Protein Domains

"Protein Domains" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Discrete protein structural units that may fold independently of the rest of the protein and have their own functions.

Descriptor ID	D000072417
MeSH Number(s)	G02.111.570.820.709.275.750 G02.111.570.820.709.610.500
Concept/Terms	Protein Domains Protein Domains Peptide Domain Domain, Peptide Domains, Peptide Peptide Domains Protein Domain Domain, Protein Domains, Protein

Below are MeSH descriptors whose meaning is more general than "Protein Domains".

Biological Sciences [G]
Chemical Phenomena [G02]
Biochemical Phenomena [G02.111]
Molecular Structure [G02.111.570]
Molecular Conformation [G02.111.570.820]
Protein Conformation [G02.111.570.820.709]
Protein Structural Elements [G02.111.570.820.709.275]
Protein Domains [G02.111.570.820.709.275.750]
Protein Structure, Tertiary [G02.111.570.820.709.610]
Protein Domains [G02.111.570.820.709.610.500]

Below are MeSH descriptors whose meaning is related to "Protein Domains".

Below are MeSH descriptors whose meaning is more specific than "Protein Domains".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Protein Domains" by people in this website by year, and whether "Protein Domains" was a major or minor topic of these publications.

Bar chart showing 106 publications over 9 distinct years, with a maximum of 21 publications in 2018

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2016	0	13	13
2017	1	17	18
2018	2	19	21
2019	1	12	13
2020	1	17	18
2021	2	11	13
2022	0	1	1
2023	0	3	3
2024	0	6	6

Below are the most recent publications written about "Protein Domains" by people in Profiles.

Dey S, Pahari P, Mukherjee S, Munro JB, Das DK. Conformational dynamics of SARS-CoV-2 Omicron spike trimers during fusion activation at single molecule resolution. Structure. 2024 Nov 07; 32(11):1910-1925.e6.

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Ertekin A, Morgan BR, Ryder SP, Massi F. Structure and Dynamics of the CCCH-Type Tandem Zinc Finger Domain of POS-1 and Implications for RNA Binding Specificity. Biochemistry. 2024 10 15; 63(20):2632-2647.

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D?az-Salinas MA, Jain A, Durham ND, Munro JB. Single-molecule imaging reveals allosteric stimulation of SARS-CoV-2 spike receptor binding domain by host sialic acid. Sci Adv. 2024 Jul 19; 10(29):eadk4920.

View in: PubMed
Marriott H, Spargo TP, Al Khleifat A, Andersen PM, Basak NA, Cooper-Knock J, Corcia P, Couratier P, de Carvalho M, Drory V, Gotkine M, Landers JE, McLaughlin R, Pardina JSM, Morrison KE, Pinto S, Shaw CE, Shaw PJ, Silani V, Ticozzi N, van Damme P, van den Berg LH, Vourc'h P, Weber M, Veldink JH, Dobson RJ, Schwab P, Al-Chalabi A, Iacoangeli A. Mutations in the tail and rod domains of the neurofilament heavy-chain gene increase the risk of ALS. Ann Clin Transl Neurol. 2024 Jul; 11(7):1775-1786.

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Leo G, Leone P, Ataie Kachoie E, Tolomeo M, Galluccio M, Indiveri C, Barile M, Capaldi S. Structural insights into the bifunctional enzyme human FAD synthase. Structure. 2024 Jul 11; 32(7):953-965.e5.

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Cocanougher BT, Liu SW, Francescatto L, Behura A, Anneling M, Jackson DG, Deak KL, Hornik CD, ElMallah MK, Pizoli CE, Smith EC, Tan KGQ, McDonald MT. The severity of MUSK pathogenic variants is predicted by the protein domain they disrupt. HGG Adv. 2024 Jul 18; 5(3):100288.

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Ray S, DeSilva C, Dasgupta I, Mana-Capelli S, Cruz-Calderon N, McCollum D. The ability of the LIMD1 and TRIP6 LIM domains to bind strained f-actin is critical for their tension dependent localization to adherens junctions and association with the Hippo pathway kinase LATS1. Cytoskeleton (Hoboken). 2024 Sep; 81(9-10):436-447.

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Koch KC, Bizmark TM, Tew GN. Alcohol-containing protein transduction domain mimics. J Control Release. 2024 01; 365:950-956.

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Rossi MA, Pozhidaeva AK, Clerico EM, Petridis C, Gierasch LM. New insights into the structure and function of the complex?between the Escherichia coli Hsp70, DnaK, and its nucleotide-exchange factor, GrpE. J Biol Chem. 2024 01; 300(1):105574.

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Horton CA, Alexandari AM, Hayes MGB, Marklund E, Schaepe JM, Aditham AK, Shah N, Suzuki PH, Shrikumar A, Afek A, Greenleaf WJ, Gord?n R, Zeitlinger J, Kundaje A, Fordyce PM. Short tandem repeats bind transcription factors to tune eukaryotic gene expression. Science. 2023 09 22; 381(6664):eadd1250.

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