alpha7 Nicotinic Acetylcholine Receptor

"alpha7 Nicotinic Acetylcholine Receptor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A member of the NICOTINIC ACETYLCHOLINE RECEPTOR subfamily of the LIGAND-GATED ION CHANNEL family. It consists entirely of pentameric α7 subunits expressed in the CNS, autonomic nervous system, vascular system, lymphocytes and spleen.

Descriptor ID	D064569
MeSH Number(s)	D12.776.157.530.400.400.100.500.500 D12.776.543.550.450.500.100.500.500 D12.776.543.585.400.500.100.500.500 D12.776.543.750.130.687.500 D12.776.543.750.720.360.550.500
Concept/Terms	alpha7 Nicotinic Acetylcholine Receptor alpha7 Nicotinic Acetylcholine Receptor nAChR alpha7 Subunit Subunit, nAChR alpha7 alpha7 Subunit, nAChR Nicotinic Acetylcholine Receptor alpha7 alpha7nAChR Receptor, alpha-Bungarotoxin Receptor, alpha-Bungarotoxin Receptor, alpha Bungarotoxin alpha-Bungarotoxin Receptor alpha-Bungarotoxin Receptors Receptors, alpha-Bungarotoxin alpha Bungarotoxin Receptors

Below are MeSH descriptors whose meaning is more general than "alpha7 Nicotinic Acetylcholine Receptor".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Carrier Proteins [D12.776.157]
Membrane Transport Proteins [D12.776.157.530]
Ion Channels [D12.776.157.530.400]
Ligand-Gated Ion Channels [D12.776.157.530.400.400]
Cysteine Loop Ligand-Gated Ion Channel Receptors [D12.776.157.530.400.400.100]
Receptors, Nicotinic [D12.776.157.530.400.400.100.500]
alpha7 Nicotinic Acetylcholine Receptor [D12.776.157.530.400.400.100.500.500]
Membrane Proteins [D12.776.543]
Membrane Glycoproteins [D12.776.543.550]
Ion Channels [D12.776.543.550.450]
Ligand-Gated Ion Channels [D12.776.543.550.450.500]
Cysteine Loop Ligand-Gated Ion Channel Receptors [D12.776.543.550.450.500.100]
Receptors, Nicotinic [D12.776.543.550.450.500.100.500]
alpha7 Nicotinic Acetylcholine Receptor [D12.776.543.550.450.500.100.500.500]
Membrane Transport Proteins [D12.776.543.585]
Ion Channels [D12.776.543.585.400]
Ligand-Gated Ion Channels [D12.776.543.585.400.500]
Cysteine Loop Ligand-Gated Ion Channel Receptors [D12.776.543.585.400.500.100]
Receptors, Nicotinic [D12.776.543.585.400.500.100.500]
alpha7 Nicotinic Acetylcholine Receptor [D12.776.543.585.400.500.100.500.500]
Receptors, Cell Surface [D12.776.543.750]
Cysteine Loop Ligand-Gated Ion Channel Receptors [D12.776.543.750.130]
Receptors, Nicotinic [D12.776.543.750.130.687]
alpha7 Nicotinic Acetylcholine Receptor [D12.776.543.750.130.687.500]
Receptors, Neurotransmitter [D12.776.543.750.720]
Receptors, Cholinergic [D12.776.543.750.720.360]
Receptors, Nicotinic [D12.776.543.750.720.360.550]
alpha7 Nicotinic Acetylcholine Receptor [D12.776.543.750.720.360.550.500]

Below are MeSH descriptors whose meaning is related to "alpha7 Nicotinic Acetylcholine Receptor".

Below are MeSH descriptors whose meaning is more specific than "alpha7 Nicotinic Acetylcholine Receptor".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "alpha7 Nicotinic Acetylcholine Receptor" by people in this website by year, and whether "alpha7 Nicotinic Acetylcholine Receptor" was a major or minor topic of these publications.

Bar chart showing 7 publications over 5 distinct years, with a maximum of 2 publications in 2007 and 2016

To see the data from this visualization as text, click here.

Year	Minor Topic	Total
2001	1	1
2003	1	1
2007	2	2
2012	1	1
2016	2	2

Below are the most recent publications written about "alpha7 Nicotinic Acetylcholine Receptor" by people in Profiles.

Hosseinzadeh A, Thompson PR, Segal BH, Urban CF. Nicotine induces neutrophil extracellular traps. J Leukoc Biol. 2016 11; 100(5):1105-1112.

View in: PubMed
Slater CA, Jackson A, Muldoon PP, Dawson A, O'Brien M, Soll LG, Abdullah R, Carroll FI, Tapper AR, Miles MF, Banks ML, Bettinger JC, Damaj IM. Nicotine Enhances the Hypnotic and Hypothermic Effects of Alcohol in the Mouse. Alcohol Clin Exp Res. 2016 Jan; 40(1):62-72.

View in: PubMed
Akbarian S, Kundakovic M. CHRNA7 and CHRFAM7A: psychosis and smoking? Blame the neighbors! Am J Psychiatry. 2015 Nov 01; 172(11):1054-6.

View in: PubMed
Williams NM, Franke B, Mick E, Anney RJ, Freitag CM, Gill M, Thapar A, O'Donovan MC, Owen MJ, Holmans P, Kent L, Middleton F, Zhang-James Y, Liu L, Meyer J, Nguyen TT, Romanos J, Romanos M, Seitz C, Renner TJ, Walitza S, Warnke A, Palmason H, Buitelaar J, Rommelse N, Vasquez AA, Hawi Z, Langley K, Sergeant J, Steinhausen HC, Roeyers H, Biederman J, Zaharieva I, Hakonarson H, Elia J, Lionel AC, Crosbie J, Marshall CR, Schachar R, Scherer SW, Todorov A, Smalley SL, Loo S, Nelson S, Shtir C, Asherson P, Reif A, Lesch KP, Faraone SV. Genome-wide analysis of copy number variants in attention deficit hyperactivity disorder: the role of rare variants and duplications at 15q13.3. Am J Psychiatry. 2012 Feb; 169(2):195-204.

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Ren K, King MA, Liu J, Siemann J, Altman M, Meyers C, Hughes JA, Meyer EM. The alpha7 nicotinic receptor agonist 4OH-GTS-21 protects axotomized septohippocampal cholinergic neurons in wild type but not amyloid-overexpressing transgenic mice. Neuroscience. 2007 Aug 10; 148(1):230-7.

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Ren K, Thinschmidt J, Liu J, Ai L, Papke RL, King MA, Hughes JA, Meyer EM. alpha7 Nicotinic receptor gene delivery into mouse hippocampal neurons leads to functional receptor expression, improved spatial memory-related performance, and tau hyperphosphorylation. Neuroscience. 2007 Mar 02; 145(1):314-22.

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Lester HA, Fonck C, Tapper AR, McKinney S, Damaj MI, Balogh S, Owens J, Wehner JM, Collins AC, Labarca C. Hypersensitive knockin mouse strains identify receptors and pathways for nicotine action. Curr Opin Drug Discov Devel. 2003 Sep; 6(5):633-9.

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Francis MM, Cheng EY, Weiland GA, Oswald RE. Specific activation of the alpha 7 nicotinic acetylcholine receptor by a quaternary analog of cocaine. Mol Pharmacol. 2001 Jul; 60(1):71-9.

View in: PubMed

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