"Axotomy" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Transection or severing of an axon. This type of denervation is used often in experimental studies on neuronal physiology and neuronal death or survival, toward an understanding of nervous system disease.
| Descriptor ID |
D019771
|
| MeSH Number(s) |
E04.525.210.158
|
| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Axotomy".
Below are MeSH descriptors whose meaning is more specific than "Axotomy".
This graph shows the total number of publications written about "Axotomy" by people in this website by year, and whether "Axotomy" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 0 | 1 | 1 |
| 2004 | 0 | 1 | 1 |
| 2006 | 0 | 1 | 1 |
| 2007 | 0 | 1 | 1 |
| 2008 | 0 | 1 | 1 |
| 2011 | 1 | 0 | 1 |
| 2012 | 0 | 1 | 1 |
| 2018 | 0 | 1 | 1 |
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Below are the most recent publications written about "Axotomy" by people in Profiles.
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Hsu JM, Kang Y, Corty MM, Mathieson D, Peters OM, Freeman MR. Injury-Induced Inhibition of Bystander Neurons Requires dSarm and Signaling from Glia. Neuron. 2021 02 03; 109(3):473-487.e5.
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Peters OM, Lewis EA, Osterloh JM, Weiss A, Salameh JS, Metterville J, Brown RH, Freeman MR. Loss of Sarm1 does not suppress motor neuron degeneration in the SOD1G93A mouse model of amyotrophic lateral sclerosis. Hum Mol Genet. 2018 11 01; 27(21):3761-3771.
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Neukomm LJ, Burdett TC, Seeds AM, Hampel S, Coutinho-Budd JC, Farley JE, Wong J, Karadeniz YB, Osterloh JM, Sheehan AE, Freeman MR. Axon Death Pathways Converge on Axundead to Promote Functional and Structural Axon Disassembly. Neuron. 2017 Jul 05; 95(1):78-91.e5.
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Freeman MR. Signaling mechanisms regulating Wallerian degeneration. Curr Opin Neurobiol. 2014 Aug; 27:224-31.
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Rooney TM, Freeman MR. Drosophila models of neuronal injury. ILAR J. 2014; 54(3):291-5.
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Ziegenfuss JS, Doherty J, Freeman MR. Distinct molecular pathways mediate glial activation and engulfment of axonal debris after axotomy. Nat Neurosci. 2012 Jun 17; 15(7):979-87.
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Osterloh JM, Yang J, Rooney TM, Fox AN, Adalbert R, Powell EH, Sheehan AE, Avery MA, Hackett R, Logan MA, MacDonald JM, Ziegenfuss JS, Milde S, Hou YJ, Nathan C, Ding A, Brown RH, Conforti L, Coleman M, Tessier-Lavigne M, Z?chner S, Freeman MR. dSarm/Sarm1 is required for activation of an injury-induced axon death pathway. Science. 2012 Jul 27; 337(6093):481-4.
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Logan MA, Hackett R, Doherty J, Sheehan A, Speese SD, Freeman MR. Negative regulation of glial engulfment activity by Draper terminates glial responses to axon injury. Nat Neurosci. 2012 Mar 18; 15(5):722-30.
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Avery MA, Rooney TM, Pandya JD, Wishart TM, Gillingwater TH, Geddes JW, Sullivan PG, Freeman MR. WldS prevents axon degeneration through increased mitochondrial flux and enhanced mitochondrial Ca2+ buffering. Curr Biol. 2012 Apr 10; 22(7):596-600.
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Byrne AB, Edwards TJ, Hammarlund M. In vivo laser axotomy in C. elegans. J Vis Exp. 2011 May 19; (51).