"V(D)J Recombination" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The process by which the V (variable), D (diversity), and J (joining) segments of IMMUNOGLOBULIN GENES or T-CELL RECEPTOR GENES are assembled during the development of LYMPHOID CELLS using NONHOMOLOGOUS DNA END-JOINING.
| Descriptor ID |
D060152
|
| MeSH Number(s) |
G05.344.900 G05.728.932
|
| Concept/Terms |
V(D)J Recombination- V(D)J Recombination
- VDJ Recombination
- Recombination, VDJ
- Recombinations, VDJ
- VDJ Recombinations
|
Below are MeSH descriptors whose meaning is more general than "V(D)J Recombination".
Below are MeSH descriptors whose meaning is more specific than "V(D)J Recombination".
This graph shows the total number of publications written about "V(D)J Recombination" by people in this website by year, and whether "V(D)J Recombination" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2013 | 1 | 0 | 1 |
| 2016 | 1 | 1 | 2 |
| 2017 | 1 | 0 | 1 |
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Below are the most recent publications written about "V(D)J Recombination" by people in Profiles.
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Carmona LM, Schatz DG. New insights into the evolutionary origins of the recombination-activating gene proteins and V(D)J recombination. FEBS J. 2017 06; 284(11):1590-1605.
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Brauer PM, Pessach IM, Clarke E, Rowe JH, Ott de Bruin L, Lee YN, Dominguez-Brauer C, Comeau AM, Awong G, Felgentreff K, Zhang YH, Bredemeyer A, Al-Herz W, Du L, Ververs F, Kennedy M, Giliani S, Keller G, Sleckman BP, Schatz DG, Bushman FD, Notarangelo LD, Z??iga-Pfl?cker JC. Modeling altered T-cell development with induced pluripotent stem cells from patients with RAG1-dependent immune deficiencies. Blood. 2016 08 11; 128(6):783-93.
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Carmona LM, Fugmann SD, Schatz DG. Collaboration of RAG2 with RAG1-like proteins during the evolution of V(D)J recombination. Genes Dev. 2016 Apr 15; 30(8):909-17.
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Selimyan R, Gerstein RM, Ivanova I, Precht P, Subrahmanyam R, Perlot T, Alt FW, Sen R. Localized DNA demethylation at recombination intermediates during immunoglobulin heavy chain gene assembly. PLoS Biol. 2013; 11(1):e1001475.