter CS, Carragher B, Henderson R, Grigorieff N. Beam-induced motion of vitrified specimen on holey carbon film. J Struct Biol. 2012 Mar; 177(3):630-7. PMID: 22366277; PMCID: PMC3322646.
    46. Deaconescu AM, Sevostyanova A, Artsimovitch I, Grigorieff N. Nucleotide excision repair (NER) machinery recruitment by the transcription-repair coupling factor involves unmasking of a conserved intramolecular interface. Proc Natl Acad Sci U S A. 2012 Feb 28; 109(9):3353-8. PMID: 22331906; PMCID: PMC3295266.
    47. Henderson R, Sali A, Baker ML, Carragher B, Devkota B, Downing KH, Egelman EH, Feng Z, Frank J, Grigorieff N, Jiang W, Ludtke SJ, Medalia O, Penczek PA, Rosenthal PB, Rossmann MG, Schmid MF, Schröder GF, Steven AC, Stokes DL, Westbrook JD, Wriggers W, Yang H, Young J, Berman HM, Chiu W, Kleywegt GJ, Lawson CL. Outcome of the first electron microscopy validation task force meeting. Structure. 2012 Feb 08; 20(2):205-14. PMID: 22325770; PMCID: PMC3328769.
    48. Henderson R, Chen S, Chen JZ, Grigorieff N, Passmore LA, Ciccarelli L, Rubinstein JL, Crowther RA, Stewart PL, Rosenthal PB. Tilt-pair analysis of images from a range of different specimens in single-particle electron cryomicroscopy. J Mol Biol. 2011 Nov 11; 413(5):1028-46. PMID: 21939668; PMCID: PMC3220764.
    49. Lewandowski JR, van der Wel PC, Rigney M, Grigorieff N, Griffin RG. Structural complexity of a composite amyloid fibril. J Am Chem Soc. 2011 Sep 21; 133(37):14686-98. PMID: 21766841; PMCID: PMC3190136.
    50. Sindelar CV, Grigorieff N. An adaptation of the Wiener filter suitable for analyzing images of isolated single particles. J Struct Biol. 2011 Oct; 176(1):60-74. PMID: 21757012; PMCID: PMC3184790.
    51. Fändrich M, Schmidt M, Grigorieff N. Recent progress in understanding Alzheimer's ß-amyloid structures. Trends Biochem Sci. 2011 Jun; 36(6):338-45. PMID: 21411326; PMCID: PMC3144754.
    52. Grigorieff N, Harrison SC. Near-atomic resolution reconstructions of icosahedral viruses from electron cryo-microscopy. Curr Opin Struct Biol. 2011 Apr; 21(2):265-73. PMID: 21333526; PMCID: PMC3088881.
    53. Settembre EC, Chen JZ, Dormitzer PR, Grigorieff N, Harrison SC. Atomic model of an infectious rotavirus particle. EMBO J. 2011 Jan 19; 30(2):408-16. PMID: 21157433; PMCID: PMC3025467.
    54. Alushin GM, Ramey VH, Pasqualato S, Ball DA, Grigorieff N, Musacchio A, Nogales E. The Ndc80 kinetochore complex forms oligomeric arrays along microtubules. Nature. 2010 Oct 14; 467(7317):805-10. PMID: 20944740; PMCID: PMC2957311.
    55. Okada K, Bartolini F, Deaconescu AM, Moseley JB, Dogic Z, Grigorieff N, Gundersen GG, Goode BL. Adenomatous polyposis coli protein nucleates actin assembly and synergizes with the formin mDia1. J Cell Biol. 2010 Jun 28; 189(7):1087-96. PMID: 20566685; PMCID: PMC2894447.
    56. Li X, Grigorieff N, Cheng Y. GPU-enabled FREALIGN: accelerating single particle 3D reconstruction and refinement in Fourier space on graphics processors. J Struct Biol. 2010 Dec; 172(3):407-12. PMID: 20558298; PMCID: PMC2964447.
    57. Wolf M, Garcea RL, Grigorieff N, Harrison SC. Subunit interactions in bovine papillomavirus. Proc Natl Acad Sci U S A. 2010 Apr 06; 107(14):6298-303. PMID: 20308582; PMCID: PMC2852008.
    58. Sachse C, Grigorieff N, Fändrich M. Nanoscale flexibility parameters of Alzheimer amyloid fibrils determined by electron cryo-microscopy. Angew Chem Int Ed Engl. 2010 Feb 08; 49(7):1321-3. PMID: 20069616; PMCID: PMC2913414.
    59. Xing Y, Böcking T, Wolf M, Grigorieff N, Kirchhausen T, Harrison SC. Structure of clathrin coat with bound Hsc70 and auxilin: mechanism of Hsc70-facilitated disassembly. EMBO J. 2010 Feb 03; 29(3):655-65. PMID: 20033059; PMCID: PMC2830701.
    60. Schmidt M, Sachse C, Richter W, Xu C, Fändrich M, Grigorieff N. Comparison of Alzheimer Abeta(1-40) and Abeta(1-42) amyloid fibrils reveals similar protofilament structures. Proc Natl Acad Sci U S A. 2009 Nov 24; 106(47):19813-8. PMID: 19843697.
      View in: PubMed
    61. Chen JZ, Settembre EC, Aoki ST, Zhang X, Bellamy AR, Dormitzer PR, Harrison SC, Grigorieff N. Molecular interactions in rotavirus assembly and uncoating seen by high-resolution cryo-EM. Proc Natl Acad Sci U S A. 2009 Jun 30; 106(26):10644-8. PMID: 19487668; PMCID: PMC2689313.
    62. Fändrich M, Meinhardt J, Grigorieff N. Structural polymorphism of Alzheimer Abeta and other amyloid fibrils. Prion. 2009 Apr-Jun; 3(2):89-93. PMID: 19597329; PMCID: PMC2712605.
    63. Dementieva IS, Tereshko V, McCrossan ZA, Solomaha E, Araki D, Xu C, Grigorieff N, Goldstein SA. Pentameric assembly of potassium channel tetramerization domain-containing protein 5. J Mol Biol. 2009 Mar 20; 387(1):175-91. PMID: 19361449; PMCID: PMC2670943.
    64. Sachse C, Grigorieff N, Fändrich M. Bioforum. 2009; 32(2):26. PMID: 20126429.
      View in: PubMed
    65. Stroupe ME, Xu C, Goode BL, Grigorieff N. Actin filament labels for localizing protein components in large complexes viewed by electron microscopy. RNA. 2009 Feb; 15(2):244-8. PMID: 19095618; PMCID: PMC2648703.
    66. Meinhardt J, Sachse C, Hortschansky P, Grigorieff N, Fändrich M. Abeta(1-40) fibril polymorphism implies diverse interaction patterns in amyloid fibrils. J Mol Biol. 2009 Feb 27; 386(3):869-77. PMID: 19038266.
      View in: PubMed
    67. Sachse C, Fändrich M, Grigorieff N. Paired beta-sheet structure of an Abeta(1-40) amyloid fibril revealed by electron microscopy. Proc Natl Acad Sci U S A. 2008 May 27; 105(21):7462-6. PMID: 18483195; PMCID: PMC2396686.
    68. Zhang X, Settembre E, Xu C, Dormitzer PR, Bellamy R, Harrison SC, Grigorieff N. Near-atomic resolution using electron cryomicroscopy and single-particle reconstruction. Proc Natl Acad Sci U S A. 2008 Feb 12; 105(6):1867-72. PMID: 18238898; PMCID: PMC2542862.
    69. Zolotarev AS, Unnikrishnan M, Shmukler BE, Clark JS, Vandorpe DH, Grigorieff N, Rubin EJ, Alper SL. Increased sulfate uptake by E. coli overexpressing the SLC26-related SulP protein Rv1739c from Mycobacterium tuberculosis. Comp Biochem Physiol A Mol Integr Physiol. 2008 Mar; 149(3):255-66. PMID: 18255326; PMCID: PMC2712756.
    70. Chen JZ, Sachse C, Xu C, Mielke T, Spahn CM, Grigorieff N. A dose-rate effect in single-particle electron microscopy. J Struct Biol. 2008 Jan; 161(1):92-100. PMID: 17977018; PMCID: PMC2213720.
    71. Zeng X, Stahlberg H, Grigorieff N. A maximum likelihood approach to two-dimensional crystals. J Struct Biol. 2007 Dec; 160(3):362-74. PMID: 17964808; PMCID: PMC2147720.
    72. Sachse C, Chen JZ, Coureux PD, Stroupe ME, Fändrich M, Grigorieff N. High-resolution electron microscopy of helical specimens: a fresh look at tobacco mosaic virus. J Mol Biol. 2007 Aug 17; 371(3):812-35. PMID: 17585939; PMCID: PMC2025690.
    73. Sachse C, Xu C, Wieligmann K, Diekmann S, Grigorieff N, Fändrich M. Quaternary structure of a mature amyloid fibril from Alzheimer's Abeta(1-40) peptide. J Mol Biol. 2006 Sep 15; 362(2):347-54. PMID: 16920151.
      View in: PubMed
    74. Sousa D, Grigorieff N. Ab initio resolution measurement for single particle structures. J Struct Biol. 2007 Jan; 157(1):201-10. PMID: 17029845.
      View in: PubMed
    75. Fotin A, Kirchhausen T, Grigorieff N, Harrison SC, Walz T, Cheng Y. Structure determination of clathrin coats to subnanometer resolution by single particle cryo-electron microscopy. J Struct Biol. 2006 Dec; 156(3):453-60. PMID: 16908193; PMCID: PMC2910098.
    76. Chen JZ, Grigorieff N. SIGNATURE: a single-particle selection system for molecular electron microscopy. J Struct Biol. 2007 Jan; 157(1):168-73. PMID: 16870473.
      View in: PubMed
    77. Stroupe ME, Tange TØ, Thomas DR, Moore MJ, Grigorieff N. The three-dimensional arcitecture of the EJC core. J Mol Biol. 2006 Jul 21; 360(4):743-9. PMID: 16797590.
      View in: PubMed
    78. Grigorieff N. FREALIGN: high-resolution refinement of single particle structures. J Struct Biol. 2007 Jan; 157(1):117-25. PMID: 16828314.
      View in: PubMed
    79. Wolf M, DeRosier DJ, Grigorieff N. Ewald sphere correction for single-particle electron microscopy. Ultramicroscopy. 2006 Mar; 106(4-5):376-82. PMID: 16384646.
      View in: PubMed
    80. Cheng Y, Wolf E, Larvie M, Zak O, Aisen P, Grigorieff N, Harrison SC, Walz T. Single particle reconstructions of the transferrin-transferrin receptor complex obtained with different specimen preparation techniques. J Mol Biol. 2006 Feb 03; 355(5):1048-65. PMID: 16343539.
      View in: PubMed
    81. Rodal AA, Sokolova O, Robins DB, Daugherty KM, Hippenmeyer S, Riezman H, Grigorieff N, Goode BL. Conformational changes in the Arp2/3 complex leading to actin nucleation. Nat Struct Mol Biol. 2005 Jan; 12(1):26-31. PMID: 15592479.
      View in: PubMed
    82. Stewart A, Grigorieff N. Noise bias in the refinement of structures derived from single particles. Ultramicroscopy. 2004 Dec; 102(1):67-84. PMID: 15556702.
      View in: PubMed
    83. Fotin A, Cheng Y, Sliz P, Grigorieff N, Harrison SC, Kirchhausen T, Walz T. Molecular model for a complete clathrin lattice from electron cryomicroscopy. Nature. 2004 Dec 02; 432(7017):573-9. PMID: 15502812.
      View in: PubMed
    84. Fotin A, Cheng Y, Grigorieff N, Walz T, Harrison SC, Kirchhausen T. Structure of an auxilin-bound clathrin coat and its implications for the mechanism of uncoating. Nature. 2004 Dec 02; 432(7017):649-53. PMID: 15502813.
      View in: PubMed
    85. Kim LA, Furst J, Gutierrez D, Butler MH, Xu S, Goldstein SA, Grigorieff N. Three-dimensional structure of I(to); Kv4.2-KChIP2 ion channels by electron microscopy at 21 Angstrom resolution. Neuron. 2004 Feb 19; 41(4):513-9. PMID: 14980201.
      View in: PubMed
    86. Jurica MS, Sousa D, Moore MJ, Grigorieff N. Three-dimensional structure of C complex spliceosomes by electron microscopy. Nat Struct Mol Biol. 2004 Mar; 11(3):265-9. PMID: 14981503.
      View in: PubMed
    87. Kim LA, Furst J, Butler MH, Xu S, Grigorieff N, Goldstein SA. Ito channels are octomeric complexes with four subunits of each Kv4.2 and K+ channel-interacting protein 2. J Biol Chem. 2004 Feb 13; 279(7):5549-54. PMID: 14623880.
      View in: PubMed
    88. Sokolova O, Accardi A, Gutierrez D, Lau A, Rigney M, Grigorieff N. Conformational changes in the C terminus of Shaker K+ channel bound to the rat Kvbeta2-subunit. Proc Natl Acad Sci U S A. 2003 Oct 28; 100(22):12607-12. PMID: 14569011; PMCID: PMC240665.
    89. Chen JZ, Fürst J, Chapman MS, Grigorieff N. Low-resolution structure refinement in electron microscopy. J Struct Biol. 2003 Oct-Nov; 144(1-2):144-51. PMID: 14643217.
      View in: PubMed
    90. Wolf M, Eberhart A, Glossmann H, Striessnig J, Grigorieff N. Visualization of the domain structure of an L-type Ca2+ channel using electron cryo-microscopy. J Mol Biol. 2003 Sep 05; 332(1):171-82. PMID: 12946355.
      View in: PubMed
    91. Furst J, Sutton RB, Chen J, Brunger AT, Grigorieff N. Electron cryomicroscopy structure of N-ethyl maleimide sensitive factor at 11 A resolution. EMBO J. 2003 Sep 01; 22(17):4365-74. PMID: 12941689; PMCID: PMC202363.
    92. Mindell JA, Grigorieff N. Accurate determination of local defocus and specimen tilt in electron microscopy. J Struct Biol. 2003 Jun; 142(3):334-47. PMID: 12781660.
      View in: PubMed
    93. McGovern SL, Caselli E, Grigorieff N, Shoichet BK. A common mechanism underlying promiscuous inhibitors from virtual and high-throughput screening. J Med Chem. 2002 Apr 11; 45(8):1712-22. PMID: 11931626.
      View in: PubMed
    94. Jurica MS, Licklider LJ, Gygi SR, Grigorieff N, Moore MJ. Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. RNA. 2002 Apr; 8(4):426-39. PMID: 11991638.
      View in: PubMed
    95. Pirruccello MM, Grigorieff N, Mindell JA. Electron diffraction of a bacterial ClC-type chloride channel. Novartis Found Symp. 2002; 245:193-203; discussion 203-6, 261-4. PMID: 12027008.
      View in: PubMed
    96. Sokolova O, Kolmakova-Partensky L, Grigorieff N. Three-dimensional structure of a voltage-gated potassium channel at 2.5 nm resolution. Structure. 2001 Mar 07; 9(3):215-20. PMID: 11286888.
      View in: PubMed
    97. Mindell JA, Maduke M, Miller C, Grigorieff N. Projection structure of a ClC-type chloride channel at 6.5 A resolution. Nature. 2001 Jan 11; 409(6817):219-23. PMID: 11196649.
      View in: PubMed
    98. Nogales E, Grigorieff N. Molecular Machines: putting the pieces together. J Cell Biol. 2001 Jan 08; 152(1):F1-10. PMID: 11149934; PMCID: PMC2193665.
    99. Grigorieff N. Resolution measurement in structures derived from single particles. Acta Crystallogr D Biol Crystallogr. 2000 Oct; 56(Pt 10):1270-7. PMID: 10998623.
      View in: PubMed
    100. Grigorieff N. Structure of the respiratory NADH:ubiquinone oxidoreductase (complex I) Curr Opin Struct Biol. 1999 Aug; 9(4):476-83. PMID: 10449365.
      View in: PubMed
    101. Smith CJ, Grigorieff N, Pearse BM. Clathrin coats at 21 A resolution: a cellular assembly designed to recycle multiple membrane receptors. EMBO J. 1998 Sep 01; 17(17):4943-53. PMID: 9724631; PMCID: PMC1170823.
    102. Grigorieff N. Three-dimensional structure of bovine NADH:ubiquinone oxidoreductase (complex I) at 22 A in ice. J Mol Biol. 1998 Apr 17; 277(5):1033-46. PMID: 9571020.
      View in: PubMed
    103. Grigorieff N, Ceska TA, Downing KH, Baldwin JM, Henderson R. Electron-crystallographic refinement of the structure of bacteriorhodopsin. J Mol Biol. 1996 Jun 14; 259(3):393-421. PMID: 8676377.
      View in: PubMed
    104. Grigorieff N, Beckmann E, Zemlin F. Lipid location in deoxycholate-treated purple membrane at 2.6 A. J Mol Biol. 1995 Dec 01; 254(3):404-15. PMID: 7490759.
      View in: PubMed
    For assistance with using Profiles, please refer to the online tutorials or contact UMMS Help Desk or call 508-856-8643.
    Grigorieff's Networks
    Click the "See All" links for more information and interactive visualizations!
    Concepts Expand Description
    _
    Co-Authors Expand Description
    _
    Similar People Expand Description
    _
    Same Department Expand Description