2',5'-Oligoadenylate Synthetase

"2',5'-Oligoadenylate Synthetase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

An enzyme that catalyzes the conversion of ATP into a series of (2'-5') linked oligoadenylates and pyrophosphate in the presence of double-stranded RNA. These oligonucleotides activate an endoribonuclease (RNase L) which cleaves single-stranded RNA. Interferons can act as inducers of these reactions.

Descriptor ID	D015088
MeSH Number(s)	D08.811.913.696.445.625
Concept/Terms	2',5'-Oligoadenylate Synthetase 2',5'-Oligoadenylate Synthetase 2',5' Oligoadenylate Synthetase Synthetase, 2',5'-Oligoadenylate 2,5 Oligoadenylate Polymerase Oligoadenylate Polymerase, 2,5 Polymerase, 2,5 Oligoadenylate 2',5'-Oligoadenylate Polymerase 2',5' Oligoadenylate Polymerase Polymerase, 2',5'-Oligoadenylate (2'-5')An Polymerase ATP-(2'-5')oligo(A)adenylyltransferase 2',5'-Oligo(A) Synthetase 2',5'-Oligo(A) Polymerase 2,5 Oligoadenylate Synthetase Oligoadenylate Synthetase, 2,5 Synthetase, 2,5 Oligoadenylate 2-5A Synthetase

Below are MeSH descriptors whose meaning is more general than "2',5'-Oligoadenylate Synthetase".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Transferases [D08.811.913]
Phosphotransferases [D08.811.913.696]
Nucleotidyltransferases [D08.811.913.696.445]
2',5'-Oligoadenylate Synthetase [D08.811.913.696.445.625]

Below are MeSH descriptors whose meaning is related to "2',5'-Oligoadenylate Synthetase".

Below are MeSH descriptors whose meaning is more specific than "2',5'-Oligoadenylate Synthetase".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "2',5'-Oligoadenylate Synthetase" by people in this website by year, and whether "2',5'-Oligoadenylate Synthetase" was a major or minor topic of these publications.

Bar chart showing 5 publications over 5 distinct years, with a maximum of 1 publications in 2006 and 2010 and 2011 and 2012 and 2021

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2006	0	1	1
2010	0	1	1
2011	0	1	1
2012	0	1	1
2021	1	0	1

Below are the most recent publications written about "2',5'-Oligoadenylate Synthetase" by people in Profiles.

Wickenhagen A, Sugrue E, Lytras S, Kuchi S, Noerenberg M, Turnbull ML, Loney C, Herder V, Allan J, Jarmson I, Cameron-Ruiz N, Varjak M, Pinto RM, Lee JY, Iselin L, Palmalux N, Stewart DG, Swingler S, Greenwood EJD, Crozier TWM, Gu Q, Davies EL, Clohisey S, Wang B, Trindade Maranh?o Costa F, Freire Santana M, de Lima Ferreira LC, Murphy L, Fawkes A, Meynert A, Grimes G, Da Silva Filho JL, Marti M, Hughes J, Stanton RJ, Wang ECY, Ho A, Davis I, Jarrett RF, Castello A, Robertson DL, Semple MG, Openshaw PJM, Palmarini M, Lehner PJ, Baillie JK, Rihn SJ, Wilson SJ. A prenylated dsRNA sensor protects against severe COVID-19. Science. 2021 Oct 29; 374(6567):eabj3624.

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Liu X, Nakamura K, Cheng D, Peng C, Xiao N, Liu Y, Chen L, Rusckowski M, Hnatowich DJ. Her2/neu small interfering RNA delivered in culture by a streptavidin nanoparticle. Curr Drug Deliv. 2012 Jul; 9(4):431-6.

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Bigham AW, Buckingham KJ, Husain S, Emond MJ, Bofferding KM, Gildersleeve H, Rutherford A, Astakhova NM, Perelygin AA, Busch MP, Murray KO, Sejvar JJ, Green S, Kriesel J, Brinton MA, Bamshad M. Host genetic risk factors for West Nile virus infection and disease progression. PLoS One. 2011; 6(9):e24745.

View in: PubMed
Nichani AK, Dar MA, Mirakhur KK, Krieg AM, Booth JS, Townsend HG, Potter AA, Babiuk LA, Mutwiri GK. Subcutaneous, but not intratracheal administration of the TLR9 agonist, CpG DNA transiently reduces parainfluenza-3 virus shedding in newborn lambs. Comp Immunol Microbiol Infect Dis. 2010 Dec; 33(6):e111-7.

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Nichani AK, Dar MA, Krieg AM, Mirakhur KK, Kaushik RS, Griebel PJ, Manuja A, Townsend HG, Babiuk LA, Mutwiri GK. Systemic innate immune responses following intrapulmonary delivery of CpG oligodeoxynucleotides in sheep. Vet Immunol Immunopathol. 2007 Feb 15; 115(3-4):357-68.

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