Single agent BMS-911543 Jak2 inhibitor has distinct inhibitory effects on STAT5 signaling in genetically engineered mice with pancreatic cancer.
Mace TA, Shakya R, Elnaggar O, Wilson K, Komar HM, Yang J, Pitarresi JR, Young GS, Ostrowski MC, Ludwig T, Bekaii-Saab T, Bloomston M, Lesinski GB. Single agent BMS-911543 Jak2 inhibitor has distinct inhibitory effects on STAT5 signaling in genetically engineered mice with pancreatic cancer. Oncotarget. 2015 Dec 29; 6(42):44509-22.
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Animals
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Antineoplastic Agents
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Carcinoma, Pancreatic Ductal
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Cell Survival
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Disease Models, Animal
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Dose-Response Relationship, Drug
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Forkhead Transcription Factors
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Genes, BRCA1
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Genes, p53
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Genes, ras
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Genetic Predisposition to Disease
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Heterocyclic Compounds, 3-Ring
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Janus Kinase 2
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Lymphocytes, Tumor-Infiltrating
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Mice, Transgenic
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Molecular Targeted Therapy
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Mutation
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Pancreatic Neoplasms
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Phenotype
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Phosphorylation
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Protein Kinase Inhibitors
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Signal Transduction
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STAT5 Transcription Factor
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Time Factors
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T-Lymphocytes, Regulatory
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Tumor Burden