"Bestrophins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A protein family characterized by a highly conserved N-terminus and four to six transmembrane helices; they function as bicarbonate permeable, calcium-activated chloride channels. Bestrophin-1 (BEST-1) and bestrophin-2 are highly expressed in human RETINAL PIGMENT EPITHELIUM cells and mutations in the BEST-1 gene are associated with VITELLIFORM MACULAR DYSTROPHY, TYPE 2.
| Descriptor ID |
D000075002
|
| MeSH Number(s) |
D12.776.157.530.400.175.063 D12.776.306.228 D12.776.543.550.450.175.063 D12.776.543.585.400.175.063
|
| Concept/Terms |
Bestrophins- Bestrophins
- Bestrophin Proteins
- Bestrophin Family
Bestrophin-1- Bestrophin-1
- Bestrophin 1
- BEST-1 Protein
- BEST 1 Protein
Bestrophin-2- Bestrophin-2
- Bestrophin 2
- BEST-2 Protein
- BEST 2 Protein
|
Below are MeSH descriptors whose meaning is more general than "Bestrophins".
Below are MeSH descriptors whose meaning is more specific than "Bestrophins".
This graph shows the total number of publications written about "Bestrophins" by people in this website by year, and whether "Bestrophins" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 0 | 1 | 1 |
| 2001 | 0 | 1 | 1 |
| 2003 | 0 | 1 | 1 |
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Below are the most recent publications written about "Bestrophins" by people in Profiles.
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Seddon JM, Sharma S, Chong S, Hutchinson A, Allikmets R, Adelman RA. Phenotype and genotype correlations in two best families. Ophthalmology. 2003 Sep; 110(9):1724-31.
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Seddon JM, Afshari MA, Sharma S, Bernstein PS, Chong S, Hutchinson A, Petrukhin K, Allikmets R. Assessment of mutations in the Best macular dystrophy (VMD2) gene in patients with adult-onset foveomacular vitelliform dystrophy, age-related maculopathy, and bull's-eye maculopathy. Ophthalmology. 2001 Nov; 108(11):2060-7.
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Allikmets R, Seddon JM, Bernstein PS, Hutchinson A, Atkinson A, Sharma S, Gerrard B, Li W, Metzker ML, Wadelius C, Caskey CT, Dean M, Petrukhin K. Evaluation of the Best disease gene in patients with age-related macular degeneration and other maculopathies. Hum Genet. 1999 Jun; 104(6):449-53.