Protein-Arginine Deiminases

"Protein-Arginine Deiminases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A family of ENZYMES that, in the presence of calcium ion, converts ARGININE to CITRULLINE in proteins.

Descriptor ID	D000076342
MeSH Number(s)	D08.811.277.721
Concept/Terms	Protein-Arginine Deiminases Protein-Arginine Deiminases Deiminases, Protein-Arginine Protein Arginine Deiminases Protein-L-Arginine Iminohydrolase Iminohydrolase, Protein-L-Arginine Protein L Arginine Iminohydrolase Protein-Arginine Deiminase Deiminase, Protein-Arginine Protein Arginine Deiminase Peptidylarginine Deiminase Deiminase, Peptidylarginine Peptidylarginine Deiminases Deiminases, Peptidylarginine Protein-L-Arginine Iminohydrolases Iminohydrolases, Protein-L-Arginine Protein L Arginine Iminohydrolases

Below are MeSH descriptors whose meaning is more general than "Protein-Arginine Deiminases".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Hydrolases [D08.811.277]
Protein-Arginine Deiminases [D08.811.277.721]

Below are MeSH descriptors whose meaning is related to "Protein-Arginine Deiminases".

Below are MeSH descriptors whose meaning is more specific than "Protein-Arginine Deiminases".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Protein-Arginine Deiminases" by people in this website by year, and whether "Protein-Arginine Deiminases" was a major or minor topic of these publications.

Bar chart showing 72 publications over 17 distinct years, with a maximum of 8 publications in 2014 and 2018

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2005	0	1	1
2006	0	4	4
2007	0	2	2
2008	0	2	2
2009	0	1	1
2010	0	4	4
2011	0	7	7
2012	0	4	4
2013	0	3	3
2014	0	8	8
2015	0	6	6
2016	4	3	7
2017	1	3	4
2018	5	3	8
2019	4	1	5
2020	1	1	2
2021	1	3	4

Below are the most recent publications written about "Protein-Arginine Deiminases" by people in Profiles.

Maurais AJ, Salinger AJ, Tobin M, Shaffer SA, Weerapana E, Thompson PR. A Streamlined Data Analysis Pipeline for the Identification of Sites of Citrullination. Biochemistry. 2021 09 28; 60(38):2902-2914.

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Sun B, Tomita B, Salinger A, Tilvawala RR, Li L, Hakami H, Liu T, Tsoyi K, Rosas IO, Reinhardt DP, Thompson PR, Ho IC. PAD2-mediated citrullination of Fibulin-5 promotes elastogenesis. Matrix Biol. 2021 08; 102:70-84.

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Griffante G, Gugliesi F, Pasquero S, Dell'Oste V, Biolatti M, Salinger AJ, Mondal S, Thompson PR, Weerapana E, Lebbink RJ, Soppe JA, Stamminger T, Girault V, Pichlmair A, Oroszl?n G, Coen DM, De Andrea M, Landolfo S. Human cytomegalovirus-induced host protein citrullination is crucial for viral replication. Nat Commun. 2021 06 23; 12(1):3910.

View in: PubMed
Mondal S, Thompson PR. Chemical biology of protein citrullination by the protein A arginine deiminases. Curr Opin Chem Biol. 2021 08; 63:19-27.

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Sodr? FMC, Bissenova S, Bruggeman Y, Tilvawala R, Cook DP, Berthault C, Mondal S, Callebaut A, You S, Scharfmann R, Mallone R, Thompson PR, Mathieu C, Buitinga M, Overbergh L. Peptidylarginine Deiminase Inhibition Prevents Diabetes Development in NOD Mice. Diabetes. 2021 02; 70(2):516-528.

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Li G, Young CH, Snow B, Christensen AO, Demoruelle MK, Nemmara VV, Thompson PR, Rothfuss HM, Cherrington BD. Identification and Characterization of the Lactating Mouse Mammary Gland Citrullinome. Int J Mol Sci. 2020 Apr 10; 21(7).

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Mishra N, Schwerdtner L, Sams K, Mondal S, Ahmad F, Schmidt RE, Coonrod SA, Thompson PR, Lerch MM, Bossaller L. Cutting Edge: Protein Arginine Deiminase 2 and 4 Regulate NLRP3 Inflammasome-Dependent IL-1? Maturation and ASC Speck Formation in Macrophages. J Immunol. 2019 08 15; 203(4):795-800.

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Stadinski BD, Blevins SJ, Spidale NA, Duke BR, Huseby PG, Stern LJ, Huseby ES. A temporal thymic selection switch and ligand binding kinetics constrain neonatal Foxp3+ Treg cell development. Nat Immunol. 2019 08; 20(8):1046-1058.

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Mondal S, Thompson PR. Protein Arginine Deiminases (PADs): Biochemistry and Chemical Biology of Protein Citrullination. Acc Chem Res. 2019 03 19; 52(3):818-832.

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Tilvawala R, Thompson PR. Peptidyl arginine deiminases: detection and functional analysis of protein citrullination. Curr Opin Struct Biol. 2019 12; 59:205-215.

View in: PubMed

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