Altered Runx1 subnuclear targeting enhances myeloid cell proliferation and blocks differentiation by activating a miR-24/MKP-7/MAPK network.
Zaidi SK, Dowdy CR, van Wijnen AJ, Lian JB, Raza A, Stein JL, Croce CM, Stein GS. Altered Runx1 subnuclear targeting enhances myeloid cell proliferation and blocks differentiation by activating a miR-24/MKP-7/MAPK network. Cancer Res. 2009 Nov 01; 69(21):8249-55.
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Blotting, Western
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Cell Differentiation
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Cell Nucleus
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Cell Proliferation
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Chromatin Immunoprecipitation
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Chromosomes, Human, Pair 21
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Chromosomes, Human, Pair 8
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Core Binding Factor Alpha 2 Subunit
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Dual-Specificity Phosphatases
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Granulocytes
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Humans
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Immunoenzyme Techniques
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Interleukin-3
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Leukemia, Myeloid, Acute
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MicroRNAs
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Mitogen-Activated Protein Kinase Phosphatases
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Mitogen-Activated Protein Kinases
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Myeloid Progenitor Cells
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Oncogene Proteins, Fusion
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Reverse Transcriptase Polymerase Chain Reaction
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RNA, Messenger
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RUNX1 Translocation Partner 1 Protein
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Translocation, Genetic