25-Hydroxyvitamin D3 1-alpha-Hydroxylase
"25-Hydroxyvitamin D3 1-alpha-Hydroxylase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A mitochondrial cytochrome P450 enzyme that catalyzes the 1-alpha-hydroxylation of 25-hydroxyvitamin D3 (also known as 25-hydroxycholecalciferol) in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP27B1 gene, converts 25-hydroxyvitamin D3 to 1-alpha,25-dihydroxyvitamin D3 which is the active form of VITAMIN D in regulating bone growth and calcium metabolism. This enzyme is also active on plant 25-hydroxyvitamin D2 (ergocalciferol).
| Descriptor ID |
D015090
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| MeSH Number(s) |
D08.244.453.499.500 D08.244.453.915.400 D08.811.682.690.708.170.493.500 D08.811.682.690.708.170.915.400 D12.776.422.220.453.499.500 D12.776.422.220.453.915.400
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| Concept/Terms |
25-Hydroxyvitamin D3 1-alpha-Hydroxylase- 25-Hydroxyvitamin D3 1-alpha-Hydroxylase
- 25 Hydroxyvitamin D3 1 alpha Hydroxylase
- 25-Hydroxycholecalciferol 1-Hydroxylase
- Calcidiol 1-Monooxygenase
- Calcidiol 1 Monooxygenase
- 25-Hydroxyvitamin D(3) 1 alpha-Hydroxylase
- 25-Hydroxyvitamin D 1-alpha-Hydroxylase
- 1-alpha-Hydroxylase, 25-Hydroxyvitamin D
- 25 Hydroxyvitamin D 1 alpha Hydroxylase
- CYP27B1
- Cytochrome P-450 CYP27B1
- Cytochrome P 450 CYP27B1
- 25-Hydroxyergocalciferol 1-alpha-Hydroxylase
- 1-alpha-Hydroxylase, 25-Hydroxyergocalciferol
- 25 Hydroxyergocalciferol 1 alpha Hydroxylase
- 25-Hydroxycholecalciferol-1-Hydroxylase
- 25 Hydroxycholecalciferol 1 Hydroxylase
- 25-Hydroxyvitamin D2 1-hydroxylase
- 1-hydroxylase, 25-Hydroxyvitamin D2
- 25 Hydroxyvitamin D2 1 hydroxylase
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Below are MeSH descriptors whose meaning is more general than "25-Hydroxyvitamin D3 1-alpha-Hydroxylase".
Below are MeSH descriptors whose meaning is more specific than "25-Hydroxyvitamin D3 1-alpha-Hydroxylase".
This graph shows the total number of publications written about "25-Hydroxyvitamin D3 1-alpha-Hydroxylase" by people in this website by year, and whether "25-Hydroxyvitamin D3 1-alpha-Hydroxylase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2010 | 0 | 1 | 1 |
| 2012 | 0 | 1 | 1 |
| 2016 | 1 | 0 | 1 |
| 2023 | 0 | 1 | 1 |
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click here.
Below are the most recent publications written about "25-Hydroxyvitamin D3 1-alpha-Hydroxylase" by people in Profiles.
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Yoon SH, Meyer MB, Arevalo C, Tekguc M, Zhang C, Wang JS, Castro Andrade CD, Strauss K, Sato T, Benkusky NA, Lee SM, Berdeaux R, Foretz M, Sundberg TB, Xavier RJ, Adelmann CH, Brooks DJ, Anselmo A, Sadreyev RI, Rosales IA, Fisher DE, Gupta N, Morizane R, Greka A, Pike JW, Mannstadt M, Wein MN. A parathyroid hormone/salt-inducible kinase signaling axis controls renal vitamin D activation and organismal calcium homeostasis. J Clin Invest. 2023 05 01; 133(9).
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Ide N, Olauson H, Sato T, Densmore MJ, Wang H, Hanai JI, Larsson TE, Lanske B. In?vivo evidence for a limited role of proximal tubular Klotho in renal phosphate handling. Kidney Int. 2016 08; 90(2):348-362.
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Epstein MM, Andr?n O, Kasperzyk JL, Shui IM, Penney KL, Fall K, Rider JR, Stampfer MJ, Andersson SO, Giovannucci E, Mucci LA. Seasonal variation in expression of markers in the vitamin D pathway in prostate tissue. Cancer Causes Control. 2012 Aug; 23(8):1359-66.
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Sharma V, Fretwell D, Crees Z, Kerege A, Klopper JP. Thyroid cancer resistance to vitamin D receptor activation is associated with 24-hydroxylase levels but not the ff FokI polymorphism. Thyroid. 2010 Oct; 20(10):1103-11.