5-Methylcytosine

"5-Methylcytosine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A methylated nucleotide base found in eukaryotic DNA. In ANIMALS, the DNA METHYLATION of CYTOSINE to form 5-methylcytosine is found primarily in the palindromic sequence CpG. In PLANTS, the methylated sequence is CpNpGp, where N can be any base.

Descriptor ID	D044503
MeSH Number(s)	D03.383.742.698.421.500
Concept/Terms	5-Methylcytosine 5-Methylcytosine 5 Methylcytosine 5-Methylcytosine Monohydrochloride 5-Methylcytosine Monohydrochloride 5 Methylcytosine Monohydrochloride Monohydrochloride, 5-Methylcytosine

Below are MeSH descriptors whose meaning is more general than "5-Methylcytosine".

Chemicals and Drugs [D]
Heterocyclic Compounds [D03]
Heterocyclic Compounds, 1-Ring [D03.383]
Pyrimidines [D03.383.742]
Pyrimidinones [D03.383.742.698]
Cytosine [D03.383.742.698.421]
5-Methylcytosine [D03.383.742.698.421.500]

Below are MeSH descriptors whose meaning is related to "5-Methylcytosine".

Below are MeSH descriptors whose meaning is more specific than "5-Methylcytosine".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "5-Methylcytosine" by people in this website by year, and whether "5-Methylcytosine" was a major or minor topic of these publications.

Bar chart showing 11 publications over 8 distinct years, with a maximum of 2 publications in 2011 and 2012 and 2016

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2011	0	2	2
2012	1	1	2
2013	0	1	1
2014	0	1	1
2015	0	1	1
2016	1	1	2
2020	1	0	1
2021	0	1	1

Below are the most recent publications written about "5-Methylcytosine" by people in Profiles.

Yu T, Fan K, ?zata DM, Zhang G, Fu Y, Theurkauf WE, Zamore PD, Weng Z. Long first exons and epigenetic marks distinguish conserved pachytene piRNA clusters from other mammalian genes. Nat Commun. 2021 01 04; 12(1):73.

View in: PubMed
Liu S, de Medeiros MC, Fernandez EM, Zarins KR, Cavalcante RG, Qin T, Wolf GT, Figueroa ME, D'Silva NJ, Rozek LS, Sartor MA. 5-Hydroxymethylation highlights the heterogeneity in keratinization and cell junctions in head and neck cancers. Clin Epigenetics. 2020 11 17; 12(1):175.

View in: PubMed
Zhu X, Dresser K, Chen BJ. Loss of 5-hydroxymethylcytosine immunohistochemical expression is a useful diagnostic aid for distinguishing hepatocellular carcinoma in cytology fine needle aspiration specimens. Cytopathology. 2019 09; 30(5):492-498.

View in: PubMed
Hainer SJ, McCannell KN, Yu J, Ee LS, Zhu LJ, Rando OJ, Fazzio TG. DNA methylation directs genomic localization of Mbd2 and Mbd3 in embryonic stem cells. Elife. 2016 11 16; 5.

View in: PubMed
Magotra M, Sakhdari A, Lee PJ, Tomaszewicz K, Dresser K, Hutchinson LM, Woda BA, Chen BJ. Immunohistochemical loss of 5-hydroxymethylcytosine expression in acute myeloid leukaemia: relationship to somatic gene mutations affecting epigenetic pathways. Histopathology. 2016 Dec; 69(6):1055-1065.

View in: PubMed
Pacis A, Tailleux L, Morin AM, Lambourne J, MacIsaac JL, Yotova V, Dumaine A, Danckaert A, Luca F, Grenier JC, Hansen KD, Gicquel B, Yu M, Pai A, He C, Tung J, Pastinen T, Kobor MS, Pique-Regi R, Gilad Y, Barreiro LB. Bacterial infection remodels the DNA methylation landscape of human dendritic cells. Genome Res. 2015 Dec; 25(12):1801-11.

View in: PubMed
Larson AR, Dresser KA, Zhan Q, Lezcano C, Woda BA, Yosufi B, Thompson JF, Scolyer RA, Mihm MC, Shi YG, Murphy GF, Lian CG. Loss of 5-hydroxymethylcytosine correlates with increasing morphologic dysplasia in melanocytic tumors. Mod Pathol. 2014 Jul; 27(7):936-44.

View in: PubMed
Stembalska A, Leszczynski P, Gil J, Ramsey D, Pitala G, Maciejczyk A, Fraczek M. Global DNA methylation status in laryngeal cancer. Head Neck. 2014 Mar; 36(3):419-24.

View in: PubMed
Morgan GT, Jones P, Bellini M. Association of modified cytosines and the methylated DNA-binding protein MeCP2 with distinctive structural domains of lampbrush chromatin. Chromosome Res. 2012 Dec; 20(8):925-42.

View in: PubMed
Lian CG, Xu Y, Ceol C, Wu F, Larson A, Dresser K, Xu W, Tan L, Hu Y, Zhan Q, Lee CW, Hu D, Lian BQ, Kleffel S, Yang Y, Neiswender J, Khorasani AJ, Fang R, Lezcano C, Duncan LM, Scolyer RA, Thompson JF, Kakavand H, Houvras Y, Zon LI, Mihm MC, Kaiser UB, Schatton T, Woda BA, Murphy GF, Shi YG. Loss of 5-hydroxymethylcytosine is an epigenetic hallmark of melanoma. Cell. 2012 Sep 14; 150(6):1135-46.

View in: PubMed

People

Explore

Similar Concepts

Top Journals