Lysine Acetyltransferase 5
"Lysine Acetyltransferase 5" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A catalytic subunit of the NuA4 histone acetyltransferase complex that functions in transcriptional activation of genes by acetylation of nucleosomal HISTONES H4 and H2A, altering nucleosome-DNA interactions and interaction of the modified histones with other activating transcription factors. It may control gene expression changes associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest; CELL AGING; APOPTOSIS; and DNA REPAIR. It is polyubiquitinated and degraded during HIV-1 infection through its interaction with the viral TAT PROTEIN.
| Descriptor ID |
D000074443
|
| MeSH Number(s) |
D08.811.913.050.134.415.500.062
|
| Concept/Terms |
Lysine Acetyltransferase 5- Lysine Acetyltransferase 5
- KAT5 (TIP60) Protein
- HIV-1-Tat Interactive Protein Tip60
- HIV 1 Tat Interactive Protein Tip60
- HTATIP
|
Below are MeSH descriptors whose meaning is more general than "Lysine Acetyltransferase 5".
Below are MeSH descriptors whose meaning is more specific than "Lysine Acetyltransferase 5".
This graph shows the total number of publications written about "Lysine Acetyltransferase 5" by people in this website by year, and whether "Lysine Acetyltransferase 5" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2004 | 0 | 1 | 1 |
| 2008 | 0 | 1 | 1 |
| 2013 | 0 | 1 | 1 |
| 2015 | 0 | 1 | 1 |
| 2017 | 1 | 0 | 1 |
| 2018 | 1 | 0 | 1 |
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Below are the most recent publications written about "Lysine Acetyltransferase 5" by people in Profiles.
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Acharya D, Nera B, Milstone ZJ, Bourke L, Yoon Y, Rivera-P?rez JA, Trivedi CM, Fazzio TG. TIP55, a splice isoform of the KAT5 acetyltransferase, is essential for developmental gene regulation and organogenesis. Sci Rep. 2018 10 08; 8(1):14908.
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Acharya D, Hainer SJ, Yoon Y, Wang F, Bach I, Rivera-P?rez JA, Fazzio TG. KAT-Independent Gene Regulation by Tip60 Promotes ESC Self-Renewal but Not Pluripotency. Cell Rep. 2017 04 25; 19(4):671-679.
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Chen PB, Chen HV, Acharya D, Rando OJ, Fazzio TG. R loops regulate promoter-proximal chromatin architecture and cellular differentiation. Nat Struct Mol Biol. 2015 Dec; 22(12):999-1007.
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Chen PB, Hung JH, Hickman TL, Coles AH, Carey JF, Weng Z, Chu F, Fazzio TG. Hdac6 regulates Tip60-p400 function in stem cells. Elife. 2013 Dec 03; 2:e01557.
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Fazzio TG, Huff JT, Panning B. An RNAi screen of chromatin proteins identifies Tip60-p400 as a regulator of embryonic stem cell identity. Cell. 2008 Jul 11; 134(1):162-74.
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Ceol CJ, Horvitz HR. A new class of C. elegans synMuv genes implicates a Tip60/NuA4-like HAT complex as a negative regulator of Ras signaling. Dev Cell. 2004 Apr; 6(4):563-76.